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Article ; Online: Urine Biomarkers in the Management of Adult Neurogenic Lower Urinary Tract Dysfunction

Periklis Koukourikis / Maria Papaioannou / Dimitrios Papanikolaou / Apostolos Apostolidis

Diagnostics, Vol 13, Iss 468, p

A Systematic Review

2023 Volume 468

Abstract: Background: Neurogenic lower urinary tract dysfunction requires lifelong surveillance and management for the perseveration of patients’ quality of life and the prevention of significant morbidity and mortality. Urine biomarkers are an attractive ... ...

Abstract	Background: Neurogenic lower urinary tract dysfunction requires lifelong surveillance and management for the perseveration of patients’ quality of life and the prevention of significant morbidity and mortality. Urine biomarkers are an attractive noninvasive method of surveillance for these patients. The aim of this systematic review is to search for and critically appraise studies that investigate the clinical usefulness of urine biomarkers in the management of neurogenic lower urinary tract dysfunction (NLUTD) in adults. Methods: This review was conducted according to PRISMA and MOOSE guidelines. Search strategy included PubMed, CENTRAL, and Scopus (until October 2022). Studies investigating potential urine biomarkers for the management of adults with NLUTD were included. Results: Fifteen studies fulfilled the criteria. To date, a variety of different urine molecules have been investigated for the diagnosis and management of neurogenic overactive bladder and detrusor overactivity (nerve growth factor, brain-derived neurotrophic factor, prostaglandin E2, prostaglandin F2α, transformation growth factor β-1, tissue inhibitor metalloproteinase-2, matrix metalloproteinase-2, substance P, microRNA), diagnosis of vesicoureteral reflux (exosomal vitronectin), urinary tract infection (neutrophil gelatinase-associated lipocalin, interleukin 6) and bladder cancer screening (cytology, BTA stat, survivin) in neurological patients. Conclusion: Further studies are needed to specify the utility of each molecule in the management algorithm of adult NLUTD.
Keywords	neurogenic lower urinary tract dysfunction ; neurogenic bladder ; urine biomarkers ; Medicine (General) ; R5-920
Subject code	306
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Overcoming phenotypic switching

Christos Ladias / Pavlos Papakotoulas / Maria Papaioannou / Nikolaos A. Papanikolaou

Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 5, Pp 1071-

targeting protein-protein interactions in cancer

2023 Volume 1081

Abstract: Alternative protein-protein interactions (PPIs) arising from mutations or post-translational modifications (PTMs), termed phenotypic switching (PS), are critical for the transmission of alternative pathogenic signals and are particularly significant in ... ...

Abstract	Alternative protein-protein interactions (PPIs) arising from mutations or post-translational modifications (PTMs), termed phenotypic switching (PS), are critical for the transmission of alternative pathogenic signals and are particularly significant in cancer. In recent years, PPIs have emerged as promising targets for rational drug design, primarily because their high specificity facilitates targeting of disease-related signaling pathways. However, obstacles exist at the molecular level that arise from the properties of the interaction interfaces and the propensity of small molecule drugs to interact with more than one cleft surface. The difficulty in identifying small molecules that act as activators or inhibitors to counteract the biological effects of mutations raises issues that have not been encountered before. For example, small molecules can bind tightly but may not act as drugs or bind to multiple sites (interaction promiscuity). Another reason is the absence of significant clefts on protein surfaces; if a pocket is present, it may be too small, or its geometry may prevent binding. PS, which arises from oncogenic (alternative) signaling, causes drug resistance and forms the basis for the systemic robustness of tumors. In this review, the properties of PPI interfaces relevant to the design and development of targeting drugs are examined. In addition, the interactions between three tyrosine kinase inhibitors (TKIs) employed as drugs are discussed. Finally, potential novel targets of one of these drugs were identified in silico.
Keywords	protein-protein interactions ; phenotypic switching ; imatinib ; ponatinib ; ibrutinib ; Internal medicine ; RC31-1245
Subject code	612
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Open Exploration Publishing Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Dynamic and Crucial Role of the Arginine Methylproteome in Myoblast Cell Differentiation

Nikolaos A. Papanikolaou / Marios Nikolaidis / Grigorios D. Amoutzias / Ariadni Fouza / Maria Papaioannou / Akhilesh Pandey / Athanasios G. Papavassiliou

International Journal of Molecular Sciences, Vol 24, Iss 2124, p

2023 Volume 2124

Abstract: Protein arginine methylation is an extensive and functionally significant post-translational modification. However, little is known about its role in differentiation at the systems level. Using stable isotope labeling by amino acids in cell culture ( ... ...

