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  1. Article: Advanced Esophageal Squamous Cell Carcinoma in Young Female Patient With Durable Complete Response on Treatment.

    Jankarashvili, Natalia / Melkadze, Tamar / Tchiabrishvili, Mariam / Mariamidze, Armaz / Arveladze, Giorgi

    Cureus

    2021  Volume 13, Issue 5, Page(s) e15255

    Abstract: Esophageal carcinoma is the seventh most common cancer and the sixth most lethal cancer worldwide. There are two main histological types of esophageal carcinoma: adenocarcinoma (AC) and squamous cell carcinoma (SCC). Both histological types are more ... ...

    Abstract Esophageal carcinoma is the seventh most common cancer and the sixth most lethal cancer worldwide. There are two main histological types of esophageal carcinoma: adenocarcinoma (AC) and squamous cell carcinoma (SCC). Both histological types are more common in males than females. Menopause is an independent risk factor for esophageal cancer while usage of hormonal therapy (estrogen plus progesterone) is associated with a lower risk of esophageal SCC in postmenopausal women. Gender differences have an impact on SCC incidence, however, it is unclear if gender has a prognostic value for survival. The present case report describes a young woman who developed SCC of the esophagus. The disease was diagnosed in the locally advanced stage. Definitive chemo-radiotherapy induced complete response. These findings might suggest that in young women esophageal SCC may have a better prognosis.
    Language English
    Publishing date 2021-05-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.15255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Acute Disseminated Encephalomyelitis Following Chemoradiotherapy in an Adult Patient With Nasopharyngeal Cancer.

    Esakia, Tamar / Antia, Tamar / Janelidze, Marina / Mariamidze, Armaz / Okujava, Mikheil

    Cureus

    2021  Volume 13, Issue 3, Page(s) e14137

    Abstract: Acute disseminated encephalomyelitis (ADEM) is a monophasic demyelinating disorder predominantly affecting children. It typically follows a viral illness or vaccination. We present a case of a 34-year-old white male treated with chemo-radiotherapy for ... ...

    Abstract Acute disseminated encephalomyelitis (ADEM) is a monophasic demyelinating disorder predominantly affecting children. It typically follows a viral illness or vaccination. We present a case of a 34-year-old white male treated with chemo-radiotherapy for nasopharyngeal cancer who developed ADEM. Prompt initiation of intravenous steroids led to the resolution of symptoms and normalization of the brain imaging. We hypothesized that direct brain tissue damage by chemotherapy and radiation therapy, combined possibly with a viral infection, triggered an immune inflammatory response and subsequent demyelination.
    Language English
    Publishing date 2021-03-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.14137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Computed tomography guided radiofrequency ablation of multifocal osteoid osteoma.

    Onashvili, Nikoloz / Loria, George / Gogichaishvili, Tamar / Mariamidze, Armaz / Sirbiladze, Manana / Sainishvili, Nikoloz

    Radiology case reports

    2020  Volume 15, Issue 8, Page(s) 1275–1279

    Abstract: Osteoid osteoma is a benign osteoblastic tumor characterized mostly by presence of one nidus, butvery infrequentlyniduses can be multiple. Radiofrequency ablation is a well-established treatment method for this disease. We report a case of a 19-year-old ... ...

    Abstract Osteoid osteoma is a benign osteoblastic tumor characterized mostly by presence of one nidus, butvery infrequentlyniduses can be multiple. Radiofrequency ablation is a well-established treatment method for this disease. We report a case of a 19-year-old male patient with bifocal osteoid osteoma which was partially missed on the initial magnetic resonance imaging and treated successfully with two sessions of radiofrequency ablation. Following the second session of ablation, the pain resolved immediately and the patient remains pain-free for 6 months since the procedure. Our case report underlines the fact that although very rare, multifocal osteoid osteomas do exist and its niduses can be obscured during the magnetic resonance imaging due to the edema. It emphasizes the role of the initial computed tomography evaluation.
    Language English
    Publishing date 2020-06-18
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2020.05.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas

    Abeshouse, Adam / Adebamowo, Clement / Adebamowo, Sally N / Akbani, Rehan / Akeredolu, Teniola / Ally, Adrian / Anderson, Matthew L / Anur, Pavana / Appelbaum, Elizabeth L / Armenia, Joshua / Auman, J. Todd / Bailey, Matthew H / Baker, Laurence / Balasundaram, Miruna / Balu, Saianand / Barthel, Floris P / Bartlett, John / Baylin, Stephen B / Behera, Madhusmita /
    Belyaev, Dmitry / Bennett, Joesph / Benz, Christopher / Beroukhim, Rameen / Birrer, Michael / Bocklage, Thèrése / Bodenheimer, Tom / Boice, Lori / Bootwalla, Moiz S / Bowen, Jay / Bowlby, Reanne / Boyd, Jeff / Brohl, Andrew S / Brooks, Denise / Byers, Lauren / Carlsen, Rebecca / Castro, Patricia / Chen, Hsiao-Wei / Cherniack, Andrew D / Chibon, Fréderic / Chin, Lynda / Cho, Juok / Chuah, Eric / Chudamani, Sudha / Cibulskis, Carrie / Cooper, Lee A.D / Cope, Leslie / Cordes, Matthew G / Crain, Daniel / Curley, Erin / Danilova, Ludmila / Dao, Fanny / Davis, Ian J / Davis, Lara E / Defreitas, Timothy / Delman, Keith / Demchok, John A / Demetri, George D / Demicco, Elizabeth G / Dhalla, Noreen / Diao, Lixia / Ding, Li / DiSaia, Phil / Dottino, Peter / Doyle, Leona A / Drill, Esther / Dubina, Michael / Eschbacher, Jennifer / Fedosenko, Konstantin / Felau, Ina / Ferguson, Martin L / Frazer, Scott / Fronick, Catrina C / Fulidou, Victoria / Fulton, Lucinda A / Fulton, Robert S / Gabriel, Stacey B / Gao, Jianjiong / Gao, Qingsong / Gardner, Johanna / Gastier-Foster, Julie M / Gay, Carl M / Gehlenborg, Nils / Gerken, Mark / Getz, Gad / Godwin, Andrew K / Godwin, Eryn M / Gordienko, Elena / Grilley-Olson, Juneko E / Gutman, David A / Gutmann, David H / Hayes, D. Neil / Hegde, Apurva M / Heiman, David I / Heins, Zachary / Helsel, Carmen / Hepperla, Austin J / Higgins, Kelly / Hoadley, Katherine A / Hobensack, Shital / Holt, Robert A / Hoon, Dave B / Hornick, Jason L / Hoyle, Alan P / Hu, Xin / Huang, Mei / Hutter, Carolyn M / Iacocca, Mary / Ingram, Davis R / Ittmann, Michael / Iype, Lisa / Jefferys, Stuart R / Jones, Kevin B / Jones, Corbin D / Jones, Steven J.M / Kalir, Tamara / Karlan, Beth Y / Karseladze, Apollon / Kasaian, Katayoon / Kim, Jaegil / Kundra, Ritika / Kuo, Hanluen / Ladanyi, Marc / Lai, Phillip H / Laird, Peter W / Larsson, Erik / Lawrence, Michael S / Lazar, Alexander J / Lee, Sanghoon / Lee, Darlene / Lehmann, Kjong-Van / Leraas, Kristen M / Lester, Jenny / Levine, Douglas A / Li, Irene / Lichtenberg, Tara M / Lin, Pei / Liu, Jia / Liu, Wenbin / Liu, Eric Minwei / Lolla, Laxmi / Lu, Yiling / Ma, Yussanne / Madan, Rashna / Maglinte, Dennis T / Magliocco, Anthony / Maki, Robert G / Mallery, David / Manikhas, Georgy / Mardis, Elaine R / Mariamidze, Armaz / Marra, Marco A / Martignetti, John A / Martinez, Cathleen / Mayo, Michael / McLellan, Michael D / Meier, Sam / Meng, Shaowu / Meyerson, Matthew / Mieczkowski, Piotr A / Miller, Christopher A / Mills, Gordon B / Moore, Richard A / Morris, Scott / Mose, Lisle E / Mozgovoy, Evgeny / Mungall, Andrew J / Mungall, Karen / Nalisnik, Michael / Naresh, Rashi / Newton, Yulia / Noble, Michael S / Novak, Janet E / Ochoa, Angelica / Olvera, Narciso / Owonikoko, Taofeek K / Paklina, Oxana / Parfitt, Jeremy / Parker, Joel S / Pastore, Alessandro / Paulauskis, Joseph / Penny, Robert / Pereira, Elena / Perou, Charles M / Perou, Amy H / Pihl, Todd / Pollock, Raphael E / Potapova, Olga / Radenbaugh, Amie J / Ramalingam, Suresh S / Ramirez, Nilsa C / Rathmell, W. Kimryn / Raut, Chandrajit P / Riedel, Richard F / Reilly, Colleen / Reynolds, Sheila M / Roach, Jeffrey / Robertson, A. Gordon / Roszik, Jason / Rubin, Brian P / Sadeghi, Sara / Saksena, Gordon / Salner, Andrew / Sanchez-Vega, Francisco / Sander, Chris / Schein, Jacqueline E / Schmidt, Heather K / Schultz, Nikolaus / Schumacher, Steven E / Sekhon, Harman / Senbabaoglu, Yasin / Setdikova, Galiya / Shelton, Candace / Shelton, Troy / Shen, Ronglai / Shi, Yan / Shih, Juliann / Shmulevich, Ilya / Sica, Gabriel L / Simons, Janae V / Singer, Samuel / Sipahimalani, Payal / Skelly, Tara / Socci, Nicholas / Sofia, Heidi J / Soloway, Matthew G / Spellman, Paul / Sun, Qiang / Swanson, Patricia / Tam, Angela / Tan, Donghui / Tarnuzzer, Roy / Thiessen, Nina / Thompson, Eric / Thorne, Leigh B / Tong, Pan / Torres, Keila E / van de Rijn, Matt / Van Den Berg, David J / Van Tine, Brian A / Veluvolu, Umadevi / Verhaak, Roel / Voet, Doug / Voronina, Olga / Wan, Yunhu / Wang, Zhining / Wang, Jing / Weinstein, John N / Weisenberger, Daniel J / Wilkerson, Matthew D / Wilson, Richard K / Wise, Lisa / Wong, Tina / Wong, Winghing / Wrangle, John / Wu, Ye / Wyczalkowski, Matthew / Yang, Liming / Yau, Christina / Yellapantula, Venkata / Zenklusen, Jean C / Zhang, Jiashan (Julia) / Zhang, Hailei / Zhang, Hongxin / Zmuda, Erik

    Cell. 2017 Nov. 02, v. 171, no. 4

    2017  

    Abstract: Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the ... ...

    Institution The Cancer Genome Atlas Research Network
    Abstract Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (TP53, ATRX, RB1) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Overall, this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining sarcoma therapy and relationships to other cancer types.
    Keywords DNA methylation ; adults ; clinical trials ; epithelium ; genes ; genomics ; histology ; messenger RNA ; patients ; sarcoma ; therapeutics
    Language English
    Dates of publication 2017-1102
    Size p. 950-965.e28.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2017.10.014
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

