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Article ; Online: Enhancing Spermatogenesis in Non-obstructive Azoospermia through Mesenchymal Stem Cell Therapy.

Margiana, Ria

2024

Abstract: Stem cells hold great promise as novel and encouraging therapeutic tools in the treatment of degenerative disorders due to their differentiation potential while maintaining the capability to self-renewal and their unlimited ability to divide and ... ...

Abstract	Stem cells hold great promise as novel and encouraging therapeutic tools in the treatment of degenerative disorders due to their differentiation potential while maintaining the capability to self-renewal and their unlimited ability to divide and regenerate tissue. A variety of different types of stem cells can be used in cell therapy. Among these, mesenchymal stem cell (MSC) therapy has gradually established itself as a novel method for treating damaged tissues that need restoration and renewal. Male infertility is an important health challenge affecting approximately 8-12% of people around the world. This abnormality can be caused by primary, congenital, acquired, or idiopathic reasons. Men with no sperm in their semen have a condition called azoospermia, caused by non-obstructive (NOA) causes and post-testicular obstructive causes. Accumulating evidence has shown that various types of MSCs can differentiate into germ cells and improve spermatogenesis in the seminiferous tubules of animal models. In addition, recent studies in animal models have exhibited that extracellular vesicles derived from MSCs can stimulate the progression of spermatogenesis and germ cell regeneration in the recipient testes. In spite of the fact that various improvements have been made in the treatment of azoospermia disorder in animal models by MSC or their extracellular vesicles, no clinical trials have been carried out to test their therapeutic effect on the NOA. In this review, we summarize the potential of MSC transplantation for treating infertility caused by NOA.
Language	English
Publishing date	2024-01-12
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2251937-3
ISSN	2212-3946 ; 1574-888X
ISSN (online)	2212-3946
ISSN	1574-888X
DOI	10.2174/011574888X283311231226081845
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Zs.A 6399: Show issues

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Article ; Online: Mesenchymal stem cell-derived exosomes in preeclampsia: A next-generation therapeutic tool.

Margiana, Ria

Cell biochemistry and function

2024 Volume 42, Issue 1, Page(s) e3908

Abstract: Preeclampsia (PE) is a major gestational disorder that causes both long- and short-term damage to both the mother and the fetus. Endometrium decidualization and the formation of the placenta are orchestrated by mesenchymal stem cells (MSCs). MSCs ... ...

Abstract	Preeclampsia (PE) is a major gestational disorder that causes both long- and short-term damage to both the mother and the fetus. Endometrium decidualization and the formation of the placenta are orchestrated by mesenchymal stem cells (MSCs). MSCs obtained from patients with PE exhibit an elevated rate of aging and apoptosis, which impairs the interplay between MSCs and endothelium, trophoblast, and immune cells in the placenta, accelerating the onset of PE. Preclinical and clinical evidence imply that the MSC-based therapy approach for PE is prospective. Importantly, as a novel cell-free approach, MSC-derived exosomes can improve symptoms and maternal-fetal survival in PE models by raising cell metabolism, encouraging angiogenesis balance, and regulating immune responses. Even following allogeneic administration, the likelihood of immune rejection is very limited as a result of the small quantity of exosome membrane-bound proteins. Furthermore, because exosomes do not expand, developing tumors is not probable. As a result, MSC-derived exosomes show superiority over MSCs in terms of safety. For the first time, we outline the properties of MSC-exosomes and highlight their functions and potential as a new paradigm for PE therapy in this review.
MeSH term(s)	Female ; Pregnancy ; Humans ; Exosomes ; Pre-Eclampsia/therapy ; Prospective Studies ; Aging ; Membrane Proteins ; Mesenchymal Stem Cells
Chemical Substances	Membrane Proteins
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	283643-9
ISSN	1099-0844 ; 0263-6484
ISSN (online)	1099-0844
ISSN	0263-6484
DOI	10.1002/cbf.3908
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Zs.A 1994: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: The comparison of decrease in mice mass preserved with formalin 4% and neutralize with sodium bicarbonate.

Evelyn, Florencia / Margiana, Ria

Anatomy & cell biology

2022 Volume 55, Issue 4, Page(s) 459–466

Abstract: Anatomy studies require cadavers to study the human body. Generally in Indonesia, the dead human body will be buried. This causes problems because the decomposition process of a cadaver that is preserved with formalin will be delayed and it causes ... ...

