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  1. Article: Prevention of bronchial fistulas after pneumonectomies for selected cavitary drug resistant lung tuberculosis.

    Bazhenov, Alexander V / Mariandyshev, Andrei O / Hinderaker, Sven G / Heldal, Einar / Motus, Igor Ya / Vasilyeva, Irina A

    Frontiers in surgery

    2023  Volume 10, Page(s) 1151137

    Abstract: Background: The World Health Organization guidelines for management drug resistant tuberculosis include surgery as an additional method in selected cases. Pneumonectomies have higher risk of morbidity such as bronchial fistulas which may be prevented by ...

    Abstract Background: The World Health Organization guidelines for management drug resistant tuberculosis include surgery as an additional method in selected cases. Pneumonectomies have higher risk of morbidity such as bronchial fistulas which may be prevented by bronchial stump covering. We compare two methods of bronchial stump reinforcement.
    Methods and materials: A retrospective single center follow-up study was done in 52 patients who underwent pneumonectomy for drug resistant pulmonary tuberculosis. Between 2000 and 2017 we performed pneumonectomies with pericardial fat reinforcement of bronchial stump in group 1 (
    Results: Bronchial fistulas occurred in 17/42 (41%) of patients group 1 and there was no fistula in group 2, and this was statistically different (Fisher's test
    Conclusions: The use of pedicle muscle flap for bronchial stump coverage during the pneumonectomies for destructive drug resistant tuberculosis can prevent severe postoperative fistulas and improve postoperative life.
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1151137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Drug-resistant tuberculosis threatens WHO's End-TB strategy.

    Mariandyshev, Andrei / Eliseev, Platon

    The Lancet. Infectious diseases

    2017  Volume 17, Issue 7, Page(s) 674–675

    MeSH term(s) Antitubercular Agents ; Humans ; Tuberculosis ; Tuberculosis, Multidrug-Resistant ; World Health Organization
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2017-05-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(17)30246-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Treatment of Rifampicin-Resistant Tuberculosis Disease and Infection in Children: Key Updates, Challenges and Opportunities.

    Howell, Pauline / Achar, Jay / Huang, G Khai Lin / Mariandyshev, Andrei / Schaaf, H Simon / Garcia-Prats, Anthony J

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: Children affected by rifampicin-resistant tuberculosis (RR-TB; TB resistant to at least rifampicin) are a neglected group. Each year an estimated 25,000-30,000 children develop RR-TB disease globally. Improving case detection and treatment initiation is ... ...

    Abstract Children affected by rifampicin-resistant tuberculosis (RR-TB; TB resistant to at least rifampicin) are a neglected group. Each year an estimated 25,000-30,000 children develop RR-TB disease globally. Improving case detection and treatment initiation is a priority since RR-TB disease is underdiagnosed and undertreated. Untreated paediatric TB has particularly high morbidity and mortality. However, children receiving TB treatment, including for RR-TB, respond well. RR-TB treatment remains a challenge for children, their caregivers and TB programmes, requiring treatment regimens of up to 18 months in duration, often associated with severe and long-term adverse effects. Shorter, safer, effective child-friendly regimens for RR-TB are needed. Preventing progression to disease following
    Language English
    Publishing date 2022-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11040381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Diagnosis and treatment of patients with pulmonary nontuberculous mycobacterial diseases in Arkhangelsk, Russia

    Eliseev, Platon / Hinderaker, Sven Gudmund / Heldal, Einar / Tarasova, Irina / Grjibovski, Andrej / Mariandyshev, Andrei

    Infection, genetics, and evolution. 2019 Sept., v. 73

    2019  

    Abstract: Nontuberculous mycobacteria (NTM) are acid-fast bacilli (AFB) that can cause disease in human. Patients with NTM pulmonary disease can be falsely diagnosed with pulmonary tuberculosis (TB) due detection of AFB in sputum and similar clinical and chest X- ... ...