Abstract	Protein arginine methylation is an extensive and functionally significant post-translational modification. However, little is known about its role in differentiation at the systems level. Using stable isotope labeling by amino acids in cell culture (SILAC) proteomics of whole proteome analysis in proliferating or five-day differentiated mouse C2C12 myoblasts, followed by high-resolution mass spectrometry, biochemical assays, and specific immunoprecipitation of mono- or dimethylated arginine peptides, we identified several protein families that were differentially methylated on arginine. Our study is the first to reveal global changes in the arginine mono- or dimethylation of proteins in proliferating myoblasts and differentiated myocytes and to identify enriched protein domains and novel short linear motifs (SLiMs). Our data may be crucial for dissecting the links between differentiation and cancer growth.
Keywords	arginine ; C2C12 ; differentiation ; methylproteome ; myoblast ; SILAC ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Maternal and Neonatal Characteristics and Outcomes of COVID-19 in Pregnancy

Michail Papapanou / Maria Papaioannou / Aikaterini Petta / Eleni Routsi / Maria Farmaki / Nikolaos Vlahos / Charalampos Siristatidis

International Journal of Environmental Research and Public Health, Vol 18, Iss 596, p

An Overview of Systematic Reviews

2021 Volume 596

Abstract: 1) Background: A considerable number of systematic reviews, with substantial heterogeneity regarding their methods and included populations, on the impact of COVID-19 on infected pregnant women and their neonates, has emerged. The aim was to describe ... ...

Abstract	(1) Background: A considerable number of systematic reviews, with substantial heterogeneity regarding their methods and included populations, on the impact of COVID-19 on infected pregnant women and their neonates, has emerged. The aim was to describe the obstetric-perinatal and neonatal outcome of infected pregnant women and their newborns during the COVID-19 pandemic; (2) Methods: Three bibliographical databases were searched (last search: September 10, 2020). Quality assessment was performed using the AMSTAR-2 tool. Primary outcomes included mode of delivery, preterm delivery/labor, premature rupture of membranes (PROM/pPROM) and abortions/miscarriages. Outcomes were mainly presented as ranges. A separate analysis, including only moderate and high-quality systematic reviews, was also conducted. The protocol was registered with PROSPERO (CRD42020214447); (3) Results: Thirty-nine reviews were analyzed. Reported rates, regarding both preterm and term gestations, varied between 52.3 and 95.8% for cesarean sections; 4.2–44.7% for vaginal deliveries; 14.3–63.8% specifically for preterm deliveries and 22.7–32.2% for preterm labor; 5.3–12.7% for PROM and 6.4–16.1% for pPROM. Maternal anxiety for potential fetal infection contributed to abortion decisions, while SARS-CoV-2-related miscarriages could not be excluded. Maternal ICU admission and mechanical ventilation rates were 3–28.5% and 1.4–12%, respectively. Maternal mortality rate was <2%, while stillbirth, neonatal ICU admission and mortality rates were <2.5%, 3.1–76.9% and <3%, respectively. Neonatal PCR positivity rates ranged between 1.6% and 10%. After accounting for quality of studies, ranges of our primary outcomes remained almost unchanged, while among our secondary outcomes, maternal ICU admission (3–10%) and mechanical ventilation rates (1.4–5.5%) were found to be relatively lower; (4) Conclusions: Increased rates of cesarean sections and preterm birth rates were found, with iatrogenic reasons potentially involved. In cases of symptomatic women ...
Keywords	COVID-19 ; SARS-CoV-2 ; pregnancy ; mother ; maternal outcomes ; neonate ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Integration of Biobanks in National eHealth Ecosystems Facilitating Long-Term Longitudinal Clinical-Omics Studies and Citizens' Engagement in Research Through eHealthBioR

Athos Antoniades / Maria Papaioannou / Apostolos Malatras / Gregory Papagregoriou / Heimo Müller / Petr Holub / Constantinos Deltas / Christos N. Schizas

Frontiers in Digital Health, Vol

2021 Volume 3

Abstract: Biobanks have long existed to support research activities with BBMRI-ERIC formed as a European research infrastructure supporting the coordination for biobanking with 20 country members and one international organization. Although the benefits of ... ...

