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  1. Article ; Online: Comparing national infectious disease surveillance systems

    Willemijn L. Vlieg / Ewout B. Fanoy / Liselotte van Asten / Xiaobo Liu / Jun Yang / Eva Pilot / Paul Bijkerk / Wim van der Hoek / Thomas Krafft / Marianne A. van der Sande / Qi-Yong Liu

    BMC Public Health, Vol 17, Iss 1, Pp 1-

    China and the Netherlands

    2017  Volume 9

    Abstract: Abstract Background Risk assessment and early warning (RAEW) are essential components of any infectious disease surveillance system. In light of the International Health Regulations (IHR)(2005), this study compares the organisation of RAEW in China and ... ...

    Abstract Abstract Background Risk assessment and early warning (RAEW) are essential components of any infectious disease surveillance system. In light of the International Health Regulations (IHR)(2005), this study compares the organisation of RAEW in China and the Netherlands. The respective approaches towards surveillance of arboviral disease and unexplained pneumonia were analysed to gain a better understanding of the RAEW mode of operation. This study may be used to explore options for further strengthening of global collaboration and timely detection and surveillance of infectious disease outbreaks. Methods A qualitative study design was used, combining data retrieved from the literature and from semi-structured interviews with Chinese (5 national-level and 6 provincial-level) and Dutch (5 national-level) experts. Results The results show that some differences exist such as in the use of automated electronic components of the early warning system in China (‘CIDARS’), compared to a more limited automated component in the Netherlands (‘barometer’). Moreover, RAEW units in the Netherlands focus exclusively on infectious diseases, while China has a broader ‘all hazard’ approach (including for example chemical incidents). In the Netherlands, veterinary specialists take part at the RAEW meetings, to enable a structured exchange/assessment of zoonotic signals. Conclusion Despite these differences, the main conclusion is that for the two infections studied, the early warning system in China and the Netherlands are remarkably similar considering their large differences in infectious disease history, population size and geographical setting. Our main recommendations are continued emphasis on international corporation that requires insight into national infectious disease surveillance systems, the usage of a One Health approach in infectious disease surveillance, and further exploration/strengthening of a combined syndromic and laboratory surveillance system.
    Keywords Risk assessment and early warning ; Infectious disease surveillance systems ; Surveillance of unexplained pneumonia ; Arthropod borne virus disease surveillance ; China ; The Netherlands ; Public aspects of medicine ; RA1-1270
    Subject code 950
    Language English
    Publishing date 2017-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Correction

    Kelli K. Ryckman / Katherine Fielding / Adrian V. Hill / Maimuna Mendy / Pura Rayco-Solon / Giorgio Sirugo / Marianne A. van der Sande / Pauline Waight / Hilton C. Whittle / Andrew J. Hall / Scott M. Williams / Branwen J. Hennig

    PLoS ONE, Vol 6, Iss

    Host Genetic Factors and Vaccine-Induced Immunity to HBV Infection: Haplotype Analysis.

    2011  Volume 2

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Correction

    Branwen J. Hennig / Katherine Fielding / John Broxholme / Mathurin Diatta / Maimuna Mendy / Catrin Moore / Andrew J. Pollard / Pura Rayco-Solon / Giorgio Sirugo / Marianne A. van der Sande / Pauline Waight / Hilton C. Whittle / Syed M. Zaman / Adrian V. Hill / Andrew J. Hall

    PLoS ONE, Vol 6, Iss

    Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection

    2011  Volume 2

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Correction

    Branwen J. Hennig / Katherine Fielding / John Broxholme / Mathurin Diatta / Maimuna Mendy / Catrin Moore / Andrew J. Pollard / Pura Rayco-Solon / Giorgio Sirugo / Marianne A. van der Sande / Pauline Waight / Hilton C. Whittle / Syed M. Zaman / Adrian V. Hill / Andrew J. Hall

    PLoS ONE, Vol 6, Iss

    Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection.

    2011  Volume 2

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Correction

    Kelli K. Ryckman / Katherine Fielding / Adrian V. Hill / Maimuna Mendy / Pura Rayco-Solon / Giorgio Sirugo / Marianne A. van der Sande / Pauline Waight / Hilton C. Whittle / Andrew J. Hall / Scott M. Williams / Branwen J. Hennig

    PLoS ONE, Vol 6, Iss

    Host Genetic Factors and Vaccine-Induced Immunity to HBV Infection: Haplotype Analysis

    2011  Volume 2

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Host genetic factors and vaccine-induced immunity to HBV infection

    Kelli K Ryckman / Katherine Fielding / Adrian V Hill / Maimuna Mendy / Pura Rayco-Solon / Giorgio Sirugo / Marianne A van der Sande / Pauline Waight / Hilton C Whittle / Andrew J Hall / Scott M Williams / Branwen J Hennig

    PLoS ONE, Vol 5, Iss 8, p e

    haplotype analysis.

