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  1. Article ; Online: Simple multi-signal calibrations exploiting flow analysis systems.

    Maringolo, Vivian / Carvalho, Alexandre Z / Rocha, Diogo L

    Talanta

    2024  Volume 272, Page(s) 125787

    Abstract: Multi-signal calibrations have been recently exploited in molecular spectrochemical analysis alternatively to traditional calibration methods, improving analytical frequency and accuracy. The application of these strategies is simple and minimizes ... ...

    Abstract Multi-signal calibrations have been recently exploited in molecular spectrochemical analysis alternatively to traditional calibration methods, improving analytical frequency and accuracy. The application of these strategies is simple and minimizes efficiently matrix effects by analyzing two calibration solutions comprising sample plus standard (S1), and sample plus blank (S2). The plot of the signals obtained with S1 and S2 at multiple settings (e.g. different wavelengths) yield a slope that can be related to the analyte concentration in the sample. Similarly, transient signals could also be related to the analyte concentration exploiting a similar strategy. Thus, in this work, two multi-signal approaches developed in flow-based systems are proposed, based on the responses at multiple wavelengths (online multi-energy calibration, OMEC), and on the dispersion profile of the samples, herein denominated multi-dispersion calibration (MDC). The calibrations were carried out with sample solutions after 2-fold dilution with a standard solution and with water. The feasibility of OMEC and MDC were demonstrated using KMnO
    Language English
    Publishing date 2024-02-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2024.125787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A novel online dispersive liquid-liquid microextraction for the spectrophotometric determination of free glycerol in biodiesel.

    Maringolo, Vivian / Carvalho, Alexandre Zatkovskis / Rocha, Diogo Librandi

    Analytical methods : advancing methods and applications

    2023  Volume 15, Issue 24, Page(s) 2997–3004

    Abstract: Biodiesel is an important alternative fuel produced from animal fats or vegetable oils. According to several world regulatory agencies, the acceptable threshold content for free glycerol in biodiesel is 200 mg ... ...

    Abstract Biodiesel is an important alternative fuel produced from animal fats or vegetable oils. According to several world regulatory agencies, the acceptable threshold content for free glycerol in biodiesel is 200 mg kg
    MeSH term(s) Animals ; Glycerol/analysis ; Liquid Phase Microextraction/methods ; Biofuels/analysis ; Water/chemistry ; Liquid-Liquid Extraction
    Chemical Substances Glycerol (PDC6A3C0OX) ; Biofuels ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d3ay00366c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploitation of flow-based procedures for reagentless hydrochlorothiazide determination and accelerated degradation studies of pharmaceutical preparations.

    Maringolo, Vivian / Aleixo, Fernanda Caroline / Carvalho, Alexandre Zatkovskis / Rocha, Diogo Librandi

    Analytical methods : advancing methods and applications

    2021  Volume 13, Issue 4, Page(s) 497–503

    Abstract: Drug quality assessment and stress testing are important to ensure both treatment efficacy and patient safety. High performance liquid chromatography may be considered a standard technique for pharmaceutical analysis, showing good precision and accuracy, ...

    Abstract Drug quality assessment and stress testing are important to ensure both treatment efficacy and patient safety. High performance liquid chromatography may be considered a standard technique for pharmaceutical analysis, showing good precision and accuracy, but it also involves relatively high cost and low analytical frequency. Flow injection analysis presents high sample throughput, lower cost and might be used for selective drug analysis with an appropriate assay and/or detector. In this paper, for the first time, photoreactions promoted by UV radiation were employed for reagentless spectrophotometric determination of hydrochlorothiazide. Optimized parameters led to a linear range of 50 to 500 mg L
    MeSH term(s) Chromatography, High Pressure Liquid ; Electrophoresis, Capillary ; Humans ; Hydrochlorothiazide ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations ; Hydrochlorothiazide (0J48LPH2TH)
    Language English
    Publishing date 2021-01-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d0ay02070b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Exploitation of flow-based procedures for reagentless hydrochlorothiazide determination and accelerated degradation studies of pharmaceutical preparations

    Maringolo, Vivian / Aleixo, Fernanda Caroline / Carvalho, Alexandre Zatkovskis / Rocha, Diogo Librandi

    Analytical methods. 2021 Feb. 4, v. 13, no. 4

    2021  

    Abstract: Drug quality assessment and stress testing are important to ensure both treatment efficacy and patient safety. High performance liquid chromatography may be considered a standard technique for pharmaceutical analysis, showing good precision and accuracy, ...

    Abstract Drug quality assessment and stress testing are important to ensure both treatment efficacy and patient safety. High performance liquid chromatography may be considered a standard technique for pharmaceutical analysis, showing good precision and accuracy, but it also involves relatively high cost and low analytical frequency. Flow injection analysis presents high sample throughput, lower cost and might be used for selective drug analysis with an appropriate assay and/or detector. In this paper, for the first time, photoreactions promoted by UV radiation were employed for reagentless spectrophotometric determination of hydrochlorothiazide. Optimized parameters led to a linear range of 50 to 500 mg L⁻¹, estimated limit of detection of 3.0 mg L⁻¹ and 24 determinations per hour. The use of diluted NaOH solution as a carrier allowed solubilization of hydrochlorothiazide and analysis without organic solvents. The presence of the most common excipients was evaluated and no significant interferences were observed. The results from the analysis of samples by the proposed and by the reference procedures demonstrated accuracy and matching results. The proposed in-line photolysis of the pharmaceutical, performed in 5 min, is a promising alternative to the conventional hydrolytic forced degradation, which requires elevated temperature and prolonged time period. To evaluate the degree of photoconversion, a capillary zone electrophoresis method was developed, which performed well for separations manifesting good analytical frequency and reduced amount of waste. The combination of in-line photodegradation followed by separation by capillary electrophoresis is a promising approach for the stress test of hydrochlorothiazide in pharmaceutical formulations.
    Keywords capillary zone electrophoresis ; detection limit ; drugs ; flow injection analysis ; high performance liquid chromatography ; hydrochlorothiazide ; patients ; photolysis ; solubilization ; temperature ; ultraviolet radiation ; wastes
    Language English
    Dates of publication 2021-0204
    Size p. 497-503.
    Publishing place The Royal Society of Chemistry
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d0ay02070b
    Database NAL-Catalogue (AGRICOLA)

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