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  1. AU="Marie I. Samanovic"
  2. AU="Journeaux, Alexandre"
  3. AU="Cao, Mei Juan"
  4. AU="Wang, Hua-Yu"
  5. AU="Posner, Clara"
  6. AU="Gomes Da Silva, G"
  7. AU="Thoma, Tizia"
  8. AU="Liu, Huixing"
  9. AU="Mita-Mendoza, Neida K"
  10. AU="Anderson, Richard C E"
  11. AU="Garcia, Paula"
  12. AU="Soumya Nayak"

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  1. Artikel ; Online: Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera

    Takuya Tada / Hao Zhou / Belinda M. Dcosta / Marie I. Samanovic / Mark J. Mulligan / Nathaniel R. Landau

    iScience, Vol 24, Iss 11, Pp 103341- (2021)

    2021  

    Abstract: Summary: Highly transmissible SARS-CoV-2 variants identified in India and designated B.1.617, Kappa (B.1.617.1), Delta (B.1.617.2), B.1.618, and B.1.36.29 contain spike mutations L452R, T478K, E484K, E484Q, and N440K located within the spike receptor- ... ...

    Abstract Summary: Highly transmissible SARS-CoV-2 variants identified in India and designated B.1.617, Kappa (B.1.617.1), Delta (B.1.617.2), B.1.618, and B.1.36.29 contain spike mutations L452R, T478K, E484K, E484Q, and N440K located within the spike receptor-binding domain and thus could contribute to increased transmissibility and potentially allow re-infection or cause resistance to vaccine-elicited antibody. To address these issues, we used lentiviruses pseudotyped by variant spikes to measure their neutralization by convalescent sera, vaccine-elicited and Regeneron therapeutic antibodies, and ACE2 affinity. Convalescent sera and vaccine-elicited antibodies neutralized viruses with Delta spike with 2- to 5-fold decrease in titer in different donors. Regeneron antibody cocktail neutralized virus with the Delta spike with a 2.6-fold decrease in titer. Neutralization resistance to serum antibodies and monoclonal antibodies was mediated by L452R mutation. These relatively modest decreases in antibody neutralization titer for viruses with variant spike proteins suggest that current vaccines will remain protective against the family of Delta variants.
    Schlagwörter Biological sciences ; Immune response ; Virology ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Cytokinins beyond plants

    Marie I. Samanovic / K. Heran Darwin

    Microbial Cell, Vol 2, Iss 5, Pp 168-

    synthesis by Mycobacterium tuberculosis

    2015  Band 170

    Abstract: Mycobacterium tuberculosis (M. tuberculosis) resides mainly inside macrophages, which produce nitric oxide (NO) to combat microbial infections. Earlier studies revealed that proteasome-associated genes are required for M. tuberculosis to resist NO via a ... ...

    Abstract Mycobacterium tuberculosis (M. tuberculosis) resides mainly inside macrophages, which produce nitric oxide (NO) to combat microbial infections. Earlier studies revealed that proteasome-associated genes are required for M. tuberculosis to resist NO via a previously uncharacterized mechanism. Twelve years later, we elucidated the link between proteasome function and NO resistance in M. tuberculosis in Molecular Cell, 57 (2015), pp. 984–994. In a proteasome degradation-defective mutant, Rv1205, a homologue of the plant enzyme LONELY GUY (LOG) that is involved in the synthesis of phytohormones called cytokinins, accumulates and as a consequence results in the overproduction of cytokinins. Cytokinins break down into aldehydes that kill mycobacteria in the presence of NO. Importantly, this new discovery reveals for the first time that a mammalian bacterial pathogen produces cytokinins and leaves us with the question: why is M. tuberculosis, an exclusively human pathogen, producing cytokinins?
    Schlagwörter Mycobacterium tuberculosis ; proteasome ; nitric oxide ; LONELY GUY ; cytokinins ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2015-05-01T00:00:00Z
    Verlag Shared Science Publishers OG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection

    Ellie N. Ivanova / Jasmine Shwetar / Joseph C. Devlin / Terkild B. Buus / Sophie Gray-Gaillard / Akiko Koide / Amber Cornelius / Marie I. Samanovic / Alberto Herrera / Eleni P. Mimitou / Chenzhen Zhang / Trishala Karmacharya / Ludovic Desvignes / Niels Ødum / Peter Smibert / Robert J. Ulrich / Mark J. Mulligan / Shohei Koide / Kelly V. Ruggles /
    Ramin S. Herati / Sergei B. Koralov

    iScience, Vol 26, Iss 12, Pp 108572- (2023)

    2023  

    Abstract: Summary: SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell analysis of blood from COVID-19 patients and healthy volunteers receiving the SARS-CoV-2 vaccine and booster. We ... ...