Abstract	Anatomy studies require cadavers to study the human body. Generally in Indonesia, the dead human body will be buried. This causes problems because the decomposition process of a cadaver that is preserved with formalin will be delayed and it causes environmental pollution. The toxicity of formalin can be reduced by neutralizing the formalin. This study aimed to compare the decrease of mice mass that were preserved with formalin then neutralized with sodium bicarbonate and those that were not neutralized. This study used 18 mice (Mus musculus) which were divided into 3 groups. They were the control group (not given preservative), group preserved with 4% formalin, and group preserved with 4% formalin then neutralized with sodium bicarbonate. All groups of mice were buried for 6 weeks. The changes in mass were assessed with an analysis of the percentage loss in mass. Based on the results of this study, the formalin group had a greater percentage of total mass reduction than the neutralize group. The formalin group had a higher decomposition rate than the neutralizing sodium bicarbonate group. The effectiveness of reducing the concentration of formalin is similar with neutralize group. Therefore, it can be concluded that 4% formalin is recommended for use to accelerate the occurrence of decay and decrease in mass.
Language	English
Publishing date	2022-10-19
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2590173-4
ISSN	2093-3673 ; 2093-3665
ISSN (online)	2093-3673
ISSN	2093-3665
DOI	10.5115/acb.21.232
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Article ; Online: Exploring the future potential of mesenchymal stem/stromal cells and their derivatives to support assisted reproductive technology for female infertility applications.

Rizano, Andrew / Margiana, Ria / Supardi, Supardi / Narulita, Pety

Human cell

2023 Volume 36, Issue 5, Page(s) 1604–1619

Abstract: Women's infertility impacts the quality of life of both patients and couples and has multifaceted dimensions that increase the number of challenges associated with female infertility and how to face them. Female reproductive disorders, such as premature ... ...

Abstract	Women's infertility impacts the quality of life of both patients and couples and has multifaceted dimensions that increase the number of challenges associated with female infertility and how to face them. Female reproductive disorders, such as premature ovarian failure (POF), endometriosis, Asherman syndrome (AS), polycystic ovary syndrome (PCOS), and preeclampsia, can stimulate infertility. In the last decade, translational medicine has advanced, and scientists are focusing on infertility therapy with innovative attitudes. Recent investigations have suggested that stem cell treatments could be safe and effective. Stem cell therapy has established a novel method for treating women's infertility as part of a regeneration approach. The chief properties and potential of mesenchymal stem/stromal cells (MSCs) in the future of women's infertility should be considered by researchers. Due to their high abundance, great ability to self-renew, and high differentiation capacity, as well as less ethical concerns, MSC-based therapy has been found to be an effective alternative strategy to the previous methods for treating female infertility, such as intrauterine insemination, in vitro fertilization, medicines, and surgical procedures. These types of stem cells exert their beneficial role by releasing active mediators, promoting cell homing, and contributing to immune modulation. Here we first provide an overview of MSCs and their crucial roles in both biological and immunological processes. The next large chapter covers current preclinical and clinical studies on the application of MSCs to treat various female reproductive disorders. Finally, we deliberate on the extant challenges that hinder the application of MSCs in female infertility and suggest plausible measures to alleviate these impediments.
MeSH term(s)	Pregnancy ; Humans ; Female ; Infertility, Female/therapy ; Quality of Life ; Reproductive Techniques, Assisted ; Fertilization in Vitro/methods ; Mesenchymal Stem Cells ; Mesenchymal Stem Cell Transplantation
Language	English
Publishing date	2023-07-05
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1149134-6
ISSN	1749-0774 ; 0914-7470
ISSN (online)	1749-0774
ISSN	0914-7470
DOI	10.1007/s13577-023-00941-3
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Zs.A 3676: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Analyzing the factors that contribute to the development of embryological classical type of bladder exstrophy.

Margiana, Ria / Juwita, Widya / Ima, Khoirul / Faizah, Zakiyatul / Supardi, Supardi

Anatomy & cell biology

2023 Volume 56, Issue 4, Page(s) 421–427

Abstract: Bladder exstrophy is a rare congenital condition of the pelvis, bladder, and lower abdomen that opens the bladder against the abdominal wall, produces aberrant growth, short penis, upward curvature during erection, wide penis, and undescended testes. ... ...

Abstract	Bladder exstrophy is a rare congenital condition of the pelvis, bladder, and lower abdomen that opens the bladder against the abdominal wall, produces aberrant growth, short penis, upward curvature during erection, wide penis, and undescended testes. Exstrophy affects 1/30,000 newborns. The bladder opens against the abdominal wall in bladder exstrophy, a rare genitourinary condition. This study is vital to provide appropriate therapy choices as a basis to improve patient outcomes. This study may explain bladder exstrophy and provide treatment. Epispadias, secretory placenta, cloacal exstrophy, and other embryonic abnormalities comprise the exstrophy-spades complex. The mesenchymal layer does not migrate from the ectoderm and endoderm layers in the first trimester, affecting the cloacal membrane. Embryological problems define the exstrophy-aspidistra complex, which resembles epimedium, classic bladder, cloacal exstrophy, and other diseases. Urogenital ventral body wall anomalies expose the bladder mucosa, causing bladder exstrophy. Genetic mutations in the Hedgehog cascade pathway, Wnt signal, FGF, BMP4, Alx4, Gli3, and ISL1 cause ventral body wall closure and urinary bladder failure. External factors such as high maternal age, smoking moms, and high maternal body mass index have also been associated to bladder exstrophy. Valproic acid increases bladder exstrophy risk; chemicals and pollutants during pregnancy may increase bladder exstrophy risk. Bladder exstrophy has no identified cause despite these risk factors. Exstrophy reconstruction seals the bladder, improves bowel function, reconstructs the vaginal region, and restores urination.
Language	English
Publishing date	2023-08-31
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2590173-4
ISSN	2093-3673 ; 2093-3665
ISSN (online)	2093-3673
ISSN	2093-3665
DOI	10.5115/acb.23.056
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Article ; Online: Current Progress in Stem Cell Therapy for Male Infertility.

