Result 1 - 10 of total 556
Multiple Sclerosis Journal - Experimental, Translational and Clinical
| Keywords | covid19 |
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| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #881049 |
| Database | COVID19 |
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2023 Volume 13, Issue 1, Page(s) 264
Abstract: Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of mood, affect, and behavior and abnormalities affecting cognition. Among these conditions, clinical depression, anxiety and neurocognitive disorders are the most common ... ...
| Abstract | Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of mood, affect, and behavior and abnormalities affecting cognition. Among these conditions, clinical depression, anxiety and neurocognitive disorders are the most common in multiple sclerosis (MS), with a substantial impact on patients' quality of life and adherence to treatments. Such manifestations may occur from the earliest phases of the disease but become more frequent in MS patients with a progressive disease course and more severe clinical disability. Although the pathogenesis of these neuropsychiatric manifestations has not been fully defined yet, brain structural and functional abnormalities, consistently observed with magnetic resonance imaging (MRI), together with genetic and immunologic factors, have been suggested to be key players. Even though the detrimental clinical impact of such manifestations in MS patients is a matter of crucial importance, at present, they are often overlooked in the clinical setting. Moreover, the efficacy of pharmacologic and non-pharmacologic approaches for their amelioration has been poorly investigated, with the majority of studies showing marginal or no beneficial effect of different therapeutic approaches, possibly due to the presence of multiple and heterogeneous underlying pathological mechanisms and intrinsic methodological limitations. A better evaluation of these manifestations in the clinical setting and improvements in the understanding of their pathophysiology may offer the potential to develop tools for differentiating these mechanisms in individual patients and ultimately provide a principled basis for treatment selection. This review provides an updated overview regarding the pathophysiology of the most common neuropsychiatric symptoms in MS, the clinical and MRI characteristics that have been associated with mood disorders (i.e., depression and anxiety) and cognitive impairment, and the treatment approaches currently available or under investigation. |
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| MeSH term(s) | Humans ; Depression/etiology ; Multiple Sclerosis/complications ; Multiple Sclerosis/therapy ; Quality of Life/psychology ; Anxiety/complications ; Anxiety/psychology ; Cognitive Dysfunction/therapy ; Cognitive Dysfunction/complications |
| Language | English |
| Publishing date | 2023-07-19 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 2609311-X |
| ISSN | 2158-3188 ; 2158-3188 |
| ISSN (online) | 2158-3188 |
| ISSN | 2158-3188 |
| DOI | 10.1038/s41398-023-02555-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Multiple sclerosis journal - experimental, translational and clinical
2020 Volume 6, Issue 4, Page(s) 2055217320966346
| Keywords | covid19 |
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| Language | English |
| Publishing date | 2020-10-12 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2841884-0 |
| ISSN | 2055-2173 ; 2055-2173 |
| ISSN (online) | 2055-2173 |
| ISSN | 2055-2173 |
| DOI | 10.1177/2055217320966346 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2021 Volume 12, Page(s) 676095
Abstract: Treatment of pediatric-onset multiple sclerosis (POMS) has been tailored after observational studies and data obtained from clinical trials in adult-onset multiple sclerosis (AOMS) patients. There are an increasing number of new therapeutic agents for ... ...
| Abstract | Treatment of pediatric-onset multiple sclerosis (POMS) has been tailored after observational studies and data obtained from clinical trials in adult-onset multiple sclerosis (AOMS) patients. There are an increasing number of new therapeutic agents for AOMS, and many will be formally studied for use also in POMS. However, there are important efficacy and safety concerns regarding the use of these therapies in children and young adults. This review will discuss the current state of the art of POMS therapy and will focus on the newer therapies (oral and infusion disease-modifying drugs) and on those still currently under investigation. |
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| Language | English |
| Publishing date | 2021-05-17 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2564214-5 |
| ISSN | 1664-2295 |
| ISSN | 1664-2295 |
| DOI | 10.3389/fneur.2021.676095 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2024
Abstract: In multiple sclerosis (MS), a non-random and clinically relevant pattern of gray matter (GM) volume loss has been described. Whether differences in regional gene expression might underlay distinctive pathological processes contributing to this regional ... ...