    Ding, Li / Bailey, Matthew H. / Porta-Pardo, Eduard / Thorsson, Vesteinn / Colaprico, Antonio / Bertrand, Denis / Gibbs, David L. / Weerasinghe, Amila / Huang, Kuan-lin / Tokheim, Collin / Cortés-Ciriano, Isidro / Jayasinghe, Reyka / Chen, Feng / Yu, Lihua / Sun, Sam / Olsen, Catharina / Kim, Jaegil / Taylor, Alison M. / Cherniack, Andrew D. /
    Akbani, Rehan / Suphavilai, Chayaporn / Nagarajan, Niranjan / Stuart, Joshua M. / Mills, Gordon B. / Wyczalkowski, Matthew A. / Vincent, Benjamin G. / Hutter, Carolyn M. / Zenklusen, Jean Claude / Hoadley, Katherine A. / Wendl, Michael C. / Shmulevich, llya / Lazar, Alexander / Wheeler, David A. / Getz, Gad / Caesar-Johnson, Samantha J. / Demchok, John A. / Felau, Ina / Kasapi, Melpomeni / Ferguson, Martin L. / Sofia, Heidi J. / Tarnuzzer, Roy / Wang, Zhining / Yang, Liming / Zenklusen, Jean C. / Zhang, Jiashan (Julia) / Chudamani, Sudha / Liu, Jia / Lolla, Laxmi / Naresh, Rashi / Pihl, Todd / Sun, Qiang / Wan, Yunhu / Wu, Ye / Cho, Juok / DeFreitas, Timothy / Frazer, Scott / Gehlenborg, Nils / Heiman, David I. / Lawrence, Michael S. / Lin, Pei / Meier, Samuel A. / Noble, Michael S. / Saksena, Gordon / Voet, Doug / Zhang, Hailei / Bernard, Brady / Chambwe, Nyasha / Dhankani, Varsha / Knijnenburg, Theo / Kramer, Roger / Leinonen, Kalle / Liu, Yuexin / Miller, Michael / Reynolds, Sheila / Shmulevich, Ilya / Zhang, Wei / Broom, Bradley M. / Hegde, Apurva M. / Ju, Zhenlin / Kanchi, Rupa S. / Korkut, Anil / Li, Jun / Liang, Han / Ling, Shiyun / Liu, Wenbin / Lu, Yiling / Ng, Kwok-Shing / Rao, Arvind / Ryan, Michael / Wang, Jing / Weinstein, John N. / Zhang, Jiexin / Abeshouse, Adam / Armenia, Joshua / Chakravarty, Debyani / Chatila, Walid K. / de Bruijn, Ino / Gao, Jianjiong / Gross, Benjamin E. / Heins, Zachary J. / Kundra, Ritika / La, Konnor / Ladanyi, Marc / Luna, Augustin / Nissan, Moriah G. / Ochoa, Angelica / Phillips, Sarah M. / Reznik, Ed / Sanchez-Vega, Francisco / Sander, Chris / Schultz, Nikolaus / Sheridan, Robert / Sumer, S. Onur / Sun, Yichao / Taylor, Barry S. / Wang, Jioajiao / Zhang, Hongxin / Anur, Pavana / Peto, Myron / Spellman, Paul / Benz, Christopher / Wong, Christopher K. / Yau, Christina / Hayes, D. Neil / Parker, Joel S. / Wilkerson, Matthew D. / Ally, Adrian / Balasundaram, Miruna / Bowlby, Reanne / Brooks, Denise / Carlsen, Rebecca / Chuah, Eric / Dhalla, Noreen / Holt, Robert / Jones, Steven J.M. / Kasaian, Katayoon / Lee, Darlene / Ma, Yussanne / Marra, Marco A. / Mayo, Michael / Moore, Richard A. / Mungall, Andrew J. / Mungall, Karen / Robertson, A. Gordon / Sadeghi, Sara / Schein, Jacqueline E. / Sipahimalani, Payal / Tam, Angela / Thiessen, Nina / Tse, Kane / Wong, Tina / Berger, Ashton C. / Beroukhim, Rameen / Cibulskis, Carrie / Gabriel, Stacey B. / Gao, Galen F. / Ha, Gavin / Meyerson, Matthew / Schumacher, Steven E. / Shih, Juliann / Kucherlapati, Melanie H. / Kucherlapati, Raju S. / Baylin, Stephen / Cope, Leslie / Danilova, Ludmila / Bootwalla, Moiz S. / Lai, Phillip H. / Maglinte, Dennis T. / Van Den Berg, David J. / Weisenberger, Daniel J. / Auman, J. Todd / Balu, Saianand / Bodenheimer, Thomas / Fan, Cheng / Hoyle, Alan P. / Jefferys, Stuart R. / Jones, Corbin D. / Meng, Shaowu / Mieczkowski, Piotr A. / Mose, Lisle E. / Perou, Amy H. / Perou, Charles M. / Roach, Jeffrey / Shi, Yan / Simons, Janae V. / Skelly, Tara / Soloway, Matthew G. / Tan, Donghui / Veluvolu, Umadevi / Fan, Huihui / Hinoue, Toshinori / Laird, Peter W. / Shen, Hui / Zhou, Wanding / Bellair, Michelle / Chang, Kyle / Covington, Kyle / Creighton, Chad J. / Dinh, Huyen / Doddapaneni, HarshaVardhan / Donehower, Lawrence A. / Drummond, Jennifer / Gibbs, Richard / Glenn, Robert / Hale, Walker / Han, Yi / Hu, Jianhong / Korchina, Viktoriya / Lee, Sandra / Lewis, Lora / Li, Wei / Liu, Xiuping / Morgan, Margaret / Morton, Donna / Muzny, Donna / Santibanez, Jireh / Sheth, Margi / Shinbrot, Eve / Wang, Linghua / Wang, Min / Xi, Liu / Zhao, Fengmei / Hess, Julian / Appelbaum, Elizabeth L. / Bailey, Matthew / Cordes, Matthew G. / Fronick, Catrina C. / Fulton, Lucinda A. / Fulton, Robert S. / Kandoth, Cyriac / Mardis, Elaine R. / McLellan, Michael D. / Miller, Christopher A. / Schmidt, Heather K. / Wilson, Richard K. / Crain, Daniel / Curley, Erin / Gardner, Johanna / Lau, Kevin / Mallery, David / Morris, Scott / Paulauskis, Joseph / Penny, Robert / Shelton, Candace / Shelton, Troy / Sherman, Mark / Thompson, Eric / Yena, Peggy / Bowen, Jay / Gastier-Foster, Julie M. / Gerken, Mark / Leraas, Kristen M. / Lichtenberg, Tara M. / Ramirez, Nilsa C. / Wise, Lisa / Zmuda, Erik / Corcoran, Niall / Costello, Tony / Hovens, Christopher / Carvalho, Andre L. / de Carvalho, Ana C. / Fregnani, José H. / Filho, Adhemar Longatto / Reis, Rui M. / Scapulatempo-Neto, Cristovam / Silveira, Henrique C.S. / Vidal, Daniel O. / Burnette, Andrew / Eschbacher, Jennifer / Hermes, Beth / Noss, Ardene / Singh, Rosy / Anderson, Matthew L. / Castro, Patricia D. / Ittmann, Michael / Huntsman, David / Kohl, Bernard / Lệ Xuân / Thorp, Richard / Andry, Chris / Duffy, Elizabeth R. / Lyadov, Vladimir / Paklina, Oxana / Setdikova, Galiya / Shabunin, Alexey / Tavobilov, Mikhail / McPherson, Christopher / Warnick, Ronald / Berkowitz, Ross / Cramer, Daniel / Feltmate, Colleen / Horowitz, Neil / Kibel, Adam / Muto, Michael / Raut, Chandrajit P. / Malykh, Andrei / Barnholtz-Sloan, Jill S. / Barrett, Wendi / Devine, Karen / Fulop, Jordonna / Ostrom, Quinn T. / Shimmel, Kristen / Wolinsky, Yingli / Sloan, Andrew E. / De Rose, Agostino / Giuliante, Felice / Goodman, Marc / Karlan, Beth Y. / Hagedorn, C. H. / Eckman, John / Harr, Jodi / Myers, Jerome / Tucker, Kelinda / Zach, Leigh Anne / Deyarmin, Brenda / Hu, Hai / Kvecher, Leonid / Larson, Caroline / Mural, Richard J. / Somiari, Stella / Vicha, Ales / Zelinka, Tomas / Bennett, Joseph / Iacocca, Mary / Rabeno, Brenda / Swanson, Patricia / Latour, Mathieu / Lacombe, Louis / Têtu, Bernard / Bergeron, Alain / McGraw, Mary / Staugaitis, Susan M. / Chabot, John / Hibshoosh, Hanina / Sepulveda, Antonia / Su, Tao / Wang, Timothy / Potapova, Olga / Voronina, Olga / Desjardins, Laurence / Mariani, Odette / Roman-Roman, Sergio / Sastre, Xavier / Stern, Marc-Henri / Cheng, Feixiong / Signoretti, Sabina / Berchuck, Andrew / Bigner, Darell / Lipp, Eric / Marks, Jeffrey / McCall, Shannon / McLendon, Roger / Secord, Angeles / Sharp, Alexis / Behera, Madhusmita / Brat, Daniel J. / Chen, Amy / Delman, Keith / Force, Seth / Khuri, Fadlo / Magliocca, Kelly / Maithel, Shishir / Olson, Jeffrey J. / Owonikoko, Taofeek / Pickens, Alan / Ramalingam, Suresh / Shin, Dong M. / Sica, Gabriel / Van Meir, Erwin G. / Zhang, Hongzheng / Eijckenboom, Wil / Gillis, Ad / Korpershoek, Esther / Looijenga, Leendert / Oosterhuis, Wolter / Stoop, Hans / van Kessel, Kim E. / Zwarthoff, Ellen C. / Calatozzolo, Chiara / Cuppini, Lucia / Cuzzubbo, Stefania / DiMeco, Francesco / Finocchiaro, Gaetano / Mattei, Luca / Perin, Alessandro / Pollo, Bianca / Chen, Chu / Houck, John / Lohavanichbutr, Pawadee / Hartmann, Arndt / Stoehr, Christine / Stoehr, Robert / Taubert, Helge / Wach, Sven / Wullich, Bernd / Kycler, Witold / Murawa, Dawid / Wiznerowicz, Maciej / Chung, Ki / Edenfield, W. Jeffrey / Martin, Julie / Baudin, Eric / Bubley, Glenn / Bueno, Raphael / De Rienzo, Assunta / Richards, William G. / Kalkanis, Steven / Mikkelsen, Tom / Noushmehr, Houtan / Scarpace, Lisa / Girard, Nicolas / Aymerich, Marta / Campo, Elias / Giné, Eva / Guillermo, Armando López / Van Bang, Nguyen / Hanh, Phan Thi / Phu, Bui Duc / Tang, Yufang / Colman, Howard / Evason, Kimberley / Dottino, Peter R. / Martignetti, John A. / Gabra, Hani / Juhl, Hartmut / Akeredolu, Teniola / Stepa, Serghei / Hoon, Dave / Ahn, Keunsoo / Kang, Koo Jeong / Beuschlein, Felix / Breggia, Anne / Birrer, Michael / Bell, Debra / Borad, Mitesh / Bryce, Alan H. / Castle, Erik / Chandan, Vishal / Cheville, John / Copland, John A. / Farnell, Michael / Flotte, Thomas / Giama, Nasra / Ho, Thai / Kendrick, Michael / Kocher, Jean-Pierre / Kopp, Karla / Moser, Catherine / Nagorney, David / O’Brien, Daniel / O’Neill, Brian Patrick / Patel, Tushar / Petersen, Gloria / Que, Florencia / Rivera, Michael / Roberts, Lewis / Smallridge, Robert / Smyrk, Thomas / Stanton, Melissa / Thompson, R. Houston / Torbenson, Michael / Yang, Ju Dong / Zhang, Lizhi / Brimo, Fadi / Ajani, Jaffer A. / Gonzalez, Ana Maria Angulo / Behrens, Carmen / Bondaruk, Jolanta / Broaddus, Russell / Czerniak, Bogdan / Esmaeli, Bita / Fujimoto, Junya / Gershenwald, Jeffrey / Guo, Charles / Logothetis, Christopher / Meric-Bernstam, Funda / Moran, Cesar / Ramondetta, Lois / Rice, David / Sood, Anil / Tamboli, Pheroze / Thompson, Timothy / Troncoso, Patricia / Tsao, Anne / Wistuba, Ignacio / Carter, Candace / Haydu, Lauren / Hersey, Peter / Jakrot, Valerie / Kakavand, Hojabr / Kefford, Richard / Lee, Kenneth / Long, Georgina / Mann, Graham / Quinn, Michael / Saw, Robyn / Scolyer, Richard / Shannon, Kerwin / Spillane, Andrew / Stretch, Jonathan / Synott, Maria / Thompson, John / Wilmott, James / Al-Ahmadie, Hikmat / Chan, Timothy A. / Ghossein, Ronald / Gopalan, Anuradha / Levine, Douglas A. / Reuter, Victor / Singer, Samuel / Singh, Bhuvanesh / Tien, Nguyen Viet / Broudy, Thomas / Mirsaidi, Cyrus / Nair, Praveen / Drwiega, Paul / Miller, Judy / Smith, Jennifer / Zaren, Howard / Park, Joong-Won / Hung, Nguyen Phi / Kebebew, Electron / Linehan, Marston / Metwalli, Adam R. / Pacak, Karel / Pinto, Peter A. / Schiffman, Mark / Schmidt, Laura S. / Vocke, Cathy D. / Wentzensen, Nicolas / Worrell, Robert / Yang, Hannah / Moncrieff, Marc / Goparaju, Chandra / Melamed, Jonathan / Pass, Harvey / Botnariuc, Natalia / Caraman, Irina / Cernat, Mircea / Chemencedji, Inga / Clipca, Adrian / Doruc, Serghei / Gorincioi, Ghenadie / Mura, Sergiu / Pirtac, Maria / Stancul, Irina / Tcaciuc, Diana / Albert, Monique / Alexopoulou, Iakovina / Arnaout, Angel / Bartlett, John / Engel, Jay / Gilbert, Sebastien / Parfitt, Jeremy / Sekhon, Harman / Thomas, George / Rassl, Doris M. / Rintoul, Robert C. / Bifulco, Carlo / Tamakawa, Raina / Urba, Walter / Hayward, Nicholas / Timmers, Henri / Antenucci, Anna / Facciolo, Francesco / Grazi, Gianluca / Marino, Mirella / Merola, Roberta / de Krijger, Ronald / Gimenez-Roqueplo, Anne-Paule / Piché, Alain / Chevalier, Simone / McKercher, Ginette / Birsoy, Kivanc / Barnett, Gene / Brewer, Cathy / Farver, Carol / Naska, Theresa / Pennell, Nathan A. / Raymond, Daniel / Schilero, Cathy / Smolenski, Kathy / Williams, F. / Morrison, Carl / Borgia, Jeffrey A. / Liptay, Michael J. / Pool, Mark / Seder, Christopher W. / Junker, Kerstin / Omberg, Larsson / Dinkin, Mikhail / Manikhas, George / Alvaro, Domenico / Bragazzi, Maria Consiglia / Cardinale, Vincenzo / Carpino, Guido / Gaudio, Eugenio / Chesla, David / Cottingham, Sandra / Dubina, Michael / Moiseenko, Fedor / Dhanasekaran, Renumathy / Becker, Karl Friedrich / Janssen, Klaus-Peter / Slotta-Huspenina, Julia / Abdel-Rahman, Mohamed H. / Aziz, Dina / Bell, Sue / Cebulla, Colleen M. / Davis, Amy / Duell, Rebecca / Elder, J. Bradley / Hilty, Joe / Kumar, Bahavna / Lang, James / Lehman, Norman L. / Mandt, Randy / Nguyen, Phuong / Pilarski, Robert / Rai, Karan / Schoenfield, Lynn / Senecal, Kelly / Wakely, Paul / Hansen, Paul / Lechan, Ronald / Powers, James / Tischler, Arthur / Grizzle, William E. / Sexton, Katherine C. / Kastl, Alison / Henderson, Joel / Porten, Sima / Waldmann, Jens / Fassnacht, Martin / Asa, Sylvia L. / Schadendorf, Dirk / Couce, Marta / Graefen, Markus / Huland, Hartwig / Sauter, Guido / Schlomm, Thorsten / Simon, Ronald / Tennstedt, Pierre / Olabode, Oluwole / Nelson, Mark / Bathe, Oliver / Carroll, Peter R. / Chan, June M. / Disaia, Philip / Glenn, Pat / Kelley, Robin K. / Landen, Charles N. / Phillips, Joanna / Prados, Michael / Simko, Jeffry / Smith-McCune, Karen / VandenBerg, Scott / Roggin, Kevin / Fehrenbach, Ashley / Kendler, Ady / Sifri, Suzanne / Steele, Ruth / Jimeno, Antonio / Carey, Francis / Forgie, Ian / Mannelli, Massimo / Carney, Michael / Hernandez, Brenda / Campos, Benito / Herold-Mende, Christel / Jungk, Christin / Unterberg, A. / Deimling, Andreas von / Bossler, Aaron / Galbraith, Joseph / Jacobus, Laura / Knudson, Michael / Knutson, Tina / Ma, Deqin / Milhem, Mohammed / Sigmund, Rita / Godwin, Andrew K. / Madan, Rashna / Rosenthal, Howard G. / Adebamowo, Clement / Adebamowo, Sally N. / Boussioutas, Alex / Beer, David / Giordano, Thomas / Mes-Masson, Anne-Marie / Saad, Fred / Bocklage, Therese / Landrum, Lisa / Mannel, Robert / Moore, Kathleen / Moxley, Katherine / Postier, Russel / Walker, Joan / Zuna, Rosemary / Feldman, Michael / Valdivieso, Federico / Dhir, Rajiv / Luketich, James / Pinero, Edna M. Mora / Quintero-Aguilo, Mario / Carlotti, Carlos Gilberto / Santos, José Sebastião dos / Kemp, Rafael / Sankarankuty, Ajith / Tirapelli, Daniela / Catto, James / Agnew, Kathy / Swisher, Elizabeth / Creaney, Jenette / Robinson, Bruce / Shelley, Carl Simon / Godwin, Eryn M. / Kendall, Sara / Shipman, Cassaundra / Bradford, Carol / Carey, Thomas / Haddad, Andrea / Moyer, Jeffey / Peterson, Lisa / Prince, Mark / Rozek, Laura / Wolf, Gregory / Bowman, Rayleen / Fong, Kwun M. / Yang, Ian / Korst, Robert / Rathmell, W. Kimryn / Fantacone-Campbell, J. Leigh / Hooke, Jeffrey A. / Kovatich, Albert J. / Shriver, Craig D. / DiPersio, John / Drake, Bettina / Govindan, Ramaswamy / Heath, Sharon / Ley, Timothy / Van Tine, Brian / Westervelt, Peter / Rubin, Mark A. / Lee, Jung Il / Aredes, Natália D. / Mariamidze, Armaz

    Cell. 2018 Apr. 05, v. 173, no. 2 p.305-320.e10

    2018  

    Abstract: The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we ... ...

