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  1. Article ; Online: Tumoral melanosis after immunotherapy with pembrolizumab - a response sign mimicking melanoma.

    Relvas, Maria / Alves, Francisca / Mariano, Angelina / Cardoso, José / Coutinho, Inês

    Dermatology online journal

    2020  Volume 26, Issue 10

    Abstract: Tumoral melanosis is a rare histopathological finding characterized by aggregates of melanophages, in the absence of melanocytes, usually observed in sites of regressed melanocytic lesions, including melanoma. A 72-year-old woman with a history of a ... ...

    Abstract Tumoral melanosis is a rare histopathological finding characterized by aggregates of melanophages, in the absence of melanocytes, usually observed in sites of regressed melanocytic lesions, including melanoma. A 72-year-old woman with a history of a completely excised melanoma on her right arm (T3bN0M0, Stage IIb) presented with clinically-evident regional lymph node metastasis. This was treated with right axillary lymphadenectomy. Subsequently, a 2-centimeter blue-colored patch over the excision scar was identified, along with a blue nodule within the posterior aspect of the same arm, consistent with in-transit metastases. Additional metastases on the right hilar region of the lungs were detected by PET/CT. Hence, the patient began immunotherapy with pembrolizumab. After three months, a second PET/CT revealed a complete response, but the patient maintained the blue-colored patch previously observed. Given the discrepancy between the clinical and metabolic response she underwent a skin biopsy; histological examination showed findings compatible with tumoral melanosis resulting from complete regression of a metastatic lesion. In cases of metastatic melanoma under immunotherapy with anti-PD1 agents, especially pembrolizumab, tumoral melanosis has been anecdotally associated with tumor regression and favorable treatment response. The patient has been maintained on pembrolizumab, accomplishing 15 cycles, and has had a complete response to date.
    MeSH term(s) Aged ; Antibodies, Monoclonal, Humanized/adverse effects ; Biopsy ; Diagnosis, Differential ; Female ; Humans ; Immunotherapy/adverse effects ; Lymph Node Excision ; Lymphatic Metastasis ; Melanoma/diagnosis ; Melanoma/secondary ; Melanoma/surgery ; Melanosis/diagnosis ; Melanosis/etiology ; Skin Neoplasms/pathology
    Chemical Substances Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2026239-5
    ISSN 1087-2108 ; 1087-2108
    ISSN (online) 1087-2108
    ISSN 1087-2108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Demyelinating disease of the central nervous system associated with Pembrolizumab treatment for metastatic melanoma.

    Durães, João / Coutinho, Inês / Mariano, Angelina / Geraldo, Argemiro / Macário, Maria Carmo

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2018  Volume 25, Issue 7, Page(s) 1005–1008

    Abstract: Immune checkpoint inhibitors are used in metastatic melanoma with good efficacy and safety profile. We report the first case of an inflammatory demyelinating disease of the central nervous system during treatment with Pembrolizumab and discuss the ... ...

    Abstract Immune checkpoint inhibitors are used in metastatic melanoma with good efficacy and safety profile. We report the first case of an inflammatory demyelinating disease of the central nervous system during treatment with Pembrolizumab and discuss the evidence in the literature supporting its causative role. The patient had a good clinical recovery after intravenous steroids, plasma exchange and discontinuation of Pembrolizumab. Due to the expected increase in the importance of immune checkpoint inhibitors in cancer treatment, it is important to be aware of neurological adverse events, as early treatment usually leads to good clinical responses.
    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; Antineoplastic Agents, Immunological/adverse effects ; Demyelinating Diseases/chemically induced ; Demyelinating Diseases/diagnosis ; Female ; Humans ; Melanoma/drug therapy ; Middle Aged ; Neoplasm Metastasis ; Skin Neoplasms/drug therapy ; White Matter/diagnostic imaging ; White Matter/pathology
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Immunological ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2018-10-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458518803724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4428: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Recurrent bullous scabies.

    Serra, David / Pedro Reis, José / Mariano, Angelina / Machado, Alvaro / Figueiredo, Américo

    Journal of cutaneous medicine and surgery

    2010  Volume 14, Issue 4, Page(s) 175–177

    Abstract: Background: scabies is a common infestation that usually presents as a pruriginous eruption consisting of erythematous papules, nodules, and excoriations. Diagnosis relies mostly on clinical features, including the identification of scabietic burrows. ... ...

    Abstract Background: scabies is a common infestation that usually presents as a pruriginous eruption consisting of erythematous papules, nodules, and excoriations. Diagnosis relies mostly on clinical features, including the identification of scabietic burrows. Several atypical clinical manifestations have been reported; bullous presentations are particularly rare and intriguing.
    Objective: a case of recurrent bullous scabies is reported.
    Methods and results: an 87-year-old institutionalized woman developed a pruriginous eruption that mimicked bullous pemphigoid. Histopathologic examination revealed blistering at the subepidermal level and a mixed inflammatory infiltrate with numerous eosinophils. Scabies mites were identified on dermoscopy and on skin scrapings, allowing a diagnosis of bullous scabies. Despite effective treatment with topical lindane, failure to control scabies in her institution led to recurrences of her peculiar blistering infestation. Immunofluorescence studies were always negative.
    Conclusions: these observations underscore the mite's role in the pathogenesis of blister formation and illustrate current challenges in scabies' diagnosis and management.
    MeSH term(s) Aged, 80 and over ; Blister/parasitology ; Blister/pathology ; Dermoscopy ; Female ; Humans ; Insecticides/therapeutic use ; Lindane/therapeutic use ; Recurrence ; Scabies/complications ; Scabies/diagnosis ; Scabies/drug therapy ; Scabies/pathology ; Skin/pathology
    Chemical Substances Insecticides ; Lindane (59NEE7PCAB)
    Language English
    Publishing date 2010-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.2310/7750.2010.09028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4987: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Epidemiology of basal cell carcinomas and squamous cell carcinomas in a Department of Dermatology: a 5 year review.