    Abstract Summary: SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell analysis of blood from COVID-19 patients and healthy volunteers receiving the SARS-CoV-2 vaccine and booster. We profiled immune responses via transcriptional analysis and lymphocyte repertoire reconstruction. COVID-19 patients displayed an enhanced interferon signature and cytotoxic gene upregulation, absent in vaccine recipients. B and T cell repertoire analysis revealed clonal expansion among effector cells in COVID-19 patients and memory cells in vaccine recipients. Furthermore, while clonal αβ T cell responses were observed in both COVID-19 patients and vaccine recipients, expansion of clonal γδ T cells was found only in infected individuals. Our dataset enables side-by-side comparison of immune responses to infection versus vaccination, including clonal B and T cell responses. Our comparative analysis shows that vaccination induces a robust, durable clonal B and T cell responses, without the severe inflammation associated with infection.
    Schlagwörter Immunology ; Immune response ; Transcriptomics ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities

    Maria G. Noval / Maria E. Kaczmarek / Akiko Koide / Bruno A. Rodriguez-Rodriguez / Ping Louie / Takuya Tada / Takamitsu Hattori / Tatyana Panchenko / Larizbeth A. Romero / Kai Wen Teng / Andrew Bazley / Maren de Vries / Marie I. Samanovic / Jeffrey N. Weiser / Ioannis Aifantis / Joan Cangiarella / Mark J. Mulligan / Ludovic Desvignes / Meike Dittmann /
    Nathaniel R. Landau / Maria Aguero-Rosenfeld / Shohei Koide / Kenneth A. Stapleford

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Band 11

    Abstract: Abstract Understanding antibody responses to SARS-CoV-2 is indispensable for the development of containment measures to overcome the current COVID-19 pandemic. Recent studies showed that serum from convalescent patients can display variable ... ...

    Abstract Abstract Understanding antibody responses to SARS-CoV-2 is indispensable for the development of containment measures to overcome the current COVID-19 pandemic. Recent studies showed that serum from convalescent patients can display variable neutralization capacities. Still, it remains unclear whether there are specific signatures that can be used to predict neutralization. Here, we performed a detailed analysis of sera from a cohort of 101 recovered healthcare workers and we addressed their SARS-CoV-2 antibody response by ELISA against SARS-CoV-2 Spike receptor binding domain and nucleoprotein. Both ELISA methods detected sustained levels of serum IgG against both antigens. Yet, the majority of individuals from our cohort generated antibodies with low neutralization capacity and only 6% showed high neutralizing titers against both authentic SARS-CoV-2 virus and the Spike pseudotyped virus. Interestingly, higher neutralizing sera correlate with detection of -IgG, IgM and IgA antibodies against both antigens, while individuals with positive IgG alone showed poor neutralization response. These results suggest that having a broader repertoire of antibodies may contribute to more potent SARS-CoV-2 neutralization. Altogether, our work provides a cross sectional snapshot of the SARS-CoV-2 neutralizing antibody response in recovered healthcare workers and provides preliminary evidence that possessing multiple antibody isotypes can play an important role in predicting SARS-CoV-2 neutralization.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Sequencing analysis of the spread of SARS-CoV2 in the Greater New York City region

    Matthew T Maurano / Sitharam Ramaswami / Gael Westby / Paul Zappile / Dacia Dimartino / Guomiao Shen / Xiaojun Feng / Andre M Ribeiro-dos-Santos / Nicholas A Vulpescu / Margaret Black / Megan Hogan / Christian Marier / Peter Meyn / Yutong Zhang / John Cadley / Raquel Ordonez / Raven Luther / Emily Huang / Emily Guzman /
    Antonio Serrano / Brendan Belovarac / Tatyana Gindin / Andrew Lytle / Jared Pinnell / Theodore Vougiouklakis / Ludovic Boytard / John Chen / Lawrence H Lin / Amy Rapkiewicz / Vanessa Raabe / Marie I Samanovic-Golden / George Jour / Iman Osman / Maria Aguero-Rosenfeld / Mark J Mulligan / Paolo Cotzia / Matija Snuderl / Adriana Heguy

    Abstract: Effective public response to a pandemic relies upon accurate measurement of the extent and dynamics of an outbreak. Viral genome sequencing has emerged as a powerful means to link seemingly unrelated cases, and large-scale sequencing surveillance can ... ...

    Abstract Effective public response to a pandemic relies upon accurate measurement of the extent and dynamics of an outbreak. Viral genome sequencing has emerged as a powerful means to link seemingly unrelated cases, and large-scale sequencing surveillance can inform on critical epidemiological parameters. Here, we report analysis of 156 SARS-CoV2 sequences from individuals in the New York City metropolitan area during the initial stages of the 2020 COVID-19 outbreak. The majority of samples had no recent travel history or known exposure. Comparison to global viral sequences showed that the majority of sequences were most related to samples from Europe. Our data are consistent with numerous seed transmissions and a period of unrecognized community spreading. This work highlights the complementary role of genomic surveillance to traditional epidemiological indicators.
    Schlagwörter covid19
    Verlag medrxiv
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2020.04.15.20064931
    Datenquelle COVID19

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