Abstract	Biobanks have long existed to support research activities with BBMRI-ERIC formed as a European research infrastructure supporting the coordination for biobanking with 20 country members and one international organization. Although the benefits of biobanks to the research community are well-established, the direct benefit to citizens is limited to the generic benefit of promoting future research. Furthermore, the advent of General Data Protection Regulation (GDPR) legislation raised a series of challenges for scientific research especially related to biobanking associate activities and longitudinal research studies. Electronic health record (EHR) registries have long existed in healthcare providers. In some countries, even at the national level, these record the state of the health of citizens through time for the purposes of healthcare and data portability between different providers. The potential of EHRs in research is great and has been demonstrated in many projects that have transformed EHR data into retrospective medical history information on participating subjects directly from their physician's collected records; many key challenges, however, remain. In this paper, we present a citizen-centric framework called eHealthBioR, which would enable biobanks to link to EHR systems, thus enabling not just retrospective but also lifelong prospective longitudinal studies of participating citizens. It will also ensure strict adherence to legal and ethical requirements, enabling greater control that encourages participation. Citizens would benefit from the real and direct control of their data and samples, utilizing technology, to empower them to make informed decisions about providing consent and practicing their rights related to the use of their data, as well as by having access to knowledge and data generated from samples they provided to biobanks. This is expected to motivate patient engagement in future research and even leads to participatory design methodologies with citizen/patient-centric designed studies. The development of platforms based on the eHealthBioR framework would need to overcome significant challenges. However, it would shift the burden of addressing these to experts in the field while providing solutions enabling in the long term the lower monetary and time cost of longitudinal studies coupled with the option of lifelong monitoring through EHRs.
Keywords	biobanks ; ethical ; national health ; legal and social issues (ELSI) ; electronic health record ; Medicine ; R ; Public aspects of medicine ; RA1-1270 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	306
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prevalence and correlates of persistent intracellular HIV transcription in individuals on efavirenz versus atazanavir-based regimens

Dimitrios Pilalas / Lemonia Skoura / Apostolia Margariti / Fani Chatzopoulou / Dimitrios Chatzidimitriou / Olga Tsachouridou / Pantelis Zebekakis / Simeon Metallidis / Maria Papaioannou

PLoS ONE, Vol 13, Iss 3, p e

A prospective cohort study.

2018 Volume 0194262

Abstract: Despite successful virological suppression, HIV transcription frequently persists intracellularly. In this study, we hypothesize that HIV persistent transcription(HIVpt) may affect to a different extent patients on stable efavirenz(EFV) versus atazanavir( ...

Abstract	Despite successful virological suppression, HIV transcription frequently persists intracellularly. In this study, we hypothesize that HIV persistent transcription(HIVpt) may affect to a different extent patients on stable efavirenz(EFV) versus atazanavir(ATV)-based regimens. The role of the expression of drug efflux transporters in HIVpt was also investigated.We prospectively enrolled 51 virologically suppressed patients on first-line treatment for one year with EFV or ATV combined with emtricitabine and tenofovir and followed them up for one year. Simultaneous ultrasensitive subpopulation staining/hybridization in situ(SUSHI) was performed to identify HIVpt in CD4+ T-cells and in the CD4+CD45RO+ T-cell subpopulation. The differential mRNA expression of P-glycoprotein(P-gp/ABCB1) and multidrug resistance-associated protein-1(MRP1/ABCC1) was also evaluated. Univariate logistic regression models were used to evaluate predictors of HIVpt.In the CD4+ T-cell population, HIVpt affected 13/30 of patients on EFV versus 10/21 on ATV. In the CD4+CD45RO+ T-cell population, HIVpt was present in 14/30 of patients on EFV versus 15/21 on ATV. A trend for association was observed between the risk of HIVpt and ATV treatment in the CD4+CD45RO+ T-cell population (OR 2.86, 95% CI 0.87-9.37, p = 0.083). HIVpt status was not associated with loss of virological suppression or CD4 evolution. We found no evidence of differential expression of the drug efflux transporters P-gp and MRP1.Further study is required to evaluate whether the HIVpt profile in specific cell populations may differ across different antiretroviral regimens and to elucidate the potential clinical impact.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Persistent intracellular HIV transcription in individuals on stable antiretroviral regimens