    Institution The Cancer Genome Atlas Research Network
    Abstract The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing.
    Keywords ancestry ; carcinogenesis ; epigenome ; genomics ; germ cells ; humans ; neoplasms ; proteome ; transcriptome ; oncogenic process ; TCGA ; omics ; cancer ; cancer genomics
    Language English
    Dates of publication 2018-0405
    Size p. 305-320.e10.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note NAL-AP-2-clean ; Resource is Open Access
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.03.033
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

    Liu, Jianfang / Lichtenberg, Tara / Hoadley, Katherine A. / Poisson, Laila M. / Lazar, Alexander / Cherniack, Andrew D. / Kovatich, Albert J. / Benz, Christopher C. / Levine, Douglas A. / Lee, Adrian V. / Omberg, Larsson / Wolf, Denise M. / Shriver, Craig D. / Thorsson, Vesteinn / Hu, Hai / Caesar-Johnson, Samantha J. / Demchok, John A. / Felau, Ina / Kasapi, Melpomeni /
    Ferguson, Martin L. / Hutter, Carolyn M. / Sofia, Heidi J. / Tarnuzzer, Roy / Wang, Zhining / Yang, Liming / Zenklusen, Jean C. / Zhang, Jiashan (Julia) / Chudamani, Sudha / Liu, Jia / Lolla, Laxmi / Naresh, Rashi / Pihl, Todd / Sun, Qiang / Wan, Yunhu / Wu, Ye / Cho, Juok / DeFreitas, Timothy / Frazer, Scott / Gehlenborg, Nils / Getz, Gad / Heiman, David I. / Kim, Jaegil / Lawrence, Michael S. / Lin, Pei / Meier, Samuel A. / Noble, Michael S. / Saksena, Gordon / Voet, Doug / Zhang, Hailei / Bernard, Brady / Chambwe, Nyasha / Dhankani, Varsha / Knijnenburg, Theo / Kramer, Roger / Leinonen, Kalle / Liu, Yuexin / Miller, Michael / Reynolds, Sheila / Shmulevich, Ilya / Zhang, Wei / Akbani, Rehan / Broom, Bradley M. / Hegde, Apurva M. / Ju, Zhenlin / Kanchi, Rupa S. / Korkut, Anil / Li, Jun / Liang, Han / Ling, Shiyun / Liu, Wenbin / Lu, Yiling / Mills, Gordon B. / Ng, Kwok-Shing / Rao, Arvind / Ryan, Michael / Wang, Jing / Weinstein, John N. / Zhang, Jiexin / Abeshouse, Adam / Armenia, Joshua / Chakravarty, Debyani / Chatila, Walid K. / de Bruijn, Ino / Gao, Jianjiong / Gross, Benjamin E. / Heins, Zachary J. / Kundra, Ritika / La, Konnor / Ladanyi, Marc / Luna, Augustin / Nissan, Moriah G. / Ochoa, Angelica / Phillips, Sarah M. / Reznik, Ed / Sanchez-Vega, Francisco / Sander, Chris / Schultz, Nikolaus / Sheridan, Robert / Sumer, S. Onur / Sun, Yichao / Taylor, Barry S. / Wang, Jioajiao / Zhang, Hongxin / Anur, Pavana / Peto, Myron / Spellman, Paul / Benz, Christopher / Stuart, Joshua M. / Wong, Christopher K. / Yau, Christina / Hayes, D. Neil / Parker, Joel S. / Wilkerson, Matthew D. / Ally, Adrian / Balasundaram, Miruna / Bowlby, Reanne / Brooks, Denise / Carlsen, Rebecca / Chuah, Eric / Dhalla, Noreen / Holt, Robert / Jones, Steven J.M. / Kasaian, Katayoon / Lee, Darlene / Ma, Yussanne / Marra, Marco A. / Mayo, Michael / Moore, Richard A. / Mungall, Andrew J. / Mungall, Karen / Robertson, A. Gordon / Sadeghi, Sara / Schein, Jacqueline E. / Sipahimalani, Payal / Tam, Angela / Thiessen, Nina / Tse, Kane / Wong, Tina / Berger, Ashton C. / Beroukhim, Rameen / Cibulskis, Carrie / Gabriel, Stacey B. / Gao, Galen F. / Ha, Gavin / Meyerson, Matthew / Schumacher, Steven E. / Shih, Juliann / Kucherlapati, Melanie H. / Kucherlapati, Raju S. / Baylin, Stephen / Cope, Leslie / Danilova, Ludmila / Bootwalla, Moiz S. / Lai, Phillip H. / Maglinte, Dennis T. / Van Den Berg, David J. / Weisenberger, Daniel J. / Auman, J. Todd / Balu, Saianand / Bodenheimer, Thomas / Fan, Cheng / Hoyle, Alan P. / Jefferys, Stuart R. / Jones, Corbin D. / Meng, Shaowu / Mieczkowski, Piotr A. / Mose, Lisle E. / Perou, Amy H. / Perou, Charles M. / Roach, Jeffrey / Shi, Yan / Simons, Janae V. / Skelly, Tara / Soloway, Matthew G. / Tan, Donghui / Veluvolu, Umadevi / Fan, Huihui / Hinoue, Toshinori / Laird, Peter W. / Shen, Hui / Zhou, Wanding / Bellair, Michelle / Chang, Kyle / Covington, Kyle / Creighton, Chad J. / Dinh, Huyen / Doddapaneni, HarshaVardhan / Donehower, Lawrence A. / Drummond, Jennifer / Gibbs, Richard / Glenn, Robert / Hale, Walker / Han, Yi / Hu, Jianhong / Korchina, Viktoriya / Lee, Sandra / Lewis, Lora / Li, Wei / Liu, Xiuping / Morgan, Margaret / Morton, Donna / Muzny, Donna / Santibanez, Jireh / Sheth, Margi / Shinbro, Eve / Wang, Linghua / Wang, Min / Wheeler, David A. / Xi, Liu / Zhao, Fengmei / Hess, Julian / Appelbaum, Elizabeth L. / Bailey, Matthew / Cordes, Matthew G. / Ding, Li / Fronick, Catrina C. / Fulton, Lucinda A. / Fulton, Robert S. / Kandoth, Cyriac / Mardis, Elaine R. / McLellan, Michael D. / Miller, Christopher A. / Schmidt, Heather K. / Wilson, Richard K. / Crain, Daniel / Curley, Erin / Gardner, Johanna / Lau, Kevin / Mallery, David / Morris, Scott / Paulauskis, Joseph / Penny, Robert / Shelton, Candace / Shelton, Troy / Sherman, Mark / Thompson, Eric / Yena, Peggy / Bowen, Jay / Gastier-Foster, Julie M. / Gerken, Mark / Leraas, Kristen M. / Lichtenberg, Tara M. / Ramirez, Nilsa C. / Wise, Lisa / Zmuda, Erik / Corcoran, Niall / Costello, Tony / Hovens, Christopher / Carvalho, Andre L. / de Carvalho, Ana C. / Fregnani, José H. / Filho, Adhemar Longatto / Reis, Rui M. / Scapulatempo-Neto, Cristovam / Silveira, Henrique C.S. / Vidal, Daniel O. / Burnette, Andrew / Eschbacher, Jennifer / Hermes, Beth / Noss, Ardene / Singh, Rosy / Anderson, Matthew L. / Castro, Patricia D. / Ittmann, Michael / Huntsman, David / Kohl, Bernard / Lệ Xuân / Thorp, Richard / Andry, Chris / Duffy, Elizabeth R. / Lyadov, Vladimir / Paklina, Oxana / Setdikova, Galiya / Shabunin, Alexey / Tavobilov, Mikhail / McPherson, Christopher / Warnick, Ronald / Berkowitz, Ross / Cramer, Daniel / Feltmate, Colleen / Horowitz, Neil / Kibel, Adam / Muto, Michael / Raut, Chandrajit P. / Malykh, Andrei / Barnholtz-Sloan, Jill S. / Barrett, Wendi / Devine, Karen / Fulop, Jordonna / Ostrom, Quinn T. / Shimmel, Kristen / Wolinsky, Yingli / Sloan, Andrew E. / De Rose, Agostino / Giuliante, Felice / Goodman, Marc / Karlan, Beth Y. / Hagedorn, C. H. / Eckman, John / Harr, Jodi / Myers, Jerome / Tucker, Kelinda / Zach, Leigh Anne / Deyarmin, Brenda / Kvecher, Leonid / Larson, Caroline / Mural, Richard J. / Somiari, Stella / Vicha, Ales / Zelinka, Tomas / Bennett, Joseph / Iacocca, Mary / Rabeno, Brenda / Swanson, Patricia / Latour, Mathieu / Lacombe, Louis / Têtu, Bernard / Bergeron, Alain / McGraw, Mary / Staugaitis, Susan M. / Chabot, John / Hibshoosh, Hanina / Sepulveda, Antonia / Su, Tao / Wang, Timothy / Potapova, Olga / Voronina, Olga / Desjardins, Laurence / Mariani, Odette / Roman-Roman, Sergio / Sastre, Xavier / Stern, Marc-Henri / Cheng, Feixiong / Signoretti, Sabina / Berchuck, Andrew / Bigner, Darell / Lipp, Eric / Marks, Jeffrey / McCall, Shannon / McLendon, Roger / Secord, Angeles / Sharp, Alexis / Behera, Madhusmita / Brat, Daniel J. / Chen, Amy / Delman, Keith / Force, Seth / Khuri, Fadlo / Magliocca, Kelly / Maithel, Shishir / Olson, Jeffrey J. / Owonikoko, Taofeek / Pickens, Alan / Ramalingam, Suresh / Shin, Dong M. / Sica, Gabriel / Van Meir, Erwin G. / Zhang, Hongzheng / Eijckenboom, Wil / Gillis, Ad / Korpershoek, Esther / Looijenga, Leendert / Oosterhuis, Wolter / Stoop, Hans / van Kessel, Kim E. / Zwarthoff, Ellen C. / Calatozzolo, Chiara / Cuppini, Lucia / Cuzzubbo, Stefania / DiMeco, Francesco / Finocchiaro, Gaetano / Mattei, Luca / Perin, Alessandro / Pollo, Bianca / Chen, Chu / Houck, John / Lohavanichbutr, Pawadee / Hartmann, Arndt / Stoehr, Christine / Stoehr, Robert / Taubert, Helge / Wach, Sven / Wullich, Bernd / Kycler, Witold / Murawa, Dawid / Wiznerowicz, Maciej / Chung, Ki / Edenfield, W. Jeffrey / Martin, Julie / Baudin, Eric / Bubley, Glenn / Bueno, Raphael / De Rienzo, Assunta / Richards, William G. / Kalkanis, Steven / Mikkelsen, Tom / Noushmehr, Houtan / Scarpace, Lisa / Girard, Nicolas / Aymerich, Marta / Campo, Elias / Giné, Eva / Guillermo, Armando López / Van Bang, Nguyen / Hanh, Phan Thi / Phu, Bui Duc / Tang, Yufang / Colman, Howard / Evason, Kimberley / Dottino, Peter R. / Martignetti, John A. / Gabra, Hani / Juhl, Hartmut / Akeredolu, Teniola / Stepa, Serghei / Hoon, Dave / Ahn, Keunsoo / Kang, Koo Jeong / Beuschlein, Felix / Breggia, Anne / Birrer, Michael / Bell, Debra / Borad, Mitesh / Bryce, Alan H. / Castle, Erik / Chandan, Vishal / Cheville, John / Copland, John A. / Farnell, Michael / Flotte, Thomas / Giama, Nasra / Ho, Thai / Kendrick, Michael / Kocher, Jean-Pierre / Kopp, Karla / Moser, Catherine / Nagorney, David / O’Brien, Daniel / O’Neill, Brian Patrick / Patel, Tushar / Petersen, Gloria / Que, Florencia / Rivera, Michael / Roberts, Lewis / Smallridge, Robert / Smyrk, Thomas / Stanton, Melissa / Thompson, R. Houston / Torbenson, Michael / Yang, Ju Dong / Zhang, Lizhi / Brimo, Fadi / Ajani, Jaffer A. / Angulo Gonzalez, Ana Maria / Behrens, Carmen / Bondaruk, Jolanta / Broaddus, Russell / Czerniak, Bogdan / Esmaeli, Bita / Fujimoto, Junya / Gershenwald, Jeffrey / Guo, Charles / Logothetis, Christopher / Meric-Bernstam, Funda / Moran, Cesar / Ramondetta, Lois / Rice, David / Sood, Anil / Tamboli, Pheroze / Thompson, Timothy / Troncoso, Patricia / Tsao, Anne / Wistuba, Ignacio / Carter, Candace / Haydu, Lauren / Hersey, Peter / Jakrot, Valerie / Kakavand, Hojabr / Kefford, Richard / Lee, Kenneth / Long, Georgina / Mann, Graham / Quinn, Michael / Saw, Robyn / Scolyer, Richard / Shannon, Kerwin / Spillane, Andrew / Stretch, Jonathan / Synott, Maria / Thompson, John / Wilmott, James / Al-Ahmadie, Hikmat / Chan, Timothy A. / Ghossein, Ronald / Gopalan, Anuradha / Reuter, Victor / Singer, Samuel / Singh, Bhuvanesh / Tien, Nguyen Viet / Broudy, Thomas / Mirsaidi, Cyrus / Nair, Praveen / Drwiega, Paul / Miller, Judy / Smith, Jennifer / Zaren, Howard / Park, Joong-Won / Hung, Nguyen Phi / Kebebew, Electron / Linehan, Marston / Metwalli, Adam R. / Pacak, Karel / Pinto, Peter A. / Schiffman, Mark / Schmidt, Laura S. / Vocke, Cathy D. / Wentzensen, Nicolas / Worrell, Robert / Yang, Hannah / Moncrieff, Marc / Goparaju, Chandra / Melamed, Jonathan / Pass, Harvey / Botnariuc, Natalia / Caraman, Irina / Cernat, Mircea / Chemencedji, Inga / Clipca, Adrian / Doruc, Serghei / Gorincioi, Ghenadie / Mura, Sergiu / Pirtac, Maria / Stancul, Irina / Tcaciuc, Diana / Albert, Monique / Alexopoulou, Iakovina / Arnaout, Angel / Bartlett, John / Engel, Jay / Gilbert, Sebastien / Parfitt, Jeremy / Sekhon, Harman / Thomas, George / Rassl, Doris M. / Rintoul, Robert C. / Bifulco, Carlo / Tamakawa, Raina / Urba, Walter / Hayward, Nicholas / Timmers, Henri / Antenucci, Anna / Facciolo, Francesco / Grazi, Gianluca / Marino, Mirella / Merola, Roberta / de Krijger, Ronald / Gimenez-Roqueplo, Anne-Paule / Piché, Alain / Chevalier, Simone / McKercher, Ginette / Birsoy, Kivanc / Barnett, Gene / Brewer, Cathy / Farver, Carol / Naska, Theresa / Pennell, Nathan A. / Raymond, Daniel / Schilero, Cathy / Smolenski, Kathy / Williams, F. / Morrison, Carl / Borgia, Jeffrey A. / Liptay, Michael J. / Pool, Mark / Seder, Christopher W. / Junker, Kerstin / Dinkin, Mikhail / Manikhas, George / Alvaro, Domenico / Bragazzi, Maria Consiglia / Cardinale, Vincenzo / Carpino, Guido / Gaudio, Eugenio / Chesla, David / Cottingham, Sandra / Dubina, Michael / Moiseenko, Fedor / Dhanasekaran, Renumathy / Becker, Karl Friedrich / Janssen, Klaus-Peter / Slotta-Huspenina, Julia / Abdel-Rahman, Mohamed H. / Aziz, Dina / Bell, Sue / Cebulla, Colleen M. / Davis, Amy / Duell, Rebecca / Elder, J. Bradley / Hilty, Joe / Kumar, Bahavna / Lang, James / Lehman, Norman L. / Mandt, Randy / Nguyen, Phuong / Pilarski, Robert / Rai, Karan / Schoenfield, Lynn / Senecal, Kelly / Wakely, Paul / Hansen, Paul / Lechan, Ronald / Powers, James / Tischler, Arthur / Grizzle, William E. / Sexton, Katherine C. / Kastl, Alison / Henderson, Joel / Porten, Sima / Waldmann, Jens / Fassnacht, Martin / Asa, Sylvia L. / Schadendorf, Dirk / Couce, Marta / Graefen, Markus / Huland, Hartwig / Sauter, Guido / Schlomm, Thorsten / Simon, Ronald / Tennstedt, Pierre / Olabode, Oluwole / Nelson, Mark / Bathe, Oliver / Carroll, Peter R. / Chan, June M. / Disaia, Philip / Glenn, Pat / Kelley, Robin K. / Landen, Charles N. / Phillips, Joanna / Prados, Michael / Simko, Jeffry / Smith-McCune, Karen / VandenBerg, Scott / Roggin, Kevin / Fehrenbach, Ashley / Kendler, Ady / Sifri, Suzanne / Steele, Ruth / Jimeno, Antonio / Carey, Francis / Forgie, Ian / Mannelli, Massimo / Carney, Michael / Hernandez, Brenda / Campos, Benito / Herold-Mende, Christel / Jungk, Christin / Unterberg, A. / Deimling, Andreas von / Bossler, Aaron / Galbraith, Joseph / Jacobus, Laura / Knudson, Michael / Knutson, Tina / Ma, Deqin / Milhem, Mohammed / Sigmund, Rita / Godwin, Andrew K. / Madan, Rashna / Rosenthal, Howard G. / Adebamowo, Clement / Adebamowo, Sally N. / Boussioutas, Alex / Beer, David / Giordano, Thomas / Mes-Masson, Anne-Marie / Saad, Fred / Bocklage, Therese / Landrum, Lisa / Mannel, Robert / Moore, Kathleen / Moxley, Katherine / Postier, Russel / Walker, Joan / Zuna, Rosemary / Feldman, Michael / Valdivieso, Federico / Dhir, Rajiv / Luketich, James / Mora Pinero, Edna M. / Quintero-Aguilo, Mario / Carlotti, Jr, Carlos Gilberto / Santos, José Sebastião dos / Kemp, Rafael / Sankarankuty, Ajith / Tirapelli, Daniela / Catto, James / Agnew, Kathy / Swisher, Elizabeth / Creaney, Jenette / Robinson, Bruce / Shelley, Carl Simon / Godwin, Eryn M. / Kendall, Sara / Shipman, Cassaundra / Bradford, Carol / Carey, Thomas / Haddad, Andrea / Moyer, Jeffey / Peterson, Lisa / Prince, Mark / Rozek, Laura / Wolf, Gregory / Bowman, Rayleen / Fong, Kwun M. / Yang, Ian / Korst, Robert / Rathmell, W. Kimryn / Fantacone-Campbell, J. Leigh / Hooke, Jeffrey A. / DiPersio, John / Drake, Bettina / Govindan, Ramaswamy / Heath, Sharon / Ley, Timothy / Van Tine, Brian / Westervelt, Peter / Rubin, Mark A. / Lee, Jung Il / Aredes, Natália D. / Mariamidze, Armaz

    Elsevier Inc. Cell. 2018 Apr. 05, v. 173, no. 2 p.400-416.e11

    2018  

    Abstract: For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features ... ...

