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Article ; Online: Architecture of Cocoa Genotypes in Colombia as Affected by Bud Type, Grafting Technique, and Pruning

Maria Denis Lozano Tovar / Jose Arboney Guzman / Luis Enrique Ramirez / Jairo Garcia

Coffee and Cocoa Research Journal, Vol 38, Iss

2022 Volume 1

Abstract: Organization of plant aerial parts and root distribution, environmental conditions such as light, temperature, humidity and agronomic practices (grafting and pruning) influences the final architecture of the plant. Most of cocoa plantations in Colombia ... ...

Abstract	Organization of plant aerial parts and root distribution, environmental conditions such as light, temperature, humidity and agronomic practices (grafting and pruning) influences the final architecture of the plant. Most of cocoa plantations in Colombia belong to the plagiotropic type that emit branches and suckers in a disorderly way, which leads to an unbalanced development, this makes it difficult to manage. To search for cocoa plants with better architecture, we evaluated the effect of the type of the bud (orthotropic and plagiotropic), the grafting techniques (approximation and patch grafting) and pruning (structural and conventional) on ICS 95 and CCN 51 clones. The monitoring was carried out at an open greenhouse and field. Plants obtained from orthotropic buds and approximation grafting had lower bifurcation angles, 42% more leaves and 50% more branches. The structural pruning had a positive influence on the architectural variables, which presented a higher conversion (8.68%) of fresh weight of cocoa pod into dry weight of cocoa beans, meanwhile CCN 51 trees showed a higher conversion (9.76%) compared to ICS 95 (7.34%). CCN 51 had the highest bean index (1.30) and the lowest pod index (22.0). This study demonstrated that structural pruning improved bean index and pod index. We concluded that for CCN 51 by approximation grafting technique is a good alternative for a tropical dry forest, as its production between 1995 and 2277 kg of dry cocoa beans ha-1 year-1.
Keywords	Orthotropic plants ; Plagiotropic plants ; Theobroma cacao ; Plant architecture ; approximation graft ; patch graft ; Agriculture ; S
Subject code	580
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Indonesian Coffee and Cocoa Research Institute
Document type	Article ; Online
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Article ; Online: Study on the insecticidal activity of entomopathogenic fungi for the control of the fruit fly (Anastrepha obliqua), the main pest in mango crop in Colombia.

Lozano-Tovar, María Denis / Ballestas Álvarez, Karen Lorena / Sandoval-Lozano, Luis Andrés / Palma Mendez, Gloria Milena / Barrera-Cubillos, Gloria Patricia

Archives of microbiology

2023 Volume 205, Issue 3, Page(s) 83

Abstract: The aim of this study was to evaluate and select entomopathogenic fungi that produces insecticidal compounds for the control of adults of Anastrepha obliqua Macquart (Diptera: tephritidae) that are the main pest of mango (Mangifera indica L. Bark) in ... ...

Abstract	The aim of this study was to evaluate and select entomopathogenic fungi that produces insecticidal compounds for the control of adults of Anastrepha obliqua Macquart (Diptera: tephritidae) that are the main pest of mango (Mangifera indica L. Bark) in Colombia. Nine entomopathogenic fungi isolates were evaluated, five belonging to the genus Metarhizium and four belonging to the genus Beauveria. One strain of the species Metarhizium robertsii with insecticidal activity was selected. By column fractionation, an active fraction was obtained, which caused mortalities higher than 90% after 48 h of exposure. Through HPLC it was determined that the active fraction is composed of more than 22 metabolites. Identification of the metabolites by UHPLC MS/MS revealed the presence of destruxin in E, D, A and B groups (destruxin E-diol, destruxin D, destruxin D1, destruxin D2, destruxin A2, destruxin A, destruxin A3, dihydrodestruxin A, desmB, destruxin B2, destruxin B and destruxin B1). The evaluation of the insecticidal capacity of the organic fractions obtained by HPLC indicated that the extract obtained from the isolate M. robertsii had a compound with high activity on adults of A. obliqua (destruxin A) causing massive mortality of up to 100%, after 48 h of the treatment administration. Furthermore, two other compounds with medium activity were found (destruxin A2 and destruxin B), showing mortalities between 60.0 and 81.3%, respectively. The extract of the isolate MT008 of M. robertsii showed higher insecticidal activity and a potential source for the control of A. obliqua.
MeSH term(s)	Animals ; Mangifera ; Insecticides/pharmacology ; Colombia ; Tandem Mass Spectrometry ; Tephritidae ; Plant Extracts
Chemical Substances	Insecticides ; Plant Extracts
Language	English
Publishing date	2023-02-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-023-03405-2
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Article ; Online: Study on the insecticidal activity of entomopathogenic fungi for the control of the fruit fly (Anastrepha obliqua), the main pest in mango crop in Colombia

