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  1. Article ; Online: Proposal of set-up standardization for general surgery procedures with the CMR Versius system, a new robotic platform: our initial experience.

    Pisani Ceretti, Andrea / Mariani, Nicolò Maria / Perego, Marta / Giovenzana, Marco / Salaj, Adelona / Formisano, Giampaolo / Gheza, Federico / Gloria, Gaia / Bernardo, Rocco / Bianchi, Paolo Pietro

    Langenbeck's archives of surgery

    2024  Volume 409, Issue 1, Page(s) 107

    Abstract: Background: The article describes our initial experience using CMR Versius platform for several procedures in general surgery.: Methods: Between September 2022 and April 2023, seventy patients underwent robotic surgery in a multi-robotic referral ... ...

    Abstract Background: The article describes our initial experience using CMR Versius platform for several procedures in general surgery.
    Methods: Between September 2022 and April 2023, seventy patients underwent robotic surgery in a multi-robotic referral center (San Paolo University Hospital, Milan, Italy). Three surgeons with only laparoscopic experience performed 24 cholecystectomies, 13 inguinal hernia repairs, 9 ventral hernia repairs, 7 right hemicolectomies, 11 left hemicolectomies, 1 sigmoidectomy, 1 ileocecal resection, 1 ventral rectopexy, 1 Nissen fundoplication, 1 total splenectomy, and 1 exploration with multiple biopsies.
    Results: All surgeries were full-robotic, with only one conversion to laparoscopy. The short length of stay and low rate of severe morbidity are promising findings. Although operative time was lengthened, clinical outcomes were not affected.
    Conclusions: Our experience demonstrates that the adoption of Versius system is safe and feasible in general surgery. The standardization of port placement and BSU set-up can certainly reduce the operative time.
    MeSH term(s) Humans ; Robotic Surgical Procedures/methods ; Robotics ; Laparoscopy/methods ; Hernia, Inguinal/surgery ; Colectomy
    Language English
    Publishing date 2024-04-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-024-03291-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: LI-RADS to categorize liver nodules in patients at risk of HCC: tool or a gadget in daily practice?

    Barabino, Matteo / Gurgitano, Martina / Fochesato, Cecilia / Angileri, Salvatore Alessio / Franceschelli, Giuseppe / Santambrogio, Roberto / Mariani, Nicolò Maria / Opocher, Enrico / Carrafiello, Gianpaolo

    La Radiologia medica

    2020  Volume 126, Issue 1, Page(s) 5–13

    Abstract: Purpose: To determine the effectiveness of liver reporting and data system (LI-RADS) to diagnose hepatocellular carcinoma (HCC) and to retrospectively evaluate its impact on the adopted therapeutic strategy.: Materials and methods: Preoperative ... ...

    Abstract Purpose: To determine the effectiveness of liver reporting and data system (LI-RADS) to diagnose hepatocellular carcinoma (HCC) and to retrospectively evaluate its impact on the adopted therapeutic strategy.
    Materials and methods: Preoperative imaging of 40 of 350 patients (median age 66, 31 M/9 F) submitted to liver resection for suspected HCC, between January 2008 and August 2019, has been retrospectively analyzed by two radiologists with different expertise, according to CT/MRI LI-RADS
    Results: The perfect agreement between the readers was about 62.5% (25/40) (Cohen k: 0.41), better for LR-5 category (16/25) and higher in magnetic resonance imaging (MRI) investigations (68%; 13/19), which has been demonstrated the modality of choice for diagnosis of high probable and certain HCC, with arterial phase hyperenhancement as the most sensitive and accurate major feature. Compared to final histology, LR4 and LR5 scores assigned by senior radiologist reached sensitivity, specificity, positive and negative predictive values (PPV, PNV) and diagnostic accuracy of 90,9%, 29,0%, 93,8%, 62,5% and 87,5%, respectively, slightly higher than junior's ones. Misdiagnosis of HCC was done by both radiologists in the same two patients: 1 primary hepatic lymphoma (PHL) and 1 regenerative liver nodule (RLN). If LI-RADS would have been applied at the time of pre-surgical imaging, treatment planning would be modified in 10% of patients (4/40); the patient scheduled as LR-3 and finally resulted a focal nodular hyperplasia would have avoided liver resection.
    Conclusions: Application of LI-RADS, especially on MRI, may provide a more accurate evaluation of suspected HCC. PHL and RLN are the Achille's heels according to our experience.
    MeSH term(s) Aged ; Algorithms ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/surgery ; Diagnosis, Differential ; Female ; Humans ; Image Enhancement ; Image Interpretation, Computer-Assisted ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/surgery ; Magnetic Resonance Imaging ; Male ; Predictive Value of Tests ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-05-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-020-01225-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Can Surgery for Inflammatory Bowel Disease be Personalized?

