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  1. AU="Marie‐Alix Derieppe"
  2. AU="Dindar, Kemal" AU="Dindar, Kemal"
  3. AU="Dupéré-Richer, Daphne"
  4. AU="Talia Gutman"
  5. AU="Coroyer, Lucas"
  6. AU="Norred, Carol L"
  7. AU="Pejić, Tomislav"
  8. AU=Popovitchenko Tatiana AU=Popovitchenko Tatiana
  9. AU=Lee Jiun
  10. AU="Ricklund, Niklas"
  11. AU="Doyle, Taylor"
  12. AU="McLaughlin, Katie A" AU="McLaughlin, Katie A"
  13. AU="Konrad Grützmann"
  14. AU=Pulido Amada
  15. AU="Malawski, Maciej"
  16. AU="Luquain-Costaz, Céline"
  17. AU=Channin David S
  18. AU="Chiba, Takahito"
  19. AU="Jeffcoat, A. Robert"
  20. AU=Scappatura Giuseppe
  21. AU=Sakaguchi Atsumi
  22. AU="Rodriguez-Cabello, Jose C"
  23. AU=Merter Ayse Arducoglu
  24. AU="Ewers, U."
  25. AU="Reichling, Jürgen"
  26. AU="Eichner, Timo"
  27. AU="Seunghee Kim-Schulze"
  28. AU=Ozaki Shoichi
  29. AU="Clerici, Giovanna" AU="Clerici, Giovanna"
  30. AU="Firoz Ahmed"
  31. AU="Dżugan, Małgorzata"
  32. AU="Rolf Bjerkvig"
  33. AU=Khosravi-Far Roya
  34. AU="Udeochu, Joe C"
  35. AU="Osoba, Osonde A." AU="Osoba, Osonde A."
  36. AU="Palani, Sowmiya"
  37. AU="Manfred Frick"
  38. AU="Jensen, Leonard"
  39. AU="Pakhomov, Evgeny A."
  40. AU="Subramanyam, Chithirala Bala"
  41. AU=Petrek J A
  42. AU="Thomson-Baker, B"
  43. AU=Shahidi Shahrzad
  44. AU="Taylor, Holly A"
  45. AU="Yeong Jeong Jeon"
  46. AU="Bueno-Cavanillas, Aurora"
  47. AU="Kavčič, Tina"
  48. AU="Arias-Jiménez, José Luís"
  49. AU="Tünçok, Ekin"
  50. AU="Roberto Toro"
  51. AU="Bharti Sahu"
  52. AU="Soo-Yeon Choi"
  53. AU="Nono, Sandra"
  54. AU="Diepens, Robin J W"
  55. AU="Baselga-Garriga, Clara"

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  1. Artikel ; Online: Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice

    Georges Raad / Fabrizio Serra / Luc Martin / Marie-Alix Derieppe / Jérôme Gilleron / Vera L Costa / Didier F Pisani / Ez-Zoubir Amri / Michele Trabucchi / Valerie Grandjean

    eLife, Vol

    2021  Band 10

    Abstract: Obesity is a growing societal scourge. Recent studies have uncovered that paternal excessive weight induced by an unbalanced diet affects the metabolic health of offspring. These reports mainly employed single-generation male exposure. However, the ... ...

    Abstract Obesity is a growing societal scourge. Recent studies have uncovered that paternal excessive weight induced by an unbalanced diet affects the metabolic health of offspring. These reports mainly employed single-generation male exposure. However, the consequences of multigenerational unbalanced diet feeding on the metabolic health of progeny remain largely unknown. Here, we show that maintaining paternal Western diet feeding for five consecutive generations in mice induces an enhancement in fat mass and related metabolic diseases over generations. Strikingly, chow-diet-fed progenies from these multigenerational Western-diet-fed males develop a ‘healthy’ overweight phenotype characterized by normal glucose metabolism and without fatty liver that persists for four subsequent generations. Mechanistically, sperm RNA microinjection experiments into zygotes suggest that sperm RNAs are sufficient for establishment but not for long-term maintenance of epigenetic inheritance of metabolic pathologies. Progressive and permanent metabolic deregulation induced by successive paternal Western-diet-fed generations may contribute to the worldwide epidemic of metabolic diseases.
    Schlagwörter epigenetic ; inheritance ; sperm ; obesity ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag eLife Sciences Publications Ltd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis

    Joris Guyon / Ignacio Fernandez‐Moncada / Claire M Larrieu / Cyrielle L Bouchez / Antonio C Pagano Zottola / Johanna Galvis / Tiffanie Chouleur / Audrey Burban / Kevin Joseph / Vidhya M Ravi / Heidi Espedal / Gro Vatne Røsland / Boutaina Daher / Aurélien Barre / Benjamin Dartigues / Slim Karkar / Justine Rudewicz / Irati Romero‐Garmendia / Barbara Klink /
    Konrad Grützmann / Marie‐Alix Derieppe / Thibaut Molinié / Nina Obad / Céline Léon / Giorgio Seano / Hrvoje Miletic / Dieter Henrik Heiland / Giovanni Marsicano / Macha Nikolski / Rolf Bjerkvig / Andreas Bikfalvi / Thomas Daubon

    EMBO Molecular Medicine, Vol 14, Iss 12, Pp n/a-n/a (2022)

    2022  

    Abstract: Abstract Lactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, in addition to its ... ...

    Abstract Abstract Lactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, in addition to its altered metabolism. We show herein that lactate fuels GB anaplerosis by replenishing the tricarboxylic acid (TCA) cycle in absence of glucose. Lactate dehydrogenases (LDHA and LDHB), which we found spatially expressed in GB tissues, catalyze the interconversion of pyruvate and lactate. However, ablation of both LDH isoforms, but not only one, led to a reduction in tumor growth and an increase in mouse survival. Comparative transcriptomics and metabolomics revealed metabolic rewiring involving high oxidative phosphorylation (OXPHOS) in the LDHA/B KO group which sensitized tumors to cranial irradiation, thus improving mouse survival. When mice were treated with the antiepileptic drug stiripentol, which targets LDH activity, tumor growth decreased. Our findings unveil the complex metabolic network in which both LDHA and LDHB are integrated and show that the combined inhibition of LDHA and LDHB strongly sensitizes GB to therapy.
    Schlagwörter antiepileptic drug ; energy metabolism ; glioblastoma ; invasion ; lactate dehydrogenases ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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