Lozano-Tovar, María Denis / Ballestas Álvarez, Karen Lorena / Sandoval-Lozano, Luis Andrés / Palma Mendez, Gloria Milena / Barrera-Cubillos, Gloria Patricia

Arch Microbiol. 2023 Mar., v. 205, no. 3 p.83-83

2023

Abstract	The aim of this study was to evaluate and select entomopathogenic fungi that produces insecticidal compounds for the control of adults of Anastrepha obliqua Macquart (Diptera: tephritidae) that are the main pest of mango (Mangifera indica L. Bark) in Colombia. Nine entomopathogenic fungi isolates were evaluated, five belonging to the genus Metarhizium and four belonging to the genus Beauveria. One strain of the species Metarhizium robertsii with insecticidal activity was selected. By column fractionation, an active fraction was obtained, which caused mortalities higher than 90% after 48 h of exposure. Through HPLC it was determined that the active fraction is composed of more than 22 metabolites. Identification of the metabolites by UHPLC MS/MS revealed the presence of destruxin in E, D, A and B groups (destruxin E-diol, destruxin D, destruxin D1, destruxin D2, destruxin A2, destruxin A, destruxin A3, dihydrodestruxin A, desmB, destruxin B2, destruxin B and destruxin B1). The evaluation of the insecticidal capacity of the organic fractions obtained by HPLC indicated that the extract obtained from the isolate M. robertsii had a compound with high activity on adults of A. obliqua (destruxin A) causing massive mortality of up to 100%, after 48 h of the treatment administration. Furthermore, two other compounds with medium activity were found (destruxin A2 and destruxin B), showing mortalities between 60.0 and 81.3%, respectively. The extract of the isolate MT008 of M. robertsii showed higher insecticidal activity and a potential source for the control of A. obliqua
Keywords	Anastrepha obliqua ; Beauveria ; Mangifera indica ; Metarhizium robertsii ; bark ; fractionation ; fruit flies ; insecticidal properties ; mangoes ; metabolites ; mortality ; pests ; Colombia
Language	English
Dates of publication	2023-03
Size	p. 83.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-023-03405-2
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Growth, respiration and physicochemical changes during the maturation of cacao fruits.

López-Hernández, Martha Del Pilar / Criollo-Núñez, Jenifer / Jaramillo-Barrios, Camilo Ignacio / Lozano-Tovar, María Denis

Journal of the science of food and agriculture

2021 Volume 101, Issue 13, Page(s) 5398–5408

Abstract: Background: Cacao is important for the economy of many countries in the humid tropics. Its quality is affected when fruits are not collected at the optimal harvest point. The aim of this study was to obtain maturity indices for producers to facilitate ... ...

Abstract	Background: Cacao is important for the economy of many countries in the humid tropics. Its quality is affected when fruits are not collected at the optimal harvest point. The aim of this study was to obtain maturity indices for producers to facilitate the timely harvest and improve the development of fermentation and the sensorial quality of cacao. The growth and respiration processes, and the physicochemical changes during the maturation of three cacao genotypes were determined. Physiological follow-ups measuring fruit length and diameter were performed from 30 days after anthesis to fruit deterioration in the tree. Results: Growth equations were obtained, establishing four maturity stages based on days after anthesis, and fruit length and diameter. Nineteen descriptors were used for the characterization, and through Pearson's correlation and principal component analysis (PCA), five descriptors were identified as representative of the maturity stages of the cacao fruit. PCA results and respiration measurements established that stage 3 presented the highest substrate availability for obtaining good fermentation and quality cacao. This stage showed values between 124 and 197 days after anthesis with lengths between 167.7 and 249.73 mm, and diameters between 64.4 and 95.8 mm, according to the locality. Conclusion: Three growth phases of the cacao fruits were established considering days after anthesis. Both the edaphoclimatic conditions and the cacao genotype characteristics influenced this determination. Stage 3 of fruit maturation shows the best physicochemical conditions for good fermentation. © 2021 Society of Chemical Industry.
MeSH term(s)	Cacao/chemistry ; Cacao/growth & development ; Cacao/metabolism ; Fruit/chemistry ; Fruit/growth & development ; Fruit/metabolism ; Oxygen/metabolism ; Respiration ; Trees/chemistry ; Trees/growth & development ; Trees/metabolism
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2021-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.11188
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Article: Growth, respiration and physicochemical changes during the maturation of cacao fruits

