Article ; Online: A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.
ACS chemical biology
2021 Volume 16, Issue 3, Page(s) 548–556
Abstract: We report a general approach to engineering multivalent d-proteins with antibody-like ... ...
Abstract | We report a general approach to engineering multivalent d-proteins with antibody-like activities |
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MeSH term(s) | Amino Acid Sequence ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Bevacizumab/pharmacology ; Binding Sites ; Drug Evaluation, Preclinical ; Eye/drug effects ; Female ; Humans ; Mice ; Models, Molecular ; Neoplasms/drug therapy ; Peptide Library ; Peptides/chemistry ; Peptides/pharmacology ; Protein Binding ; Protein Conformation ; Protein Multimerization ; Rabbits ; Receptors, Vascular Endothelial Growth Factor/chemistry ; Receptors, Vascular Endothelial Growth Factor/metabolism ; Retinal Vessels/drug effects ; Vascular Endothelial Growth Factor A/antagonists & inhibitors |
Chemical Substances | Antineoplastic Agents ; Peptide Library ; Peptides ; Vascular Endothelial Growth Factor A ; Bevacizumab (2S9ZZM9Q9V) ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1) |
Language | English |
Publishing date | 2021-02-23 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ISSN | 1554-8937 |
ISSN (online) | 1554-8937 |
DOI | 10.1021/acschembio.1c00017 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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