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  1. Article ; Online: Pharmacoeconomic evaluation of the tixagevimab and cilgavimab combination using for pre-exposure prophylaxis of COVID-19

    Marina V. Zhuravleva / Vladimir P. Chulanov / Julia V. Gagarina / Elena A. Shabalina

    Терапевтический архив, Vol 95, Iss 1, Pp 66-

    2023  Volume 77

    Abstract: Aim. To evaluate pharmacoeconomic feasibility using of the tixagevimab and cilgavimab combination for pre-exposure prophylaxis of COVID-19 in immunocompromised patients. Materials and methods. Cost-effectiveness of tixagevimab and cilgavimab in persons ... ...

    Abstract Aim. To evaluate pharmacoeconomic feasibility using of the tixagevimab and cilgavimab combination for pre-exposure prophylaxis of COVID-19 in immunocompromised patients. Materials and methods. Cost-effectiveness of tixagevimab and cilgavimab in persons 12 years old who weigh 40 kg and have either a history of allergy that prevents their vaccination against COVID-19 or moderate or immunocompromised was assessed based on PROVENT phase III study results. The quantity of life years or quality-adjusted life years gained was calculated. Direct medical cost associated with prophylaxis of COVID-19, treatment of infected patients and those experiencing long COVID post infection were assessed. Results were compared with wiliness-to-pay threshold, measured as tripled gross domestic product per capita and equal to 2.69 mln RUB in 2022. Results. Pre-exposure prophylaxis of COVID-19 results in additional 0.0287 life years or 0.0247 quality-adjusted life years. The cost of additional life year gained is equal to 1.12 mln RUB, the cost of additional quality-adjusted life years is 1.30 mln RUB. Both costs of additional life year and cost of quality-adjusted life years appeared to be significantly less compared to wiliness-to-pay threshold. Conclusion. Pre-exposure prophylaxis of COVID-19 with combination of tixagevimab and cilgavimab is economically feasible and may be recommended for wide use in Russian healthcare system.
    Keywords covid-19 ; sars-cov-2 ; tixagevimab and cilgavimab ; pharmacoeconomic analysis ; pre-exposure prophylaxis ; cost-effectiveness ; wiliness-to-pay threshold ; Medicine ; R
    Language Russian
    Publishing date 2023-02-01T00:00:00Z
    Publisher "Consilium Medicum" Publishing house
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Multi-Proxy Paleoecological Reconstruction of Peatland Initiation, Development and Restoration in an Urban Area (Moscow, Russia)

    Yuri A. Mazei / Andrey N. Tsyganov / Ekaterina G. Ershova / Natalia G. Mazei / Valery E. Pimenov / Elizaveta V. Kotlyarova / Natalia V. Kuzmenkova / Mikhail S. Paramonov / Artemii D. Chulei / Anastasiya D. Makarova / Ivan A. Zhirov / Anna A. Tsaregorodtseva / Marina V. Zhuravleva / Andrey V. Kitashov / Ping Ding / Stepan N. Kalmykov

    Diversity, Vol 15, Iss 448, p

    2023  Volume 448

    Abstract: Peatlands play an important role in the global carbon cycle but have been exploited over many centuries, which reduces their carbon storage capacity. To investigate peatland development during the late Holocene and their restoration after peat extraction, ...

    Abstract Peatlands play an important role in the global carbon cycle but have been exploited over many centuries, which reduces their carbon storage capacity. To investigate peatland development during the late Holocene and their restoration after peat extraction, we applied a multi-proxy paleoecological (pollen, plant macrofossils, testate amoebae, loss on ignition, peat humification, etc.) approach to undisturbed and floating vegetation mat deposits of the Gorenki peatland (Meshchera Lowlands, East European Plain). Peatland development started around 2550 before the common era (BCE) as a waterlogged eutrophic birch forest (terrestrial paludification) surrounded by a broadleaf forest. Around 2400 BCE, the peatland turned into an open mire with Sphagnum mosses, sedges, and willows. During 900–800 BCE, the mire transformed into a wet mesotrophic peatland surrounded by a spruce forest. The first human settlements and deforestation around 300–400 CE coincided with oligotrophization of the mire. The growth of the Slavic population in the region in 14th century CE caused transformation of indigenous spruce–broadleaf forests into croplands, and the mire became drier and forested. Since peat extraction was abandoned in the beginning of 20th century CE, the mire has undergone self-restoration starting with the formation of a Sphagnum cuspidatum/obtusum quagmire on the floating peat remains. The Sphagnum mat stabilized during 1960–2000 CE. During the last twenty years, agricultural activity decreased and pine forests were restored in the adjacent area; the floating mat became drier and more oligotrophic, which can lead to the formation of a bog in the absence of considerable anthropogenic impact.
    Keywords pollen ; plant macrofossils ; testate amoebae ; macrocharcoal ; peat humification ; 14 C AMS dating ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Pharmacokinetics of enalapril in patients with arterial hypertension depending on the glomerular filtration rate