López‐Hernández, Martha del Pilar / Criollo‐Núñez, Jenifer / Jaramillo‐Barrios, Camilo Ignacio / Lozano‐Tovar, María Denis

Journal of the science of food and agriculture. 2021 Oct., v. 101, no. 13

2021

Abstract: BACKGROUND: Cacao is important for the economy of many countries in the humid tropics. Its quality is affected when fruits are not collected at the optimal harvest point. The aim of this study was to obtain maturity indices for producers to facilitate ... ...

Abstract	BACKGROUND: Cacao is important for the economy of many countries in the humid tropics. Its quality is affected when fruits are not collected at the optimal harvest point. The aim of this study was to obtain maturity indices for producers to facilitate the timely harvest and improve the development of fermentation and the sensorial quality of cacao. The growth and respiration processes, and the physicochemical changes during the maturation of three cacao genotypes were determined. Physiological follow‐ups measuring fruit length and diameter were performed from 30 days after anthesis to fruit deterioration in the tree. RESULTS: Growth equations were obtained, establishing four maturity stages based on days after anthesis, and fruit length and diameter. Nineteen descriptors were used for the characterization, and through Pearson's correlation and principal component analysis (PCA), five descriptors were identified as representative of the maturity stages of the cacao fruit. PCA results and respiration measurements established that stage 3 presented the highest substrate availability for obtaining good fermentation and quality cacao. This stage showed values between 124 and 197 days after anthesis with lengths between 167.7 and 249.73 mm, and diameters between 64.4 and 95.8 mm, according to the locality. CONCLUSION: Three growth phases of the cacao fruits were established considering days after anthesis. Both the edaphoclimatic conditions and the cacao genotype characteristics influenced this determination. Stage 3 of fruit maturation shows the best physicochemical conditions for good fermentation. © 2021 Society of Chemical Industry
Keywords	agriculture ; fermentation ; flowering ; fruits ; genotype ; principal component analysis ; sensory properties ; trees
Language	English
Dates of publication	2021-10
Size	p. 5398-5408.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.11188
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of Addition of a Specific Mixture of Yeast, Lactic and Acetic Bacteria in the Fermentation Process to Improve the Quality and Flavor of Cocoa Beans in Colombia

Jorge Daniel Fonseca Blanco / Martha del Pilar López Hernandez / Laura Sabrina Ortiz Galeano / Jenifer Criollo Nuñez / María Denis Lozano Tovar

Coffee and Cocoa Research Journal, Vol 36, Iss

2020 Volume 2

Abstract: Cocoa fermentation process is fundamental to generate flavors and aromas that are characteristics of chocolate. In Colombia, this process is carried out by microbiota that spontaneously colonizes cocoa beans, therefore the quality of the fermentation is ... ...