    Abstract Nontuberculous mycobacteria (NTM) are acid-fast bacilli (AFB) that can cause disease in human. Patients with NTM pulmonary disease can be falsely diagnosed with pulmonary tuberculosis (TB) due detection of AFB in sputum and similar clinical and chest X-ray picture. Laboratory detection of NTM is complicated and does not always mean presence of the disease, but can be attributed to colonization or sample contamination. Molecular tests, such as Genotype Mycobacterium CM/AS, allow quick and reliable detection of NTM.To assess the NTM identification rate, to estimate the incidence of pulmonary NTM disease and to report the treatment outcomes among patients with NTM disease.Retrospective cohort design.NTM were detected among 92 (0.98 per 100,000 population) presumptive pulmonary TB patients in Arkhangelsk region in 2010–2017 among who 39 (0.42 per 100,000 population) patients were diagnosed with NTM disease. The most prevalent species found in our study were M. avium (33%) and M.intracellulare (11%). 69% of patients with NTM disease completed their treatment, 15% died, 13% were lost to follow up and 3% failed treatment.A system of diagnostics and treatment for NTM disease was set up in the Arkhangelsk region in Russia. Average NTM identification rate and incidence of pulmonary NTM disease were 0.98 per 100,000 and 0.42 per 100,000 population accordingly and were lower than reported in other studies. Treatment success rate in our study was 69% encouraging further improvements in diagnostics and treatment of patients with NTM.
    Keywords Bacilli ; Mycobacterium avium ; X-radiation ; chest ; diagnostic techniques ; genotype ; humans ; patients ; respiratory tract diseases ; tuberculosis ; Russia
    Language English
    Dates of publication 2019-09
    Size p. 358-361.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2019.05.022
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Early access to bedaquiline for extensively drug-resistant (XDR) and pre-XDR tuberculosis.

    Vasilyeva, Irina / Mariandyshev, Andrei / Kazennyy, Boris / Davidavičienė, Edita / Lounis, Nacer / Keim, Sofia

    The European respiratory journal

    2019  Volume 54, Issue 1

    MeSH term(s) Adolescent ; Adult ; Antitubercular Agents/therapeutic use ; Diarylquinolines/therapeutic use ; Extensively Drug-Resistant Tuberculosis/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Treatment Outcome ; Tuberculosis, Multidrug-Resistant/drug therapy ; Young Adult
    Chemical Substances Antitubercular Agents ; Diarylquinolines ; bedaquiline (78846I289Y)
    Language English
    Publishing date 2019-07-25
    Publishing country England
    Document type Clinical Trial, Phase II ; Letter ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02208-2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Diagnosis and treatment of patients with pulmonary nontuberculous mycobacterial diseases in Arkhangelsk, Russia.

    Eliseev, Platon / Hinderaker, Sven Gudmund / Heldal, Einar / Tarasova, Irina / Grjibovski, Andrej / Mariandyshev, Andrei

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2019  Volume 73, Page(s) 358–361

    Abstract: Background: Nontuberculous mycobacteria (NTM) are acid-fast bacilli (AFB) that can cause disease in human. Patients with NTM pulmonary disease can be falsely diagnosed with pulmonary tuberculosis (TB) due detection of AFB in sputum and similar clinical ... ...

    Abstract Background: Nontuberculous mycobacteria (NTM) are acid-fast bacilli (AFB) that can cause disease in human. Patients with NTM pulmonary disease can be falsely diagnosed with pulmonary tuberculosis (TB) due detection of AFB in sputum and similar clinical and chest X-ray picture. Laboratory detection of NTM is complicated and does not always mean presence of the disease, but can be attributed to colonization or sample contamination. Molecular tests, such as Genotype Mycobacterium CM/AS, allow quick and reliable detection of NTM.
    Objective: To assess the NTM identification rate, to estimate the incidence of pulmonary NTM disease and to report the treatment outcomes among patients with NTM disease.
    Design: Retrospective cohort design.
    Results: NTM were detected among 92 (0.98 per 100,000 population) presumptive pulmonary TB patients in Arkhangelsk region in 2010-2017 among who 39 (0.42 per 100,000 population) patients were diagnosed with NTM disease. The most prevalent species found in our study were M. avium (33%) and M.intracellulare (11%). 69% of patients with NTM disease completed their treatment, 15% died, 13% were lost to follow up and 3% failed treatment.
    Conclusion: A system of diagnostics and treatment for NTM disease was set up in the Arkhangelsk region in Russia. Average NTM identification rate and incidence of pulmonary NTM disease were 0.98 per 100,000 and 0.42 per 100,000 population accordingly and were lower than reported in other studies. Treatment success rate in our study was 69% encouraging further improvements in diagnostics and treatment of patients with NTM.
    MeSH term(s) Female ; Humans ; Incidence ; Lung/drug effects ; Lung Diseases/diagnosis ; Lung Diseases/drug therapy ; Lung Diseases/microbiology ; Male ; Middle Aged ; Mycobacterium/drug effects ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Nontuberculous Mycobacteria/drug effects ; Retrospective Studies ; Russia ; Sputum/microbiology ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/microbiology
    Language English
    Publishing date 2019-06-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2019.05.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Tuberculosis in BRICS: challenges and opportunities for leadership within the post-2015 agenda.