Adriansyah, Rajendra Falah / Margiana, Ria / Supardi, Supardi / Narulita, Pety

Stem cell reviews and reports

2023 Volume 19, Issue 7, Page(s) 2073–2093

Abstract: Infertility has become one of the most common issues worldwide, which has negatively affected society and infertile couples. Meanwhile, male infertility is responsible for about 50% of infertility. Accordingly, a great number of researchers have focused ... ...

Abstract	Infertility has become one of the most common issues worldwide, which has negatively affected society and infertile couples. Meanwhile, male infertility is responsible for about 50% of infertility. Accordingly, a great number of researchers have focused on its treatment during the last few years; however, current therapies such as assisted reproductive technology (ART) are not effective enough in treating male infertility. Because of their self-renewal and differentiation capabilities and unlimited sources, stem cells have recently raised great hope in the treatment of reproductive system disorders. Stem cells are undifferentiated cells that can induce different numbers of specific cells, such as male and female gametes, demonstrating their potential application in the treatment of infertility. The present review aimed at identifying the causes and potential factors that influence male fertility. Besides, we highlighted the recent studies that investigated the efficiency of stem cells such as spermatogonial stem cells (SSCs), embryonic stem cells (ESCs), very small embryonic-like stem cells (VSELs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs) in the treatment of various types of male infertility.
MeSH term(s)	Male ; Humans ; Female ; Infertility, Male/therapy ; Infertility, Male/metabolism ; Embryonic Stem Cells ; Stem Cell Transplantation ; Cell Differentiation ; Induced Pluripotent Stem Cells
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-023-10577-3
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Zs.A 6198: Show issues

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Article ; Online: A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application.

Margiana, Ria / Pakpahan, Cennikon / Pangestu, Mulyoto

F1000Research

2022 Volume 11, Page(s) 552

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Germ Cells ; Humans ; Infertility, Male ; Male ; Observational Studies as Topic ; Spermatogenesis/physiology ; Spermatozoa ; Tretinoin/metabolism ; Tretinoin/pharmacology
Chemical Substances	Tretinoin (5688UTC01R)
Language	English
Publishing date	2022-05-20
Publishing country	England
Document type	Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.110510.2
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Article ; Online: Dietary Soybean (Glycine max (L.) Merr.) Improved the ZP2 Expression in Female Swiss Mice.

Margiana, Ria / Lestari, Silvia Werdhy / Alawiyah, Kamila / Narulita, Pety / Jusuf, Ahmad Aulia / Ima, Khoirul

JBRA assisted reproduction

2023 Volume 27, Issue 2, Page(s) 147–155

Abstract: Objective: This study aimed to determine the effects of soybean (Glycine max) administration on ZP2 expression in female mice.: Methods: This research used Mus musculus, six-week-old female SWISS strain mice divided into three groups (group without ... ...

Abstract	Objective: This study aimed to determine the effects of soybean (Glycine max) administration on ZP2 expression in female mice. Methods: This research used Mus musculus, six-week-old female SWISS strain mice divided into three groups (group without soybean administration and groups with mixed feed with soybeans and pelleted 50:50 and 25:75). Soybean feed for mice was 360 grams per kilogram of mouse body weight for 2 weeks. The percentage of follicles was measured and analyzed using Hematoxylin-Eosin staining, and the expression of ZP2 was analyzed using immunohistochemistry. We assessed the data using one-way ANOVA and paired t-test using the SPSS 17. Results: Some of the follicles in the ovaries do not develop until their final stage of follicle maturation. The administration of soybean before and after treatment in all groups was not significantly different, but the numbers of atretic follicles in groups 1 and 2 were significantly different. Soybean administration at a ratio of 50:50 has the effect of increasing the percentage of the ZP2 expression in tertiary follicles (p=0.001), whereas soybean administration at a ratio of 25:75 was not able to maintain or increase the formation of ZP2 in tertiary follicles (p=0.77). Conclusion: Soybean administration with a ratio of 50:50 significantly increased the percentage of the ZP2 expression in tertiary follicles.
MeSH term(s)	Animals ; Female ; Mice ; Glycine max ; Ovary ; Ovarian Follicle
Language	English
Publishing date	2023-06-22
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2856226-4
ISSN	1518-0557 ; 1517-5693
ISSN (online)	1518-0557
ISSN	1517-5693
DOI	10.5935/1518-0557.20220020
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Article: Comparison of decomposition rate of hind limbs of preserved mice with ethanol-glycerin and formaldehyde of advanced fixative solution.