    Institution The Cancer Genome Atlas Research Network
    Abstract For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale.
    Keywords data collection ; genome ; genomics ; humans ; The Cancer Genome Atlas ; TCGA ; clinical data resource ; translational research ; follow-up time ; overall survival ; disease-specific survival ; disease-free interval ; progression-free interval ; Cox proportional hazards regression model
    Language English
    Dates of publication 2018-0405
    Size p. 400-416.e11.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note NAL-AP-2-clean ; Resource is Open Access
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.02.052
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

    Hoadley, Katherine A. / Yau, Christina / Hinoue, Toshinori / Wolf, Denise M. / Lazar, Alexander / Drill, Esther / Shen, Ronglai / Taylor, Alison M. / Cherniack, Andrew D. / Thorsson, Vésteinn / Akbani, Rehan / Bowlby, Reanne / Wong, Christopher K. / Wiznerowicz, Maciej / Sanchez-Vega, Francisco / Robertson, A. Gordon / Schneider, Barbara G. / Lawrence, Michael S. / Noushmehr, Houtan /
    Malta, Tathiane M. / Stuart, Joshua M. / Benz, Christopher C. / Laird, Peter W. / Caesar-Johnson, Samantha J. / Demchok, John A. / Felau, Ina / Kasapi, Melpomeni / Ferguson, Martin L. / Hutter, Carolyn M. / Sofia, Heidi J. / Tarnuzzer, Roy / Wang, Zhining / Yang, Liming / Zenklusen, Jean C. / Zhang, Jiashan (Julia) / Chudamani, Sudha / Liu, Jia / Lolla, Laxmi / Naresh, Rashi / Pihl, Todd / Sun, Qiang / Wan, Yunhu / Wu, Ye / Cho, Juok / DeFreitas, Timothy / Frazer, Scott / Gehlenborg, Nils / Getz, Gad / Heiman, David I. / Kim, Jaegil / Lin, Pei / Meier, Samuel A. / Noble, Michael S. / Saksena, Gordon / Voet, Doug / Zhang, Hailei / Bernard, Brady / Chambwe, Nyasha / Dhankani, Varsha / Knijnenburg, Theo / Kramer, Roger / Leinonen, Kalle / Liu, Yuexin / Miller, Michael / Reynolds, Sheila / Shmulevich, Ilya / Thorsson, Vesteinn / Zhang, Wei / Broom, Bradley M. / Hegde, Apurva M. / Ju, Zhenlin / Kanchi, Rupa S. / Korkut, Anil / Li, Jun / Liang, Han / Ling, Shiyun / Liu, Wenbin / Lu, Yiling / Mills, Gordon B. / Ng, Kwok-Shing / Rao, Arvind / Ryan, Michael / Wang, Jing / Weinstein, John N. / Zhang, Jiexin / Abeshouse, Adam / Armenia, Joshua / Chakravarty, Debyani / Chatila, Walid K. / de Bruijn, Ino / Gao, Jianjiong / Gross, Benjamin E. / Heins, Zachary J. / Kundra, Ritika / La, Konnor / Ladanyi, Marc / Luna, Augustin / Nissan, Moriah G. / Ochoa, Angelica / Phillips, Sarah M. / Reznik, Ed / Sander, Chris / Schultz, Nikolaus / Sheridan, Robert / Sumer, S. Onur / Sun, Yichao / Taylor, Barry S. / Wang, Jioajiao / Zhang, Hongxin / Anur, Pavana / Peto, Myron / Spellman, Paul / Benz, Christopher / Hayes, D. Neil / Parker, Joel S. / Wilkerson, Matthew D. / Ally, Adrian / Balasundaram, Miruna / Brooks, Denise / Carlsen, Rebecca / Chuah, Eric / Dhalla, Noreen / Holt, Robert / Jones, Steven J.M. / Kasaian, Katayoon / Lee, Darlene / Ma, Yussanne / Marra, Marco A. / Mayo, Michael / Moore, Richard A. / Mungall, Andrew J. / Mungall, Karen / Sadeghi, Sara / Schein, Jacqueline E. / Sipahimalani, Payal / Tam, Angela / Thiessen, Nina / Tse, Kane / Wong, Tina / Berger, Ashton C. / Beroukhim, Rameen / Cibulskis, Carrie / Gabriel, Stacey B. / Gao, Galen F. / Ha, Gavin / Meyerson, Matthew / Schumacher, Steven E. / Shih, Juliann / Kucherlapati, Melanie H. / Kucherlapati, Raju S. / Baylin, Stephen / Cope, Leslie / Danilova, Ludmila / Bootwalla, Moiz S. / Lai, Phillip H. / Maglinte, Dennis T. / Van Den Berg, David J. / Weisenberger, Daniel J. / Auman, J. Todd / Balu, Saianand / Bodenheimer, Thomas / Fan, Cheng / Hoyle, Alan P. / Jefferys, Stuart R. / Jones, Corbin D. / Meng, Shaowu / Mieczkowski, Piotr A. / Mose, Lisle E. / Perou, Amy H. / Perou, Charles M. / Roach, Jeffrey / Shi, Yan / Simons, Janae V. / Skelly, Tara / Soloway, Matthew G. / Tan, Donghui / Veluvolu, Umadevi / Fan, Huihui / Shen, Hui / Zhou, Wanding / Bellair, Michelle / Chang, Kyle / Covington, Kyle / Creighton, Chad J. / Dinh, Huyen / Doddapaneni, HarshaVardhan / Donehower, Lawrence A. / Drummond, Jennifer / Gibbs, Richard / Glenn, Robert / Hale, Walker / Han, Yi / Hu, Jianhong / Korchina, Viktoriya / Lee, Sandra / Lewis, Lora / Li, Wei / Liu, Xiuping / Morgan, Margaret / Morton, Donna / Muzny, Donna / Santibanez, Jireh / Sheth, Margi / Shinbrot, Eve / Wang, Linghua / Wang, Min / Wheeler, David A. / Xi, Liu / Zhao, Fengmei / Hess, Julian / Appelbaum, Elizabeth L. / Bailey, Matthew / Cordes, Matthew G. / Ding, Li / Fronick, Catrina C. / Fulton, Lucinda A. / Fulton, Robert S. / Kandoth, Cyriac / Mardis, Elaine R. / McLellan, Michael D. / Miller, Christopher A. / Schmidt, Heather K. / Wilson, Richard K. / Crain, Daniel / Curley, Erin / Gardner, Johanna / Lau, Kevin / Mallery, David / Morris, Scott / Paulauskis, Joseph / Penny, Robert / Shelton, Candace / Shelton, Troy / Sherman, Mark / Thompson, Eric / Yena, Peggy / Bowen, Jay / Gastier-Foster, Julie M. / Gerken, Mark / Leraas, Kristen M. / Lichtenberg, Tara M. / Ramirez, Nilsa C. / Wise, Lisa / Zmuda, Erik / Corcoran, Niall / Costello, Tony / Hovens, Christopher / Carvalho, Andre L. / de Carvalho, Ana C. / Fregnani, José H. / Filho, Adhemar Longatto / Reis, Rui M. / Scapulatempo-Neto, Cristovam / Silveira, Henrique C.S. / Vidal, Daniel O. / Burnette, Andrew / Eschbacher, Jennifer / Hermes, Beth / Noss, Ardene / Singh, Rosy / Anderson, Matthew L. / Castro, Patricia D. / Ittmann, Michael / Huntsman, David / Kohl, Bernard / Lệ Xuân / Thorp, Richard / Andry, Chris / Duffy, Elizabeth R. / Lyadov, Vladimir / Paklina, Oxana / Setdikova, Galiya / Shabunin, Alexey / Tavobilov, Mikhail / McPherson, Christopher / Warnick, Ronald / Berkowitz, Ross / Cramer, Daniel / Feltmate, Colleen / Horowitz, Neil / Kibel, Adam / Muto, Michael / Raut, Chandrajit P. / Malykh, Andrei / Barnholtz-Sloan, Jill S. / Barrett, Wendi / Devine, Karen / Fulop, Jordonna / Ostrom, Quinn T. / Shimmel, Kristen / Wolinsky, Yingli / Sloan, Andrew E. / De Rose, Agostino / Giuliante, Felice / Goodman, Marc / Karlan, Beth Y. / Hagedorn, C. H. / Eckman, John / Harr, Jodi / Myers, Jerome / Tucker, Kelinda / Zach, Leigh Anne / Deyarmin, Brenda / Hu, Hai / Kvecher, Leonid / Larson, Caroline / Mural, Richard J. / Somiari, Stella / Vicha, Ales / Zelinka, Tomas / Bennett, Joseph / Iacocca, Mary / Rabeno, Brenda / Swanson, Patricia / Latour, Mathieu / Lacombe, Louis / Têtu, Bernard / Bergeron, Alain / McGraw, Mary / Staugaitis, Susan M. / Chabot, John / Hibshoosh, Hanina / Sepulveda, Antonia / Su, Tao / Wang, Timothy / Potapova, Olga / Voronina, Olga / Desjardins, Laurence / Mariani, Odette / Roman-Roman, Sergio / Sastre, Xavier / Stern, Marc-Henri / Cheng, Feixiong / Signoretti, Sabina / Berchuck, Andrew / Bigner, Darell / Lipp, Eric / Marks, Jeffrey / McCall, Shannon / McLendon, Roger / Secord, Angeles / Sharp, Alexis / Behera, Madhusmita / Brat, Daniel J. / Chen, Amy / Delman, Keith / Force, Seth / Khuri, Fadlo / Magliocca, Kelly / Maithel, Shishir / Olson, Jeffrey J. / Owonikoko, Taofeek / Pickens, Alan / Ramalingam, Suresh / Shin, Dong M. / Sica, Gabriel / Van Meir, Erwin G. / Zhang, Hongzheng / Eijckenboom, Wil / Gillis, Ad / Korpershoek, Esther / Looijenga, Leendert / Oosterhuis, Wolter / Stoop, Hans / van Kessel, Kim E. / Zwarthoff, Ellen C. / Calatozzolo, Chiara / Cuppini, Lucia / Cuzzubbo, Stefania / DiMeco, Francesco / Finocchiaro, Gaetano / Mattei, Luca / Perin, Alessandro / Pollo, Bianca / Chen, Chu / Houck, John / Lohavanichbutr, Pawadee / Hartmann, Arndt / Stoehr, Christine / Stoehr, Robert / Taubert, Helge / Wach, Sven / Wullich, Bernd / Kycler, Witold / Murawa, Dawid / Chung, Ki / Edenfield, W. Jeffrey / Martin, Julie / Baudin, Eric / Bubley, Glenn / Bueno, Raphael / De Rienzo, Assunta / Richards, William G. / Kalkanis, Steven / Mikkelsen, Tom / Scarpace, Lisa / Girard, Nicolas / Aymerich, Marta / Campo, Elias / Giné, Eva / Guillermo, Armando López / Van Bang, Nguyen / Hanh, Phan Thi / Phu, Bui Duc / Tang, Yufang / Colman, Howard / Evason, Kimberley / Dottino, Peter R. / Martignetti, John A. / Gabra, Hani / Juhl, Hartmut / Akeredolu, Teniola / Stepa, Serghei / Hoon, Dave / Ahn, Keunsoo / Kang, Koo Jeong / Beuschlein, Felix / Breggia, Anne / Birrer, Michael / Bell, Debra / Borad, Mitesh / Bryce, Alan H. / Castle, Erik / Chandan, Vishal / Cheville, John / Copland, John A. / Farnell, Michael / Flotte, Thomas / Giama, Nasra / Ho, Thai / Kendrick, Michael / Kocher, Jean-Pierre / Kopp, Karla / Moser, Catherine / Nagorney, David / O’Brien, Daniel / O’Neill, Brian Patrick / Patel, Tushar / Petersen, Gloria / Que, Florencia / Rivera, Michael / Roberts, Lewis / Smallridge, Robert / Smyrk, Thomas / Stanton, Melissa / Thompson, R. Houston / Torbenson, Michael / Yang, Ju Dong / Zhang, Lizhi / Brimo, Fadi / Ajani, Jaffer A. / Gonzalez, Ana Maria Angulo / Behrens, Carmen / Bondaruk, olanta / Broaddus, Russell / Czerniak, Bogdan / Esmaeli, Bita / Fujimoto, Junya / Gershenwald, Jeffrey / Guo, Charles / Logothetis, Christopher / Meric-Bernstam, Funda / Moran, Cesar / Ramondetta, Lois / Rice, David / Sood, Anil / Tamboli, Pheroze / Thompson, Timothy / Troncoso, Patricia / Tsao, Anne / Wistuba, Ignacio / Carter, Candace / Haydu, Lauren / Hersey, Peter / Jakrot, Valerie / Kakavand, Hojabr / Kefford, Richard / Lee, Kenneth / Long, Georgina / Mann, Graham / Quinn, Michael / Saw, Robyn / Scolyer, Richard / Shannon, Kerwin / Spillane, Andrew / Stretch, Jonathan / Synott, Maria / Thompson, John / Wilmott, James / Al-Ahmadie, Hikmat / Chan, Timothy A. / Ghossein, Ronald / Gopalan, Anuradha / Levine, Douglas A. / Reuter, Victor / Singer, Samuel / Singh, Bhuvanesh / Tien, Nguyen Viet / Broudy, Thomas / Mirsaidi, Cyrus / Nair, Praveen / Drwiega, Paul / Miller, Judy / Smith, Jennifer / Zaren, Howard / Park, Joong-Won / Hung, Nguyen Phi / Kebebew, Electron / Linehan, Marston / Metwalli, Adam R. / Pacak, Karel / Pinto, Peter A. / Schiffman, Mark / Schmidt, Laura S. / Vocke, Cathy D. / Wentzensen, Nicolas / Worrell, Robert / Yang, Hannah / Moncrieff, Marc / Goparaju, Chandra / Melamed, Jonathan / Pass, Harvey / Botnariuc, Natalia / Caraman, Irina / Cernat, Mircea / Chemencedji, Inga / Clipca, Adrian / Doruc, Serghei / Gorincioi, Ghenadie / Mura, Sergiu / Pirtac, Maria / Stancul, Irina / Tcaciuc, Diana / Albert, Monique / Alexopoulou, Iakovina / Arnaout, Angel / Bartlett, John / Engel, Jay / Gilbert, Sebastien / Parfitt, Jeremy / Sekhon, Harman / Thomas, George / Rassl, Doris M. / Rintoul, Robert C. / Bifulco, Carlo / Tamakawa, Raina / Urba, Walter / Hayward, Nicholas / Timmers, Henri / Antenucci, Anna / Facciolo, Francesco / Grazi, Gianluca / Marino, Mirella / Merola, Roberta / de Krijger, Ronald / Gimenez-Roqueplo, Anne-Paule / Piché, Alain / Chevalier, Simone / McKercher, Ginette / Birsoy, Kivanc / Barnett, Gene / Brewer, Cathy / Farver, Carol / Naska, Theresa / Pennell, Nathan A. / Raymond, Daniel / Schilero, Cathy / Smolenski, Kathy / Williams, F. / Morrison, Carl / Borgia, Jeffrey A. / Liptay, Michael J. / Pool, Mark / Seder, Christopher W. / Junker, Kerstin / Omberg, Larsson / Dinkin, Mikhail / Manikhas, George / Alvaro, Domenico / Bragazzi, Maria Consiglia / Cardinale, Vincenzo / Carpino, Guido / Gaudio, Eugenio / Chesla, David / Cottingham, Sandra / Dubina, Michael / Moiseenko, Fedor / Dhanasekaran, Renumathy / Becker, Karl Friedrich / Janssen, Klaus-Peter / Slotta-Huspenina, Julia / Abdel-Rahman, Mohamed H. / Aziz, Dina / Bell, Sue / Cebulla, Colleen M. / Davis, Amy / Duell, Rebecca / Elder, J. Bradley / Hilty, Joe / Kumar, Bahavna / Lang, James / Lehman, Norman L. / Mandt, Randy / Nguyen, Phuong / Pilarski, Robert / Rai, Karan / Schoenfield, Lynn / Senecal, Kelly / Wakely, Paul / Hansen, Paul / Lechan, Ronald / Powers, James / Tischler, Arthur / Grizzle, William E. / Sexton, Katherine C. / Kastl, Alison / Henderson, Joel / Porten, Sima / Waldmann, Jens / Fassnacht, Martin / Asa, Sylvia L. / Schadendorf, Dirk / Couce, Marta / Graefen, Markus / Huland, Hartwig / Sauter, Guido / Schlomm, Thorsten / Simon, Ronald / Tennstedt, Pierre / Olabode, Oluwole / Nelson, Mark / Bathe, Oliver / Carroll, Peter R. / Chan, June M. / Disaia, Philip / Glenn, Pat / Kelley, Robin K. / Landen, Charles N. / Phillips, Joanna / Prados, Michael / Simko, Jeffry / Smith-McCune, Karen / VandenBerg, Scott / Roggin, Kevin / Fehrenbach, Ashley / Kendler, Ady / Sifri, Suzanne / Steele, Ruth / Jimeno, Antonio / Carey, Francis / Forgie, Ian / Mannelli, Massimo / Carney, Michael / Hernandez, Brenda / Campos, Benito / Herold-Mende, Christel / Jungk, Christin / Unterberg, A. / Deimling, Andreas von / Bossler, Aaron / Galbraith, Joseph / Jacobus, Laura / Knudson, Michael / Knutson, Tina / Ma, Deqin / Milhem, Mohammed / Sigmund, Rita / Godwin, Andrew K. / Madan, Rashna / Rosenthal, Howard G. / Adebamowo, Clement / Adebamowo, Sally N. / Boussioutas, Alex / Beer, David / Giordano, Thomas / Mes-Masson, Anne-Marie / Saad, Fred / Bocklage, Therese / Landrum, Lisa / Mannel, Robert / Moore, Kathleen / Moxley, Katherine / Postier, Russel / Walker, Joan / Zuna, Rosemary / Feldman, Michael / Valdivieso, Federico / Dhir, Rajiv / Luketich, James / Pinero, Edna M. Mora / Quintero-Aguilo, Mario / Carlotti, Carlos Gilberto / Santos, José Sebastião dos / Kemp, Rafael / Sankarankuty, Ajith / Tirapelli, Daniela / Catto, James / Agnew, Kathy / Swisher, Elizabeth / Creaney, Jenette / Robinson, Bruce / Shelley, Carl Simon / Godwin, Eryn M. / Kendall, Sara / Shipman, Cassaundra / Bradford, Carol / Carey, Thomas / Haddad, Andrea / Moyer, Jeffey / Peterson, Lisa / Prince, Mark / Rozek, Laura / Wolf, Gregory / Bowman, Rayleen / Fong, Kwun M. / Yang, Ian / Korst, Robert / Rathmell, W. Kimryn / Fantacone-Campbell, J. Leigh / Hooke, Jeffrey A. / Kovatich, Albert J. / Shriver, Craig D. / DiPersio, John / Drake, Bettina / Govindan, Ramaswamy / Heath, Sharon / Ley, Timothy / Van Tine, Brian / Westervelt, Peter / Rubin, Mark A. / Lee, Jung Il / Aredes, Natália D. / Mariamidze, Armaz