    Andrade, Pedro / Brites, Maria Manuel / Vieira, Ricardo / Mariano, Angelina / Reis, José Pedro / Tellechea, Oscar / Figueiredo, Américo

    Anais brasileiros de dermatologia

    2012  Volume 87, Issue 2, Page(s) 212–219

    Abstract: Background: Non-melanoma skin cancer, a common designation for both basal cell carcinomas and squamous cell carcinomas, is the most frequent malignant skin neoplasm.: Objective: Epidemiologic characterization of the population with Non-melanoma skin ... ...

    Abstract Background: Non-melanoma skin cancer, a common designation for both basal cell carcinomas and squamous cell carcinomas, is the most frequent malignant skin neoplasm.
    Objective: Epidemiologic characterization of the population with Non-melanoma skin cancer.
    Methods: Retrospective analysis of all patients diagnosed with Non-melanoma skin cancer based on histopathologic analysis of all incisional or excisional skin biopsies performed between 2004 and 2008 in a Department of Dermatology.
    Results: A total of 3075 Non-melanoma skin cancers were identified, representing 88% of all malignant skin neoplasms (n=3493) diagnosed in the same period. Of those, 68,3% were basal cell carcinomas. Most Non-melanoma skin cancer patients were female and over 60 years old. Of all Non-melanoma skin cancer, 81,7% (n=1443) were located in sun-exposed skin, and represented 95,1% of malignant skin neoplasms in sun-exposed skin. Non-melanoma skin cancer was the most frequent malignant skin neoplasm in most topographic locations, except for abdomen and pelvis - over 95% of all malignant skin neoplasms in the face, neck and scalp were Non-melanoma skin cancer. Basal cell carcinomas were clearly predominant in all locations, except in upper and lower limbs, lower lip and genitals, where squamous cell carcinomas represented respectively 77,7%, 77,4%, 94,7% and 95,3% of the Non-melanoma skin cancers.
    Conclusion: Being the most common skin cancer, Non-melanoma skin cancer should be under constant surveillance, in order to monitor its epidemiologic dynamics, the efficiency of preventive measures and the adaptation of the healthcare resources.
    MeSH term(s) Aged ; Brazil/epidemiology ; Carcinoma, Basal Cell/epidemiology ; Carcinoma, Squamous Cell/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Skin Neoplasms/epidemiology
    Language English
    Publishing date 2012-05-04
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1590/s0365-05962012000200004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 359: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 344: Show issues

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  5. Article: Vancomycin-associated linear IgA bullous dermatosis mimicking toxic epidermal necrolysis.

    Coelho, Sónia / Tellechea, Oscar / Reis, José Pedro / Mariano, Angelina / Figueiredo, Américo

    International journal of dermatology

    2006  Volume 45, Issue 8, Page(s) 995–996

    MeSH term(s) Aged ; Anti-Bacterial Agents/adverse effects ; Diagnosis, Differential ; Female ; Humans ; Immunoglobulin A/analysis ; Skin Diseases, Vesiculobullous/diagnosis ; Skin Diseases, Vesiculobullous/immunology ; Skin Diseases, Vesiculobullous/pathology ; Stevens-Johnson Syndrome/diagnosis ; Vancomycin/adverse effects
    Chemical Substances Anti-Bacterial Agents ; Immunoglobulin A ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2006-08
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/j.1365-4632.2006.02752.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.189: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Multiple cutaneous reticulohistiocytomas in a patient with rheumatoid arthritis.

    Vieira, Ricardo / Cordeiro, Margarida Robalo / Mariano, Angelina / Reis, Jose Pedro / Tellechea, Oscar / Figueiredo, Americo

    Dermatology online journal

    2004  Volume 10, Issue 2, Page(s) 11

    Abstract: A 64-year-old woman with a long-standing peripheral symmetric polyarthritis with positive rheumatoid serology was evaluated for multiple asymptotic papulonodules of fingers, mentum, lower lip, ears, and eyelids. Histopathologic examination showed a ... ...

    Abstract A 64-year-old woman with a long-standing peripheral symmetric polyarthritis with positive rheumatoid serology was evaluated for multiple asymptotic papulonodules of fingers, mentum, lower lip, ears, and eyelids. Histopathologic examination showed a dermal infiltrate composed of histiocytes, multinucleate giant cells with ground-glass cytoplasm, and lymphocytes, suggestive of reticulohistiocytoma. The possibilities of multicentric reticulohistiocytosis with positive rheumatoid serology or coexistence of multiple cutaneous reticulohistiocytomas and rheumatoid arthritis are discussed.
    MeSH term(s) Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/pathology ; Female ; Histiocytosis, Non-Langerhans-Cell/complications ; Histiocytosis, Non-Langerhans-Cell/pathology ; Humans ; Middle Aged ; Skin Diseases/complications ; Skin Diseases/pathology
    Language English
    Publishing date 2004-10-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2026239-5
    ISSN 1087-2108 ; 1087-2108
    ISSN (online) 1087-2108
    ISSN 1087-2108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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