Wijaya, Amanda Natalie / Margiana, Ria / Kusumaningtyas, Sasanthy / Furqonita, Deswaty

Anatomy & cell biology

2021 Volume 54, Issue 2, Page(s) 225–231

Abstract: Learning anatomy in medical school is still closely based on the use of cadavers. The burial of preserved cadaver poses a problem, specifically, it contaminates the soil with formalin. Many studies have been conducted to find an alternative fixative to ... ...

Abstract	Learning anatomy in medical school is still closely based on the use of cadavers. The burial of preserved cadaver poses a problem, specifically, it contaminates the soil with formalin. Many studies have been conducted to find an alternative fixative to update or modify formalin usage. One of them is ethanol-glycerin (EG), which suggests promising results. Despite that fact, there has yet to be any research comparing the decomposition rate between EG and formalin. This study is conducted to compare the rate of decomposition between the two fixative solutions, EG and 4% formalin on the hind limb of mice. The mice were first preserved using a standard primary fixative solution which is 10% formalin, following that procedure is preservation using advanced fixative solution, EG or 4% formalin. Upon completing the preservation steps, the mice were buried for 6 weeks and observed weekly. The stages of decomposition were assessed semi-quantitatively depending on its appearance. The hind limbs of mice that were fixed with EG solution managed to reach the last stage of decomposition, dry & remains, while the 4% formalin group of mice still remained in the previous stage, advanced decay. It is concluded that the mice hind limbs that have been previously preserved with EG advanced fixative solution has a faster decomposition rate compared to 4% formalin.
Language	English
Publishing date	2021-05-04
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2590173-4
ISSN	2093-3673 ; 2093-3665
ISSN (online)	2093-3673
ISSN	2093-3665
DOI	10.5115/acb.20.314
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Article ; Online: The Association Between Lipid Serum and Semen Parameters: a Systematic Review.

Pakpahan, Cennikon / Rezano, Andri / Margiana, Ria / Amanda, Bella / Agustinus, Agustinus / Darmadi, Darmadi

Reproductive sciences (Thousand Oaks, Calif.)

2022 Volume 30, Issue 3, Page(s) 761–771

Abstract: Increased lipid levels sometimes not only affect sexual function but also are considered to harm semen quality. It is often a suspicion that elevated lipids are a factor in infertility. We conduct a systematic review. Articles that met the criteria were ... ...

Abstract	Increased lipid levels sometimes not only affect sexual function but also are considered to harm semen quality. It is often a suspicion that elevated lipids are a factor in infertility. We conduct a systematic review. Articles that met the criteria were identified according to The Preferred Reporting Items for Systematic Review and Meta-analysis of recommendations in the PubMed, ProQuest, EBSCO, Web of Science Wiley Online, Springer Link, Scopus, and Science Direct databases with no time restriction for publication. Seven studies are eligible for qualitative analysis from nine studies that have the potential to be assessed. These studies measure the correlation of serum lipids (VLDL, HDL, LDL, triglycerides, total cholesterol, free cholesterol, phospholipids, free fatty acids) with semen parameters (concentration, motility, morphology, DNA fragmentation index). Although not all studies consistently report that lipids impact semen quality, this review suspects that lipids have a significant impact on sperm quality. This study implies that it is necessary to maintain lipid levels to maintain sperm quality and quality of life. However, further investigation with an observational cohort study design needs to be carried out to assess the effect of lipids on semen quality more precisely for the promotion of reproductive health care.
MeSH term(s)	Humans ; Male ; Cholesterol/adverse effects ; Cholesterol/blood ; Infertility, Male/blood ; Infertility, Male/etiology ; Quality of Life ; Semen/physiology ; Semen Analysis ; Sperm Count ; Sperm Motility ; Spermatozoa/physiology ; Triglycerides/adverse effects ; Triglycerides/blood ; Lipids/adverse effects ; Lipids/blood ; Hyperlipidemias/blood ; Hyperlipidemias/complications
Chemical Substances	Cholesterol (97C5T2UQ7J) ; Triglycerides ; Lipids
Language	English
Publishing date	2022-07-28
Publishing country	United States
Document type	Systematic Review ; Meta-Analysis ; Journal Article ; Review
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-022-01040-8
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