    Elsevier Inc. Cell. 2018 Apr. 05, v. 173, no. 2 p.291-304.e6

    2018  

    Abstract: We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on ... ...

    Institution The Cancer Genome Atlas Network
    Abstract We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chromosome-arm-level aneuploidy, DNA hypermethylation, mRNA, and miRNA expression levels and reverse-phase protein arrays, of which all, except for aneuploidy, revealed clustering primarily organized by histology, tissue type, or anatomic origin. The influence of cell type was evident in DNA-methylation-based clustering, even after excluding sites with known preexisting tissue-type-specific methylation. Integrative clustering further emphasized the dominant role of cell-of-origin patterns. Molecular similarities among histologically or anatomically related cancer types provide a basis for focused pan-cancer analyses, such as pan-gastrointestinal, pan-gynecological, pan-kidney, and pan-squamous cancers, and those related by stemness features, which in turn may inform strategies for future therapeutic development.
    Keywords DNA hypermethylation ; aneuploidy ; genome ; histology ; microRNA ; therapeutics ; cancer ; TCGA ; transcriptome ; proteome ; methylome ; subtypes ; tissues ; organs ; cell-of-origin
    Language English
    Dates of publication 2018-0405
    Size p. 291-304.e6.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note NAL-AP-2-clean ; Resource is Open Access
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.03.022
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

    Chen, Han / Li, Chunyan / Peng, Xinxin / Zhou, Zhicheng / Weinstein, John N / Liang, Han / Caesar-Johnson, Samantha J / Demchok, John A / Felau, Ina / Kasapi, Melpomeni / Ferguson, Martin L / Hutter, Carolyn M / Sofia, Heidi J / Tarnuzzer, Roy / Wang, Zhining / Yang, Liming / Zenklusen, Jean C / Zhang, Jiashan (Julia) / Chudamani, Sudha /
    Liu, Jia / Lolla, Laxmi / Naresh, Rashi / Pihl, Todd / Sun, Qiang / Wan, Yunhu / Wu, Ye / Cho, Juok / DeFreitas, Timothy / Frazer, Scott / Gehlenborg, Nils / Getz, Gad / Heiman, David I / Kim, Jaegil / Lawrence, Michael S / Lin, Pei / Meier, Sam / Noble, Michael S / Saksena, Gordon / Voet, Doug / Zhang, Hailei / Bernard, Brady / Chambwe, Nyasha / Dhankani, Varsha / Knijnenburg, Theo / Kramer, Roger / Leinonen, Kalle / Liu, Yuexin / Miller, Michael / Reynolds, Sheila / Shmulevich, Ilya / Thorsson, Vesteinn / Zhang, Wei / Akbani, Rehan / Broom, Bradley M / Hegde, Apurva M / Ju, Zhenlin / Kanchi, Rupa S / Korkut, Anil / Li, Jun / Ling, Shiyun / Liu, Wenbin / Lu, Yiling / Mills, Gordon B / Ng, Kwok-Shing / Rao, Arvind / Ryan, Michael / Wang, Jing / Zhang, Jiexin / Abeshouse, Adam / Armenia, Joshua / Chakravarty, Debyani / Chatila, Walid K / de Bruijn, Ino / Gao, Jianjiong / Gross, Benjamin E / Heins, Zachary J / Kundra, Ritika / La, Konnor / Ladanyi, Marc / Luna, Augustin / Nissan, Moriah G / Ochoa, Angelica / Phillips, Sarah M / Reznik, Ed / Sanchez-Vega, Francisco / Sander, Chris / Schultz, Nikolaus / Sheridan, Robert / Sumer, S. Onur / Sun, Yichao / Taylor, Barry S / Wang, Jioajiao / Zhang, Hongxin / Anur, Pavana / Peto, Myron / Spellman, Paul / Benz, Christopher / Stuart, Joshua M / Wong, Christopher K / Yau, Christina / Hayes, D. Neil / Parker, Joel S / Wilkerson, Matthew D / Ally, Adrian / Balasundaram, Miruna / Bowlby, Reanne / Brooks, Denise / Carlsen, Rebecca / Chuah, Eric / Dhalla, Noreen / Holt, Robert / Jones, Steven J.M / Kasaian, Katayoon / Lee, Darlene / Ma, Yussanne / Marra, Marco A / Mayo, Michael / Moore, Richard A / Mungall, Andrew J / Mungall, Karen / Robertson, A. Gordon / Sadeghi, Sara / Schein, Jacqueline E / Sipahimalani, Payal / Tam, Angela / Thiessen, Nina / Tse, Kane / Wong, Tina / Berger, Ashton C / Beroukhim, Rameen / Cherniack, Andrew D / Cibulskis, Carrie / Gabriel, Stacey B / Gao, Galen F / Ha, Gavin / Meyerson, Matthew / Schumacher, Steven E / Shih, Juliann / Kucherlapati, Melanie H / Kucherlapati, Raju S / Baylin, Stephen / Cope, Leslie / Danilova, Ludmila / Bootwalla, Moiz S / Lai, Phillip H / Maglinte, Dennis T / Van Den Berg, David J / Weisenberger, Daniel J / Auman, J. Todd / Balu, Saianand / Bodenheimer, Tom / Fan, Cheng / Hoadley, Katherine A / Hoyle, Alan P / Jefferys, Stuart R / Jones, Corbin D / Meng, Shaowu / Mieczkowski, Piotr A / Mose, Lisle E / Perou, Amy H / Perou, Charles M / Roach, Jeffrey / Shi, Yan / Simons, Janae V / Skelly, Tara / Soloway, Matthew G / Tan, Donghui / Veluvolu, Umadevi / Fan, Huihui / Hinoue, Toshinori / Laird, Peter W / Shen, Hui / Zhou, Wanding / Bellair, Michelle / Chang, Kyle / Covington, Kyle / Creighton, Chad J / Dinh, Huyen / Doddapaneni, HarshaVardhan / Donehower, Lawrence A / Drummond, Jennifer / Gibbs, Richard A / Glenn, Robert / Hale, Walker / Han, Yi / Hu, Jianhong / Korchina, Viktoriya / Lee, Sandra / Lewis, Lora / Li, Wei / Liu, Xiuping / Morgan, Margaret / Morton, Donna / Muzny, Donna / Santibanez, Jireh / Sheth, Margi / Shinbrot, Eve / Wang, Linghua / Wang, Min / Wheeler, David A / Xi, Liu / Zhao, Fengmei / Hess, Julian / Appelbaum, Elizabeth L / Bailey, Matthew / Cordes, Matthew G / Ding, Li / Fronick, Catrina C / Fulton, Lucinda A / Fulton, Robert S / Kandoth, Cyriac / Mardis, Elaine R / McLellan, Michael D / Miller, Christopher A / Schmidt, Heather K / Wilson, Richard K / Crain, Daniel / Curley, Erin / Gardner, Johanna / Lau, Kevin / Mallery, David / Morris, Scott / Paulauskis, Joseph / Penny, Robert / Shelton, Candace / Shelton, Troy / Sherman, Mark / Thompson, Eric / Yena, Peggy / Bowen, Jay / Gastier-Foster, Julie M / Gerken, Mark / Leraas, Kristen M / Lichtenberg, Tara M / Ramirez, Nilsa C / Wise, Lisa / Zmuda, Erik / Corcoran, Niall / Costello, Tony / Hovens, Christopher / Carvalho, Andre L / de Carvalho, Ana C / Fregnani, José H / Longatto-Filho, Adhemar / Reis, Rui M / Scapulatempo-Neto, Cristovam / Silveira, Henrique C.S / Vidal, Daniel O / Burnette, Andrew / Eschbacher, Jennifer / Hermes, Beth / Noss, Ardene / Singh, Rosy / Anderson, Matthew L / Castro, Patricia D / Ittmann, Michael / Huntsman, David / Kohl, Bernard / Le, Xuan / Thorp, Richard / Andry, Chris / Duffy, Elizabeth R / Lyadov, Vladimir / Paklina, Oxana / Setdikova, Galiya / Shabunin, Alexey / Tavobilov, Mikhail / McPherson, Christopher / Warnick, Ronald / Berkowitz, Ross / Cramer, Daniel / Feltmate, Colleen / Horowitz, Neil / Kibel, Adam / Muto, Michael / Raut, Chandrajit P / Malykh, Andrei / Barnholtz-Sloan, Jill S / Barrett, Wendi / Devine, Karen / Fulop, Jordonna / Ostrom, Quinn T / Shimmel, Kristen / Wolinsky, Yingli / Sloan, Andrew E / De Rose, Agostino / Giuliante, Felice / Goodman, Marc / Karlan, Beth Y / Hagedorn, Curt H / Eckman, John / Harr, Jodi / Myers, Jerome / Tucker, Kelinda / Zach, Leigh Anne / Deyarmin, Brenda / Hu, Hai / Kvecher, Leonid / Larson, Caroline / Mural, Richard J / Somiari, Stella / Vicha, Ales / Zelinka, Tomas / Bennett, Joseph / Iacocca, Mary / Rabeno, Brenda / Swanson, Patricia / Latour, Mathieu / Lacombe, Louis / Têtu, Bernard / Bergeron, Alain / McGraw, Mary / Staugaitis, Susan M / Chabot, John / Hibshoosh, Hanina / Sepulveda, Antonia / Su, Tao / Wang, Timothy / Potapova, Olga / Voronina, Olga / Desjardins, Laurence / Mariani, Odette / Roman-Roman, Sergio / Sastre, Xavier / Stern, Marc-Henri / Cheng, Feixiong / Signoretti, Sabina / Berchuck, Andrew / Bigner, Darell / Lipp, Eric / Marks, Jeffrey / McCall, Shannon / McLendon, Roger / Secord, Angeles / Sharp, Alexis / Behera, Madhusmita / Brat, Daniel J / Chen, Amy / Delman, Keith / Force, Seth / Khuri, Fadlo / Magliocca, Kelly / Maithel, Shishir / Olson, Jeffrey J / Owonikoko, Taofeek / Pickens, Alan / Ramalingam, Suresh / Shin, Dong M / Sica, Gabriel / Van Meir, Erwin G / Zhang, Hongzheng / Eijckenboom, Wil / Gillis, Ad / Korpershoek, Esther / Looijenga, Leendert / Oosterhuis, Wolter / Stoop, Hans / van Kessel, Kim E / Zwarthoff, Ellen C / Calatozzolo, Chiara / Cuppini, Lucia / Cuzzubbo, Stefania / DiMeco, Francesco / Finocchiaro, Gaetano / Mattei, Luca / Perin, Alessandro / Pollo, Bianca / Chen, Chu / Houck, John / Lohavanichbutr, Pawadee / Hartmann, Arndt / Stoehr, Christine / Stoehr, Robert / Taubert, Helge / Wach, Sven / Wullich, Bernd / Kycler, Witold / Murawa, Dawid / Wiznerowicz, Maciej / Chung, Ki / Edenfield, W. Jeffrey / Martin, Julie / Baudin, Eric / Bubley, Glenn / Bueno, Raphael / De Rienzo, Assunta / Richards, William G / Kalkanis, Steven / Mikkelsen, Tom / Noushmehr, Houtan / Scarpace, Lisa / Girard, Nicolas / Aymerich, Marta / Campo, Elias / Giné, Eva / Guillermo, Armando López / Van Bang, Nguyen / Hanh, Phan Thi / Phu, Bui Duc / Tang, Yufang / Colman, Howard / Evason, Kimberley / Dottino, Peter R / Martignetti, John A / Gabra, Hani / Juhl, Hartmut / Akeredolu, Teniola / Stepa, Serghei / Hoon, Dave / Ahn, Keunsoo / Kang, Koo Jeong / Beuschlein, Felix / Breggia, Anne / Birrer, Michael / Bell, Debra / Borad, Mitesh / Bryce, Alan H / Castle, Erik / Chandan, Vishal / Cheville, John / Copland, John A / Farnell, Michael / Flotte, Thomas / Giama, Nasra / Ho, Thai / Kendrick, Michael / Kocher, Jean-Pierre / Kopp, Karla / Moser, Catherine / Nagorney, David / O’Brien, Daniel / O’Neill, Brian Patrick / Patel, Tushar / Petersen, Gloria / Que, Florencia / Rivera, Michael / Roberts, Lewis / Smallridge, Robert / Smyrk, Thomas / Stanton, Melissa / Thompson, R. Houston / Torbenson, Michael / Yang, Ju Dong / Zhang, Lizhi / Brimo, Fadi / Ajani, Jaffer A / Gonzalez, Ana Maria Angulo / Behrens, Carmen / Bondaruk, Jolanta / Broaddus, Russell / Czerniak, Bogdan / Esmaeli, Bita / Fujimoto, Junya / Gershenwald, Jeffrey / Guo, Charles / Lazar, Alexander J / Logothetis, Christopher / Meric-Bernstam, Funda / Moran, Cesar / Ramondetta, Lois / Rice, David / Sood, Anil / Tamboli, Pheroze / Thompson, Timothy / Troncoso, Patricia / Tsao, Anne / Wistuba, Ignacio / Carter, Candace / Haydu, Lauren / Hersey, Peter / Jakrot, Valerie / Kakavand, Hojabr / Kefford, Richard / Lee, Kenneth / Long, Georgina / Mann, Graham / Quinn, Michael / Saw, Robyn / Scolyer, Richard / Shannon, Kerwin / Spillane, Andrew / Stretch, Jonathan / Synott, Maria / Thompson, John / Wilmott, James / Al-Ahmadie, Hikmat / Chan, Timothy A / Ghossein, Ronald / Gopalan, Anuradha / Levine, Douglas A / Reuter, Victor / Singer, Samuel / Singh, Bhuvanesh / Tien, Nguyen Viet / Broudy, Thomas / Mirsaidi, Cyrus / Nair, Praveen / Drwiega, Paul / Miller, Judy / Smith, Jennifer / Zaren, Howard / Park, Joong-Won / Hung, Nguyen Phi / Kebebew, Electron / Linehan, W. Marston / Metwalli, Adam R / Pacak, Karel / Pinto, Peter A / Schiffman, Mark / Schmidt, Laura S / Vocke, Cathy D / Wentzensen, Nicolas / Worrell, Robert / Yang, Hannah / Moncrieff, Marc / Goparaju, Chandra / Melamed, Jonathan / Pass, Harvey / Botnariuc, Natalia / Caraman, Irina / Cernat, Mircea / Chemencedji, Inga / Clipca, Adrian / Doruc, Serghei / Gorincioi, Ghenadie / Mura, Sergiu / Pirtac, Maria / Stancul, Irina / Tcaciuc, Diana / Albert, Monique / Alexopoulou, Iakovina / Arnaout, Angel / Bartlett, John / Engel, Jay / Gilbert, Sebastien / Parfitt, Jeremy / Sekhon, Harman / Thomas, George / Rassl, Doris M / Rintoul, Robert C / Bifulco, Carlo / Tamakawa, Raina / Urba, Walter / Hayward, Nicholas / Timmers, Henri / Antenucci, Anna / Facciolo, Francesco / Grazi, Gianluca / Marino, Mirella / Merola, Roberta / de Krijger, Ronald / Gimenez-Roqueplo, Anne-Paule / Piché, Alain / Chevalier, Simone / McKercher, Ginette / Birsoy, Kivanc / Barnett, Gene / Brewer, Cathy / Farver, Carol / Naska, Theresa / Pennell, Nathan A / Raymond, Daniel / Schilero, Cathy / Smolenski, Kathy / Williams, Felicia / Morrison, Carl / Borgia, Jeffrey A / Liptay, Michael J / Pool, Mark / Seder, Christopher W / Junker, Kerstin / Omberg, Larsson / Dinkin, Mikhail / Manikhas, George / Alvaro, Domenico / Bragazzi, Maria Consiglia / Cardinale, Vincenzo / Carpino, Guido / Gaudio, Eugenio / Chesla, David / Cottingham, Sandra / Dubina, Michael / Moiseenko, Fedor / Dhanasekaran, Renumathy / Becker, Karl-Friedrich / Janssen, Klaus-Peter / Slotta-Huspenina, Julia / Abdel-Rahman, Mohamed H / Aziz, Dina / Bell, Sue / Cebulla, Colleen M / Davis, Amy / Duell, Rebecca / Elder, J. Bradley / Hilty, Joe / Kumar, Bahavna / Lang, James / Lehman, Norman L / Mandt, Randy / Nguyen, Phuong / Pilarski, Robert / Rai, Karan / Schoenfield, Lynn / Senecal, Kelly / Wakely, Paul / Hansen, Paul / Lechan, Ronald / Powers, James / Tischler, Arthur / Grizzle, William E / Sexton, Katherine C / Kastl, Alison / Henderson, Joel / Porten, Sima / Waldmann, Jens / Fassnacht, Martin / Asa, Sylvia L / Schadendorf, Dirk / Couce, Marta / Graefen, Markus / Huland, Hartwig / Sauter, Guido / Schlomm, Thorsten / Simon, Ronald / Tennstedt, Pierre / Olabode, Oluwole / Nelson, Mark / Bathe, Oliver / Carroll, Peter R / Chan, June M / Disaia, Philip / Glenn, Pat / Kelley, Robin K / Landen, Charles N / Phillips, Joanna / Prados, Michael / Simko, Jeffry / Smith-McCune, Karen / VandenBerg, Scott / Roggin, Kevin / Fehrenbach, Ashley / Kendler, Ady / Sifri, Suzanne / Steele, Ruth / Jimeno, Antonio / Carey, Francis / Forgie, Ian / Mannelli, Massimo / Carney, Michael / Hernandez, Brenda / Campos, Benito / Herold-Mende, Christel / Jungk, Christin / Unterberg, Andreas / von Deimling, Andreas / Bossler, Aaron / Galbraith, Joseph / Jacobus, Laura / Knudson, Michael / Knutson, Tina / Ma, Deqin / Milhem, Mohammed / Sigmund, Rita / Godwin, Andrew K / Madan, Rashna / Rosenthal, Howard G / Adebamowo, Clement / Adebamowo, Sally N / Boussioutas, Alex / Beer, David / Giordano, Thomas / Mes-Masson, Anne-Marie / Saad, Fred / Bocklage, Therese / Landrum, Lisa / Mannel, Robert / Moore, Kathleen / Moxley, Katherine / Postier, Russel / Walker, Joan / Zuna, Rosemary / Feldman, Michael / Valdivieso, Federico / Dhir, Rajiv / Luketich, James / Pinero, Edna M. Mora / Quintero-Aguilo, Mario / Carlotti, Carlos Gilberto / Dos Santos, Jose Sebastião / Kemp, Rafael / Sankarankuty, Ajith / Tirapelli, Daniela / Catto, James / Agnew, Kathy / Swisher, Elizabeth / Creaney, Jenette / Robinson, Bruce / Shelley, Carl Simon / Godwin, Eryn M / Kendall, Sara / Shipman, Cassaundra / Bradford, Carol / Carey, Thomas / Haddad, Andrea / Moyer, Jeffey / Peterson, Lisa / Prince, Mark / Rozek, Laura / Wolf, Gregory / Bowman, Rayleen / Fong, Kwun M / Yang, Ian / Korst, Robert / Rathmell, W. Kimryn / Fantacone-Campbell, J. Leigh / Hooke, Jeffrey A / Kovatich, Albert J / Shriver, Craig D / DiPersio, John / Drake, Bettina / Govindan, Ramaswamy / Heath, Sharon / Ley, Timothy / Van Tine, Brian / Westervelt, Peter / Rubin, Mark A / Lee, Jung Il / Aredes, Natália D / Mariamidze, Armaz