    Spinelli, Antonino / Marano, Alessandra / Bacchelli, Claudio / Mariani, Nicolo Maria / Montorsi, Marco / Kotze, Paulo Gustavo

    Current drug targets

    2016  Volume 19, Issue 7, Page(s) 798–804

    Abstract: Background: In the treatment of Inflammatory Bowel Diseases (IBD) despite advances in medical therapies, surgery has maintained a leading role in the management of complications of the disease, as well as in cases of failure of medical therapy.: ... ...

    Abstract Background: In the treatment of Inflammatory Bowel Diseases (IBD) despite advances in medical therapies, surgery has maintained a leading role in the management of complications of the disease, as well as in cases of failure of medical therapy.
    Objective: discuss the possible role for a personalization in debated fields of surgical treatment of Crohn's disease and ulcerative colitis.
    Conclusions: Surgery has become more and more minimally invasive, struggling for a difficult balance between guidelines and personalized treatment tailored on the single patient's need. There is no room for fixed management for surgery in IBD. A tailored approach is key to better outcome in each specific patient.
    MeSH term(s) Colitis, Ulcerative/surgery ; Crohn Disease/surgery ; Digestive System Surgical Procedures/methods ; Humans ; Minimally Invasive Surgical Procedures/methods ; Practice Guidelines as Topic ; Precision Medicine/methods
    Language English
    Publishing date 2016-12-29
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/1389450118666170105153646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Surgical Strategy During the COVID-19 Pandemic in a University Metropolitan Hospital in Milan, Italy.

    Mariani, Nicolò M / Pisani Ceretti, Andrea / Fedele, Veronica / Barabino, Matteo / Nicastro, Vincenzo / Giovenzana, Marco / Scifo, Giovanna / De Nicola, Enrico / Opocher, Enrico

    World journal of surgery

    2020  Volume 44, Issue 8, Page(s) 2471–2476

    Abstract: The COVID-19 pandemic has spread rapidly, forcing some drastic changes not only in our daily lives, but also in our clinical and surgical activities. Given our extensive Italian experience, we hereby describe how our surgical unit activity has changed ... ...

    Abstract The COVID-19 pandemic has spread rapidly, forcing some drastic changes not only in our daily lives, but also in our clinical and surgical activities. Given our extensive Italian experience, we hereby describe how our surgical unit activity has changed and how, in some cases, it was necessary to modify surgical strategies. We hope our experience can be shared with our global colleagues who are suffering under similar condition.
    MeSH term(s) Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Female ; General Surgery/legislation & jurisprudence ; Hospitals, University ; Hospitals, Urban ; Humans ; Italy ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-020-05595-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 outbreak and acute cholecystitis in a Hub Hospital in Milan: wider indications for percutaneous cholecystostomy.

    Barabino, Matteo / Piccolo, Gaetano / Trizzino, Arianna / Fedele, Veronica / Ferrari, Carlo / Nicastro, Vincenzo / Pisani Ceretti, Andrea / De Nicola, Enrico / Mariani, Nicolò Maria / Giovenzana, Marco / Scifo, Giovanna / Mazza, Massimiliano / Vercelli, Ruggero / Santambrogio, Roberto / Luigiano, Carmelo / Opocher, Enrico

    BMC surgery

    2021  Volume 21, Issue 1, Page(s) 180

    Abstract: Background: COVID-19 pandemic has impacted the Italian National Health Care system at many different levels, causing a complete reorganization of surgical wards. In this context, our study retrospectively analysed the management strategy for patients ... ...

