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  1. Article ; Online: Role of Dietary Flavonoids in Iron Homeostasis

    Marija Lesjak / Surjit K. S. Srai

    Pharmaceuticals, Vol 12, Iss 3, p

    2019  Volume 119

    Abstract: Balancing systemic iron levels within narrow limits is critical for human health, as both iron deficiency and overload lead to serious disorders. There are no known physiologically controlled pathways to eliminate iron from the body and therefore iron ... ...

    Abstract Balancing systemic iron levels within narrow limits is critical for human health, as both iron deficiency and overload lead to serious disorders. There are no known physiologically controlled pathways to eliminate iron from the body and therefore iron homeostasis is maintained by modifying dietary iron absorption. Several dietary factors, such as flavonoids, are known to greatly affect iron absorption. Recent evidence suggests that flavonoids can affect iron status by regulating expression and activity of proteins involved the systemic regulation of iron metabolism and iron absorption. We provide an overview of the links between different dietary flavonoids and iron homeostasis together with the mechanism of flavonoids effect on iron metabolism. In addition, we also discuss the clinical relevance of state-of-the-art knowledge regarding therapeutic potential that flavonoids may have for conditions that are low in iron such as anaemia or iron overload diseases.
    Keywords iron homeostasis ; iron absorption ; non-haem iron ; flavonoids ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 570
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Investigation of the chemical composition and biological activity of edible grapevine (Vitis vinifera L.) leaf varieties

    Pintać, Diandra / Dragana Četojević-Simin / Sanja Berežni / Dejan Orčić / Neda Mimica-Dukić / Marija Lesjak

    Food chemistry. 2019 July 15, v. 286

    2019  

    Abstract: Chemical composition and bioactivity of eight edible Vitis vinifera L. leaf varieties originating from Fruška Gora, Serbia, including two autochthonous varieties, were evaluated. The LC-MS/MS analysis confirmed the presence of 28 natural products in leaf ...

    Abstract Chemical composition and bioactivity of eight edible Vitis vinifera L. leaf varieties originating from Fruška Gora, Serbia, including two autochthonous varieties, were evaluated. The LC-MS/MS analysis confirmed the presence of 28 natural products in leaf samples, among which most abundant were glycosylated flavonoids, ellagic and chlorogenic acids. The highest amounts of most of the tested compounds were detected in leaves of autochthonous variety Sila. Bioactivity was assessed by a set of in vitro antioxidant, neuroprotective and cytotoxic assays. Leaves of all examined varieties exhibited average bioactivity, with leaves of autochthonous variety Župljanka standing out as the most promising sample. To conclude, investigated grapevine leaves proved to be a rich source of nutraceuticals, primarily antioxidants, and their further employment as medicinal food in human diet and beneficial raw material for food, pharmaceutical and cosmetic industries should be supported.
    Keywords Vitis vinifera ; antioxidants ; chemical composition ; chlorogenic acid ; cytotoxicity ; flavonoids ; functional foods ; glycosylation ; human nutrition ; industry ; leaves ; liquid chromatography ; raw materials ; tandem mass spectrometry ; Serbia
    Language English
    Dates of publication 2019-0715
    Size p. 686-695.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2019.02.049
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Fresh fruits and jam of Sorbus domestica L. and Sorbus intermedia (Ehrh.) Pers.

    Zorica Mrkonjić / Jelena Nađpal / Ivana Beara / Filip Šibul / Petar Knežević / Marija Lesjak / Neda Mimica-Dukić

    Botanica Serbica, Vol 43, Iss 2, Pp 187-

    phenolic profiles, antioxidant action and antimicrobial activity

    2019  Volume 196

    Abstract: A detailed examination of the phenolic profile, ascorbic acid content and antioxidant and antimicrobial capacities of extracts and jams of the fruits of two traditionally used Sorbus species, viz., S. domestica and S. intermedia, was carried out in the ... ...

    Abstract A detailed examination of the phenolic profile, ascorbic acid content and antioxidant and antimicrobial capacities of extracts and jams of the fruits of two traditionally used Sorbus species, viz., S. domestica and S. intermedia, was carried out in the present study. Use of the LC-MS/MS technique revealed the presence and content of 44 phenolics, the most dominant compounds being amentoflavone in S. domestica and chlorogenic acid in S. intermedia extracts. Jam of both species showed the highest content of аscorbic acid. In comparison with BHT (butylated hydroxytoluene) and PG (propyl gallate) antioxidant standards, both Sorbus species exhibited moderate antioxidant action. Some extracts of S. domestica and S. intermedia inhibited the growth of two clinically relevant bacterial strains. The presented results support the belief that Sorbus fruits are food with health-promoting properties.
    Keywords sorbus ; phenolics ; аscorbic acid ; antioxidant action ; antimicrobial activity ; Plant ecology ; QK900-989
    Subject code 580
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher University of Belgrade
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Solvent selection for efficient extraction of bioactive compounds from grape pomace

    Pintać, Diandra / Dejan Orčić / Ivana Beara / Ljilja Torović / Marija Lesjak / Nataša Simin / Neda Mimica–Dukić / Tatjana Majkić

    Industrial crops and products. 2018 Jan., v. 111

    2018  

    Abstract: Pomace is a winemaking by-product, rich in bioactive compounds which exert various health benefits and are used as dietary supplements, cosmetic ingredients, food colorants and preservatives. Isolation and further utilization of these compounds is an ... ...

