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  1. AU="Maria Rosaria Campitiello"
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  1. Artikel ; Online: The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures

    Giulia Sgueglia / Salvatore Longobardi / Domenico Valerio / Maria Rosaria Campitiello / Nicola Colacurci / Cinzia Di Pietro / Rosalia Battaglia / Thomas D’Hooghe / Lucia Altucci / Carmela Dell’Aversana

    Clinical Epigenetics, Vol 15, Iss 1, Pp 1-

    2023  Band 10

    Abstract: Abstract The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation ( ...

    Abstract Abstract The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation (IVF) protocols. Here, we describe the main epigenetic modifications that may influence female reproduction and could affect IVF success. Graphical Abstract
    Schlagwörter Epigenetics ; Fertility ; IVF ; Reproduction ; Medicine ; R ; Genetics ; QH426-470
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Inhibition of Galectins and the P2X7 Purinergic Receptor as a Therapeutic Approach in the Neurovascular Inflammation of Diabetic Retinopathy

    Caterina Claudia Lepre / Marina Russo / Maria Consiglia Trotta / Francesco Petrillo / Fabiana Anna D’Agostino / Gennaro Gaudino / Giovanbattista D’Amico / Maria Rosaria Campitiello / Erminia Crisci / Maddalena Nicoletti / Carlo Gesualdo / Francesca Simonelli / Michele D’Amico / Anca Hermenean / Settimio Rossi

    International Journal of Molecular Sciences, Vol 24, Iss 9721, p

    2023  Band 9721

    Abstract: Diabetic retinopathy (DR) is the most frequent microvascular retinal complication of diabetic patients, contributing to loss of vision. Recently, retinal neuroinflammation and neurodegeneration have emerged as key players in DR progression, and therefore, ...

    Abstract Diabetic retinopathy (DR) is the most frequent microvascular retinal complication of diabetic patients, contributing to loss of vision. Recently, retinal neuroinflammation and neurodegeneration have emerged as key players in DR progression, and therefore, this review examines the neuroinflammatory molecular basis of DR. We focus on four important aspects of retinal neuroinflammation: (i) the exacerbation of endoplasmic reticulum (ER) stress; (ii) the activation of the NLRP3 inflammasome; (iii) the role of galectins; and (iv) the activation of purinergic 2X7 receptor (P2X7R). Moreover, this review proposes the selective inhibition of galectins and the P2X7R as a potential pharmacological approach to prevent the progression of DR.
    Schlagwörter diabetic retinopathy ; neuroinflammation ; ROS ; ER stress ; NLRP3 inflammasome ; galectins ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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