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  1. Article ; Online: Primary Rectal Tumor With Extensive Choriocarcinoma Differentiation in a Woman With Lung, Liver and Disseminated Peritoneal Disease: A Primary Rectal Adenocarcinoma With Extensive Choriocarcinoma Differentiation or Primary Rectal Choriocarcinoma?

    Machado, Isidro / Martínez La Piedra, María Del Carmen / Martínez de Juan, Fernando / de Alcántara, Fernanda-Maia / Claramunt, Reyes / López-Guerrero, José Antonio / Marhuenda, Ana / Melian, Marcos

    International journal of surgical pathology

    2023  , Page(s) 10668969231204956

    Abstract: Primary rectal adenocarcinoma with extensive choriocarcinomatous differentiation is a rare neoplasm, with only sporadic cases reported worldwide. The prognosis is typically poor, and no standard therapy has been established for this tumor. We report a ... ...

    Abstract Primary rectal adenocarcinoma with extensive choriocarcinomatous differentiation is a rare neoplasm, with only sporadic cases reported worldwide. The prognosis is typically poor, and no standard therapy has been established for this tumor. We report a case of a 63-year-old woman who presented with lower abdominal and pelvic discomfort, as well as rectal bleeding. Endoscopy revealed a rectal tumor. She was diagnosed with primary rectal adenocarcinoma with extensive choriocarcinomatous differentiation, accompanied by liver metastasis and peritoneal carcinomatosis. The immunohistochemical profile demonstrated strong and diffuse positivity for keratin (AE1/AE3), beta-human chorionic gonadotropin (β-HCG), p53, MYC, p16, and Ki-67. Molecular analysis indicated mutations in
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969231204956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4500: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: How Imaging Advances Are Defining the Future of Precision Radiation Therapy.

    García-Figueiras, Roberto / Baleato-González, Sandra / Luna, Antonio / Padhani, Anwar R / Vilanova, Joan C / Carballo-Castro, Ana M / Oleaga-Zufiria, Laura / Vallejo-Casas, Juan Antonio / Marhuenda, Ana / Gómez-Caamaño, Antonio

    Radiographics : a review publication of the Radiological Society of North America, Inc

    2023  Volume 44, Issue 2, Page(s) e230152

    Abstract: Radiation therapy is fundamental in the treatment of cancer. Imaging has always played a central role in radiation oncology. Integrating imaging technology into irradiation devices has increased the precision and accuracy of dose delivery and decreased ... ...

    Abstract Radiation therapy is fundamental in the treatment of cancer. Imaging has always played a central role in radiation oncology. Integrating imaging technology into irradiation devices has increased the precision and accuracy of dose delivery and decreased the toxic effects of the treatment. Although CT has become the standard imaging modality in radiation therapy, the development of recently introduced next-generation imaging techniques has improved diagnostic and therapeutic decision making in radiation oncology. Functional and molecular imaging techniques, as well as other advanced imaging modalities such as SPECT, yield information about the anatomic and biologic characteristics of tumors for the radiation therapy workflow. In clinical practice, they can be useful for characterizing tumor phenotypes, delineating volumes, planning treatment, determining patients' prognoses, predicting toxic effects, assessing responses to therapy, and detecting tumor relapse. Next-generation imaging can enable personalization of radiation therapy based on a greater understanding of tumor biologic factors. It can be used to map tumor characteristics, such as metabolic pathways, vascularity, cellular proliferation, and hypoxia, that are known to define tumor phenotype. It can also be used to consider tumor heterogeneity by highlighting areas at risk for radiation resistance for focused biologic dose escalation, which can impact the radiation planning process and patient outcomes. The authors review the possible contributions of next-generation imaging to the treatment of patients undergoing radiation therapy. In addition, the possible roles of radio(geno)mics in radiation therapy, the limitations of these techniques, and hurdles in introducing them into clinical practice are discussed.
    MeSH term(s) Humans ; Diagnostic Imaging ; Neoplasms/diagnostic imaging ; Neoplasms/radiotherapy ; Radiotherapy Planning, Computer-Assisted/methods ; Radiation Oncology ; Biological Products
    Chemical Substances Biological Products
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603172-9
    ISSN 1527-1323 ; 0271-5333
    ISSN (online) 1527-1323
    ISSN 0271-5333
    DOI 10.1148/rg.230152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1751: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Angiomiolipoma epitelioide/PEComa hepático e hiperplasia nodular focal en una paciente con antecedentes de melanoma cutáneo.