    Cell. 2018 Apr. 05, v. 173, no. 2

    2018  

    Abstract: The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection and characterization of a large number of expressed enhancers in a genome-wide analysis of ... ...

    Institution The Cancer Genome Atlas Research Network
    Abstract The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection and characterization of a large number of expressed enhancers in a genome-wide analysis of 8928 tumor samples across 33 cancer types using TCGA RNA-seq data. Compared with matched normal tissues, global enhancer activation was observed in most cancers. Across cancer types, global enhancer activity was positively associated with aneuploidy, but not mutation load, suggesting a hypothesis centered on “chromatin-state” to explain their interplay. Integrating eQTL, mRNA co-expression, and Hi-C data analysis, we developed a computational method to infer causal enhancer-gene interactions, revealing enhancers of clinically actionable genes. Having identified an enhancer ∼140 kb downstream of PD-L1, a major immunotherapy target, we validated it experimentally. This study provides a systematic view of enhancer activity in diverse tumor contexts and suggests the clinical implications of enhancers.
    Keywords DNA ; aneuploidy ; carcinogenesis ; genome-wide association study ; immunotherapy ; mutation ; neoplasms ; patients ; sequence analysis
    Language English
    Dates of publication 2018-0405
    Size p. 386-399.e12.
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.03.027
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Pathogenic Germline Variants in 10,389 Adult Cancers