    Abstract Background: COVID-19 pandemic has impacted the Italian National Health Care system at many different levels, causing a complete reorganization of surgical wards. In this context, our study retrospectively analysed the management strategy for patients with acute cholecystitis.
    Methods: We analysed all patients admitted to our Emergency Department for acute cholecystitis between February and April 2020 and we graded each case according to 2018 Tokyo Guidelines. All patients were tested for positivity to SARS-CoV-2 and received an initial conservative treatment. We focused on patients submitted to cholecystostomy during the acute phase of pandemic and their subsequent disease evolution.
    Results: Thirty-seven patients were admitted for acute cholecystitis (13 grade I, 16 grade II, 8 grade III). According to Tokyo Guidelines (2018), patients were successfully treated with antibiotic only, bedside percutaneous transhepatic gallbladder drainage (PC) and laparoscopic cholecystectomy (LC) in 29.7%, 21.6% and 48.7% of cases respectively. Therapeutic strategy of three out of 8 cases, otherwise fit for surgery, submitted to bedside percutaneous transhepatic gallbladder drainage (37.5%), were directly modified by COVID-19 pandemic: one due to the SARS-CoV-2 positivity, while two others due to unavailability of operating room and intensive care unit for post-operative monitoring respectively. Overall success rate of percutaneous cholecystostomy was of 87.5%. The mean post-procedural hospitalization length was 9 days, and no related adverse events were observed apart from transient parietal bleeding, conservatively treated. Once discharged, two patients required readmission because of acute biliary symptoms. Median time of drainage removal was 43 days and only 50% patients thereafter underwent cholecystectomy.
    Conclusions: Percutaneous cholecystostomy has shown to be an effective and safe treatment thus acquiring an increased relevance in the first phase of the pandemic. Nowadays, considering we are forced to live with the SARS-CoV-2 virus, PC should be considered as a virtuous, alternative tool for potentially all COVID-19 positive patients and selectively for negative cases unresponsive to conservative therapy and unfit for surgery.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/surgery ; Cholecystitis, Acute/surgery ; Cholecystostomy ; Disease Outbreaks ; Hospitals ; Humans ; Italy/epidemiology ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2021-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-021-01137-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prior Robotic Console Expertise May Improve Basic Skills at the New Hugo RAS Simulator: Results from a Cohort Trial and Implications for Skill Transference Across Platforms.

    Sighinolfi, Maria Chiara / Terzoni, Stefano / Scanferla, Elena / Bianchi, Pietro Paolo / Formisano, Giampaolo / Piccolo, Gaetano / Barabino, Matteo / Pisani, Andrea / Salaj, Adelona / Gaia, Giorgia / Marconi, Anna Maria / Turri, Filippo / Sangalli, Mattia / Centanni, Stefano / Stocco, Matteo / Chiumello, Davide / Assumma, Simone / Sarchi, Luca / Calcagnile, Tommaso /
    Panio, Enrico / Grasso, Angelica / Dell'Orto, Paolo / Mariani, Nicolo Maria / Verrusio, Clemente / Baisi, Alessandro / Bozzini, Giorgio / Rocco, Bernardo

    European urology open science

    2023  Volume 53, Page(s) 83–89

    Abstract: Background: Robot-assisted surgery ensures minimal invasiveness; since the expiry of the Da Vinci patent, new robotic systems have entered the market. Recently, the Hugo RAS received CE approval for several surgical procedures. However, more is needed ... ...

    Abstract Background: Robot-assisted surgery ensures minimal invasiveness; since the expiry of the Da Vinci patent, new robotic systems have entered the market. Recently, the Hugo RAS received CE approval for several surgical procedures. However, more is needed to know about skill acquisition at the new simulator.
    Objective: This study aims to analyse the factors impacting basic surgical skills at the Hugo RAS simulator.
    Design setting and participants: We present a cross-sectional study involving 71 participants of different backgrounds invited to a hands-on session with the Hugo RAS simulator voluntarily. All of them had no prior expertise with the system. Participants were recruited among medical/nurse students, residents, and laparoscopic and robotic surgeons.
    Intervention: All participants underwent a hands-on "pick and place" exercise at the Hugo RAS simulator; the metrics of a second-round pick and place exercise were recorded.
    Outcome measurements and statistical analysis: Metrics were analysed with regard to the following variables: demographics, videogame use, and prior surgical experience (no surgical expertise, experience with laparoscopy, and experience with robotic console).
    Results and limitations: All participants completed the test. Of them, 77.5% were naïve to surgery, 8.5% had prior laparoscopic expertise, and 14.1% had prior robotic console experience. The time to complete the pick and place exercise was significantly lower (
    Conclusions: This is the first study analysing factors impacting basic skill acquisition at a new robotic simulator. Experience with robotic consoles may represent a major factor, raising the hypothesis of the transferability of basic robotic skills across different robotic systems. Further studies are required to explore this issue.
    Patient summary: In the present study, we analysed which characteristics may affect the basic surgical skills at a novel robotic platform.
    Language English
    Publishing date 2023-06-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2023.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Surgical Strategy During the COVID-19 Pandemic in a University Metropolitan Hospital in Milan, Italy

