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Artikel ; Online: Ketogenic Diet: A Nutritional Therapeutic Tool for Lipedema?

Verde, Ludovica / Camajani, Elisabetta / Annunziata, Giuseppe / Sojat, Antoanstefan / Marina, Ljiljana V / Colao, Annamaria / Caprio, Massimiliano / Muscogiuri, Giovanna / Barrea, Luigi

Current obesity reports

2023 Band 12, Heft 4, Seite(n) 529–543

Abstract: Purpose of review: This review aims to provide an overview of the current evidence on the efficacy, also considering the anti-inflammatory properties and safety of very low-calorie ketogenic diet (VLCKD) as a potential treatment for lipedema, ... ...

Abstract	Purpose of review: This review aims to provide an overview of the current evidence on the efficacy, also considering the anti-inflammatory properties and safety of very low-calorie ketogenic diet (VLCKD) as a potential treatment for lipedema, particularly in the context of obesity. Recent findings: Lipedema is a chronic disease characterized by abnormal and painful fat buildup on the legs and/or arms. It is often misdiagnosed as obesity or lymphedema. However, although lipedema and obesity can coexist, unlike obesity, lipedema usually affects the legs and thighs without affecting the feet or hands, and the abnormal deposition of adipose tissue in lipedema is painful. The current lifestyle interventions are often unsuccessful in the management of lipedema. There is no consensus on the most effective nutritional approach for managing lipedema. Recent studies have suggested that VLCKD may be an effective treatment for lipedema, demonstrating that it is also superior to other nutritional approaches such as Mediterranean diet or intermittent fasting. Lipedema is a chronic and debilitating disease characterized by abnormal and painful accumulation of adipose tissue in the legs. VLCKD has been shown to be an effective treatment for lipedema, especially in the context of obesity, due to its anti-inflammatory properties. However, further research is needed to determine the long-term safety and efficacy of VLCKD as a treatment for lipedema.
Mesh-Begriff(e)	Humans ; Lipedema/complications ; Lipedema/diagnosis ; Lipedema/therapy ; Diet, Ketogenic ; Obesity/complications ; Treatment Outcome ; Anti-Inflammatory Agents
Chemische Substanzen	Anti-Inflammatory Agents
Sprache	Englisch
Erscheinungsdatum	2023-11-04
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ISSN	2162-4968
ISSN (online)	2162-4968
DOI	10.1007/s13679-023-00536-x
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence?

Medenica, Sanja / Spoltore, Maria Elena / Ormazabal, Paulina / Marina, Ljiljana V / Sojat, Antoan Stefan / Faggiano, Antongiulio / Gnessi, Lucio / Mazzilli, Rossella / Watanabe, Mikiko

Clinical endocrinology

2022 Band 98, Heft 2, Seite(n) 141–152

Abstract: Obesity is an epidemic that has led to a rise in the incidence of many comorbidities: among others, reduced fertility is often under-evaluated in clinical practice. The mechanisms underlying the link between reduced fertility and obesity are numerous, ... ...

Abstract	Obesity is an epidemic that has led to a rise in the incidence of many comorbidities: among others, reduced fertility is often under-evaluated in clinical practice. The mechanisms underlying the link between reduced fertility and obesity are numerous, with insulin resistance, hyperglycaemia and the frequent coexistence of polycystic ovary syndrome being the most acknowledged. However, several other factors concur, such as gut microbiome alterations, low-grade chronic inflammation and oxidative stress. Not only do women with obesity take longer to conceive, but in vitro fertilization (IVF) is also less likely to succeed. We herein provide an updated state-of-the-art regarding the molecular bases of what we could define as dysmetabolic infertility, focusing on the clinical aspects, as well as possible treatment.
Mesh-Begriff(e)	Female ; Humans ; Infertility, Female/therapy ; Pandemics ; Obesity/complications ; Obesity/epidemiology ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/epidemiology ; Fertility ; Fertilization in Vitro/adverse effects
Sprache	Englisch
Erscheinungsdatum	2022-06-07
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.14785
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Differences in Cholesterol Metabolism, Hepato-Intestinal Aging, and Hepatic Endocrine Milieu in Rats as Affected by the Sex and Age.

