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  1. Article ; Online: Role of probiotics in preventing Clostridioides difficile infection in older adults

    Maria Lucianny Lima Barbosa / Mariana Oliveira Albano / Conceição da Silva Martins / Cirle Alcantara Warren / Gerly Anne de Castro Brito

    Frontiers in Medicine, Vol

    an integrative review

    2023  Volume 10

    Abstract: Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea. This infection can particularly affect older adults, the most susceptible to CDI. Currently, the standard therapeutic measure is antibiotic therapy, which in ...

    Abstract Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea. This infection can particularly affect older adults, the most susceptible to CDI. Currently, the standard therapeutic measure is antibiotic therapy, which in turn increases the risk of recurrence of the infection by its collateral damage to the patient’s microbiota. Probiotics are live microorganisms capable of maintaining balance in the intestinal microbiota. This study aims to perform an integrative review of the protective benefit of probiotics in CDI and diarrhea associated with C. difficile. The PubMed, Scopus, and Web of Science databases, the 10-year time cutoff, and the Prism Flow diagram were used for data collection. We observed no consensus among the studies; however, three of the seven evaluated studies demonstrated that the use of probiotics in older adults could contribute to reducing the incidence of hospital-onset CDI. We also found that the studies evaluated a wide variety of microorganisms, particularly Saccharomyces boulardii, associated with beneficial effects. More research is needed to understand the successful use of probiotics in the prevention of CDI in hospitalized older adults receiving antibiotics.
    Keywords Clostridium difficile ; microbiota ; diarrhea ; infection ; antibiotics ; Saccharomyces boulardii ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Estado nutricional e incidência de câncer de mama em mulheres atendidas em um serviço de mastologia

    Ismael Paula de Souza / Raelly Nicolau Carvalho / Lauro Venícius Sousa da Silva / Márcia Lidiane Barreto Martins / Maria Lucianny Lima Barbosa / Ana Luiza de Rezende Ferreira Mendes

    Medicina, Vol 54, Iss

    2021  Volume 2

    Abstract: Introdução: As doenças crônicas não transmissíveis são um problema de saúde global e um dos principais indicadores de mortalidade de vários países. O câncer de mama vem sendo frequente em mulheres brasileiras. Existem evidências de que o aumento do ... ...

    Abstract Introdução: As doenças crônicas não transmissíveis são um problema de saúde global e um dos principais indicadores de mortalidade de vários países. O câncer de mama vem sendo frequente em mulheres brasileiras. Existem evidências de que o aumento do índice de massa corpórea e do percentual de gordura total pode aumentar a incidência do câncer de mama em mulheres adultas, porém, os estudos não trazem correlações entre a composição corporal e o aumento dessa incidência. Objetivo: Avaliar o estado nutricional de mulheres atendidas em um serviço de mastologia e correlacionar com a incidência de câncer de mama. Métodos: A amostra foi composta por 474 mulheres adultas que realizaram exames regulares em um serviço de mastologia. Foram coletados, a partir de um questionário semiestruturado, dados como classificação do BI-RADS, peso, altura (para posterior realização do índice de massa corporal), circunferência da cintura e quadril (para determinação da razão cintura/quadril) e percentual de gordura a partir de ultrassonografia. Os cálculos estatísticos foram realizados com o auxílio do programa SPSS versão 20.0. Resultados: Observou-se que a incidência de câncer de mama na população investigada foi de 12,02% (n=57). Identificou-se uma alta prevalência de excesso de peso (n=377/79,54%), alto risco de complicações metabólicas (n=266/56,12%) e inadequado percentual de gordura (n=317/66,88%) na amostra. Conclusão: As mulheres avaliadas apresentam estado nutricional inadequado com alta prevalência de sobrepeso e obesidade, no entanto, os resultados não demonstram uma correlação entre a composição corporal e a incidência de câncer de mama.
    Keywords Doenças crônicas não-transmissíveis ; Antropometria ; Câncer de mama ; Estado nutricional ; Medicine ; R
    Language Portuguese
    Publishing date 2021-10-01T00:00:00Z
    Publisher Universidade de São Paulo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis

    Lázaro de Sousa Fideles / João Antônio Leal de Miranda / Conceição da Silva Martins / Maria Lucianny Lima Barbosa / Helder Bindá Pimenta / Paulo Vitor de Souza Pimentel / Claudio Silva Teixeira / Marina Alves Sampaio Scafuri / Samuel de Osterno Façanha / João Erivan Façanha Barreto / Poliana Moreira de Medeiros Carvalho / Ariel Gustavo Scafuri / Joabe Lima Araújo / Jefferson Almeida Rocha / Icaro Gusmão Pinto Vieira / Nágila Maria Pontes Silva Ricardo / Matheus da Silva Campelo / Maria Elenir Nobre Pinho Ribeiro / Gerly Anne de Castro Brito /
    Gilberto Santos Cerqueira

    Molecules, Vol 25, Iss 2786, p

    Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress

    2020  Volume 2786

    Abstract: Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted from ... ...

    Abstract Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted from Dimorphandra gardneriana , exhibits antioxidant, anti-inflammatory, cytoprotective, and gastroprotective properties. However, the effect of RUT on inflammatory processes in the intestine, especially on mucositis promoted by antineoplastic agents, has not yet been reported. In this study, we investigated the role of RUT on 5-FU-induced experimental intestinal mucositis. Swiss mice were randomly divided into seven groups: Saline, 5-FU, RUT-50, RUT-100, RUT-200, Celecoxib (CLX), and CLX + RUT-200 groups. The mice were weighed daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis); malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH) concentrations; mast and goblet cell counts; and cyclooxygenase-2 (COX-2) activity, as well as to perform immunohistochemical analyses. RUT treatment (200 mg/kg) prevented 5-FU-induced histopathological changes and reduced oxidative stress by decreasing MDA concentrations and increasing GSH concentrations. RUT attenuated the inflammatory response by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. These results suggest that the COX-2 pathway is one of the underlying protective mechanisms of RUT against 5-FU-induced intestinal mucositis.
    Keywords flavonoid ; inflammation ; antimetabolites ; intestine ; Organic chemistry ; QD241-441
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Troxerutin Prevents 5-Fluorouracil Induced Morphological Changes in the Intestinal Mucosa

    João Antônio Leal de Miranda / Conceição da Silva Martins / Lázaro de Sousa Fideles / Maria Lucianny Lima Barbosa / João Erivan Façanha Barreto / Helder Bindá Pimenta / Francisco Orlando Rafael Freitas / Paulo Vitor de Souza Pimentel / Claudio Silva Teixeira / Ariel Gustavo Scafuri / Maria Claudia dos Santos Luciano / Joabe Lima Araújo / Jefferson Almeida Rocha / Icaro Gusmão Pinto Vieira / Nágila Maria Pontes Silva Ricardo / Matheus da Silva Campelo / Maria Elenir Nobre Pinho Ribeiro / Gerly Anne de Castro Brito / Gilberto Santos Cerqueira

    Pharmaceuticals, Vol 13, Iss 1, p

    Role of Cyclooxygenase-2 Pathway

    2020  Volume 10

    Abstract: Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Troxerutin (TRX), a semi-synthetic flavonoid extracted from Dimorphandra gardneriana , has been reported as a potent ... ...

    Abstract Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Troxerutin (TRX), a semi-synthetic flavonoid extracted from Dimorphandra gardneriana , has been reported as a potent antioxidant and anti-inflammatory agent. In the present study, we aimed to evaluate the effect of TRX on 5-FU-induced intestinal mucositis. Swiss mice were randomly divided into seven groups: Saline, 5-FU, TRX-50, TRX-100, TRX-150, Celecoxib (CLX), and CLX + TRX-100. The weight of mice was measured daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis), levels of malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), mast and goblet cell counts, immunohistochemical analysis, and cyclooxygenase-2 (COX-2) activity. Compared to the saline treatment, the 5-FU treatment induced intense weight loss and reduction in villus height. TRX treatment (100 mg/kg) prevented the 5-FU-induced histopathological changes and decreased oxidative stress by decreasing the MDA levels and increasing GSH concentration. TRX attenuated inflammatory process by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. TRX also reversed the depletion of goblet cells. Our findings suggest that TRX at a concentration of 100 mg/kg had chemopreventive effects on 5-FU-induced intestinal mucositis via COX-2 pathway.
    Keywords chemoprevention ; inflammation ; flavonoid ; intestine ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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