    Mariani, Nicolò M / Pisani Ceretti, Andrea / Fedele, Veronica / Barabino, Matteo / Nicastro, Vincenzo / Giovenzana, Marco / Scifo, Giovanna / De Nicola, Enrico / Opocher, Enrico

    World J Surg

    Abstract: The COVID-19 pandemic has spread rapidly, forcing some drastic changes not only in our daily lives, but also in our clinical and surgical activities. Given our extensive Italian experience, we hereby describe how our surgical unit activity has changed ... ...

    Abstract The COVID-19 pandemic has spread rapidly, forcing some drastic changes not only in our daily lives, but also in our clinical and surgical activities. Given our extensive Italian experience, we hereby describe how our surgical unit activity has changed and how, in some cases, it was necessary to modify surgical strategies. We hope our experience can be shared with our global colleagues who are suffering under similar condition.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #276428
    Database COVID19

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  8. Article ; Online: Surgical Strategy During the COVID-19 Pandemic in a University Metropolitan Hospital in Milan, Italy

    Mariani, Nicolò M. / Pisani Ceretti, Andrea / Fedele, Veronica / Barabino, Matteo / Nicastro, Vincenzo / Giovenzana, Marco / Scifo, Giovanna / De Nicola, Enrico / Opocher, Enrico

    World Journal of Surgery

    2020  Volume 44, Issue 8, Page(s) 2471–2476

    Keywords Surgery ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-020-05595-y
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ.

    Della Chiara, Giulia / Gervasoni, Federica / Fakiola, Michaela / Godano, Chiara / D'Oria, Claudia / Azzolin, Luca / Bonnal, Raoul Jean Pierre / Moreni, Giulia / Drufuca, Lorenzo / Rossetti, Grazisa / Ranzani, Valeria / Bason, Ramona / De Simone, Marco / Panariello, Francesco / Ferrari, Ivan / Fabbris, Tanya / Zanconato, Francesca / Forcato, Mattia / Romano, Oriana /
    Caroli, Jimmy / Gruarin, Paola / Sarnicola, Maria Lucia / Cordenonsi, Michelangelo / Bardelli, Alberto / Zucchini, Nicola / Ceretti, Andrea Pisani / Mariani, Nicolò Maria / Cassingena, Andrea / Sartore-Bianchi, Andrea / Testa, Giuseppe / Gianotti, Luca / Opocher, Enrico / Pisati, Federica / Tripodo, Claudio / Macino, Giuseppe / Siena, Salvatore / Bicciato, Silvio / Piccolo, Stefano / Pagani, Massimiliano

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 2340

    Abstract: Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and transcriptional dependencies. Here, we epigenetically characterize human colorectal cancer (CRC) using de ...

    Abstract Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and transcriptional dependencies. Here, we epigenetically characterize human colorectal cancer (CRC) using de novo chromatin state discovery on a library of different patient-derived organoids. By exploring this resource, we unveil a tumor-specific deregulated enhancerome that is cancer cell-intrinsic and independent of interpatient heterogeneity. We show that the transcriptional coactivators YAP/TAZ act as key regulators of the conserved CRC gained enhancers. The same YAP/TAZ-bound enhancers display active chromatin profiles across diverse human tumors, highlighting a pan-cancer epigenetic rewiring which at single-cell level distinguishes malignant from normal cell populations. YAP/TAZ inhibition in established tumor organoids causes extensive cell death unveiling their essential role in tumor maintenance. This work indicates a common layer of YAP/TAZ-fueled enhancer reprogramming that is key for the cancer cell state and can be exploited for the development of improved therapeutic avenues.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Colorectal Neoplasms/genetics ; Enhancer Elements, Genetic ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Histone Code ; Humans ; Models, Genetic ; Organoids/metabolism ; RNA-Seq ; Single-Cell Analysis ; Trans-Activators/genetics ; Transcription Factors/genetics ; Tumor Cells, Cultured
    Chemical Substances Adaptor Proteins, Signal Transducing ; Trans-Activators ; Transcription Factors ; WWTR1 protein, human ; YAP1 protein, human
    Language English
    Publishing date 2021-04-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-22544-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Surgeons' fear of getting infected by COVID19