Šošić-Jurjević, Branka / Lütjohann, Dieter / Trifunović, Svetlana / Pavlović, Slađan / Borković Mitić, Slavica / Jovanović, Ljubiša / Ristić, Nataša / Marina, Ljiljana / Ajdžanović, Vladimir / Filipović, Branko

International journal of molecular sciences

2023 Band 24, Heft 16

Abstract: Age and sex influence serum cholesterol levels, but the underlying mechanisms remain unclear. To investigate further, we measured cholesterol, precursors (surrogate synthesis markers), degradation products (oxysterols and bile acid precursors) in serum, ... ...

Abstract	Age and sex influence serum cholesterol levels, but the underlying mechanisms remain unclear. To investigate further, we measured cholesterol, precursors (surrogate synthesis markers), degradation products (oxysterols and bile acid precursors) in serum, the liver, jejunum, and ileum, as well as serum plant sterols (intestinal absorption markers) in male and female Wistar rats (4 and 24 months old). The analysis of histomorphometric and oxidative stress parameters (superoxide dismutase, catalase, glutathione-related enzyme activities, lipid peroxide, and protein carbonyl concentrations) in the liver and jejunum offered further insights into the age- and sex-related differences. The hepatic gene expression analysis included AR, ERα, and sex-specific growth hormone-regulated (Cyp2c11 and Cyp2c12) and thyroid-responsive (Dio1, Tbg, and Spot 14) genes by qPCR. We observed age-related changes in both sexes, with greater prominence in females. Aged females had significantly higher serum cholesterol (
Mesh-Begriff(e)	Female ; Male ; Rats ; Animals ; Catalase/genetics ; Estrogen Receptor alpha ; Rats, Wistar ; Liver ; Aging
Chemische Substanzen	Catalase (EC 1.11.1.6) ; Estrogen Receptor alpha
Sprache	Englisch
Erscheinungsdatum	2023-08-10
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241612624
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Comorbidities in mild autonomous cortisol secretion and the effect of treatment: systematic review and meta-analysis.

Pelsma, Iris C M / Fassnacht, Martin / Tsagarakis, Stylianos / Terzolo, Massimo / Tabarin, Antoine / Sahdev, Anju / Newell-Price, John / Marina, Ljiljana / Lorenz, Kerstin / Bancos, Irina / Arlt, Wiebke / Dekkers, Olaf M

European journal of endocrinology

2023 Band 189, Heft 4, Seite(n) S88–S101

Abstract: Objective: To assess (1) comorbidities associated with and (2) treatment strategies for patients with adrenal incidentalomas and mild autonomous cortisol secretion (MACS; > 1.8 µg/dL (>50 nmol/L) cortisol level cut-off following the 1 mg dexamethasone ... ...

Abstract	Objective: To assess (1) comorbidities associated with and (2) treatment strategies for patients with adrenal incidentalomas and mild autonomous cortisol secretion (MACS; > 1.8 µg/dL (>50 nmol/L) cortisol level cut-off following the 1 mg dexamethasone suppression test). Design: Systematic review and meta-analysis. Methods: Seven databases were searched up to July 14, 2022. Eligible studies were (randomized) trials, cohort studies, and cross-sectional studies assessing comorbidities potentially attributable to cortisol excess or mortality in patients with adrenal incidentaloma with or without MACS or the effects of conservative or surgical management of MACS. Random-effects meta-analysis was performed to estimate pooled proportions (with 95% CIs). Results: In 30 cross-sectional and 16 cohort studies (n = 17 156 patients in total), patients with MACS had a higher prevalence of diabetes (relative risk [RR] 1.44 [1.23-1.69]), hypertension (RR = 1.24 [1.16-1.32]), and dyslipidemia (RR = 1.23 [1.13-1.34]). All-cause mortality (adjusted for confounders) in patients with MACS, assessed in 4 studies (n = 5921), was increased (hazard ratio [HR] = 1.54 [1.27-1.81]). Nine observational studies (n = 856) and 2 randomized trials (n = 107) suggest an improvement in glucometabolic control (RR = 7.99 [2.95-21.90]), hypertension (RR = 8.75 [3.99-19.18]), and dyslipidemia (RR = 3.24 [1.19-8.82]) following adrenalectomy. Conclusions: The present systematic review and meta-analysis highlight the relevance of MACS, since both cardiometabolic morbidities and mortality appeared to have increased in patients with MACS compared to patients with non-functioning incidentalomas. However, due to heterogeneous definitions, various outcomes, selective reporting, and missing data, the reported pooled estimates need to be interpreted with caution. The small number of patients in randomized trials prevents any strong conclusion on the causality between MACS and these comorbidities.
Mesh-Begriff(e)	Humans ; Adrenal Gland Neoplasms/complications ; Hydrocortisone ; Cross-Sectional Studies ; Hypertension/complications ; Dyslipidemias/complications
Chemische Substanzen	Hydrocortisone (WI4X0X7BPJ)
Sprache	Englisch
Erscheinungsdatum	2023-10-05
Erscheinungsland	England
Dokumenttyp	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1183856-5
ISSN	1479-683X ; 0804-4643
ISSN (online)	1479-683X
ISSN	0804-4643
DOI	10.1093/ejendo/lvad134
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.

