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  1. Article ; Online: Ultrasound of the hand in systemic sclerosis

    Horatiu Ioan Popov / Maria Magdalena Tamas / Cristina Pamfil / Simona Rednic

    Romanian Journal of Rheumatology, Vol 30, Iss 2, Pp 55-

    2021  Volume 60

    Abstract: Systemic sclerosis is a chronic connective tissue disease characterized by multi-organ involvement but the main clinical changes occur in the hands, secondary to skin, joint and microvascular damage. Therefore the hand received a special attention for ... ...

    Abstract Systemic sclerosis is a chronic connective tissue disease characterized by multi-organ involvement but the main clinical changes occur in the hands, secondary to skin, joint and microvascular damage. Therefore the hand received a special attention for imaging and especially for ultrasound evaluation. In rheumatology US become an extension of the clinical examination and particularly in systemic sclerosis it has been proven to help with a better assessment of the skin, blood vessels, joints and tendons involvement. This evolution was allowed by permanent improvement of technology along with expanding the range of ultrasound applications which happened especially in past decade.
    Keywords systemic sclerosis ; ultrasound ; hand ; musculoskeletal ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Amaltea Medical Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Diagnosis Accuracy of Carpal Tunnel Syndrome in Diabetic Neuropathy

    Nicu Cătălin Drăghici / Maria Magdalena Tămaș / Daniel Corneliu Leucuța / Tudor Dimitrie Lupescu / Ștefan Strilciuc / Simona Rednic / Dafin Fior Mureșanu

    Medicina, Vol 56, Iss 279, p

    2020  Volume 279

    Abstract: Background and objectives: Carpal tunnel syndrome (CTS) is a common pathology, but sometimes the diagnosis is delayed in patients with diabetic neuropathy (DN). The aim of the study is twofold: first, to compare the accuracy of ultrasound (US) with that ... ...

    Abstract Background and objectives: Carpal tunnel syndrome (CTS) is a common pathology, but sometimes the diagnosis is delayed in patients with diabetic neuropathy (DN). The aim of the study is twofold: first, to compare the accuracy of ultrasound (US) with that of electroneurography (ENG) in the diagnosis of CTS associated with DN, using the clinical diagnosis as a reference standard, and second, to investigate the correlation between morphological US parameters and electrodiagnosis (EDX) measurements in patients with CTS and DN. Materials and Methods: This study included patients with DN. They were divided into two groups: Control (patients without CTS) and Cases (patients with CTS). We performed US and ENG in both hands, totaling 56 wrists, with 28 wrists in each group. Results: We found that the difference in the sensory distal latencies between the median and the ulnar nerves (ring finger) exhibited the highest diagnostic accuracy of all the US and ENG parameters, areas under the receiver operating characteristic (AUC) = 0.99 (95% CI 0.97–1), and it was significantly different from the best US diagnostic method. The wrist cross-sectional area (CSA) had the most accurate US diagnosis, while the wrist-to-forearm ratio had the worst AUC. Moreover, in the group of CTS and DN patients, the wrist CSA enlargement was statistically directly proportional to the median compound muscle action potential (CMAP) distal latency and inversely proportional to the antidromic median nerve conduction study (NCS) and the orthodromic median palm–wrist NCS. Conclusions: Both examinations can be used with confidence in the diagnosis of CTS overlapping with DN, but the EDX examination seems to be more accurate. Furthermore, we found a positive correlation between the US and EDX parameters.
    Keywords carpal tunnel syndrome ; diabetic neuropathy ; median nerve ; ultrasonography ; electromyography ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: THE ”JOINT CRITERIA” FOR FIBROMYALGIA DIAGNOSIS IN RHEUMATOID ARTHRITIS PATIENTS

    Linda-Jessica Ghib / Maria-Magdalena Tamas / Laura-Mirela Muntean / Simona Rednic

    Romanian Journal of Rheumatology, Vol 27, Iss 2, Pp 61-

    VALIDATION AND ASSESSMENT OF DISEASE ACTIVITY

    2018  Volume 66

    Abstract: The objectives of this study where to validate the ”joint criteria” for fibromyalgia (FM) diagnosis represented by the difference between tender joint count (TJC) and swollen joint count (SJC) in rheumatoid arthritis (RA) patients undergoing biological ... ...