    Huang, Kuan-lin / Mashl, R. Jay / Wu, Yige / Ritter, Deborah I. / Wang, Jiayin / Oh, Clara / Paczkowska, Marta / Reynolds, Sheila / Wyczalkowski, Matthew A. / Oak, Ninad / Scott, Adam D. / Krassowski, Michal / Cherniack, Andrew D. / Houlahan, Kathleen E. / Jayasinghe, Reyka / Wang, Liang-Bo / Zhou, Daniel Cui / Liu, Di / Cao, Song /
    Kim, Young-Won / Koire, Amanda / McMichael, Joshua F. / Hucthagowder, Vishwanathan / Kim, Tae-Beom / Hahn, Abigail / Wang, Chen / McLellan, Michael D. / Al-Mulla, Fahd / Johnson, Kimberly J. / Lichtarge, Olivier / Boutros, Paul C. / Raphael, Benjamin / Lazar, Alexander / Zhang, Wei / Wendl, Michael C. / Govindan, Ramaswamy / Jaina, Sañjaya / Wheeler, David / Kulkarni, Shashikant / DiPersio, John F. / Reimand, Jüri / Meric-Bernstam, Funda / Chen, Ken / Shmulevich, Ilya / Plon, Sharon E. / Chen, Feng / Ding, Li / Caesar-Johnson, Samantha J. / Demchok, John A. / Felau, Ina / Kasapi, Melpomeni / Ferguson, Martin L. / Hutter, Carolyn M. / Sofia, Heidi J. / Tarnuzzer, Roy / Wang, Zhining / Yang, Liming / Zenklusen, Jean C. / Zhang, Jiashan (Julia) / Chudamani, Sudha / Liu, Jia / Lolla, Laxmi / Naresh, Rashi / Pihl, Todd / Sun, Qiang / Wan, Yunhu / Wu, Ye / Cho, Juok / DeFreitas, Timothy / Frazer, Scott / Gehlenborg, Nils / Getz, Gad / Heiman, David I. / Kim, Jaegil / Lawrence, Michael S. / Lin, Pei / Meier, Samuel A. / Noble, Michael S. / Saksena, Gordon / Voet, Doug / Zhang, Hailei / Bernard, Brady / Chambwe, Nyasha / Dhankani, Varsha / Knijnenburg, Theo / Kramer, Roger / Leinonen, Kalle / Liu, Yuexin / Miller, Michael / Thorsson, Vesteinn / Akbani, Rehan / Broom, Bradley M. / Hegde, Apurva M. / Ju, Zhenlin / Kanchi, Rupa S. / Korkut, Anil / Li, Jun / Liang, Han / Ling, Shiyun / Liu, Wenbin / Lu, Yiling / Mills, Gordon B. / Ng, Kwok-Shing / Rao, Arvind / Ryan, Michael / Wang, Jing / Weinstein, John N. / Zhang, Jiexin / Abeshouse, Adam / Armenia, Joshua / Chakravarty, Debyani / Chatila, Walid K. / de Bruijn, Ino / Gao, Jianjiong / Gross, Benjamin E. / Heins, Zachary J. / Kundra, Ritika / La, Konnor / Ladanyi, Marc / Luna, Augustin / Nissan, Moriah G. / Ochoa, Angelica / Phillips, Sarah M. / Reznik, Ed / Sanchez-Vega, Francisco / Sander, Chris / Schultz, Nikolaus / Sheridan, Robert / Sumer, S. Onur / Sun, Yichao / Taylor, Barry S. / Wang, Jioajiao / Zhang, Hongxin / Anur, Pavana / Peto, Myron / Spellman, Paul / Benz, Christopher / Stuart, Joshua M. / Wong, Christopher K. / Yau, Christina / Hayes, D. Neil / Parker, Joel S. / Wilkerson, Matthew D. / Ally, Adrian / Balasundaram, Miruna / Bowlby, Reanne / Brooks, Denise / Carlsen, Rebecca / Chuah, Eric / Dhalla, Noreen / Holt, Robert / Jones, Steven J.M. / Kasaian, Katayoon / Lee, Darlene / Ma, Yussanne / Marra, Marco A. / Mayo, Michael / Moore, Richard A. / Mungall, Andrew J. / Mungall, Karen / Robertson, A. Gordon / Sadeghi, Sara / Schein, Jacqueline E. / Sipahimalani, Payal / Tam, Angela / Thiessen, Nina / Tse, Kane / Wong, Tina / Berger, Ashton C. / Beroukhim, Rameen / Cibulskis, Carrie / Gabriel, Stacey B. / Gao, Galen F. / Ha, Gavin / Meyerson, Matthew / Schumacher, Steven E. / Shih, Juliann / Kucherlapati, Melanie H. / Kucherlapati, Raju S. / Baylin, Stephen / Cope, Leslie / Danilova, Ludmila / Bootwalla, Moiz S. / Lai, Phillip H. / Maglinte, Dennis T. / Van Den Berg, David J. / Weisenberger, Daniel J. / Auman, J. Todd / Balu, Saianand / Bodenheimer, Thomas / Fan, Cheng / Hoadley, Katherine A. / Hoyle, Alan P. / Jefferys, Stuart R. / Jones, Corbin D. / Meng, Shaowu / Mieczkowski, Piotr A. / Mose, Lisle E. / Perou, Amy H. / Perou, Charles M. / Roach, Jeffrey / Shi, Yan / Simons, Janae V. / Skelly, Tara / Soloway, Matthew G. / Tan, Donghui / Veluvolu, Umadevi / Fan, Huihui / Hinoue, Toshinori / Laird, Peter W. / Shen, Hui / Zhou, Wanding / Bellair, Michelle / Chang, Kyle / Covington, Kyle / Creighton, Chad J. / Dinh, Huyen / Doddapaneni, HarshaVardhan / Donehower, Lawrence A. / Drummond, Jennifer / Gibbs, Richard / Glenn, Robert / Hale, Walker / Han, Yi / Hu, Jianhong / Korchina, Viktoriya / Lee, Sandra / Lewis, Lora / Li, Wei / Liu, Xiuping / Morgan, Margaret / Morton, Donna / Muzny, Donna / Santibanez, Jireh / Sheth, Margi / Shinbrot, Eve / Wang, Linghua / Wang, Min / Wheeler, David A. / Xi, Liu / Zhao, Fengmei / Hess, Julian / Appelbaum, Elizabeth L. / Bailey, Matthew / Cordes, Matthew G. / Fronick, Catrina C. / Fulton, Lucinda A. / Fulton, Robert S. / Kandoth, Cyriac / Mardis, Elaine R. / Miller, Christopher A. / Schmidt, Heather K. / Wilson, Richard K. / Crain, Daniel / Curley, Erin / Gardner, Johanna / Lau, Kevin / Mallery, David / Morris, Scott / Paulauskis, Joseph / Penny, Robert / Shelton, Candace / Shelton, Troy / Sherman, Mark / Thompson, Eric / Yena, Peggy / Bowen, Jay / Gastier-Foster, Julie M. / Gerken, Mark / Leraas, Kristen M. / Lichtenberg, Tara M. / Ramirez, Nilsa C. / Wise, Lisa / Zmuda, Erik / Corcoran, Niall / Costello, Tony / Hovens, Christopher / Carvalho, Andre L. / de Carvalho, Ana C. / Fregnani, José H. / Filho, Adhemar Longatto / Reis, Rui M. / Scapulatempo-Neto, Cristovam / Silveira, Henrique C.S. / Vidal, Daniel O. / Burnette, Andrew / Eschbacher, Jennifer / Hermes, Beth / Noss, Ardene / Singh, Rosy / Anderson, Matthew L. / Castro, Patricia D. / Ittmann, Michael / Huntsman, David / Kohl, Bernard / Lệ Xuân / Thorp, Richard / Andry, Chris / Duffy, Elizabeth R. / Lyadov, Vladimir / Paklina, Oxana / Setdikova, Galiya / Shabunin, Alexey / Tavobilov, Mikhail / McPherson, Christopher / Warnick, Ronald / Berkowitz, Ross / Cramer, Daniel / Feltmate, Colleen / Horowitz, Neil / Kibel, Adam / Muto, Michael / Raut, Chandrajit P. / Malykh, Andrei / Barnholtz-Sloan, Jill S. / Barrett, Wendi / Devine, Karen / Fulop, Jordonna / Ostrom, Quinn T. / Shimmel, Kristen / Wolinsky, Yingli / Sloan, Andrew E. / De Rose, Agostino / Giuliante, Felice / Goodman, Marc / Karlan, Beth Y. / Hagedorn, C. H. / Eckman, John / Harr, Jodi / Myers, Jerome / Tucker, Kelinda / Zach, Leigh Anne / Deyarmin, Brenda / Hu, Hai / Kvecher, Leonid / Larson, Caroline / Mural, Richard J. / Somiari, Stella / Vicha, Ales / Zelinka, Tomas / Bennett, Joseph / Iacocca, Mary / Rabeno, Brenda / Swanson, Patricia / Latour, Mathieu / Lacombe, Louis / Têtu, Bernard / Bergeron, Alain / McGraw, Mary / Staugaitis, Susan M. / Chabot, John / Hibshoosh, Hanina / Sepulveda, Antonia / Su, Tao / Wang, Timothy / Potapova, Olga / Voronina, Olga / Desjardins, Laurence / Mariani, Odette / Roman-Roman, Sergio / Sastre, Xavier / Stern, Marc-Henri / Cheng, Feixiong / Signoretti, Sabina / Berchuck, Andrew / Bigner, Darell / Lipp, Eric / Marks, Jeffrey / McCall, Shannon / McLendon, Roger / Secord, Angeles / Sharp, Alexis / Behera, Madhusmita / Brat, Daniel J. / Chen, Amy / Delman, Keith / Force, Seth / Khuri, Fadlo / Magliocca, Kelly / Maithel, Shishir / Olson, Jeffrey J. / Owonikoko, Taofeek / Pickens, Alan / Ramalingam, Suresh / Shin, Dong M. / Sica, Gabriel / Van Meir, Erwin G. / Zhang, Hongzheng / Eijckenboom, Wil / Gillis, Ad / Korpershoek, Esther / Looijenga, Leendert / Oosterhuis, Wolter / Stoop, Hans / van Kessel, Kim E. / Zwarthoff, Ellen C. / Calatozzolo, Chiara / Cuppini, Lucia / Cuzzubbo, Stefania / DiMeco, Francesco / Finocchiaro, Gaetano / Mattei, Luca / Perin, Alessandro / Pollo, Bianca / Chen, Chu / Houck, John / Lohavanichbutr, Pawadee / Hartmann, Arndt / Stoehr, Christine / Stoehr, Robert / Taubert, Helge / Wach, Sven / Wullich, Bernd / Kycler, Witold / Murawa, Dawid / Wiznerowicz, Maciej / Chung, Ki / Edenfield, W. Jeffrey / Martin, Julie / Baudin, Eric / Bubley, Glenn / Bueno, Raphael / De Rienzo, Assunta / Richards, William G. / Kalkanis, Steven / Mikkelsen, Tom / Noushmehr, Houtan / Scarpace, Lisa / Girard, Nicolas / Aymerich, Marta / Campo, Elias / Giné, Eva / Guillermo, Armando López / Van Bang, Nguyen / Hanh, Phan Thi / Phu, Bui Duc / Tang, Yufang / Colman, Howard / Evason, Kimberley / Dottino, Peter R. / Martignetti, John A. / Gabra, Hani / Juhl, Hartmut / Akeredolu, Teniola / Stepa, Serghei / Hoon, Dave / Ahn, Keunsoo / Kang, Koo Jeong / Beuschlein, Felix / Breggia, Anne / Birrer, Michael / Bell, Debra / Borad, Mitesh / Bryce, Alan H. / Castle, Erik / Chandan, Vishal / Cheville, John / Copland, John A. / Farnell, Michael / Flotte, Thomas / Giama, Nasra / Ho, Thai / Kendrick, Michael / Kocher, Jean-Pierre / Kopp, Karla / Moser, Catherine / Nagorney, David / O’Brien, Daniel / O’Neill, Brian Patrick / Patel, Tushar / Petersen, Gloria / Que, Florencia / Rivera, Michael / Roberts, Lewis / Smallridge, Robert / Smyrk, Thomas / Stanton, Melissa / Thompson, R. Houston / Torbenson, Michael / Yang, Ju Dong / Zhang, Lizhi / Brimo, Fadi / Ajani, Jaffer A. / Gonzalez, Ana Maria Angulo / Behrens, Carmen / Bondaruk, Jolanta / Broaddus, Russell / Czerniak, Bogdan / Esmaeli, Bita / Fujimoto, Junya / Gershenwald, Jeffrey / Guo, Charles / Logothetis, Christopher / Moran, Cesar / Ramondetta, Lois / Rice, David / Sood, Anil / Tamboli, Pheroze / Thompson, Timothy / Troncoso, Patricia / Tsao, Anne / Wistuba, Ignacio / Carter, Candace / Haydu, Lauren / Hersey, Peter / Jakrot, Valerie / Kakavand, Hojabr / Kefford, Richard / Lee, Kenneth / Long, Georgina / Mann, Graham / Quinn, Michael / Saw, Robyn / Scolyer, Richard / Shannon, Kerwin / Spillane, Andrew / Stretch, Jonathan / Synott, Maria / Thompson, John / Wilmott, James / Al-Ahmadie, Hikmat / Chan, Timothy A. / Ghossein, Ronald / Gopalan, Anuradha / Levine, Douglas A. / Reuter, Victor / Singer, Samuel / Singh, Bhuvanesh / Tien, Nguyen Viet / Broudy, Thomas / Mirsaidi, Cyrus / Nair, Praveen / Drwiega, Paul / Miller, Judy / Smith, Jennifer / Zaren, Howard / Park, Joong-Won / Hung, Nguyen Phi / Kebebew, Electron / Linehan, Marston / Metwalli, Adam R. / Pacak, Karel / Pinto, Peter A. / Schiffman, Mark / Schmidt, Laura S. / Vocke, Cathy D. / Wentzensen, Nicolas / Worrell, Robert / Yang, Hannah / Moncrieff, Marc / Goparaju, Chandra / Melamed, Jonathan / Pass, Harvey / Botnariuc, Natalia / Caraman, Irina / Cernat, Mircea / Chemencedji, Inga / Clipca, Adrian / Doruc, Serghei / Gorincioi, Ghenadie / Mura, Sergiu / Pirtac, Maria / Stancul, Irina / Tcaciuc, Diana / Albert, Monique / Alexopoulou, Iakovina / Arnaout, Angel / Bartlett, John / Engel, Jay / Gilbert, Sebastien / Parfitt, Jeremy / Sekhon, Harman / Thomas, George / Rassl, Doris M. / Rintoul, Robert C. / Bifulco, Carlo / Tamakawa, Raina / Urba, Walter / Hayward, Nicholas / Timmers, Henri / Antenucci, Anna / Facciolo, Francesco / Grazi, Gianluca / Marino, Mirella / Merola, Roberta / de Krijger, Ronald / Gimenez-Roqueplo, Anne-Paule / Piché, Alain / Chevalier, Simone / McKercher, Ginette / Birsoy, Kivanc / Barnett, Gene / Brewer, Cathy / Farver, Carol / Naska, Theresa / Pennell, Nathan A. / Raymond, Daniel / Schilero, Cathy / Smolenski, Kathy / Williams, F. / Morrison, Carl / Borgia, Jeffrey A. / Liptay, Michael J. / Pool, Mark / Seder, Christopher W. / Junker, Kerstin / Omberg, Larsson / Dinkin, Mikhail / Manikhas, George / Alvaro, Domenico / Bragazzi, Maria Consiglia / Cardinale, Vincenzo / Carpino, Guido / Gaudio, Eugenio / Chesla, David / Cottingham, Sandra / Dubina, Michael / Moiseenko, Fedor / Dhanasekaran, Renumathy / Becker, Karl Friedrich / Janssen, Klaus-Peter / Slotta-Huspenina, Julia / Abdel-Rahman, Mohamed H. / Aziz, Dina / Bell, Sue / Cebulla, Colleen M. / Davis, Amy / Duell, Rebecca / Elder, J. Bradley / Hilty, Joe / Kumar, Bahavna / Lang, James / Lehman, Norman L. / Mandt, Randy / Nguyen, Phuong / Pilarski, Robert / Rai, Karan / Schoenfield, Lynn / Senecal, Kelly / Wakely, Paul / Hansen, Paul / Lechan, Ronald / Powers, James / Tischler, Arthur / Grizzle, William E. / Sexton, Katherine C. / Kastl, Alison / Henderson, Joel / Porten, Sima / Waldmann, Jens / Fassnacht, Martin / Asa, Sylvia L. / Schadendorf, Dirk / Couce, Marta / Graefen, Markus / Huland, Hartwig / Sauter, Guido / Schlomm, Thorsten / Simon, Ronald / Tennstedt, Pierre / Olabode, Oluwole / Nelson, Mark / Bathe, Oliver / Carroll, Peter R. / Chan, June M. / Disaia, Philip / Glenn, Pat / Kelley, Robin K. / Landen, Charles N. / Phillips, Joanna / Prados, Michael / Simko, Jeffry / Smith-McCune, Karen / VandenBerg, Scott / Roggin, Kevin / Fehrenbach, Ashley / Kendler, Ady / Sifri, Suzanne / Steele, Ruth / Jimeno, Antonio / Carey, Francis / Forgie, Ian / Mannelli, Massimo / Carney, Michael / Hernandez, Brenda / Campos, Benito / Herold-Mende, Christel / Jungk, Christin / Unterberg, A. / Deimling, Andreas von / Bossler, Aaron / Galbraith, Joseph / Jacobus, Laura / Knudson, Michael / Knutson, Tina / Ma, Deqin / Milhem, Mohammed / Sigmund, Rita / Godwin, Andrew K. / Madan, Rashna / Rosenthal, Howard G. / Adebamowo, Clement / Adebamowo, Sally N. / Boussioutas, Alex / Beer, David / Giordano, Thomas / Mes-Masson, Anne-Marie / Saad, Fred / Bocklage, Therese / Landrum, Lisa / Mannel, Robert / Moore, Kathleen / Moxley, Katherine / Postier, Russel / Walker, Joan / Zuna, Rosemary / Feldman, Michael / Valdivieso, Federico / Dhir, Rajiv / Luketich, James / Pinero, Edna M. Mora / Quintero-Aguilo, Mario / Carlotti, Carlos Gilberto / Santos, José Sebastião dos / Kemp, Rafael / Sankarankuty, Ajith / Tirapelli, Daniela / Catto, James / Agnew, Kathy / Swisher, Elizabeth / Creaney, Jenette / Robinson, Bruce / Shelley, Carl Simon / Godwin, Eryn M. / Kendall, Sara / Shipman, Cassaundra / Bradford, Carol / Carey, Thomas / Haddad, Andrea / Moyer, Jeffey / Peterson, Lisa / Prince, Mark / Rozek, Laura / Wolf, Gregory / Bowman, Rayleen / Fong, Kwun M. / Yang, Ian / Korst, Robert / Rathmell, W. Kimryn / Fantacone-Campbell, J. Leigh / Hooke, Jeffrey A. / Kovatich, Albert J. / Shriver, Craig D. / DiPersio, John / Drake, Bettina / Heath, Sharon / Ley, Timothy / Van Tine, Brian / Westervelt, Peter / Rubin, Mark A. / Lee, Jung Il / Aredes, Natália D. / Mariamidze, Armaz

    Cell. 2018 Apr. 05, v. 173, no. 2 p.355-370.e14

    2018  

    Abstract: We conducted the largest investigation of predisposition variants in cancer to date, discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types. Twenty-one genes showed single or cross-cancer associations, ... ...

    Institution The Cancer Genome Atlas Research Network
    Abstract We conducted the largest investigation of predisposition variants in cancer to date, discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types. Twenty-one genes showed single or cross-cancer associations, including novel associations of SDHA in melanoma and PALB2 in stomach adenocarcinoma. The 659 predisposition variants and 18 additional large deletions in tumor suppressors, including ATM, BRCA1, and NF1, showed low gene expression and frequent (43%) loss of heterozygosity or biallelic two-hit events. We also discovered 33 such variants in oncogenes, including missenses in MET, RET, and PTPN11 associated with high gene expression. We nominated 47 additional predisposition variants from prioritized VUSs supported by multiple evidences involving case-control frequency, loss of heterozygosity, expression effect, and co-localization with mutations and modified residues. Our integrative approach links rare predisposition variants to functional consequences, informing future guidelines of variant classification and germline genetic testing in cancer.
    Keywords adenocarcinoma ; adults ; gene expression ; germ cells ; loss of heterozygosity ; melanoma ; oncogenes ; stomach ; tumor suppressor proteins ; cancer predisposition ; germline and somatic genomes ; LOH ; variant pathogenicity
    Language English
    Dates of publication 2018-0405
    Size p. 355-370.e14.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note NAL-AP-2-clean ; Resource is Open Access
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.03.039
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Oncogenic Signaling Pathways in The Cancer Genome Atlas