Abstract	Cocoa fermentation process is fundamental to generate flavors and aromas that are characteristics of chocolate. In Colombia, this process is carried out by microbiota that spontaneously colonizes cocoa beans, therefore the quality of the fermentation is inconsistent. Taking into account that the fermentation of cocoa beans is carried out by a consortium of microorganisms, the aim of this research was to describe the effect of the addition of a specific mixture of yeasts, acetic acid bacteria, and lactic acid bacteria on the physicochemical and organoleptic characteristics of cocoa beans (clone CCN 51). Isolates of two yeasts (Wickerhamomyces anomalus and Debaryomyces hansenii), three acetic acid bacteria (AAB), (Gluconobacter japonicus, Acetobacter tropicalis, and Acetobacter pasteurianus) and three lactic acid bacteria (LAB) (Pediococcus acidilactici, Lactobacillus brevis, and Lactobacillus plantarum) obtained from previous cocoa fermentations selected for their pectinases and acid production capacities in a specific mixture were used. Using the micro-fermentation technique, the effect of a biological starter was evaluated under different viable microorganisms ratios (Yeasts: LAB: AAB as follows, 1: 1: 1, 1: 2: 2, 1: 2: 1, 1: 1: 2, 2: 1: 1, 2: 2: 1, 2: 1: 2, and 2: 2: 2). The concentration of each microorganism was standardized at 1x107 cfu/mL, then the biomass of 4 mL for ratio 1 and 8 mL for ratio 2 of each suspension of microorganisms was added at time zero. Different doses of inoculum were 0%, 1%, 2%, 3%, 4%, and 5% v/w mL inoculum/g cocoa beans. A beneficial effect on the sensory quality of cocoa beans was evidenced by the addition of microorganisms; the best proportion of microorganisms was 2:1:2 (yeasts:LAB:AAB) and the best inoculum dose was 3% (v/w) showing lower acidity, astringency, and bitterness, and emphasizing the cocoa flavors, fruity, nutty, and panela malt.
Keywords	cocoa yeast ; lactic acid bacteria ; acetic acid bacteria ; organoleptic propperties ; CCN 51 cocoa clone ; starter cultures ; Agriculture ; S
Subject code	571 ; 660
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Indonesian Coffee and Cocoa Research Institute
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Isolation and identification of microbial species found in cocoa fermentation as microbial starter culture candidates for cocoa bean fermentation in Colombia.

Maria Denis Lozano Tovar / Geraldine Tibasosa / Carlos Mario González / Karen Ballestas Alvarez / Martha del Pilar Lopez Hernandez / Fernando Rodríguez Villamizar

Coffee and Cocoa Research Journal, Vol 36, Iss

2020 Volume 3

Abstract: Microbial activity involved in the cocoa beans fermentation process is essential to maintain and improve the organoleptic and nutritional qualities of chocolate; therefore, the aim of this investigation was to search and select microbial isolates with ... ...

Abstract	Microbial activity involved in the cocoa beans fermentation process is essential to maintain and improve the organoleptic and nutritional qualities of chocolate; therefore, the aim of this investigation was to search and select microbial isolates with the potential to improve the quality of cocoa beans. Fermentation experiments were conducted on farms located in Maceo (Antioquia), San Vicente de Chucurí (Santander), and Rivera and Algeciras (Huila), Colombia. Yeast, lactic acid bacteria (LAB), acetic acid bacteria (AAB), and mesophilic aerobic microorganisms were obtained from different fermentation batches. The growth of these microorganisms was tested in six treatments as follows: 50% cocoa pulp agar (CPA), high concentrations of glucose (10%), ethanol (5%), and acetic acid (7%), an acidic pH of 3.0, and a high temperature of 50oC for 24 h. The isolates with the highest growth were identified by 18S and 16S rRNA gene analysis, revealing a high diversity of species associated with cocoa fermentation, including eight species of yeasts (Debaryomyces hansenii, Meyerozyma guillermondii, Wickerhanomyces anomalus, Pichia guillermondii, Pichia kudriavzevii, Trichosporon asahii, Candida parapsilosis, and Pichia manshurica), six species of LAB (Pediococcus acidilactici, Lactobacillus brevis, Lactobacillus plantarum, Lactobacillus farraginis, Lactobacillus rhamnosus, and Leuconostoc mesenteroides), four species of AAB (Gluconobacter japonicus, Acetobacter tropicalis, Acetobacter pasteurianus, and Acetobacter malorum/tropicalis), and three species of Bacillus spp. (Bacillus aryabhattai /megaterium, Bacillus subtilis, and Bacillus coagulans). In general, microbial populations increased in cocoa batches after 12 h of fermentation and decreased after 84-96 h. All the yeast isolates grew in 10% glucose and CPA, 85.7% in 5% ethanol, and 95% at a pH of 3.0. All the yeast isolates were affected by 7% acetic acid and incubation at 50oC for 24 h. Eighty-five percent of the LAB grew in 10% glucose, 100% in 5% ethanol, 42.8% in CPA, ...
Keywords	cocoa bean ; fermentation ; Theobroma cocoa microorganisms ; Agriculture ; S
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Indonesian Coffee and Cocoa Research Institute
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Microorganismos rizosféricos, potenciales antagonistas de Fusarium sp. causante de la pudrición radicular de maracuyá (Passiflora edulis Sims)