    Abstract The objectives of this study where to validate the ”joint criteria” for fibromyalgia (FM) diagnosis represented by the difference between tender joint count (TJC) and swollen joint count (SJC) in rheumatoid arthritis (RA) patients undergoing biological treatment and examine clinical and ultrasound parameters in patients with and without FM. Patients and methods. RA patients on biological treatment were included during one month. ROC analysis was used to determine whether the ”joint criteria” could differentiate between patients with associated FM and those without. The disease activity score in 28 joints (DAS28) was calculated and ultrasound (US) examination was performed using the 7 joint score. Results. 39 patients were included. The ”joint criteria” had a sensitivity of 85% and specificity of 87% for FM diagnosis for a difference of ≥ 6 between TJC and SJC. Nine (23%) patients were diagnosed with FM using these criteria. Patients with RA-FM had higher values compared to RA for the DAS28 (5.1 vs 3.3, p= 0.01), TJC (12 vs 3, p < 0.001) and patient global assessment (PGA) (58 vs 41, p < 0.001), but similar values for SJC (1 vs 2, p=0.6), erythrocyte sedimentation rate (ESR) (27 vs 22, p= 0.21), C reactive protein (CRP) (8.6 vs 8.4, p= 0.6) and ultrasound parameters (Gray Scale synovitis 2.6 vs 3.8, p= 0.9; Power Doppler synovitis, 1.2 vs 1.6, p= 0.5; Gray Scale Tenosynovitis 0.4 vs 0.3, p=0.3; Power Doppler Tenosynovitis, 0.3 vs 0.2, p=0.08). Discussions. Our findings confirm previous published data on RA-FM diagnosis and disease characteristics on a sample of RA patients on biological treatment. The ”joint criteria” is a feasible tool and could easily identify patients with RA and FM in order to improve disease management. Conclusions. A difference of ≥ 6 between TJC and SJC is diagnostic of FM in RA patients. Patients that satisfy this criteria have higher DAS28 scores, TJC, PGA but similar SJC, ESR, CRP and US scores compared to RA patients without FM.
    Keywords rheumatoid arthritis ; fibromyalgia ; joint criteria ; ultrasound ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607
    Subject code 610
    Language English
    Publishing date 2018-06-01T00:00:00Z
    Publisher Amaltea Medical Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: CONCOMITANT FIBROMYALGIA IN RHEUMATOID ARTHRITIS

    Linda-Jessica Ghib / Laura Muntean / Maria-Magdalena Tamas / Simona Rednic

    Romanian Journal of Rheumatology, Vol 25, Iss 3, Pp 147-

    CHALLENGES IN DIAGNOSIS AND DISEASE ASSESSMENT

    2016  Volume 154

    Abstract: Fibromyalgia, characterized by chronic generalized pain and multiple somatic symptoms, is frequently associated with rheumatoid arthritis. This association causes worse disease outcomes and poses challenges in rheumatoid arthritis disease assessment. ... ...

    Abstract Fibromyalgia, characterized by chronic generalized pain and multiple somatic symptoms, is frequently associated with rheumatoid arthritis. This association causes worse disease outcomes and poses challenges in rheumatoid arthritis disease assessment. Recent studies found that fibromyalgia is a disease continuum. Varying degrees of symptoms can be present in patients with rheumatoid arthritis even if they do not satisfy diagnosis criteria for fibromyalgia. Classification criteria for fibromyalgia are recommended for use in research, but in clinical practice diagnosis should be based on physician judgment. Rheumatoid arthritis disease activity scores should be used with caution in patients with concomitant fibromyalgia because they are disproportionately high based on subjective variables, not inflammation. Other means of assessing disease activity such as ultrasonography or inflammation markers can be employed when trying to distinguish between inflammatory and non-inflammatory pain in patients with rheumatoid arthritis and concomitant fibromyalgia.
    Keywords pain ; polysymptomatic distress ; disease activity scores ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607
    Subject code 610
    Language English
    Publishing date 2016-09-01T00:00:00Z
    Publisher Amaltea Medical Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Early Arthritis

