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  1. Article ; Online: Critical role of bacterial dissemination in an infant rabbit model of bacillary dysentery

    Lauren K. Yum / Mariana X. Byndloss / Sanford H. Feldman / Hervé Agaisse

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 10

    Abstract: The bacterial pathogen Shigella flexneri causes bacillary dysentery (bloody diarrhoea). Here, Yum et al. present an infant rabbit model of S. flexneri infection that recapitulates human disease symptoms and features bacterial dissemination as an ... ...

    Abstract The bacterial pathogen Shigella flexneri causes bacillary dysentery (bloody diarrhoea). Here, Yum et al. present an infant rabbit model of S. flexneri infection that recapitulates human disease symptoms and features bacterial dissemination as an essential determinant of pathogenesis.
    Keywords Science ; Q
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Critical role of bacterial dissemination in an infant rabbit model of bacillary dysentery

    Lauren K. Yum / Mariana X. Byndloss / Sanford H. Feldman / Hervé Agaisse

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 10

    Abstract: The bacterial pathogen Shigella flexneri causes bacillary dysentery (bloody diarrhoea). Here, Yum et al. present an infant rabbit model of S. flexneri infection that recapitulates human disease symptoms and features bacterial dissemination as an ... ...

    Abstract The bacterial pathogen Shigella flexneri causes bacillary dysentery (bloody diarrhoea). Here, Yum et al. present an infant rabbit model of S. flexneri infection that recapitulates human disease symptoms and features bacterial dissemination as an essential determinant of pathogenesis.
    Keywords Science ; Q
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction

    Litvak, Yael / Andreas J Bäumler / Mariana X Byndloss / Renée M Tsolis

    Current opinion in microbiology. 2017 Oct., v. 39

    2017  

    Abstract: A balanced gut microbiota is important for health, but the mechanisms maintaining homeostasis are incompletely understood. Anaerobiosis of the healthy colon drives the composition of the gut microbiota towards a dominance of obligate anaerobes, while ... ...

    Abstract A balanced gut microbiota is important for health, but the mechanisms maintaining homeostasis are incompletely understood. Anaerobiosis of the healthy colon drives the composition of the gut microbiota towards a dominance of obligate anaerobes, while dysbiosis is often associated with a sustained increase in the abundance of facultative anaerobic Proteobacteria, indicative of a disruption in anaerobiosis. The colonic epithelium is hypoxic, but intestinal inflammation or antibiotic treatment increases epithelial oxygenation in the colon, thereby disrupting anaerobiosis to drive a dysbiotic expansion of facultative anaerobic Proteobacteria through aerobic respiration. These observations suggest a dysbiotic expansion of Proteobacteria is a potential diagnostic microbial signature of epithelial dysfunction, a hypothesis that could spawn novel preventative or therapeutic strategies for a broad spectrum of human diseases.
    Keywords aerobiosis ; anaerobes ; anaerobiosis ; antibiotics ; colon ; epithelium ; homeostasis ; human diseases ; inflammation ; intestinal microorganisms ; Proteobacteria ; spawning
    Language English
    Dates of publication 2017-10
    Size p. 1-6.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2017.07.003
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells

    Justin Jacobse / Rachel E. Brown / Jing Li / Jennifer M. Pilat / Ly Pham / Sarah P. Short / Christopher T. Peek / Andrea Rolong / M. Kay Washington / Ruben Martinez-Barricarte / Mariana X. Byndloss / Catherine Shelton / Janet G. Markle / Yvonne L. Latour / Margaret M. Allaman / James E. Cassat / Keith T. Wilson / Yash A. Choksi / Christopher S. Williams /
    Ken S. Lau / Charles R. Flynn / Jean-Laurent Casanova / Edmond H.H.M. Rings / Janneke N. Samsom / Jeremy A. Goettel

    Cell Reports, Vol 42, Iss 2, Pp 112128- (2023)

    2023  

    Abstract: Summary: The cytokine interleukin-23 (IL-23) is involved in the pathogenesis of inflammatory and autoimmune conditions including inflammatory bowel disease (IBD). IL23R is enriched in intestinal Tregs, yet whether IL-23 modulates intestinal Tregs remains ...