Luisa Fernanda Quiroga-Rojas / Nataly Ruiz-Quiñones / Guerly Muñoz-Motta / María Denis Lozano-Tovar

Acta Agronómica, Vol 61, Iss 3, Pp 265-

2012 Volume 272

Abstract: El cultivo de maracuyá (Passiflora edulis), de gran importancia económica para Colombia, actualmente es afectado por la enfermedad del marchitamiento vascular causado por Fusarium sp. lo que hace necesario la búsqueda de alternativas que permitan un ... ...

Abstract	El cultivo de maracuyá (Passiflora edulis), de gran importancia económica para Colombia, actualmente es afectado por la enfermedad del marchitamiento vascular causado por Fusarium sp. lo que hace necesario la búsqueda de alternativas que permitan un control eficiente de esta enfermedad. Aislados de las bacterias Azotobacter spp., Azospirillum spp. y el hongo Trichoderma spp., fueron evaluados como potenciales biocontroladores de Fusarium sp. en pruebas in vitro e in vivo. Las pruebas de “test dual” evidenciaron que un aislado nativo de Trichoderma sp. y un producto comercial (Trichoderma lignorum), provocaron la inhibición del crecimiento micelial de Fusarium sp. entre 94.2% y 93.6%, respectivamente. La evaluación de aislados de Trichoderma sobre plántulas de maracuyá en tres momentos de aplicación indicó que la inoculación previa disminuyó el porcentaje de infección de las plantas entre un 75 y 50%, mientras que con aplicaciones después o simultáneamente con el patógeno, el porcentaje de infección disminuyó en 25%. Estos resultados indican que la aplicación de organismos de biocontrol en semillas pregerminadas mejora la protección de las plantas contra el fitopatógeno estudiado y son un recurso importante en el manejo preventivo de las enfermedades de maracuyá.
Keywords	Azospirillum spp ; Azotobacter spp ; biocontrol ; Passiflora edulis ; Trichoderma spp ; Agriculture ; S
Language	English
Publishing date	2012-07-01T00:00:00Z
Publisher	Universidad Nacional de Colombia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Estrategia MIP para el control de Bemisia tabaci (Hemiptera

CARLOS ESPINEL C / MARÍA DENIS LOZANO / LAURA VILLAMIZAR R / ERIKA GRIJALBA B / ALBA MARINA COTES P

Revista Colombiana de Entomología, Vol 34, Iss 2, Pp 163-

Aleyrodidae) en melón y tomate IPM strategy for the control of Bemisia tabaci (Hemiptera: Aleyrodidae) on melon and tomato

2008 Volume 168

Abstract: Bemisia tabaci es una plaga de importancia económica en cultivos de melón y tomate. El centro de investigaciones Corpoica desarrolló productos para su control con resultados promisorios en laboratorio, surgiendo la necesidad de evaluarlos en campo. El ... ...

