Article ; Online: Routine antiemetic prophylaxis with dexamethasone during COVID-19: Should oncologists reconsider?
2020 Volume 26, Issue 6, Page(s) 1482–1485
Abstract: The ongoing pandemic caused by severe acute respiratory syndrome (SARS) coronavirus type 2 (SARS-CoV-2, also known as COVID-19) has caused unprecedented strain on the global healthcare system, causing thousands of deaths worldwide. Patients with ... ...
Abstract | The ongoing pandemic caused by severe acute respiratory syndrome (SARS) coronavirus type 2 (SARS-CoV-2, also known as COVID-19) has caused unprecedented strain on the global healthcare system, causing thousands of deaths worldwide. Patients with underlying conditions such as cancer are at substantial risk of acquiring and dying from this novel coronavirus. Numerous reports have shown that infection with SARS-CoV-2 causes depletion of B- and T-lymphocytes, including CD4 and CD8 T-cells, and is associated with severe illness and death and that patients with higher lymphocyte levels may have better outcomes. Dexamethasone, a widely prescribed antiemetic for acute and delayed nausea and vomiting from a variety of cancer drugs, causes B and T cell depletion, which may augment immunosuppression. Since it seems that lymphocytes are vital in the immune response to novel coronavirus, oncologists should reconsider the |
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MeSH term(s) | Antiemetics/administration & dosage ; COVID-19 ; Coronavirus Infections/epidemiology ; Dexamethasone/administration & dosage ; Female ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; T-Lymphocytes/immunology |
Chemical Substances | Antiemetics ; Dexamethasone (7S5I7G3JQL) |
Keywords | covid19 |
Language | English |
Publishing date | 2020-06-06 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 1330764-2 |
ISSN | 1477-092X ; 1078-1552 |
ISSN (online) | 1477-092X |
ISSN | 1078-1552 |
DOI | 10.1177/1078155220931921 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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