    Creswell, Jacob / Sahu, Suvanand / Sachdeva, Kuldeep Singh / Ditiu, Lucica / Barreira, Draurio / Mariandyshev, Andrei / Mingting, Chen / Pillay, Yogan

    Bulletin of the World Health Organization

    2014  Volume 92, Issue 6, Page(s) 459–460

    MeSH term(s) Brazil ; China ; Communicable Disease Control/economics ; Communicable Disease Control/methods ; Disease Notification ; HIV Infections/economics ; HIV Infections/prevention & control ; Health Policy ; Humans ; India ; International Cooperation ; Leadership ; Russia ; South Africa ; Tuberculosis/diagnosis ; Tuberculosis/economics ; Tuberculosis/prevention & control ; Tuberculosis/therapy
    Keywords covid19
    Language English
    Publishing date 2014-06-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 80213-x
    ISSN 1564-0604 ; 0042-9686 ; 0366-4996 ; 0510-8659
    ISSN (online) 1564-0604
    ISSN 0042-9686 ; 0366-4996 ; 0510-8659
    DOI 10.2471/BLT.13.133116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Impact of a Line Probe Assay Based Diagnostic Algorithm on Time to Treatment Initiation and Treatment Outcomes for Multidrug Resistant TB Patients in Arkhangelsk Region, Russia.

    Eliseev, Platon / Balantcev, Grigory / Nikishova, Elena / Gaida, Anastasia / Bogdanova, Elena / Enarson, Donald / Ornstein, Tara / Detjen, Anne / Dacombe, Russell / Gospodarevskaya, Elena / Phillips, Patrick P J / Mann, Gillian / Squire, Stephen Bertel / Mariandyshev, Andrei

    PloS one

    2016  Volume 11, Issue 4, Page(s) e0152761

    Abstract: Background: In the Arkhangelsk region of Northern Russia, multidrug-resistant (MDR) tuberculosis (TB) rates in new cases are amongst the highest in the world. In 2014, MDR-TB rates reached 31.7% among new cases and 56.9% among retreatment cases. The ... ...

    Abstract Background: In the Arkhangelsk region of Northern Russia, multidrug-resistant (MDR) tuberculosis (TB) rates in new cases are amongst the highest in the world. In 2014, MDR-TB rates reached 31.7% among new cases and 56.9% among retreatment cases. The development of new diagnostic tools allows for faster detection of both TB and MDR-TB and should lead to reduced transmission by earlier initiation of anti-TB therapy.
    Study aim: The PROVE-IT (Policy Relevant Outcomes from Validating Evidence on Impact) Russia study aimed to assess the impact of the implementation of line probe assay (LPA) as part of an LPA-based diagnostic algorithm for patients with presumptive MDR-TB focusing on time to treatment initiation with time from first-care seeking visit to the initiation of MDR-TB treatment rather than diagnostic accuracy as the primary outcome, and to assess treatment outcomes. We hypothesized that the implementation of LPA would result in faster time to treatment initiation and better treatment outcomes.
    Methods: A culture-based diagnostic algorithm used prior to LPA implementation was compared to an LPA-based algorithm that replaced BacTAlert and Löwenstein Jensen (LJ) for drug sensitivity testing. A total of 295 MDR-TB patients were included in the study, 163 diagnosed with the culture-based algorithm, 132 with the LPA-based algorithm.
    Results: Among smear positive patients, the implementation of the LPA-based algorithm was associated with a median decrease in time to MDR-TB treatment initiation of 50 and 66 days compared to the culture-based algorithm (BacTAlert and LJ respectively, p<0.001). In smear negative patients, the LPA-based algorithm was associated with a median decrease in time to MDR-TB treatment initiation of 78 days when compared to the culture-based algorithm (LJ, p<0.001). However, several weeks were still needed for treatment initiation in LPA-based algorithm, 24 days in smear positive, and 62 days in smear negative patients. Overall treatment outcomes were better in LPA-based algorithm compared to culture-based algorithm (p = 0.003). Treatment success rates at 20 months of treatment were higher in patients diagnosed with the LPA-based algorithm (65.2%) as compared to those diagnosed with the culture-based algorithm (44.8%). Mortality was also lower in the LPA-based algorithm group (7.6%) compared to the culture-based algorithm group (15.9%). There was no statistically significant difference in smear and culture conversion rates between the two algorithms.
    Conclusion: The results of the study suggest that the introduction of LPA leads to faster time to MDR diagnosis and earlier treatment initiation as well as better treatment outcomes for patients with MDR-TB. These findings also highlight the need for further improvements within the health system to reduce both patient and diagnostic delays to truly optimize the impact of new, rapid diagnostics.
    MeSH term(s) Adult ; Algorithms ; Female ; Humans ; Male ; Middle Aged ; Russia/epidemiology ; Tuberculosis, Multidrug-Resistant/diagnosis ; Tuberculosis, Multidrug-Resistant/epidemiology ; Tuberculosis, Multidrug-Resistant/therapy
    Language English
    Publishing date 2016-04-07
    Publishing country United States
    Document type Clinical Trial ; Comparative Study ; Journal Article ; Multicenter Study ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0152761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis.