    Machado, Isidro / Marhuenda, Ana / Trallero, Marta / Caballero, María / Santos, Jesús / Cruz, Julia / Estevan, Rafael

    Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia

    2018  Volume 52, Issue 4, Page(s) 250–255

    Abstract: Hepatic perivascular epithelioid cell tumors (PEComas) are uncommon mesenchymal neoplasms. PEComas concurrent with other hepatic lesions is a very rare occurrence, with only two previously reported cases. We report a primary hepatic PEComa associated ... ...

    Title translation Hepatic epithelioid angiomyolipoma/PEComa and focal nodular hyperplasia in a patient with a previous history of cutaneous melanoma.
    Abstract Hepatic perivascular epithelioid cell tumors (PEComas) are uncommon mesenchymal neoplasms. PEComas concurrent with other hepatic lesions is a very rare occurrence, with only two previously reported cases. We report a primary hepatic PEComa associated with focal nodular hyperplasia in a patient with a previous history of cutaneous melanoma. Diagnostic imaging studies suggested a hepatic adenoma and the patient underwent a segmentectomy. The tumor was mainly composed of epithelioid cells, adipose tissue and smooth muscle fibers intermixed with blood vessels. The neoplastic cells were diffusely immunoreactive for HMB-45, Melan-A and smooth muscle actin, but not for Hepatocyte, S100, MITF or BRAF. Molecular studies were negative for BRAFV600 mutation. The final diagnosis was hepatic epithelioid angiomyolipoma/PEComa. The differential diagnosis of hepatic PEComa is discussed.
    MeSH term(s) Adenoma/diagnosis ; Adult ; Angiomyolipoma/chemistry ; Angiomyolipoma/complications ; Angiomyolipoma/diagnosis ; Angiomyolipoma/pathology ; Biomarkers, Tumor/analysis ; Diagnosis, Differential ; Female ; Focal Nodular Hyperplasia/complications ; Focal Nodular Hyperplasia/diagnosis ; Focal Nodular Hyperplasia/pathology ; Gastrointestinal Stromal Tumors/secondary ; Humans ; Liver Neoplasms/chemistry ; Liver Neoplasms/diagnosis ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; Magnetic Resonance Imaging ; Melanoma/secondary ; Mutation ; Neoplasm Proteins/analysis ; Neoplasms, Second Primary/chemistry ; Neoplasms, Second Primary/diagnosis ; Neoplasms, Second Primary/pathology ; Perivascular Epithelioid Cell Neoplasms/classification ; Perivascular Epithelioid Cell Neoplasms/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Skin Neoplasms ; Melanoma, Cutaneous Malignant
    Chemical Substances Biomarkers, Tumor ; Neoplasm Proteins ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language Spanish
    Publishing date 2018-07-04
    Publishing country Spain
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2463888-2
    ISSN 1988-561X ; 1988-561X
    ISSN (online) 1988-561X
    ISSN 1988-561X
    DOI 10.1016/j.patol.2018.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Micrometástasis en ganglios peripancreáticos por carcinoma mamario en paciente con adenocarcinoma ductal pancreático.

    Machado, Isidro / Caballero, María / Martínez de Juan, Fernando / Marhuenda, Ana / Martínez la Piedra, Carmen / Santos, Jesús / Yaya, Ricardo / Estevan, Rafael

    Gastroenterologia y hepatologia

    2016  Volume 39, Issue 7, Page(s) 468–471

    Title translation Peripancreatic lymph node micrometastases from a mammary carcinoma in a patient with pancreatic ductal adenocarcinoma.
    Language Spanish
    Publishing date 2016-08
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2015.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2044: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Advanced Imaging Techniques in Evaluation of Colorectal Cancer.