    Sanchez-Vega, Francisco / Minà, Marco / Armenia, Joshua / Chatila, Walid K. / Luna, Augustin / La, Konnor C. / Dimitriadoy, Sofia / Liu, David L. / Kantheti, Havish S. / Saghafinia, Sadegh / Chakravarty, Debyani / Daian, Foysal / Gao, Qingsong / Bailey, Matthew H. / Liang, Wenwei / Foltz, Steven M. / Shmulevich, Ilya / Ding, Li / Heins, Zachary /
    Ochoa, Angelica / Gross, Benjamin / Gao, Jianjiong / Zhang, Hongxin / Kundra, Ritika / Kandoth, Cyriac / Bahceci, Istemi / Dervishi, Leonard / Dogrusoz, Ugur / Zhou, Wanding / Shen, Hui / Laird, Peter W. / Way, Gregory P. / Greene, Casey S. / Liang, Han / Xiao, Yonghong / Wang, Chen / Iavarone, Antonio / Berger, Alice H. / Bivona, Trever G. / Lazar, Alexander / Hammer, Gary D. / Giordano, Thomas / Kwong, Lawrence N. / McArthur, Grant / Huang, Chenfei / Tward, Aaron D. / Frederick, Mitchell J. / McCormick, Frank / Meyerson, Matthew / Van Allen, Eliezer M. / Cherniack, Andrew D. / Ciriello, Giovanni / Sander, Chris / Schultz, Nikolaus / Caesar-Johnson, Samantha J. / Demchok, John A. / Felau, Ina / Kasapi, Melpomeni / Ferguson, Martin L. / Hutter, Carolyn M. / Sofia, Heidi J. / Tarnuzzer, Roy / Wang, Zhining / Yang, Liming / Zenklusen, Jean C. / Zhang, Jiashan (Julia) / Chudamani, Sudha / Liu, Jia / Lolla, Laxmi / Naresh, Rashi / Pihl, Todd / Sun, Qiang / Wan, Yunhu / Wu, Ye / Cho, Juok / DeFreitas, Timothy / Frazer, Scott / Gehlenborg, Nils / Getz, Gad / Heiman, David I. / Kim, Jaegil / Lawrence, Michael S. / Lin, Pei / Meier, Samuel A. / Noble, Michael S. / Saksena, Gordon / Voet, Doug / Zhang, Hailei / Bernard, Brady / Chambwe, Nyasha / Dhankani, Varsha / Knijnenburg, Theo / Kramer, Roger / Leinonen, Kalle / Liu, Yuexin / Miller, Michael / Reynolds, Sheila / Thorsson, Vesteinn / Zhang, Wei / Akbani, Rehan / Broom, Bradley M. / Hegde, Apurva M. / Ju, Zhenlin / Kanchi, Rupa S. / Korkut, Anil / Li, Jun / Ling, Shiyun / Liu, Wenbin / Lu, Yiling / Mills, Gordon B. / Ng, Kwok-Shing / Rao, Arvind / Ryan, Michael / Wang, Jing / Weinstein, John N. / Zhang, Jiexin / Abeshouse, Adam / de Bruijn, Ino / Gross, Benjamin E. / Heins, Zachary J. / La, Konnor / Ladanyi, Marc / Nissan, Moriah G. / Phillips, Sarah M. / Reznik, Ed / Sheridan, Robert / Sumer, S. Onur / Sun, Yichao / Taylor, Barry S. / Wang, Jioajiao / Anur, Pavana / Peto, Myron / Spellman, Paul / Benz, Christopher / Stuart, Joshua M. / Wong, Christopher K. / Yau, Christina / Hayes, D. Neil / Parker, Joel S. / Wilkerson, Matthew D. / Ally, Adrian / Balasundaram, Miruna / Bowlby, Reanne / Brooks, Denise / Carlsen, Rebecca / Chuah, Eric / Dhalla, Noreen / Holt, Robert / Jones, Steven J.M. / Kasaian, Katayoon / Lee, Darlene / Ma, Yussanne / Marra, Marco A. / Mayo, Michael / Moore, Richard A. / Mungall, Andrew J. / Mungall, Karen / Robertson, A. Gordon / Sadeghi, Sara / Schein, Jacqueline E. / Sipahimalani, Payal / Tam, Angela / Thiessen, Nina / Tse, Kane / Wong, Tina / Berger, Ashton C. / Beroukhim, Rameen / Cibulskis, Carrie / Gabriel, Stacey B. / Gao, Galen F. / Ha, Gavin / Schumacher, Steven E. / Shih, Juliann / Kucherlapati, Melanie H. / Kucherlapati, Raju S. / Baylin, Stephen / Cope, Leslie / Danilova, Ludmila / Bootwalla, Moiz S. / Lai, Phillip H. / Maglinte, Dennis T. / Van Den Berg, David J. / Weisenberger, Daniel J. / Auman, J. Todd / Balu, Saianand / Bodenheimer, Thomas / Fan, Cheng / Hoadley, Katherine A. / Hoyle, Alan P. / Jefferys, Stuart R. / Jones, Corbin D. / Meng, Shaowu / Mieczkowski, Piotr A. / Mose, Lisle E. / Perou, Amy H. / Perou, Charles M. / Roach, Jeffrey / Shi, Yan / Simons, Janae V. / Skelly, Tara / Soloway, Matthew G. / Tan, Donghui / Veluvolu, Umadevi / Fan, Huihui / Hinoue, Toshinori / Bellair, Michelle / Chang, Kyle / Covington, Kyle / Creighton, Chad J. / Dinh, Huyen / Doddapaneni, HarshaVardhan / Donehower, Lawrence A. / Drummond, Jennifer / Gibbs, Richard / Glenn, Robert / Hale, Walker / Han, Yi / Hu, Jianhong / Korchina, Viktoriya / Lee, Sandra / Lewis, Lora / Li, Wei / Liu, Xiuping / Morgan, Margaret / Morton, Donna / Muzny, Donna / Santibanez, Jireh / Sheth, Margi / Shinbrot, Eve / Wang, Linghua / Wang, Min / Wheeler, David A. / Xi, Liu / Zhao, Fengmei / Hess, Julian / Appelbaum, Elizabeth L. / Bailey, Matthew / Cordes, Matthew G. / Fronick, Catrina C. / Fulton, Lucinda A. / Fulton, Robert S. / Mardis, Elaine R. / McLellan, Michael D. / Miller, Christopher A. / Schmidt, Heather K. / Wilson, Richard K. / Crain, Daniel / Curley, Erin / Gardner, Johanna / Lau, Kevin / Mallery, David / Morris, Scott / Paulauskis, Joseph / Penny, Robert / Shelton, Candace / Shelton, Troy / Sherman, Mark / Thompson, Eric / Yena, Peggy / Bowen, Jay / Gastier-Foster, Julie M. / Gerken, Mark / Leraas, Kristen M. / Lichtenberg, Tara M. / Ramirez, Nilsa C. / Wise, Lisa / Zmuda, Erik / Corcoran, Niall / Costello, Tony / Hovens, Christopher / Carvalho, Andre L. / de Carvalho, Ana C. / Fregnani, José H. / Filho, Adhemar Longatto / Reis, Rui M. / Scapulatempo-Neto, Cristovam / Silveira, Henrique C.S. / Vidal, Daniel O. / Burnette, Andrew / Eschbacher, Jennifer / Hermes, Beth / Noss, Ardene / Singh, Rosy / Anderson, Matthew L. / Castro, Patricia D. / Ittmann, Michael / Huntsman, David / Kohl, Bernard / Lệ Xuân / Thorp, Richard / Andry, Chris / Duffy, Elizabeth R. / Lyadov, Vladimir / Paklina, Oxana / Setdikova, Galiya / Shabunin, Alexey / Tavobilov, Mikhail / McPherson, Christopher / Warnick, Ronald / Berkowitz, Ross / Cramer, Daniel / Feltmate, Colleen / Horowitz, Neil / Kibel, Adam / Muto, Michael / Raut, Chandrajit P. / Malykh, Andrei / Barnholtz-Sloan, Jill S. / Barrett, Wendi / Devine, Karen / Fulop, Jordonna / Ostrom, Quinn T. / Shimmel, Kristen / Wolinsky, Yingli / Sloan, Andrew E. / De Rose, Agostino / Giuliante, Felice / Goodman, Marc / Karlan, Beth Y. / Hagedorn, C. H. / Eckman, John / Harr, Jodi / Myers, Jerome / Tucker, Kelinda / Zach, Leigh Anne / Deyarmin, Brenda / Hu, Hai / Kvecher, Leonid / Larson, Caroline / Mural, Richard J. / Somiari, Stella / Vicha, Ales / Zelinka, Tomas / Bennett, Joseph / Iacocca, Mary / Rabeno, Brenda / Swanson, Patricia / Latour, Mathieu / Lacombe, Louis / Têtu, Bernard / Bergeron, Alain / McGraw, Mary / Staugaitis, Susan M. / Chabot, John / Hibshoosh, Hanina / Sepulveda, Antonia / Su, Tao / Wang, Timothy / Potapova, Olga / Voronina, Olga / Desjardins, Laurence / Mariani, Odette / Roman-Roman, Sergio / Sastre, Xavier / Stern, Marc-Henri / Cheng, Feixiong / Signoretti, Sabina / Berchuck, Andrew / Bigner, Darell / Lipp, Eric / Marks, Jeffrey / McCall, Shannon / McLendon, Roger / Secord, Angeles / Sharp, Alexis / Behera, Madhusmita / Brat, Daniel J. / Chen, Amy / Delman, Keith / Force, Seth / Khuri, Fadlo / Magliocca, Kelly / Maithel, Shishir / Olson, Jeffrey J. / Owonikoko, Taofeek / Pickens, Alan / Ramalingam, Suresh / Shin, Dong M. / Sica, Gabriel / Van Meir, Erwin G. / Zhang, Hongzheng / Eijckenboom, Wil / Gillis, Ad / Korpershoek, Esther / Looijenga, Leendert / Oosterhuis, Wolter / Stoop, Hans / van Kessel, Kim E. / Zwarthoff, Ellen C. / Calatozzolo, Chiara / Cuppini, Lucia / Cuzzubbo, Stefania / DiMeco, Francesco / Finocchiaro, Gaetano / Mattei, Luca / Perin, Alessandro / Pollo, Bianca / Chen, Chu / Houck, John / Lohavanichbutr, Pawadee / Hartmann, Arndt / Stoehr, Christine / Stoehr, Robert / Taubert, Helge / Wach, Sven / Wullich, Bernd / Kycler, Witold / Murawa, Dawid / Wiznerowicz, Maciej / Chung, Ki / Edenfield, W. Jeffrey / Martin, Julie / Baudin, Eric / Bubley, Glenn / Bueno, Raphael / De Rienzo, Assunta / Richards, William G. / Kalkanis, Steven / Mikkelsen, Tom / Noushmehr, Houtan / Scarpace, Lisa / Girard, Nicolas / Aymerich, Marta / Campo, Elias / Giné, Eva / Guillermo, Armando López / Van Bang, Nguyen / Hanh, Phan Thi / Phu, Bui Duc / Tang, Yufang / Colman, Howard / Evason, Kimberley / Dottino, Peter R. / Martignetti, John A. / Gabra, Hani / Juhl, Hartmut / Akeredolu, Teniola / Stepa, Serghei / Hoon, Dave / Ahn, Keunsoo / Kang, Koo Jeong / Beuschlein, Felix / Breggia, Anne / Birrer, Michael / Bell, Debra / Borad, Mitesh / Bryce, Alan H. / Castle, Erik / Chandan, Vishal / Cheville, John / Copland, John A. / Farnell, Michael / Flotte, Thomas / Giama, Nasra / Ho, Thai / Kendrick, Michael / Kocher, Jean-Pierre / Kopp, Karla / Moser, Catherine / Nagorney, David / O’Brien, Daniel / O’Neill, Brian Patrick / Patel, Tushar / Petersen, Gloria / Que, Florencia / Rivera, Michael / Roberts, Lewis / Smallridge, Robert / Smyrk, Thomas / Stanton, Melissa / Thompson, R. Houston / Torbenson, Michael / Yang, Ju Dong / Zhang, Lizhi / Brimo, Fadi / Ajani, Jaffer A. / Gonzalez, Ana Maria Angulo / Behrens, Carmen / Bondaruk, Jolanta / Broaddus, Russell / Czerniak, Bogdan / Esmaeli, Bita / Fujimoto, Junya / Gershenwald, Jeffrey / Guo, Charles / Logothetis, Christopher / Meric-Bernstam, Funda / Moran, Cesar / Ramondetta, Lois / Rice, David / Sood, Anil / Tamboli, Pheroze / Thompson, Timothy / Troncoso, Patricia / Tsao, Anne / Wistuba, Ignacio / Carter, Candace / Haydu, Lauren / Hersey, Peter / Jakrot, Valerie / Kakavand, Hojabr / Kefford, Richard / Lee, Kenneth / Long, Georgina / Mann, Graham / Quinn, Michael / Saw, Robyn / Scolyer, Richard / Shannon, Kerwin / Spillane, Andrew / Stretch, Jonathan / Synott, Maria / Thompson, John / Wilmott, James / Al-Ahmadie, Hikmat / Chan, Timothy A. / Ghossein, Ronald / Gopalan, Anuradha / Levine, Douglas A. / Reuter, Victor / Singer, Samuel / Singh, Bhuvanesh / Tien, Nguyen Viet / Broudy, Thomas / Mirsaidi, Cyrus / Nair, Praveen / Drwiega, Paul / Miller, Judy / Smith, Jennifer / Zaren, Howard / Park, Joong-Won / Hung, Nguyen Phi / Kebebew, Electron / Linehan, Marston / Metwalli, Adam R. / Pacak, Karel / Pinto, Peter A. / Schiffman, Mark / Schmidt, Laura S. / Vocke, Cathy D. / Wentzensen, Nicolas / Worrell, Robert / Yang, Hannah / Moncrieff, Marc / Goparaju, Chandra / Melamed, Jonathan / Pass, Harvey / Botnariuc, Natalia / Caraman, Irina / Cernat, Mircea / Chemencedji, Inga / Clipca, Adrian / Doruc, Serghei / Gorincioi, Ghenadie / Mura, Sergiu / Pirtac, Maria / Stancul, Irina / Tcaciuc, Diana / Albert, Monique / Alexopoulou, Iakovina / Arnaout, Angel / Bartlett, John / Engel, Jay / Gilbert, Sebastien / Parfitt, Jeremy / Sekhon, Harman / Thomas, George / Rassl, Doris M. / Rintoul, Robert C. / Bifulco, Carlo / Tamakawa, Raina / Urba, Walter / Hayward, Nicholas / Timmers, Henri / Antenucci, Anna / Facciolo, Francesco / Grazi, Gianluca / Marino, Mirella / Merola, Roberta / de Krijger, Ronald / Gimenez-Roqueplo, Anne-Paule / Piché, Alain / Chevalier, Simone / McKercher, Ginette / Birsoy, Kivanc / Barnett, Gene / Brewer, Cathy / Farver, Carol / Naska, Theresa / Pennell, Nathan A. / Raymond, Daniel / Schilero, Cathy / Smolenski, Kathy / Williams, F. / Morrison, Carl / Borgia, Jeffrey A. / Liptay, Michael J. / Pool, Mark / Seder, Christopher W. / Junker, Kerstin / Omberg, Larsson / Dinkin, Mikhail / Manikhas, George / Alvaro, Domenico / Bragazzi, Maria Consiglia / Cardinale, Vincenzo / Carpino, Guido / Gaudio, Eugenio / Chesla, David / Cottingham, Sandra / Dubina, Michael / Moiseenko, Fedor / Dhanasekaran, Renumathy / Becker, Karl Friedrich / Janssen, Klaus-Peter / Slotta-Huspenina, Julia / Abdel-Rahman, Mohamed H. / Aziz, Dina / Bell, Sue / Cebulla, Colleen M. / Davis, Amy / Duell, Rebecca / Elder, J. Bradley / Hilty, Joe / Kumar, Bahavna / Lang, James / Lehman, Norman L. / Mandt, Randy / Nguyen, Phuong / Pilarski, Robert / Rai, Karan / Schoenfield, Lynn / Senecal, Kelly / Wakely, Paul / Hansen, Paul / Lechan, Ronald / Powers, James / Tischler, Arthur / Grizzle, William E. / Sexton, Katherine C. / Kastl, Alison / Henderson, Joel / Porten, Sima / Waldmann, Jens / Fassnacht, Martin / Asa, Sylvia L. / Schadendorf, Dirk / Couce, Marta / Graefen, Markus / Huland, Hartwig / Sauter, Guido / Schlomm, Thorsten / Simon, Ronald / Tennstedt, Pierre / Olabode, Oluwole / Nelson, Mark / Bathe, Oliver / Carroll, Peter R. / Chan, June M. / Disaia, Philip / Glenn, Pat / Kelley, Robin K. / Landen, Charles N. / Phillips, Joanna / Prados, Michael / Simko, Jeffry / Smith-McCune, Karen / VandenBerg, Scott / Roggin, Kevin / Fehrenbach, Ashley / Kendler, Ady / Sifri, Suzanne / Steele, Ruth / Jimeno, Antonio / Carey, Francis / Forgie, Ian / Mannelli, Massimo / Carney, Michael / Hernandez, Brenda / Campos, Benito / Herold-Mende, Christel / Jungk, Christin / Unterberg, A. / Deimling, Andreas von / Bossler, Aaron / Galbraith, Joseph / Jacobus, Laura / Knudson, Michael / Knutson, Tina / Ma, Deqin / Milhem, Mohammed / Sigmund, Rita / Godwin, Andrew K. / Madan, Rashna / Rosenthal, Howard G. / Adebamowo, Clement / Adebamowo, Sally N. / Boussioutas, Alex / Beer, David / Mes-Masson, Anne-Marie / Saad, Fred / Bocklage, Therese / Landrum, Lisa / Mannel, Robert / Moore, Kathleen / Moxley, Katherine / Postier, Russel / Walker, Joan / Zuna, Rosemary / Feldman, Michael / Valdivieso, Federico / Dhir, Rajiv / Luketich, James / Pinero, Edna M. Mora / Quintero-Aguilo, Mario / Carlotti, Carlos Gilberto / Santos, José Sebastião dos / Kemp, Rafael / Sankarankuty, Ajith / Tirapelli, Daniela / Catto, James / Agnew, Kathy / Swisher, Elizabeth / Creaney, Jenette / Robinson, Bruce / Shelley, Carl Simon / Godwin, Eryn M. / Kendall, Sara / Shipman, Cassaundra / Bradford, Carol / Carey, Thomas / Haddad, Andrea / Moyer, Jeffey / Peterson, Lisa / Prince, Mark / Rozek, Laura / Wolf, Gregory / Bowman, Rayleen / Fong, Kwun M. / Yang, Ian / Korst, Robert / Rathmell, W. Kimryn / Fantacone-Campbell, J. Leigh / Hooke, Jeffrey A. / Kovatich, Albert J. / Shriver, Craig D. / DiPersio, John / Drake, Bettina / Govindan, Ramaswamy / Heath, Sharon / Ley, Timothy / Van Tine, Brian / Westervelt, Peter / Rubin, Mark A. / Lee, Jung Il / Aredes, Natália D. / Mariamidze, Armaz

    Cell. 2018 Apr. 05, v. 173, no. 2 p.321-337.e10

    2018  

    Abstract: Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and ... ...

    Institution The Cancer Genome Atlas Research Network
    Abstract Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53 and β-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these pathways, and 57% percent of tumors had at least one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy.
    Keywords DNA methylation ; apoptosis ; cell cycle ; cell growth ; gene expression ; genes ; landscapes ; neoplasms ; therapeutics ; pan-cancer ; signaling pathways ; whole exome sequencing ; combination therapy ; TCGA ; PanCanAtlas ; cancer genome atlas ; cancer genomics ; precision oncology
    Language English
    Dates of publication 2018-0405
    Size p. 321-337.e10.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note NAL-AP-2-clean ; Resource is Open Access
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.03.035
    Database NAL-Catalogue (AGRICOLA)

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