    Simona REDNIC / Maria-Magdalena TĂMAŞ / Ana PETCU

    Applied Medical Informatics, Vol 32, Iss 1, Pp 77-

    A Rapid and Sustained Response to Treatment over one Year Follow-up

    2013  Volume 86

    Abstract: Aim: We aimed to assess the evolution in a group of patients diagnosed with early arthritis, by using clinical outcome measures and to find possible predictors for the clinical response. Methods: The study was conducted in the Rheumatology Department ... ...

    Abstract Aim: We aimed to assess the evolution in a group of patients diagnosed with early arthritis, by using clinical outcome measures and to find possible predictors for the clinical response. Methods: The study was conducted in the Rheumatology Department between January 2010 - December 2011. Thirty-six patients between 18-75 years of age with arthritis of at least one peripheral joint less then 12 months duration were consecutively included; other definite causes for arthritis were clinically excluded. The visits were performed at baseline, 3, 6 and 12 months. Clinical examination and biological investigations related to the disease activity were performed. Clinical remission and the EULAR (“European League Against Rheumatism”) response criteria were assessed based on the disease activity score 28 (DAS28). Results: At baseline 91.67% of patients received treatment indication with disease modifying antirheumatic drugs. A significant decrease in the number of tender, swollen joints, erythrocyte sedimentation rate was obtained at 3 months (p<0.001). The mean DAS28 decreased from 5.02±1.31 at baseline to 3.54±1.36 at 3 months (p<0.001). At 3 months, 33.3% of patients were good and 50% moderate responders (p<0.001), while at 6 months 47.2% were good and 33.3% moderate responders (p<0.001). Remission and low disease activity were achieved by 47.2% of patients at 3 and 12 months. Conclusions: A rapid response to treatment was obtained at 3 months. Low disease activity and remission were achieved by almost a half of patients at each visit. The favorable response rate was preserved at 6 and 12 months of follow-up.
    Keywords Early arthritis ; Rheumatoid arthritis ; Disease activity ; Clinical remission ; Methotrexate ; Computer applications to medicine. Medical informatics ; R858-859.7
    Subject code 610
    Language English
    Publishing date 2013-02-01T00:00:00Z
    Publisher Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Basic calcium phosphate deposition disease – a clinical and imaging analysis

    Paulina Vele / Laura Otilia Damian / Siao-Pin Simon / Ioana Felea / Laura Muntean / Ileana FilipescU / Maria Magdalena Tamas / Cristina Pamfil / Cristian Nedelcut / Simona Rednic

    Romanian Journal of Rheumatology, Vol 29, Iss 2, Pp 70-

    2020  Volume 74

    Abstract: Background. Basic calcium phosphate (BCP) deposition disease is a frequent musculoskeletal problem characterized by the intraarticular or periarticular deposition of carbonate substituted hydroxyapatite, octacalcium phosphate and tricalcium phosphate. ... ...