    García-Figueiras, Roberto / Baleato-González, Sandra / Padhani, Anwar R / Luna-Alcalá, Antonio / Marhuenda, Ana / Vilanova, Joan C / Osorio-Vázquez, Iria / Martínez-de-Alegría, Anxo / Gómez-Caamaño, Antonio

    Radiographics : a review publication of the Radiological Society of North America, Inc

    2018  Volume 38, Issue 3, Page(s) 740–765

    Abstract: Imaging techniques are clinical decision-making tools in the evaluation of patients with colorectal cancer (CRC). The aim of this article is to discuss the potential of recent advances in imaging for diagnosis, prognosis, therapy planning, and assessment ...

    Abstract Imaging techniques are clinical decision-making tools in the evaluation of patients with colorectal cancer (CRC). The aim of this article is to discuss the potential of recent advances in imaging for diagnosis, prognosis, therapy planning, and assessment of response to treatment of CRC. Recent developments and new clinical applications of conventional imaging techniques such as virtual colonoscopy, dual-energy spectral computed tomography, elastography, advanced computing techniques (including volumetric rendering techniques and machine learning), magnetic resonance (MR) imaging-based magnetization transfer, and new liver imaging techniques, which may offer additional clinical information in patients with CRC, are summarized. In addition, the clinical value of functional and molecular imaging techniques such as diffusion-weighted MR imaging, dynamic contrast material-enhanced imaging, blood oxygen level-dependent imaging, lymphography with contrast agents, positron emission tomography with different radiotracers, and MR spectroscopy is reviewed, and the advantages and disadvantages of these modalities are evaluated. Finally, the future role of imaging-based analysis of tumor heterogeneity and multiparametric imaging, the development of radiomics and radiogenomics, and future challenges for imaging of patients with CRC are discussed. Online supplemental material is available for this article.
    MeSH term(s) Colorectal Neoplasms/diagnostic imaging ; Diagnostic Imaging/trends ; Humans ; Patient Care Planning ; Prognosis
    Language English
    Publishing date 2018-04-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603172-9
    ISSN 1527-1323 ; 0271-5333
    ISSN (online) 1527-1323
    ISSN 0271-5333
    DOI 10.1148/rg.2018170044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1751: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Advanced imaging of colorectal cancer: From anatomy to molecular imaging.

    García-Figueiras, Roberto / Baleato-González, Sandra / Padhani, Anwar R / Marhuenda, Ana / Luna, Antonio / Alcalá, Lidia / Carballo-Castro, Ana / Álvarez-Castro, Ana

    Insights into imaging

    2016  Volume 7, Issue 3, Page(s) 285–309

    Abstract: Unlabelled: Imaging techniques play a key role in the management of patients with colorectal cancer. The introduction of new advanced anatomical, functional, and molecular imaging techniques may improve the assessment of diagnosis, prognosis, planning ... ...

    Abstract Unlabelled: Imaging techniques play a key role in the management of patients with colorectal cancer. The introduction of new advanced anatomical, functional, and molecular imaging techniques may improve the assessment of diagnosis, prognosis, planning therapy, and assessment of response to treatment of these patients. Functional and molecular imaging techniques in clinical practice may allow the assessment of tumour-specific characteristics and tumour heterogeneity. This paper will review recent developments in imaging technologies and the evolving roles for these techniques in colorectal cancer.
    Teaching points: • Imaging techniques play a key role in the management of patients with colorectal cancer. • Advanced imaging techniques improve the evaluation of these patients. • Functional and molecular imaging allows assessment of tumour hallmarks and tumour heterogeneity.
    Language English
    Publishing date 2016-04-30
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2543323-4
    ISSN 1869-4101
    ISSN 1869-4101
    DOI 10.1007/s13244-016-0465-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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