Fassnacht, Martin / Tsagarakis, Stylianos / Terzolo, Massimo / Tabarin, Antoine / Sahdev, Anju / Newell-Price, John / Pelsma, Iris / Marina, Ljiljana / Lorenz, Kerstin / Bancos, Irina / Arlt, Wiebke / Dekkers, Olaf M

European journal of endocrinology

2023 Band 189, Heft 1, Seite(n) G1–G42

Abstract: Adrenal incidentalomas are adrenal masses detected on imaging performed for reasons other than suspected adrenal disease. In most cases, adrenal incidentalomas are nonfunctioning adrenocortical adenomas but may also require therapeutic intervention ... ...

Abstract	Adrenal incidentalomas are adrenal masses detected on imaging performed for reasons other than suspected adrenal disease. In most cases, adrenal incidentalomas are nonfunctioning adrenocortical adenomas but may also require therapeutic intervention including that for adrenocortical carcinoma, pheochromocytoma, hormone-producing adenoma, or metastases. Here, we provide a revision of the first international, interdisciplinary guidelines on incidentalomas. We followed the Grading of Recommendations Assessment, Development and Evaluation system and updated systematic reviews on 4 predefined clinical questions crucial for the management of incidentalomas: (1) How to assess risk of malignancy?; (2) How to define and manage mild autonomous cortisol secretion?; (3) Who should have surgical treatment and how should it be performed?; and (4) What follow-up is indicated if the adrenal incidentaloma is not surgically removed? Selected Recommendations: (1) Each adrenal mass requires dedicated adrenal imaging. Recent advances now allow discrimination between risk categories: Homogeneous lesions with Hounsfield unit (HU) ≤ 10 on unenhanced CT are benign and do not require any additional imaging independent of size. All other patients should be discussed in a multidisciplinary expert meeting, but only lesions >4 cm that are inhomogeneous or have HU >20 have sufficiently high risk of malignancy that surgery will be the usual management of choice. (2) Every patient needs a thorough clinical and endocrine work-up to exclude hormone excess including the measurement of plasma or urinary metanephrines and a 1-mg overnight dexamethasone suppression test (applying a cutoff value of serum cortisol ≤50 nmol/L [≤1.8 µg/dL]). Recent studies have provided evidence that most patients without clinical signs of overt Cushing's syndrome but serum cortisol levels post dexamethasone >50 nmol/L (>1.8 µg/dL) harbor increased risk of morbidity and mortality. For this condition, we propose the term "mild autonomous cortisol secretion" (MACS). (3) All patients with MACS should be screened for potential cortisol-related comorbidities that are potentially attributably to cortisol (eg, hypertension and type 2 diabetes mellitus), to ensure these are appropriately treated. (4) In patients with MACS who also have relevant comorbidities surgical treatment should be considered in an individualized approach. (5) The appropriateness of surgical intervention should be guided by the likelihood of malignancy, the presence and degree of hormone excess, age, general health, and patient preference. We provide guidance on which surgical approach should be considered for adrenal masses with radiological findings suspicious of malignancy. (6) Surgery is not usually indicated in patients with an asymptomatic, nonfunctioning unilateral adrenal mass and obvious benign features on imaging studies. Furthermore, we offer recommendations for the follow-up of nonoperated patients, management of patients with bilateral incidentalomas, for patients with extra-adrenal malignancy and adrenal masses, and for young and elderly patients with adrenal incidentalomas. Finally, we suggest 10 important research questions for the future.
Mesh-Begriff(e)	Aged ; Humans ; Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/therapy ; Adrenal Gland Neoplasms/pathology ; Dexamethasone ; Diabetes Mellitus, Type 2 ; Hydrocortisone
Chemische Substanzen	Dexamethasone (7S5I7G3JQL) ; Hydrocortisone (WI4X0X7BPJ)
Sprache	Englisch
Erscheinungsdatum	2023-06-15
Erscheinungsland	England
Dokumenttyp	Journal Article ; Practice Guideline
ZDB-ID	1183856-5
ISSN	1479-683X ; 0804-4643
ISSN (online)	1479-683X
ISSN	0804-4643
DOI	10.1093/ejendo/lvad066
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: "Time" for obesity-related cancer: The role of the circadian rhythm in cancer pathogenesis and treatment.

