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  1. AU="Maria Camilla Cipriani"
  2. AU="Yu, Mo-Sang"
  3. AU="Arshad, Hassaan Bin"
  4. AU="Schwänke, Ulf"
  5. AU=Martin Rick
  6. AU="Narges ROUSTAEI"
  7. AU="Alsaady, Ammar"
  8. AU=Guo Zhinian
  9. AU=Dho Sascha E
  10. AU="Santiso-Quiñones, Gustavo"
  11. AU="Donovan, Lois E"
  12. AU="Xiong, Zhuo-Chao"
  13. AU="Mu, Dezhi"
  14. AU="Kaiser, Steffen"
  15. AU=Garlepp M J
  16. AU=Yang Zhenwei
  17. AU="Guillot, Loic"
  18. AU=Pocrnic Ivan
  19. AU="Rackova, Sylva"
  20. AU="Jordan Denizeau"
  21. AU="Alexandra J. Corbett"
  22. AU="Felderman, Howard E"
  23. AU="Chen, Fuxing"
  24. AU="Soekadar, Surjo R"
  25. AU="Pagotto, Sara"
  26. AU="Dominguez, Georgina Cutillas"
  27. AU=Barabutis Nektarios
  28. AU="Rumalla, Kavelin"
  29. AU=Meares Gordon P.
  30. AU="Gawron, Lori M"
  31. AU=Guettari Moez
  32. AU=Ma Xingcong
  33. AU="Greene, Kerrie" AU="Greene, Kerrie"
  34. AU="Adebayo, Abe"
  35. AU=Amoako Yaw Ampem
  36. AU="Khanna, Sakshum"

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  1. Artikel ; Online: Frailty modifies the effect of polypharmacy and multimorbidity on the risk of death among nursing home residents

    Maria Beatrice Zazzara / Emanuele Rocco Villani / Katie Palmer / Daniela Fialova / Andrea Corsonello / Luca Soraci / Domenico Fusco / Maria Camilla Cipriani / Michael Denkinger / Graziano Onder / Rosa Liperoti

    Frontiers in Medicine, Vol

    Results from the SHELTER study

    2023  Band 10

    Abstract: BackgroundFrailty, disability, and polypharmacy are prevalent in nursing home (NH) residents, often co-occurring with multimorbidity. There may be a complex interplay among them in terms of outcomes such as mortality. Aims of the study were to (i) assess ...

    Abstract BackgroundFrailty, disability, and polypharmacy are prevalent in nursing home (NH) residents, often co-occurring with multimorbidity. There may be a complex interplay among them in terms of outcomes such as mortality. Aims of the study were to (i) assess whether nursing home residents with polypharmacy (5–9 medications) or hyperpolypharmacy (≥10 drugs), have an increased risk of death and (ii) whether any association is modified by the co-presence of frailty or disability.MethodsCohort study with longitudinal mortality data including 4,023 residents from 50 European and 7 Israeli NH facilities (mean age = 83.6 years, 73.2% female) in The Services and Health for Elderly in Long Term care (SHELTER) cohort study. Participants were evaluated with the interRAI-LongTerm Care assessment tool. Frailty was evaluated with the FRAIL-NH scale. Hazard ratio (HR) of death over 12 months was assessed with stratified Cox proportional hazards models adjusted for demographics, facilities, and cognitive status.Results1,042 (25.9%) participants were not on polypharmacy, 49.8% (n = 2,002) were on polypharmacy, and 24.3% (n = 979) on hyperpolypharmacy. Frailty and disability mostly increased risk of death in the study population (frailty: HR = 1.85, 95%CI 1.49–2.28; disability: HR = 2.10, 95%CI 1.86–2.47). Among non-frail participants, multimorbidity (HR = 1.34, 95%CI = 1.01–1.82) and hyperpolypharmacy (HR = 1.61, 95%CI = 1.09–2.40) were associated with higher risk of death. Among frail participants, no other factors were associated with mortality. Polypharmacy and multimorbidity were not associated with mortality after stratification for disability.ConclusionsFrailty and disability are the strongest predictors of death in NH residents. Multimorbidity and hyperpolypharmacy increase mortality only in people without frailty. These findings may be relevant to identify patients who could benefit from tailored deprescription.
    Schlagwörter drugs ; hyperpolypharmacy ; frailty ; long-term care facility ; mortality ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Association between Older Age and Psychiatric Symptoms in a Population of Hospitalized Patients with COVID-19

    Maria Camilla Cipriani / Cristina Pais / Vezio Savoia / Cinzia Falsiroli / Andrea Bellieni / Antonella Cingolani / Massimo Fantoni / Daniela Pia Rosaria Chieffo / Gabriele Sani / Francesco Landi / Giovanni Landi / Rosa Liperoti

    Journal of Personalized Medicine, Vol 13, Iss 973, p

    2023  Band 973

    Abstract: Increased rates of anxiety and depression have been reported for older adults during the COVID-19 pandemic. However, little is known regarding the onset of mental health morbidity during the acute phase of the disease and the role of age as potential ... ...