    Abstract Background. Basic calcium phosphate (BCP) deposition disease is a frequent musculoskeletal problem characterized by the intraarticular or periarticular deposition of carbonate substituted hydroxyapatite, octacalcium phosphate and tricalcium phosphate. BCP and calcium pyrophosphate (CPP) crystals play an important role in the pathogenesis of osteoarthritis. Objectives. The primary aim was to evaluate the clinical and ultrasonographic characteristics of patients with BCP. The secondary aim was to compare the radiographic scores of patients with BCP, calcium pyrophosphate dihydrate (CPPD) deposition disease and degenerative disease (DD). Material and methods. 50 patients with BCP deposition disease diagnosed by imaging or by identification of BCP in synovial fluid (SF) were included in the study. The second part of the study included 20 patients with BCP crystals in SF, 20 patients with CPP crystals in SF and 20 patients with degenerative changes on radiography and without crystals in SF. Clinical, ultrasonographic and radiographic data were recorded. Results. The shoulder joint (56%), followed by the knee joint (36%) and the acute clinical presentation (84%) were the most common findings. The fragmented ultrasound appearance (54%) was the most frequent, followed by the arch-shaped (36%). The localization of the deposits was found most often in the tendons (68%), mainly in the supraspinatus tendon (55.88%). Higher K/L scores were found in patients with BCP and CPP crystals than in the patients with DD. K/L score ≥3, defining osteoarthritis was associated with the presence of BCP and CPP crystals. Conclusions. The shoulder and the fragmented ultrasound pattern are the most common findings in patients with BCP. Higher K/L scores are found in patients with BCP and CPP crystal associated disease than in the degenerative disease patients.
    Keywords basic calcium phosphate ; calcium pyrophosphate ; osteoarthritis ; kellgren-lawrence ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Amaltea Medical Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: CLINICAL AND RADIOGRAPHIC FINDINGS IN PATIENTS WITH CHONDROCALCINOSIS

    Paulina Vele / Laura Otilia Damian / Siao-Pin Simon / Ioana Felea / Laura Muntean / Ileana Filipescu / Maria Magdalena Tamas / Cristina Pamfil / Simona Rednic

    Romanian Journal of Rheumatology, Vol 27, Iss 2, Pp 73-

    2018  Volume 77

    Abstract: Background. Calcium pyrophosphate deposition disease results from the deposition of calcium pyrophosphate crystals and needs to fulfil McCarty criteria for diagnosis. Chondrocalcinosis is defined as cartilage and fibrocartilage calcification identified ... ...

    Abstract Background. Calcium pyrophosphate deposition disease results from the deposition of calcium pyrophosphate crystals and needs to fulfil McCarty criteria for diagnosis. Chondrocalcinosis is defined as cartilage and fibrocartilage calcification identified by imaging or histological examination. The presence of calcium-containing crystals in synovial fluid is associated strongly with the degenerative joint disease, but the exact mechanism remains to be elucidated. Objectives. To compare the clinical and radiographic characteristics in patients with and without chondrocalcinosis. Material and methods. One hundred and forty-three patients, 86 with chondrocalcinosis and 57 controls with primary osteoarthritis were consecutively enrolled in this case-control, transversal, prospective study performed in the Rheumatology Department, Emergency Clinical County Hospital Cluj-Napoca, Romania, between January 2015 and January 2018. A subgroup of 39 patients fulfilled McCarty criteria for calcium pyrophosphate deposition (CPPD) disease. Demographic data, clinical data, laboratory data, knee radiographs, knee ultrasound, were recorded in both groups. Kellgren-Lawrence score was graded in all patients at the knee level. Results. The patients with chondrocalcinosis had higher tender joint count (3.1±6.8 versus 1.9±0.1, p<0.05), swollen joint count (1.37±0.9 versus 0.28±0.3, p<0.05), visual analogue scale for pain (7.72±1.28 versus 6.5±3.5, p<0.05). Kellgren-Lawrence score at the knee level was higher in the chondrocalcinosis group (p<0.05) comparing to controls, but not when comparing the CPPD group with the chondrocalcinosis group. Osteoarthritis was associated with chondrocalcinosis when compared to controls and with definite CPPD when comparing to chondrocalcinosis subgroup. Conclusions. Chondrocalcinosis was associated with pain, arthritis and higher Kellgren-Lawrence score than the controls.
    Keywords chondrocalcinosis ; cppd ; kellgren-lawrence score ; osteoarthritis ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607
    Subject code 610
    Language English
    Publishing date 2018-06-01T00:00:00Z
    Publisher Amaltea Medical Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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