Miro, Caterina / Docimo, Annamaria / Barrea, Luigi / Verde, Ludovica / Cernea, Simona / Sojat, Antoan Stefan / Marina, Ljiljana V / Docimo, Giovanni / Colao, Annamaria / Dentice, Monica / Muscogiuri, Giovanna

Seminars in cancer biology

2023 Band 91, Seite(n) 99–109

Abstract: The circadian rhythm is regulated by an intrinsic time-tracking system, composed both of a central and a peripheral clock, which influences the cycles of activities and sleep of an individual over 24 h. At the molecular level, the circadian rhythm begins ...

Abstract	The circadian rhythm is regulated by an intrinsic time-tracking system, composed both of a central and a peripheral clock, which influences the cycles of activities and sleep of an individual over 24 h. At the molecular level, the circadian rhythm begins when two basic helix-loop-helix/Per-ARNT-SIM (bHLH-PAS) proteins, BMAL-1 and CLOCK, interact with each other to produce BMAL-1/CLOCK heterodimers in the cytoplasm. The BMAL-1/CLOCK target genes encode for the repressor components of the clock, cryptochrome (Cry1 and Cry2) and the Period proteins (Per1, Per2 and Per3). It has been recently demonstrated that the disruption of circadian rhythm is associated with an increased risk of developing obesity and obesity-related diseases. In addition, it has been demonstrated that the disruption of the circadian rhythm plays a key role in tumorigenesis. Further, an association between the circadian rhythm disruptions and an increased incidence and progression of several types of cancer (e.g., breast, prostate, colorectal and thyroid cancer) has been found. As the perturbation of circadian rhythm has adverse metabolic consequences (e.g., obesity) and at the same time tumor promoter functions, this manuscript has the aim to report how the aberrant circadian rhythms affect the development and prognosis of different types of obesity-related cancers (breast, prostate, colon rectal and thyroid cancer) focusing on both human studies and on molecular aspects.
Mesh-Begriff(e)	Male ; Humans ; Circadian Rhythm/genetics ; Cryptochromes/genetics ; Period Circadian Proteins/genetics ; Obesity/complications ; Thyroid Neoplasms
Chemische Substanzen	Cryptochromes ; Period Circadian Proteins
Sprache	Englisch
Erscheinungsdatum	2023-03-07
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	1033980-2
ISSN	1096-3650 ; 1044-579X
ISSN (online)	1096-3650
ISSN	1044-579X
DOI	10.1016/j.semcancer.2023.03.003
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Menopausal hyperinsulinism and hypertension - new approach.

Đogo, Aleksandar / Stojanovic, Milos / Ivovic, Miomira / Tancic Gajic, Milina / Marina, Ljiljana V / Citlucanin, Goran / Brkic, Milena / Popovic, Srdjan / Vujovic, Svetlana

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

2020 Band 36, Heft 8, Seite(n) 709–713

Abstract: Aim: ...