    Osman, Muhammad / Harausz, Elizabeth P / Garcia-Prats, Anthony J / Schaaf, H Simon / Moore, Brittany K / Hicks, Robert M / Achar, Jay / Amanullah, Farhana / Barry, Pennan / Becerra, Mercedes / Chiotan, Domnica I / Drobac, Peter C / Flood, Jennifer / Furin, Jennifer / Gegia, Medea / Isaakidis, Petros / Mariandyshev, Andrei / Ozere, Iveta / Shah, N Sarita /
    Skrahina, Alena / Yablokova, Elena / Seddon, James A / Hesseling, Anneke C

    Emerging infectious diseases

    2019  Volume 25, Issue 3, Page(s) 441–450

    Abstract: Extensively drug-resistant tuberculosis (XDR TB) has extremely poor treatment outcomes in adults. Limited data are available for children. We report on clinical manifestations, treatment, and outcomes for 37 children (<15 years of age) with ... ...

    Abstract Extensively drug-resistant tuberculosis (XDR TB) has extremely poor treatment outcomes in adults. Limited data are available for children. We report on clinical manifestations, treatment, and outcomes for 37 children (<15 years of age) with bacteriologically confirmed XDR TB in 11 countries. These patients were managed during 1999-2013. For the 37 children, median age was 11 years, 32 (87%) had pulmonary TB, and 29 had a recorded HIV status; 7 (24%) were infected with HIV. Median treatment duration was 7.0 months for the intensive phase and 12.2 months for the continuation phase. Thirty (81%) children had favorable treatment outcomes. Four (11%) died, 1 (3%) failed treatment, and 2 (5%) did not complete treatment. We found a high proportion of favorable treatment outcomes among children, with mortality rates markedly lower than for adults. Regimens and duration of treatment varied considerably. Evaluation of new regimens in children is required.
    MeSH term(s) Adolescent ; Age Factors ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Child ; Child, Preschool ; Coinfection ; Extensively Drug-Resistant Tuberculosis/drug therapy ; Extensively Drug-Resistant Tuberculosis/epidemiology ; Female ; Global Health ; Humans ; Infant ; Infant, Newborn ; Male ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis/drug effects ; Population Surveillance ; Treatment Failure ; Treatment Outcome
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2019-02-21
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2503.180852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Tuberculosis in BRICS

    Mingting, Chen / Barreira, Draurio / Ditiu, Lucica / Sahu, Suvanand / Creswell, Jacob / Pillay, Yogan / Mariandyshev, Andrei / Sachdeva, Kuldeep Singh

    challenges and opportunities for leadership within the post-2015 agenda

    2014  

    Abstract: ... Journal ... ...

    Abstract Journal Article
    Language English
    Publishing date 2014-06-01
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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