| Abstract | In multiple sclerosis (MS), a non-random and clinically relevant pattern of gray matter (GM) volume loss has been described. Whether differences in regional gene expression might underlay distinctive pathological processes contributing to this regional variability has not been explored yet. Two hundred eighty-six MS patients and 172 healthy controls (HC) underwent a brain 3T MRI, a complete neurological evaluation and a neuropsychological assessment. Using Allen Human Brain Atlas, voxel-based morphometry and MENGA platform, we integrated brain transcriptome and neuroimaging data to explore the spatial cross-correlations between regional GM volume loss and expressions of 2710 genes involved in MS (p < 0.05, family-wise error-corrected). Enrichment analyses were performed to evaluate overrepresented molecular functions, biological processes and cellular components involving genes significantly associated with voxel-based morphometry-derived GM maps (p < 0.05, Bonferroni-corrected). A diffuse GM volume loss was found in MS patients compared to HC and it was spatially correlated with 74 genes involved in GABA neurotransmission and mitochondrial oxidoreductase activity mainly expressed in neurons and astrocytes. A more severe GM volume loss was spatially associated, in more disabled MS patients, with 44 genes involved in mitochondrial integrity of all resident cells of the central nervous system (CNS) and, in cognitively impaired MS patients, with 64 genes involved in mitochondrial protein heterodimerization and oxidoreductase activities expressed also in microglia and endothelial cells. Specific differences in the expressions of genes involved in synaptic GABA receptor activities and mitochondrial functions in resident CNS cells may influence regional susceptibility to MS-related excitatory/inhibitory imbalance and oxidative stress, and subsequently, to GM volume loss. |
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| Language | English |
| Publishing date | 2024-02-07 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1330655-8 |
| ISSN | 1476-5578 ; 1359-4184 |
| ISSN (online) | 1476-5578 |
| ISSN | 1359-4184 |
| DOI | 10.1038/s41380-024-02452-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4812: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Expert review of neurotherapeutics
2022 Volume 22, Issue 5, Page(s) 393–403
Abstract: Introduction: Pediatric-onset (PO) multiple sclerosis (MS) accounts for about 2-10% of the total MS cases. Recently, a greater attention has been given to POMS, with substantial improvements in the understanding of its pathophysiology, in the diagnostic ...
| Abstract | Introduction: Pediatric-onset (PO) multiple sclerosis (MS) accounts for about 2-10% of the total MS cases. Recently, a greater attention has been given to POMS, with substantial improvements in the understanding of its pathophysiology, in the diagnostic work-up and in the identification of reliable prognosticators associated with long-term disability in these patients. Areas covered: This review summarizes the most recent updates regarding the pathophysiology of POMS, the current diagnostic criteria and the clinical, neuroradiological and laboratoristic markers that have been associated with disease progression (i.e. occurrence of a second clinical attack at disease onset and accumulation of disability in definite MS). Expert opinion: The study of POMS, where the clinical onset is closer to the biological onset of MS, may contribute to better understand how the different pathological processes impact brain maturation and contribute to disease progression, but also how brain plasticity may counterbalance structural damage accumulation. Although rare, POMS is a severe disease, characterized by a prominent clinical and radiological activity at disease onset and by the accumulation of physical and cognitive disability at a younger age compared to the adult counterpart, with significant detrimental consequences at long-term. Early and accurate diagnosis, together with early treatment, is highly warranted. |
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| MeSH term(s) | Adult ; Age of Onset ; Child ; Disabled Persons ; Disease Progression ; Humans ; Multiple Sclerosis/drug therapy |
| Language | English |
| Publishing date | 2022-04-13 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 2112534-X |
| ISSN | 1744-8360 ; 1473-7175 |
| ISSN (online) | 1744-8360 |
| ISSN | 1473-7175 |
| DOI | 10.1080/14737175.2022.2064743 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6155: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2019 Volume 337, Page(s) 577051
Abstract: We describe the case of a man with a very-late onset neuromyelitis optica spectrum disorder syndrome (NMOSD) who was initially diagnosed as recurrent antiphospholipid syndrome-associated myelitis. This case illustrates that a puzzle of autoreactive ... ...