    2010  Volume 12273

    Abstract: Hepatitis B virus (HBV) infection remains a significant health burden world-wide, although vaccines help decrease this problem. We previously identified associations of single nucleotide polymorphisms in several candidate genes with vaccine-induced peak ... ...

    Abstract Hepatitis B virus (HBV) infection remains a significant health burden world-wide, although vaccines help decrease this problem. We previously identified associations of single nucleotide polymorphisms in several candidate genes with vaccine-induced peak antibody level (anti-HBs), which is predictive of long-term vaccine efficacy and protection against infection and persistent carriage; here we report on a haplotype-based analysis. A total of 688 SNPs from 117 genes were examined for a two, three and four sliding window haplotype analysis in a Gambian cohort. Analysis was performed on 197 unrelated individuals, 454 individuals from 174 families, and the combined sample (N = 651). Global and individual haplotype association tests were carried out (adjusted for covariates), employing peak anti-HBs level as outcome. Five genes (CD44, CD58, CDC42, IL19 and IL1R1) had at least one significant haplotype in the unrelated or family analysis as well as the combined analysis. Previous single locus results were confirmed for CD44 (combined global p = 9.1x10(-5) for rs353644-rs353630-rs7937602) and CD58 (combined global p = 0.008 for rs1414275-rs11588376-rs1016140). Haplotypes in CDC42, IL19 and IL1R1 also associated with peak anti-HBs level. We have identified strong haplotype effects on HBV vaccine-induced antibody level in five genes, three of which, CDC42, IL19 and IL1R1, did not show evidence of association in a single SNP analyses and corroborated the majority of these effects in two datasets. The haplotype analysis identified associations with HBV vaccine-induced immunity in several new genes.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2010-08-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Host genetic factors and vaccine-induced immunity to hepatitis B virus infection.

    Branwen J Hennig / Katherine Fielding / John Broxholme / Mathurin Diatta / Maimuna Mendy / Catrin Moore / Andrew J Pollard / Pura Rayco-Solon / Giorgio Sirugo / Marianne A van der Sande / Pauline Waight / Hilton C Whittle / Syed M Zaman / Adrian V Hill / Andrew J Hall

    PLoS ONE, Vol 3, Iss 3, p e

    2008  Volume 1898

    Abstract: Vaccination against hepatitis B virus infection (HBV) is safe and effective; however, vaccine-induced antibody level wanes over time. Peak vaccine-induced anti-HBs level is directly related to antibody decay, as well as risk of infection and persistent ... ...

    Abstract Vaccination against hepatitis B virus infection (HBV) is safe and effective; however, vaccine-induced antibody level wanes over time. Peak vaccine-induced anti-HBs level is directly related to antibody decay, as well as risk of infection and persistent carriage despite vaccination. We investigated the role of host genetic factors in long-term immunity against HBV infection based on peak anti-HBs level and seroconversion to anti-HBc.We analyzed 715 SNP across 133 candidate genes in 662 infant vaccinees from The Gambia, assessing peak vaccine-induced anti-HBs level and core antibody (anti-HBc) status, whilst adjusting for covariates. A replication study comprised 43 SNPs in a further 393 individuals.In our initial screen we found variation in IFNG, MAPK8, and IL10RA to affect peak anti-HBs level (GMTratio of < 0.6 or > 1.5 and P < or = 0.001) and lesser associations in other genes. Odds of core-conversion was associated with variation in CD163. A coding change in ITGAL (R719V) with likely functional relevance showed evidence of association with increased peak anti-HBs level in both screens (1st screen: s595_22 GMTratio 1.71, P = 0.013; 2nd screen: s595_22 GMTratio 2.15, P = 0.011).This is to our knowledge the largest study to date assessing genetic determinants of HBV vaccine-induced immunity. We report on associations with anti-HBs level, which is directly related to durability of antibody level and predictive of vaccine efficacy long-term. A coding change in ITGAL, which plays a central role in immune cell interaction, was shown to exert beneficial effects on induction of peak antibody level in response to HBV vaccination. Variation in this gene does not appear to have been studied in relation to immune responses to viral or vaccine challenges previously. Our findings suggest that genetic variation in loci other than the HLA region affect immunity induced by HBV vaccination.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2008-03-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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