    Abstract Increased rates of anxiety and depression have been reported for older adults during the COVID-19 pandemic. However, little is known regarding the onset of mental health morbidity during the acute phase of the disease and the role of age as potential independent risk factor for psychiatric symptoms. The cross-sectional association between older age and psychiatric symptoms has been estimated in a sample of 130 patients hospitalized for COVID-19 during the first and second wave of the pandemic. Compared to younger patients, those who were 70 years of age or older resulted at a higher risk of psychiatric symptoms measured on the Brief Psychiatric Symptoms Rating Scale (BPRS) (adjusted (adj.) odds ratio (OR) 2.36, 95% confidence interval (CI) 1.05–5.30) and delirium (adj. OR 5.24, 95% CI 1.63–16.8)). No association was found between older age and depressive symptoms or anxiety. Age was associated with psychiatric symptoms independently of gender, marital status, history of psychiatric illness, severity of disease and cardiovascular morbidity. Older adults appear at high risk of developing psychiatric symptoms related to COVID-19 disease during hospital stay. Multidisciplinary preventive and therapeutic interventions should be implemented to reduce the risk of psychiatric morbidity and related adverse health care outcomes among older hospital inpatients with COVID-19.
    Schlagwörter older adults ; COVID-19 ; psychiatric symptoms ; delirium ; hospitalization ; Medicine ; R
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Buch ; Online: Table_1_Neuropsychiatric Symptoms in Elderly With Dementia During COVID-19 Pandemic

    Alessio Simonetti / Cristina Pais / Melissa Jones / Maria Camilla Cipriani / Delfina Janiri / Laura Monti / Francesco Landi / Roberto Bernabei / Rosa Liperoti / Gabriele Sani

    Definition, Treatment, and Future Directions.docx

    2020  

    Abstract: Background Neuropsychiatric symptoms (NPS) of dementia, such as anxiety, depression, agitation, and apathy, are complex, stressful, and costly aspects of care, and are associated to poor health outcomes and caregiver burden. A steep worsening of such ... ...

    Abstract Background Neuropsychiatric symptoms (NPS) of dementia, such as anxiety, depression, agitation, and apathy, are complex, stressful, and costly aspects of care, and are associated to poor health outcomes and caregiver burden. A steep worsening of such symptoms has been reported during Coronavirus Disease 2019 (COVID-19) pandemic. However, their causes, their impact on everyday life, and treatment strategies have not been systematically assessed. Therefore, the aim of this review is to provide a detailed description of behavioral and psychopathological alterations in subjects with dementia during COVID-19 pandemic and the associated management challenges. Methods A PubMed search was performed focusing on studies reporting alterations in behavior and mood and treatment strategies for elderly patients with dementia, in accordance with PRISMA guidelines. The following search strategy was utilized: (COVID* OR coronavirus OR “corona vir*” OR SARS-CoV-2) AND (dementia OR demented OR dement* OR alzheimer* OR “pick’s disease” OR “lewy body” OR “mild cognitive” OR mild cognitive impairment OR MCI). Results Apathy, anxiety and agitation are the most frequently NPS during the COVID-19 pandemic and are mainly triggered by protracted isolation. Most treatment strategies rely on pharmacotherapy; technology is increasingly utilized with mixed results. Conclusions NPS of dementia during COVID-19 appear to arise from social restrictions occurring as a consequence of the pandemic. Implementation of caregiver support and the presence of skilled nursing home staff are required to restore social interaction and adjust technological support to the patients’ needs.
    Schlagwörter Psychiatry (incl. Psychotherapy) ; dementia ; COVID-19 ; apathy ; anxiety ; agitation ; treatment ; covid19
    Thema/Rubrik (Code) 150
    Erscheinungsdatum 2020-09-29T04:45:07Z
    Erscheinungsland uk
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Neuropsychiatric Symptoms in Elderly With Dementia During COVID-19 Pandemic

    Alessio Simonetti / Cristina Pais / Melissa Jones / Maria Camilla Cipriani / Delfina Janiri / Laura Monti / Francesco Landi / Roberto Bernabei / Rosa Liperoti / Gabriele Sani

    Frontiers in Psychiatry, Vol

    Definition, Treatment, and Future Directions

    2020  Band 11

    Abstract: BackgroundNeuropsychiatric symptoms (NPS) of dementia, such as anxiety, depression, agitation, and apathy, are complex, stressful, and costly aspects of care, and are associated to poor health outcomes and caregiver burden. A steep worsening of such ... ...