Dimitrios Pilalas / Lemonia Skoura / Apostolia Margariti / Fani Chatzopoulou / Dimitrios Chatzidimitriou / Olga Tsachouridou / Pantelis Zebekakis / Simeon Metallidis / Maria Papaioannou

Journal of Virus Eradication, Vol 4, Iss , Pp 14- (2018)

2018

Keywords	Microbiology ; QR1-502 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Immune Thrombocytopenia in a Patient Recovering From COVID-19

Symeon Metallidis / Georgia Gioula / Maria Papaioannou / Maria Exindari / Theofilos Chrysanthidis / Olga Tsachouridou / Iordanis Mimtsoudis / Maria Christoforidi / Pantelis Zempekakis / Anna Papa-Konidari / Sotirios Tsiodras

HemaSphere, Vol 4, Iss 5, p e

2020 Volume 419

Keywords	Diseases of the blood and blood-forming organs ; RC633-647.5 ; covid19
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma

Jaime Alvarez-Benayas / Nikolaos Trasanidis / Alexia Katsarou / Kanagaraju Ponnusamy / Aristeidis Chaidos / Philippa C. May / Xiaolin Xiao / Marco Bua / Maria Atta / Irene A. G. Roberts / Holger W. Auner / Evdoxia Hatjiharissi / Maria Papaioannou / Valentina S. Caputo / Ian M. Sudbery / Anastasios Karadimitris

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 16

Abstract: Despite extensive genetic heterogeneity, nearly half of all multiple myeloma (MM) cases are driven by cyclin D2 (CCND2) over-expression. Here the authors dissect the chromatin landscape of MM to provide insights into the transcriptional regulatory ... ...

Abstract	Despite extensive genetic heterogeneity, nearly half of all multiple myeloma (MM) cases are driven by cyclin D2 (CCND2) over-expression. Here the authors dissect the chromatin landscape of MM to provide insights into the transcriptional regulatory landscape driving MM and divergent transcriptomes corresponding to different MM genetic subtypes.
Keywords	Science ; Q
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Targeted gene expression study of Salmonella enterica during biofilm formation on rocket leaves

Doulgeraki, Agapi I / George-John E. Nychas / Maria Papaioannou

Lebensmittel-Wissenschaft + [i.e. und] Technologie. 2016 Jan., v. 65

2016

Abstract: In the present study, the ability of Salmonella Typhimurium to form biofilm community on rocket leaves and rocket extract at 10 °C and 20 °C was investigated. This goal was achieved with the study of expression of genes associated with biofilm formation ... ...

Abstract	In the present study, the ability of Salmonella Typhimurium to form biofilm community on rocket leaves and rocket extract at 10 °C and 20 °C was investigated. This goal was achieved with the study of expression of genes associated with biofilm formation and other functional roles. The obtained results showed that Salmonella growth was inhibited when cultured in rocket extract (liquid and solid state) and when grew directly to rocket leaves. The observed inhibition might be attributed to nutrient starvation to the specific growth media because of plant leaves's variability, cell physiology and antimicrobial compounds of rocket. In addition, gene expression study using Real-Time PCR showed that biofilm was formatted on solid media, while the entrance and adhesion of the microorganism within the plant held more strongly through the stomata of the plant leaves. Furthermore, genes associated with managing stress situations were overexpressed at 20 °C. From these results, it is indicated that further studies are needed to better determine the survival and/or growth of the pathogen as “real” biofilm cells on plants. In addition, the study on development and gene expression of biofilm cells is necessary in order to eliminate the specific pathogen and reduce the food-borne diseases it causes.
Keywords	adhesion ; anti-infective agents ; biofilm ; cell physiology ; culture media ; foodborne illness ; gene overexpression ; genes ; growth retardation ; leaves ; pathogens ; quantitative polymerase chain reaction ; Salmonella Typhimurium ; starvation ; stomata
Language	English
Dates of publication	2016-01
Size	p. 254-260.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	241369-3
ISSN	0460-1173 ; 0023-6438
ISSN	0460-1173 ; 0023-6438
DOI	10.1016/j.lwt.2015.08.017
Database	NAL-Catalogue (AGRICOLA)

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