| Abstract | We describe the case of a man with a very-late onset neuromyelitis optica spectrum disorder syndrome (NMOSD) who was initially diagnosed as recurrent antiphospholipid syndrome-associated myelitis. This case illustrates that a puzzle of autoreactive antibodies can be detected in patients having neurological syndromes belonging to the NMOSD. Prompt identification and timely immunosuppression prevent relapses and the accumulation of irreversible disability. |
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| MeSH term(s) | Aged ; Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnostic imaging ; Autoimmunity/physiology ; Humans ; Late Onset Disorders/blood ; Late Onset Disorders/complications ; Late Onset Disorders/diagnostic imaging ; Male ; Neuromyelitis Optica/blood ; Neuromyelitis Optica/complications ; Neuromyelitis Optica/diagnostic imaging ; Recurrence |
| Language | English |
| Publishing date | 2019-09-04 |
| Publishing country | Netherlands |
| Document type | Case Reports ; Journal Article |
| ZDB-ID | 8335-5 |
| ISSN | 1872-8421 ; 0165-5728 |
| ISSN (online) | 1872-8421 |
| ISSN | 0165-5728 |
| DOI | 10.1016/j.jneuroim.2019.577051 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1646: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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2024
Abstract: Background: Fatigue is frequent in people with multiple sclerosis (pwMS) impacting physical and cognitive functions. Lower aerobic capacity and regional thalamic volume may be involved in the pathophysiology of fatigue in pwMS.: Objectives: To ... ...
| Abstract | Background: Fatigue is frequent in people with multiple sclerosis (pwMS) impacting physical and cognitive functions. Lower aerobic capacity and regional thalamic volume may be involved in the pathophysiology of fatigue in pwMS. Objectives: To identify associations between thalamic nuclei volumes, aerobic capacity and fatigue and to investigate whether the influence of aerobic capacity on fatigue in pwMS is mediated by thalamic integrity. Methods: Eighty-three pwMS underwent a clinical evaluation with assessment of fatigue (Modified Fatigue Impact Scale [MFIS]), including physical (pMFIS) and cognitive (cMFIS) components, and peak of oxygen uptake (VO2peak). PwMS and 63 sex- and age-matched healthy controls (HC) underwent a 3 T brain MRI to quantify volume of the whole thalamus and its nuclei. Results: Compared to HC, pwMS showed higher global MFIS, pMFIS and cMFIS scores, and lower VO2peak and thalamic volumes (p < 0.001). In pwMS, higher VO2peak was significantly associated with lower MFIS and pMFIS scores (r value = - 0.326 and - 0.356; pFDR ≤ 0.046) and higher laterodorsal thalamic nucleus (Dor) cluster volume (r value = 0.300; pFDR = 0.047). Moreover, lower Dor thalamic cluster volume was significantly associated with higher MFIS, pMFIS and cMFIS scores (r value range = - 0.305; - 0.293; pFDR ≤ 0.049). The volume of Dor thalamic cluster partially mediated the positive effects of VO2peak on both MFIS and cMFIS, with relative indirect effects of 21% and 32% respectively. No mediation was found for pMFIS. Conclusions: Higher VO2peak is associated with lower fatigue in pwMS, likely acting on Dor thalamic cluster volume integrity. Such an effect might be different according to the type of fatigue (cognitive or physical). |
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| Language | English |
| Publishing date | 2024-03-20 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 187050-6 |
| ISSN | 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X |
| ISSN (online) | 1432-1459 |
| ISSN | 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X |
| DOI | 10.1007/s00415-024-12277-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ui II Zs.40: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2024
Abstract: Objective: The aim of this study was to investigate whether, compared to pediatric healthy controls (HCs), the glymphatic system is impaired in pediatric multiple sclerosis (MS) patients according to their cognitive status, and to assess its association ...