    Abstract Summary: The cytokine interleukin-23 (IL-23) is involved in the pathogenesis of inflammatory and autoimmune conditions including inflammatory bowel disease (IBD). IL23R is enriched in intestinal Tregs, yet whether IL-23 modulates intestinal Tregs remains unknown. Here, investigating IL-23R signaling in Tregs specifically, we show that colonic Tregs highly express Il23r compared with Tregs from other compartments and their frequency is reduced upon IL-23 administration and impairs Treg suppressive function. Similarly, colonic Treg frequency is increased in mice lacking Il23r specifically in Tregs and exhibits a competitive advantage over IL-23R-sufficient Tregs during inflammation. Finally, IL-23 antagonizes liver X receptor pathway, cellular cholesterol transporter Abca1, and increases Treg apoptosis. Our results show that IL-23R signaling regulates intestinal Tregs by increasing cell turnover, antagonizing suppression, and decreasing cholesterol efflux. These results suggest that IL-23 negatively regulates Tregs in the intestine with potential implications for promoting chronic inflammation in patients with IBD.
    Keywords CP: Immunology ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis.

    Franziska Faber / Parameth Thiennimitr / Luisella Spiga / Mariana X Byndloss / Yael Litvak / Sara Lawhon / Helene L Andrews-Polymenis / Sebastian E Winter / Andreas J Bäumler

    PLoS Pathogens, Vol 13, Iss 1, p e

    2017  Volume 1006129

    Abstract: Intestinal inflammation caused by Salmonella enterica serovar Typhimurium increases the availability of electron acceptors that fuel a respiratory growth of the pathogen in the intestinal lumen. Here we show that one of the carbon sources driving this ... ...

    Abstract Intestinal inflammation caused by Salmonella enterica serovar Typhimurium increases the availability of electron acceptors that fuel a respiratory growth of the pathogen in the intestinal lumen. Here we show that one of the carbon sources driving this respiratory expansion in the mouse model is 1,2-propanediol, a microbial fermentation product. 1,2-propanediol utilization required intestinal inflammation induced by virulence factors of the pathogen. S. Typhimurium used both aerobic and anaerobic respiration to consume 1,2-propanediol and expand in the murine large intestine. 1,2-propanediol-utilization did not confer a benefit in germ-free mice, but the pdu genes conferred a fitness advantage upon S. Typhimurium in mice mono-associated with Bacteroides fragilis or Bacteroides thetaiotaomicron. Collectively, our data suggest that intestinal inflammation enables S. Typhimurium to sidestep nutritional competition by respiring a microbiota-derived fermentation product.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Loss of Multicellular Behavior in Epidemic African Nontyphoidal Salmonella enterica Serovar Typhimurium ST313 Strain D23580

    Larissa A. Singletary / Joyce E. Karlinsey / Stephen J. Libby / Jason P. Mooney / Kristen L. Lokken / Renée M. Tsolis / Mariana X. Byndloss / Lauren A. Hirao / Christopher A. Gaulke / Robert W. Crawford / Satya Dandekar / Robert A. Kingsley / Chisomo L. Msefula / Robert S. Heyderman / Ferric C. Fang

    mBio, Vol 7, Iss 2, p e02265-

    2016  Volume 15

    Abstract: Nontyphoidal Salmonella enterica serovar Typhimurium is a frequent cause of bloodstream infections in children and HIV-infected adults in sub-Saharan Africa. Most isolates from African patients with bacteremia belong to a single sequence type, ST313, ... ...

    Abstract Nontyphoidal Salmonella enterica serovar Typhimurium is a frequent cause of bloodstream infections in children and HIV-infected adults in sub-Saharan Africa. Most isolates from African patients with bacteremia belong to a single sequence type, ST313, which is genetically distinct from gastroenteritis-associated ST19 strains, such as 14028s and SL1344. Some studies suggest that the rapid spread of ST313 across sub-Saharan Africa has been facilitated by anthroponotic (person-to-person) transmission, eliminating the need for Salmonella survival outside the host. While these studies have not ruled out zoonotic or other means of transmission, the anthroponotic hypothesis is supported by evidence of extensive genomic decay, a hallmark of host adaptation, in the sequenced ST313 strain D23580. We have identified and demonstrated 2 loss-of-function mutations in D23580, not present in the ST19 strain 14028s, that impair multicellular stress resistance associated with survival outside the host. These mutations result in inactivation of the KatE stationary-phase catalase that protects high-density bacterial communities from oxidative stress and the BcsG cellulose biosynthetic enzyme required for the RDAR (red, dry, and rough) colonial phenotype. However, we found that like 14028s, D23580 is able to elicit an acute inflammatory response and cause enteritis in mice and rhesus macaque monkeys. Collectively, these observations suggest that African S. Typhimurium ST313 strain D23580 is becoming adapted to an anthroponotic mode of transmission while retaining the ability to infect and cause enteritis in multiple host species.
    Keywords Science ; Q ; Microbiology ; QR1-502
    Language English
    Publishing date 2016-03-01T00:00:00Z
    Publisher American Society for Microbiology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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