    Abstract Pomace is a winemaking by-product, rich in bioactive compounds which exert various health benefits and are used as dietary supplements, cosmetic ingredients, food colorants and preservatives. Isolation and further utilization of these compounds is an important issue in pomace waste management. Different industries have different requirements for specific classes of compounds and thus, selective extraction methods for isolation of these classes should be developed. In this work, the efficacy of six solvents (80% MeOH, 80% EtOH, EtOAc, acetone, acidified 50% and 80% MeOH) for the extraction of polyphenolic and triterpenoid compounds was examined. Pomaces of different grape varieties from Fruška Gora winery region in Serbia were used for extraction. 47 phenolics and 3 triterpenoids were analyzed by LC–MS/MS and 5 anthocyanin glucosides by LC-UV/VIS, while contents of total phenols and flavonoids were determined spectrophotometrically in obtained extracts. The most efficient solvent for each class and each compound was defined: EtOAc was the best for obtaining an extract rich in polyphenols, acidified 50% MeOH for isolation of anthocyanins, and acetone for ursolic acid. For industries that work on a large scale and aim at the highest utilization of raw material, 80% MeOH was found to be a solvent of choice, providing the highest yield of all polyphenols. This study confirmed that pomaces from Fruška Gora vineyards are a promising source of bioactive compounds, suggesting that their utilization could be very attractive for pharmaceutical, food and cosmetic industries.
    Keywords acetone ; anthocyanins ; bioactive compounds ; byproducts ; cosmetics ; dietary supplements ; ethanol ; ethyl acetate ; food coloring ; glucosides ; grape pomace ; grapes ; industry ; ingredients ; methanol ; polyphenols ; preservatives ; raw materials ; solvents ; ursolic acid ; vineyards ; waste management ; winemaking ; Serbia
    Language English
    Dates of publication 2018-01
    Size p. 379-390.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2017.10.038
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5577: Show issues

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  5. Article ; Online: Quercetin inhibits intestinal iron absorption and ferroportin transporter expression in vivo and in vitro.

    Marija Lesjak / Rukshana Hoque / Sara Balesaria / Vernon Skinner / Edward S Debnam / Surjit K S Srai / Paul A Sharp

    PLoS ONE, Vol 9, Iss 7, p e

    2014  Volume 102900

    Abstract: Balancing systemic iron levels within narrow limits is critical for maintaining human health. There are no known pathways to eliminate excess iron from the body and therefore iron homeostasis is maintained by modifying dietary absorption so that it ... ...

    Abstract Balancing systemic iron levels within narrow limits is critical for maintaining human health. There are no known pathways to eliminate excess iron from the body and therefore iron homeostasis is maintained by modifying dietary absorption so that it matches daily obligatory losses. Several dietary factors can modify iron absorption. Polyphenols are plentiful in human diet and many compounds, including quercetin--the most abundant dietary polyphenol--are potent iron chelators. The aim of this study was to investigate the acute and longer-term effects of quercetin on intestinal iron metabolism. Acute exposure of rat duodenal mucosa to quercetin increased apical iron uptake but decreased subsequent basolateral iron efflux into the circulation. Quercetin binds iron between its 3-hydroxyl and 4-carbonyl groups and methylation of the 3-hydroxyl group negated both the increase in apical uptake and the inhibition of basolateral iron release, suggesting that the acute effects of quercetin on iron transport were due to iron chelation. In longer-term studies, rats were administered quercetin by a single gavage and iron transporter expression measured 18 h later. Duodenal FPN expression was decreased in quercetin-treated rats. This effect was recapitulated in Caco-2 cells exposed to quercetin for 18 h. Reporter assays in Caco-2 cells indicated that repression of FPN by quercetin was not a transcriptional event but might be mediated by miRNA interaction with the FPN 3'UTR. Our study highlights a novel mechanism for the regulation of iron bioavailability by dietary polyphenols. Potentially, diets rich in polyphenols might be beneficial for patients groups at risk of iron loading by limiting the rate of intestinal iron absorption.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Phenolic profile and anti-inflammatory activity of three Veronica species

    Beara, Ivana / Jelena Živković / Marija Lesjak / Jelena Ristić / Katarina Šavikin / Zoran Maksimović / Teodora Janković

    Industrial crops and products. 2015 Jan., v. 63

    2015  

    Abstract: Aerial parts of some Veronica species are used as traditional medicine for treatment of various inflammatory conditions, including rheumatism. In the present study, phenolic content and anti-inflammatory activity of three Veronica species (Plantaginaceae) ...

    Abstract Aerial parts of some Veronica species are used as traditional medicine for treatment of various inflammatory conditions, including rheumatism. In the present study, phenolic content and anti-inflammatory activity of three Veronica species (Plantaginaceae), Veronica jacquinii Baumg., Veronica teucrium L. and Veronica urticifolia Jacq was studied. The identification and quantification of 30 phenolic compounds in aqueous-acetone extracts were performed using LC–MS/MS technique, and the main components were baicalin, hyperoside, isoquercetine, chlorogenic acid and quinic acid. Genistein and baicalein were detected for the first time in Plantaginaceae family and Veronica genus, respectively. The anti-inflammatory potential of tested extracts was determined using calcium ionophore-stimulated human platelets as a source of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) enzymes, and highly sensitive and specific LC–MS/MS technique was performed for detection of the main arachidonic acid metabolites formed by them. V. urticifolia extract exerted the strongest COX-1 inhibition (IC50<0.4mg/mL), while V. jacquinii extract exhibited the highest ability to inhibit 12-LOX activity (IC50=1.072mg/mL). The results obtained in this study may be used to promote better use of the genus Veronica as anti-inflammatory agents.
    Keywords Veronica ; aerial parts ; anti-inflammatory activity ; anti-inflammatory agents ; arachidonic acid ; baicalin ; calcium ; chlorogenic acid ; genistein ; humans ; inhibitory concentration 50 ; metabolites ; phenolic compounds ; prostaglandin synthase ; quinic acid ; traditional medicine
    Language English
    Dates of publication 2015-01
    Size p. 276-280.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2014.09.034
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5577: Show issues

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