Abstract	Aim:
Mesh-Begriff(e)	Adult ; Androstenes/administration & dosage ; Drug Administration Schedule ; Estradiol/administration & dosage ; Estrogen Replacement Therapy/methods ; Female ; Follow-Up Studies ; Glucose Tolerance Test ; Humans ; Hyperinsulinism/blood ; Hyperinsulinism/complications ; Hyperinsulinism/drug therapy ; Hypertension/blood ; Hypertension/complications ; Hypertension/drug therapy ; Insulin/blood ; Insulin Resistance/physiology ; Menopause/drug effects ; Menopause/physiology ; Middle Aged ; Retrospective Studies ; Treatment Outcome
Chemische Substanzen	Androstenes ; Insulin ; Estradiol (4TI98Z838E) ; drospirenone (N295J34A25)
Sprache	Englisch
Erscheinungsdatum	2020-05-21
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	639237-4
ISSN	1473-0766 ; 0951-3590
ISSN (online)	1473-0766
ISSN	0951-3590
DOI	10.1080/09513590.2020.1768370
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Approach to the Patient with Subclinical Cushing's Syndrome.

Ivović, Miomira / Marina, Ljiljana V / Šojat, Antoan S / Tančić-Gajić, Milina / Arizanović, Zorana / Kendereški, Aleksandra / Vujović, Svetlana

Current pharmaceutical design

2020 Band 26, Heft 43, Seite(n) 5584–5590

Abstract: A growing number of patients with adrenal incidentalomas and subclinical Cushing's syndrome (SCS) led to an increasing number of different guidelines, and diagnostic and treatment recommendations. Excess cortisol secretion in patients with SCS is ... ...

Abstract	A growing number of patients with adrenal incidentalomas and subclinical Cushing's syndrome (SCS) led to an increasing number of different guidelines, and diagnostic and treatment recommendations. Excess cortisol secretion in patients with SCS is associated with several comorbidities, such as hypertension, dyslipidemia, type 2 diabetes mellitus, and obesity, which in the long-term increase mortality of these patients. Subtle cortisol secretion affects bone health, quality of life and causes depression, but due to the unapparent clinical features, patients with SCS are often at risk between over and under treatment. This narrative review aimed to summarize the latest recommendations on the approach to the patient with subclinical Cushing's syndrome.
Mesh-Begriff(e)	Adrenal Gland Neoplasms ; Cushing Syndrome/diagnosis ; Cushing Syndrome/therapy ; Diabetes Mellitus, Type 2 ; Dyslipidemias ; Humans ; Hydrocortisone ; Quality of Life
Chemische Substanzen	Hydrocortisone (WI4X0X7BPJ)
Sprache	Englisch
Erscheinungsdatum	2020-08-12
Erscheinungsland	United Arab Emirates
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612826666200813134328
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Hot flush values of gonadotropins and estradiol in menopause

Arizanović Zorana / Vujović Svetlana / Ivović Miomira / Tančić-Gajić Milina / Marina Ljiljana / Stojanović Miloš / Micić Dragan

Srpski Arhiv za Celokupno Lekarstvo, Vol 146, Iss 7-8, Pp 403-

2018 Band 406

Abstract: Introduction/Objective. Hot flashes are one of the first clinical symptoms of menopause. The mechanism of hot flashes is still not fully understood. Changes in concentrations of the circulating follicle-stimulating hormone (FSH), luteinizing hormone (LH), ...