    Abstract BackgroundNeuropsychiatric symptoms (NPS) of dementia, such as anxiety, depression, agitation, and apathy, are complex, stressful, and costly aspects of care, and are associated to poor health outcomes and caregiver burden. A steep worsening of such symptoms has been reported during Coronavirus Disease 2019 (COVID-19) pandemic. However, their causes, their impact on everyday life, and treatment strategies have not been systematically assessed. Therefore, the aim of this review is to provide a detailed description of behavioral and psychopathological alterations in subjects with dementia during COVID-19 pandemic and the associated management challenges.MethodsA PubMed search was performed focusing on studies reporting alterations in behavior and mood and treatment strategies for elderly patients with dementia, in accordance with PRISMA guidelines. The following search strategy was utilized: (COVID* OR coronavirus OR “corona vir*” OR SARS-CoV-2) AND (dementia OR demented OR dement* OR alzheimer* OR “pick’s disease” OR “lewy body” OR “mild cognitive” OR mild cognitive impairment OR MCI).ResultsApathy, anxiety and agitation are the most frequently NPS during the COVID-19 pandemic and are mainly triggered by protracted isolation. Most treatment strategies rely on pharmacotherapy; technology is increasingly utilized with mixed results.ConclusionsNPS of dementia during COVID-19 appear to arise from social restrictions occurring as a consequence of the pandemic. Implementation of caregiver support and the presence of skilled nursing home staff are required to restore social interaction and adjust technological support to the patients’ needs.
    Schlagwörter dementia ; COVID-19 ; apathy ; anxiety ; agitation ; treatment ; Psychiatry ; RC435-571 ; covid19
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2020-09-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: The “develOpment of metabolic and functional markers of Dementia IN Older people” (ODINO) Study

    Anna Picca / Daniela Ronconi / Hélio J. Coelho-Junior / Riccardo Calvani / Federico Marini / Alessandra Biancolillo / Jacopo Gervasoni / Aniello Primiano / Cristina Pais / Eleonora Meloni / Domenico Fusco / Maria Rita Lo Monaco / Roberto Bernabei / Maria Camilla Cipriani / Emanuele Marzetti / Rosa Liperoti

    Journal of Personalized Medicine, Vol 10, Iss 22, p

    Rationale, Design and Methods

    2020  Band 22

    Abstract: Mild cognitive impairment (MCI), also termed mild neurocognitive disorder, includes a heterogeneous group of conditions characterized by declines in one or more cognitive domains greater than that expected during “normal” aging but not severe enough to ... ...

    Abstract Mild cognitive impairment (MCI), also termed mild neurocognitive disorder, includes a heterogeneous group of conditions characterized by declines in one or more cognitive domains greater than that expected during “normal” aging but not severe enough to impair functional abilities. MCI has been associated with an increased risk of developing dementia and even considered an early stage of it. Therefore, noninvasively accessible biomarkers of MCI are highly sought after for early identification of the condition. Systemic inflammation, metabolic perturbations, and declining physical performance have been described in people with MCI. However, whether biological and functional parameters differ across MCI neuropsychological subtypes is presently debated. Likewise, the predictive value of existing biomarkers toward MCI conversion into dementia is unclear. The “develOpment of metabolic and functional markers of Dementia IN Older people” (ODINO) study was conceived as a multi-dimensional investigation in which multi-marker discovery will be coupled with innovative statistical approaches to characterize patterns of systemic inflammation, metabolic perturbations, and physical performance in older adults with MCI. The ultimate aim of ODINO is to identify potential biomarkers specific for MCI subtypes and predictive of MCI conversion into Alzheimer’s disease or other forms of dementia over a three-year follow-up. Here, we describe the rationale, design, and methods of ODINO.
    Schlagwörter aging ; biomarkers ; cytokines ; cognitive decline ; Alzheimer’s disease ; metabolomics ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2020-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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