| Abstract | Objective: The aim of this study was to investigate whether, compared to pediatric healthy controls (HCs), the glymphatic system is impaired in pediatric multiple sclerosis (MS) patients according to their cognitive status, and to assess its association with clinical disability and MRI measures of brain structural damage. Methods: Sixty-five pediatric MS patients (females = 62%; median age = 15.5 [interquartile range, IQR = 14.5;17.0] years) and 23 age- and sex-matched HCs (females = 44%; median age = 14.1 [IQR = 11.8;16.2] years) underwent neurological, neuropsychological and 3.0 Tesla MRI assessment, including conventional and diffusion tensor imaging (DTI). We calculated the diffusion along the perivascular space (DTI-ALPS) index, a proxy of glymphatic function. Cognitive impairment (Co-I) was defined as impairment in at least 2 cognitive domains. Results: No significant differences in DTI-ALPS index were found between HCs and cognitively preserved (Co-P) pediatric MS patients (estimated mean difference [EMD] = -0.002 [95% confidence interval = -0.069; 0.065], FDR-p = 0.956). Compared to HCs and Co-P patients, Co-I pediatric MS patients (n = 20) showed significantly lower DTI-ALPS index (EMD = -0.136 [95% confidence interval = -0.214; -0.058], FDR-p ≤ 0.004). In HCs, no associations were observed between DTI-ALPS index and normalized brain, cortical and thalamic volumes, and normal-appearing white matter (NAWM) fractional anisotropy (FA) and mean diffusivity (MD) (FDR-p ≥ 0.348). In pediatric MS patients, higher brain WM lesion volume (LV), higher NAWM MD, lower normalized thalamic volume, and lower NAWM FA were associated with lower DTI-ALPS index (FDR-p ≤ 0.016). Random Forest selected lower DTI-ALPS index (relative importance [RI] = 100%), higher brain WM LV (RI = 59.5%) NAWM MD (RI = 57.1%) and intelligence quotient (RI = 51.3%) as informative predictors of cognitive impairment (out-of-bag area under the curve = 0.762). Interpretation: Glymphatic system dysfunction occurs in pediatric MS, is associated with brain focal lesions, irreversible tissue loss accumulation and cognitive impairment. ANN NEUROL 2024. |
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| Language | English |
| Publishing date | 2024-03-13 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 80362-5 |
| ISSN | 1531-8249 ; 0364-5134 |
| ISSN (online) | 1531-8249 |
| ISSN | 0364-5134 |
| DOI | 10.1002/ana.26911 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1370: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 478: Show issues |
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2024
Abstract: Dysregulation of monoaminergic networks might have a role in the pathogenesis of fatigue in multiple sclerosis (MS). We investigated longitudinal changes of resting state (RS) functional connectivity (FC) in monoaminergic networks and their association ... ...
| Abstract | Dysregulation of monoaminergic networks might have a role in the pathogenesis of fatigue in multiple sclerosis (MS). We investigated longitudinal changes of resting state (RS) functional connectivity (FC) in monoaminergic networks and their association with the development of fatigue in MS. Eighty-nine MS patients and 49 age- and sex-matched healthy controls (HC) underwent neurological, fatigue, and RS functional MRI assessment at baseline and after a median follow-up of 1.3 years (interquartile range = 1.01-2.01 years). Monoaminergic-related RS FC was estimated with an independent component analysis constrained to PET atlases for dopamine (DA), noradrenaline (NA), and serotonin (5-HT) transporters. At baseline, 24 (27%) MS patients were fatigued (F) and 65 were not fatigued (NF). Of these, 22 (34%) developed fatigue (DEV-FAT) at follow-up and 43 remained not fatigued (NO-FAT). At baseline, F-MS patients showed increased monoaminergic-related RS FC in the caudate nucleus vs NF-MS and in the hippocampal, postcentral, temporal, and occipital cortices vs NF-MS and HC. Moreover, F-MS patients exhibited decreased RS FC in the frontal cortex vs NF-MS and HC, and in the thalamus vs NF-MS. During the follow-up, no RS FC changes were observed in HC. NO-FAT patients showed limited DA-related RS FC modifications, whereas DEV-FAT MS patients showed increased DA-related RS FC in the left hippocampus, significant at time-by-group interaction analysis. In the NA-related network, NO-FAT patients showed decreased RS FC over time in the left superior frontal gyrus. This region showed increased RS FC in both DEV-FAT and F-MS patients; this divergent behavior was significant at time-by-group interaction analysis. Finally, DEV-FAT MS patients presented increased 5-HT-related RS FC in the angular and middle occipital gyri, while this latter region showed decreased 5-HT-related RS FC during the follow-up in F-MS patients. In MS patients, distinct patterns of alterations were observed in monoaminergic networks based on their fatigue status. Fatigue was closely linked to specific changes in the basal ganglia and hippocampal, superior frontal, and middle occipital cortices. |
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| Language | English |
| Publishing date | 2024-03-25 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1330655-8 |
| ISSN | 1476-5578 ; 1359-4184 |
| ISSN (online) | 1476-5578 |
| ISSN | 1359-4184 |
| DOI | 10.1038/s41380-024-02532-6 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4812: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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