Abstract	Introduction/Objective. Hot flashes are one of the first clinical symptoms of menopause. The mechanism of hot flashes is still not fully understood. Changes in concentrations of the circulating follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen, and other hormones can lead to thermoregulatory dysfunction. The aim of this study was to examine the association between dynamic changes in concentrations of sex hormones and the presence of vasomotor symptoms in menopausal women. Methods. The study involved 36 women divided into two groups: in the first group there were 24 women with hot flashes, BMI 26.16 ± 3.42 kg/m2; the control group comprised 12 women, BMI 26.82 ± 3.89 kg/m2. Data on the presence of hot flashes were based on medical history data. Venous blood samples were collected for the analyses of FSH, LH, prolactin, estradiol, progesterone, testosterone, sex hormone binding globulin, dehidroepiandrosteron sulfate, thyroid-stimulating hormone, and thyroxin. During the subjective feeling of hot flashes, three blood samples during the day and night were collected to determine the mean levels of FSH, LH, and estradiol in women with hot flashes. Results. Women with hot flashes had significantly higher prolactin (389.58 ± 123.69 mIU/L to 258.19 ± 122 mIU/L, p < 0.01) and dehydroepiandrosterone sulfate (3.60 ± 2.49 nmol/L vs. 1.88 ± 1.27 nmol/L, p < 0.05) levels, as well as lower mean values of FSH during hot flashes during the day (69.08 ± 28.84 IU/L vs. 107.18 ± 39.11 IU/L, p < 0.01) and night (60.72 ± 21.89 IU/L vs. 104.57 ± 38.06 IU/L, p < 0.01). Conclusion. .Women with hot flashes had significantly lower mean FSH levels during hot flashes during the day and night than the control group.
Schlagwörter	hot flushes ; menopause ; sex hormones ; Medicine ; R
Thema/Rubrik (Code)	630
Sprache	Englisch
Erscheinungsdatum	2018-01-01T00:00:00Z
Verlag	Serbian Medical Society
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: The effect of estroprogestagen therapy on lipid status in menopause depending on the drug administration route

Čitlučanin Goran / Ivović Miomira / Tančić-Gajić Milina / Canović Fadil / Stojanović Miloš / Marina Ljiljana / Arizanović Zorana / Đogo Aleksandar / Gerginić Vladimir / Vujović Svetlana

Vojnosanitetski Pregled, Vol 77, Iss 4, Pp 418-

2020 Band 425

Abstract: Background/Aim. In menopausal women lipid and lipoprotein values are important predictors of development of cardiovascular diseases (CVD). The use of estrogens reduces levels of low density lipoprotein cholesterol (LDLC) and lipoprotein A [Lp(a)], and ... ...

Abstract	Background/Aim. In menopausal women lipid and lipoprotein values are important predictors of development of cardiovascular diseases (CVD). The use of estrogens reduces levels of low density lipoprotein cholesterol (LDLC) and lipoprotein A [Lp(a)], and increases levels of triglycerides (TG) and high density lipoprotein cholesterol (HDL-C) depending on the dose and route of administration. Simultaneous administration of progesterone, depending on the type, can have different effects on lipids. The aim of the study was to examine the effect of estroprogestagen therapy on the lipid metabolism of women in menopause, depending on the administration route. Methods. A study was conducted as prospective clinical interventional study with controlled parallel groups. It included 64 women in menopause, divided into three groups: the group 1 (n = 22) on oral therapy with estroprogestagens, the group 2 (n = 17) on transdermal patch therapy with estroprogestagens and the group 3 (n = 25) treated with estroprogestagens given intramuscularly. The following biochemical parameters in the serum were determined: total cholesterol (TC), HDL-C, LDL-C, TG, Lp(a), apoprotein A (Apo-A), apoprotein B (Apo-B), follicle- stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone, testosterone, sex hormonebinding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-SO4), prolactin and thyroid-stimulating hormone (TSH), prior to administration of the menopausal hormonal therapy (MHT), as well as after sixth months and 2–5 years from the beginning of the therapy. The statistical significance of the difference in values obtained was examined independently and depending on the route of MHT application. Results. MHT, regardless of the administration route, led to a statistically significant continuous decrease of TC, LDL-C and Apo-B levels and the continuous increase of HDL-C and Apo-A levels. Serum levels of TC, LDL-C, HDL-C, Lp(a), Apo-A and Apo-B did not show a statistically significant differences among groups of women ...
Schlagwörter	hormone replacement therapy ; cardiovascular diseases ; lipids ; menopause ; Medicine (General) ; R5-920
Thema/Rubrik (Code)	610
Sprache	Englisch
Erscheinungsdatum	2020-01-01T00:00:00Z
Verlag	Military Health Department, Ministry of Defance, Serbia
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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