Abstract	Bemisia tabaci es una plaga de importancia económica en cultivos de melón y tomate. El centro de investigaciones Corpoica desarrolló productos para su control con resultados promisorios en laboratorio, surgiendo la necesidad de evaluarlos en campo. El objetivo del presente trabajo fue evaluar un esquema de manejo integrado de plagas (MIP) en melón y tomate en El Espinal (Tolima) utilizando un preformulado con base en Paecilomyces fumosoroseus comparado con un bioplaguicida con base en Lecanicillium lecanii. Otros componentes de manejo del insecto se integraron, como trampas amarillas y manejo de patógenos como solarización del suelo y la aplicación de Trichoderma koningii. Las parcelas MIP (con los bioplaguicidas) se compararon con un tratamiento tradicional agricultor. Se determinaron la presencia de adultos y estados inmaduros semanalmente y la producción total en la cosecha. En el melón se realizaron seis aplicaciones de los productos biológicos y en tomate diez. La producción de melón en la parcela aplicada con L. lecanii fue de 29,4 t/ha, mientras que en el tratamiento P. fumosoroseus y agricultor, fue de 27,3 t/ha y 25 t/ha, respectivamente. La mayor producción en tomate cherry se obtuvo con el tratamiento con P. fumosoroseus (14,7 t/ha), seguida por la parcela aplicada con L. lecanii (13,8 t/ha) y por el tratamiento agricultor (13,6 t/ha). Se sugiere que los productos biológicos con base en los entomopatógenos evaluados, introducidos dentro de un esquema de manejo integrado del cultivo, son promisorios para el manejo de B. tabaci. Bemisia tabaci is an economically important pest in melon and tomato crops. The Corpoica research center developed biopesticides for its control with promising results under laboratory conditions, leading to a need to evaluate them under field conditions. The objective of the present work was to evaluate a strategy of integrated pest management (IPM) on melon and tomato crops in El Espinal (Tolima) using a preformulation based on Paecilomyces fumosoroseus and a biopesticide based on Lecanicillium lecanii. Other components of insect management were integrated, such as yellow traps and pathogen management like soil solarization and the application of Trichoderma koningii. IPM plots (with biopesticides) were compared with a traditional farmer treatment. The presence of adults and immature stages were determined weekly and the total yield at harvest. Six applications of the biological products were carried out in melon and ten in tomato. Melon production in plots treated with L. lecanii was 29.4 t/ha, while in the plots treated with P. fumosoroseus and farmer treatment it was 27.3 t/ha and 25 t/ha, respectively. The highest production obtained in cherry tomato was in the treatment with P. fumosoroseus (14.7 t/ha), followed by L. lecanii treated plots (13.8 t/ha) and the farmer treatment (13.6 t/ha). These results suggest that the biological products based on the evaluated entomopathogens, introduced into a strategy of integrated crop management, are promising for B. tabaci control.
Keywords	Mosca blanca ; Bioplaguicida ; Entomopatógenos ; Whitefly ; Biopesticide ; Entomopathogens ; Zoology ; QL1-991 ; Science ; Q ; DOAJ:Zoology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Language	Spanish
Publishing date	2008-12-01T00:00:00Z
Publisher	Sociedad Colombiana de Entomología
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A non-innovator version of etanercept for treatment of arthritis

Maity, Sunit / Ullanat, Rajesh / Lahiri, Subhra / Shekar, Sunil / Sodhan, Geetha / Vyas, Ashutosh / Dyaga, Gopal / Ireni, Srinivas / Nair, Nirmala / Sotsios, Yannis / Maria, Denis C / Morawala-Patell, Villoo

Biologicals. 2011 Nov., v. 39, no. 6

2011

Abstract: Etanercept is a soluble tumor necrosis factor (TNF) receptor originally approved for treatment of moderate-to-severe rheumatoid arthritis, juvenile rheumatoid arthritis, and psoriatic arthritis. We have developed a non-innovator version of the ... ...

Abstract	Etanercept is a soluble tumor necrosis factor (TNF) receptor originally approved for treatment of moderate-to-severe rheumatoid arthritis, juvenile rheumatoid arthritis, and psoriatic arthritis. We have developed a non-innovator version of the recombinant protein etanercept, with the investigational name AVG01 (trade name AVENT™), using a novel expression vector-based technology. Here we show, by extensive analytical characterization, that AVG01 is highly similar to the reference product Enbrel® and demonstrates similar efficacy in pre-clinical studies.
Keywords	necrosis ; recombinant proteins ; rheumatoid arthritis ; tumor necrosis factors
Language	English
Dates of publication	2011-11
Size	p. 384-395.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1017370-5
ISSN	1095-8320 ; 1045-1056
ISSN (online)	1095-8320
ISSN	1045-1056
DOI	10.1016/j.biologicals.2011.08.014
Database	NAL-Catalogue (AGRICOLA)

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Inter-library loan at ZB MED

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Inter-library loan at ZB MED

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Inter-library loan at ZB MED

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In stock of ZB MED Cologne/Königswinter

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