    Marina V. Zhuravleva / Aleksei B. Prokofiev / Artem I. Dmitriev / Sergei A. Belkov / Evgenii S. Melnikov / Tatiana A. Rodina / Andrei A. Danko

    КардиоСоматика, Vol 10, Iss 3, Pp 37-

    2019  Volume 41

    Abstract: Aim. To study the pharmacokinetics of enalapril in patients with arterial hypertension, depending on the value of the prescribed dose of enalapril and the state of renal function to improve the efficiency and safety of treatment. Materials and methods. ... ...

    Abstract Aim. To study the pharmacokinetics of enalapril in patients with arterial hypertension, depending on the value of the prescribed dose of enalapril and the state of renal function to improve the efficiency and safety of treatment. Materials and methods. The study was performed in a group of 328 patients (107 men and 221 women aged 43 to 88 years) who received treatment for hypertension of 1-2 degrees. As the main antihypertensive drug was prescribed enalapril in doses of 2.5 to 20 mg twice a day. Patients underwent therapeutic drug monitoring to determine the concentration of enalapril and its metabolite - enalaprilat. Results. Among the examined patients in 31% of cases there was a decrease in GFR less than 60 ml/min, and in 9 (3%) patients GFR was less than 30 ml/min. This indicates a high prevalence of chronic kidney disease among patients with hypertension. During therapeutic drug monitoring enalapril in patients with hypertension and reduced GFR (less than 60 ml/min) serum concentration of the main metabolite was 1.5-2 times higher than in patients with GFR more than 60 ml/min. Conclusion. It is advisable to carry out therapeutic drug monitoring to determine the concentrations of enalapril and enalaprilat in the serum of patients receiving the drug in high doses and having impaired renal function. In the appointment of enalapril in high doses to patients with reduced GFR, the concentration of enalaprilat significantly exceeds similar indicators in patients with normal GFR and in some cases goes beyond the therapeutic range, indicating the need to consider the correction of the treatment regimen.
    Keywords arterial hypertension ; chronic kidney disease ; enalapril ; pharmacokinetics ; therapeutic drug monitoring ; personalized medicine ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
    Subject code 610
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher Concilium Medicum
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Information Competence Structure and Content of the Higher School Students

    Almira K. Garayeva / Elena P. Kartashova / Gulnaz F. Nizamutdinova / Yuri D. Kudakov / Guliya N. Akhmetzyanova / Marina V. Zhuravleva / Aygul M. Gatiatullina

    Mediterranean Journal of Social Sciences, Vol 6, Iss 2 S

    2015  Volume 3

    Abstract: For free orientation in the flow of information people should possess information competence as one of the components of professionalism. In this regard, the article reveals the structure and content of the information competence of students, including ... ...

    Abstract For free orientation in the flow of information people should possess information competence as one of the components of professionalism. In this regard, the article reveals the structure and content of the information competence of students, including motivational and values, cognitive, activity, communicative and health saving components that are in relationships and are aimed at ensuring the integrity and continuity of the process of students’ information competence forming in conditions of modern high school.The article also describes the problem of the teachers’ functions’ expansion involved in this process. The article can be recommended for use in modern practice of educational institutions, as well as in the system of teacher training. DOI:10.5901/mjss.2015.v6n2s3p254
    Keywords Social Sciences ; H
    Language English
    Publishing date 2015-03-01T00:00:00Z
    Publisher richtmann publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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