    An Y. / Bellato V. / Konishi T. / Pellino G. / Sensi B. / Siragusa L. / Franceschilli M. / Sica G.S. / Kefleyesus A. / Hoofwijk A.G.M. / Eldaly A.S. / Gonzalez A. / Jawad A. / Jooma A. / Hafez A.M. / Rubio A.V. / Landaluce-Olavarria A. / Wu A. / Nagatsu A. /
    Inoue A. / Kanamoto A. / Ouchi A. / El-Hussuna A. / Vazquez-Melero A. / Wolthuis A.M. / Peral A.M. / Lozano A.C. / Efremov A. / Ryasantsev A.V. / Di Giorgio A. / Parente A. / Tamburrini A. / Alo A. / Forero-Torres A. / Vahrmeijer A.L. / Varabei A. / Hinojosa S. / Balkan A.Z.A. / Frontali A. / Oleg A. / Soler-Silva A. / Makni A. / Andre A. / Cabrera A.M.G. / Fernandez A.M.G. / Minaya-Bravo A.M. / Rodriguez-Sanchez A. / Musina A.-M. / Pangeni A. / Zolotko A. / Tonoyan A. / Balla A. / Belli A. / Cavallaro A. / Chierici A. / Divizia A. / Bucci A.F. / Salido A.J. / Morini A. / Muratore A. / Vignali A. / Chitul A. / Sebastian D.A. / Pcolkins A. / Shchegolev A. / Hollenbeck A. / Wisneski A. / Iossa A. / D'Amore A. / Hunter A. / Hesketh A.J. / La Brocca A. / Spinelli A. / Caires A. / D'Alessandro A. / Correo A.F.S.L. / Macri A. / Navarro-Sanchez A. / Pronk A. / Akunc A. / Mehri A. / Pelta A. / Papadopoulos A. / Kechagias A. / Rashid A. / Ramazanov A. / Chandio A. / Kohyama A. / Nishimura A. / Ohkawa A. / Dulskas A. / Jamal A. / Mariani A. / Unal A.G. / Karagoz A. / Ozkan B.B. / Salih B. / Gulcu B. / Pessia B. / Martin-Perez B. / Ielpo B. / Tulelli B. / Yang B. / Mhamed B. / Murphy B. / Pirozzi B.M. / Langenhoff B. / Belevi B. / Guney B. / Ng C. / Rueda C. / Roxburgh C.S. / Feo C.V. / Ferrari C. / Gazia C. / Pratesi C. / Ratto C. / Santacruz C.C. / Arroyave C.R.M. / Macias C. / Fernandez C.G. / Fernandez C.C. / Curtis-Martinez C. / Fortmann C. / Kim C. / Galeano C.U. / Barroso C. / Baldi C. / Foppa C. / Formisano C. / Li C. / Ding C. / Wang C. / Iacusso C. / Yang C. / Pizzera C. / Skias C. / Chouliras C. / Liakos C. / Matsuda C. / Wu C.-Y. / Ozaslan C. / Tanda C. / Tommaso C.M. / Dagorno C. / Ramos C.P.A. / Arcudi C. / Coco C. / Morales C.M. / Ali M.Z. / Lozano C.C. / Sala C. / Leo C.A. / Scarpa C.R. / Ferro C.V. / Fernandez C.M. / Morales-Garcia D. / Nakano D. / Cristian D. / Hechtl D. / Canovas D.T. / Calabrese D. / Rega D. / Ferraro D. / Morezzi D. / Sommacale D. / 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    A global survey

    2020  

    Keywords covid ; covid19
    Language English
    Publisher John Wiley and Sons Ltd
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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