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  1. Article: Abscopal effects observed in cancer radiation therapy and oncolytic virotherapy: an overview.

    Romano, G / Marino, I R

    Drugs of today (Barcelona, Spain : 1998)

    2019  Volume 55, Issue 2, Page(s) 117–130

    Abstract: Immunoglobulin-mediated suppression of immune checkpoint pathways may lead to a considerable activation of host immune responses against malignancies. Substantial therapeutic benefits were reported among patients who participated in cancer immunotherapy ... ...

    Abstract Immunoglobulin-mediated suppression of immune checkpoint pathways may lead to a considerable activation of host immune responses against malignancies. Substantial therapeutic benefits were reported among patients who participated in cancer immunotherapy clinical trials which utilized monoclonal antibodies against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1). In a subsequent stage, immune checkpoint inhibitors were used in various clinical trials in combination with other therapeutic agents, such as immunomodulatory factors, chemotherapeutics, oncolytic viruses and radiation therapy. Interestingly, local antitumor interventions based either on radiation therapy or oncolytic viruses resulted in systemic immune responses in a number of oncological patients. The elimination of untreated cancer tissues that may follow a localized therapeutic intervention was termed abscopal effect, which represents a major achievement in the field of cancer therapy.
    MeSH term(s) B7-H1 Antigen/antagonists & inhibitors ; CTLA-4 Antigen/antagonists & inhibitors ; Combined Modality Therapy ; Humans ; Immunotherapy ; Neoplasms/radiotherapy ; Neoplasms/therapy ; Oncolytic Virotherapy ; Oncolytic Viruses ; Programmed Cell Death 1 Receptor/antagonists & inhibitors
    Chemical Substances B7-H1 Antigen ; CTLA-4 Antigen ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2019-04-10
    Publishing country Spain
    Document type Journal Article ; Review
    ISSN 1699-3993
    ISSN 1699-3993
    DOI 10.1358/dot.2019.55.2.2903217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Debris-Filled Duodenal Diverticulum and Lemmel's Syndrome.

    Zorzetti, Noemi / Lauro, A / Cervellera, M / Panarese, A / Khouzam, S / Marino, I R / Sorrenti, S / D'Andrea, V / Tonini, V

    Digestive diseases and sciences

    2022  Volume 67, Issue 7, Page(s) 2805–2808

    Abstract: We report a case of a 73-year-old woman affected by Lemmel's syndrome, a rare type of obstructive jaundice caused by a periampullary duodenal diverticulum. The patient was admitted to the Emergency Department for pneumonia associated with mild epigastric ...

    Abstract We report a case of a 73-year-old woman affected by Lemmel's syndrome, a rare type of obstructive jaundice caused by a periampullary duodenal diverticulum. The patient was admitted to the Emergency Department for pneumonia associated with mild epigastric pain and vomiting. While hospitalized for antibiotic treatment, the appearance of jaundice led us to discover a periampullary duodenal diverticulum by endoscopy and CT scan. The jaundice was successfully managed endoscopically with removal of food debris from the diverticulum.
    MeSH term(s) Abdominal Pain/etiology ; Aged ; Diverticulum/complications ; Diverticulum/diagnostic imaging ; Diverticulum/surgery ; Duodenal Diseases/complications ; Duodenal Diseases/diagnostic imaging ; Female ; Humans ; Jaundice ; Jaundice, Obstructive/etiology ; Syndrome
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-022-07571-z
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  3. Article ; Online: Bleeding Edge Therapy: Ileocolic Intussusception Due to Ileocecal Valve Adenocarcinoma and Its Management in an Adult Patient-Case Report and Literature Review.

    Zanni, M / Vaccari, S / Lauro, A / Marino, I R / Cervellera, M / D'Andrea, V / Tonini, V

    Digestive diseases and sciences

    2021  Volume 66, Issue 5, Page(s) 1436–1440

    Abstract: Adenocarcinoma as the primary cause of bowel intussusception is uncommon. We describe the case of a 86-year-old patient admitted for ileocecal intussusception due to the presence of adenocarcinoma, located in the ileocecal valve and right colon. The ... ...

    Abstract Adenocarcinoma as the primary cause of bowel intussusception is uncommon. We describe the case of a 86-year-old patient admitted for ileocecal intussusception due to the presence of adenocarcinoma, located in the ileocecal valve and right colon. The etiologies of intussusception, its diagnosis, and conservative or surgical treatments are discussed, with attention placed on the indications for reduction of the invagination prior to surgical resection.
    MeSH term(s) Adenocarcinoma/complications ; Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged, 80 and over ; Female ; Humans ; Ileal Diseases/diagnostic imaging ; Ileal Diseases/etiology ; Ileal Diseases/surgery ; Ileal Neoplasms/complications ; Ileal Neoplasms/diagnostic imaging ; Ileal Neoplasms/pathology ; Ileal Neoplasms/surgery ; Ileocecal Valve/diagnostic imaging ; Ileocecal Valve/pathology ; Ileocecal Valve/surgery ; Intussusception/diagnostic imaging ; Intussusception/etiology ; Intussusception/surgery ; Neoplasm Staging ; Treatment Outcome
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-021-06849-y
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  4. Article ; Online: Spontaneous Perforated Duodenal Diverticulum: Wait or Cut First?

    Farné, G M / Lauro, A / Vaccari, S / Marino, I R / Khouzam, S / D'Andrea, V / Cervellera, M / Tonini, V

    Digestive diseases and sciences

    2021  Volume 66, Issue 9, Page(s) 2876–2880

    MeSH term(s) Aged, 80 and over ; Anti-Bacterial Agents/administration & dosage ; Clinical Decision-Making/methods ; Conservative Treatment/methods ; Diagnosis, Differential ; Digestive System Surgical Procedures/methods ; Diverticulum/complications ; Diverticulum/diagnostic imaging ; Drainage/methods ; Duodenal Diseases/complications ; Duodenal Diseases/diagnostic imaging ; Endoscopy, Digestive System/methods ; Humans ; Intestinal Perforation/diagnosis ; Intestinal Perforation/physiopathology ; Intestinal Perforation/therapy ; Male ; Parenteral Nutrition, Total/methods ; Risk Adjustment/methods ; Risk Assessment ; Rupture, Spontaneous/diagnosis ; Rupture, Spontaneous/physiopathology ; Rupture, Spontaneous/therapy ; Tomography, X-Ray Computed/methods ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-021-07092-1
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  5. Article ; Online: Serial transverse enteroplasty (STEP) in case of short bowel syndrome: did we achieve our goal? A systematic review.

    Lauro, A / Santoro, A / Cirocchi, R / Michelini, M / Zorzetti, N / Cianci, M C / Bellini, M I / Casadei, C / Ripoli, M C / Coletta, R / Khouzam, S / Marino, I R / D'Andrea, V / Morabito, A

    Updates in surgery

    2022  Volume 74, Issue 4, Page(s) 1209–1223

    Abstract: Surveys on Serial Transverse Enteroplasty (STEP) published in international literature (1 January 2003- 31 May 2021) were searched. Articles were included from 17 countries: 1/23 comparative and 22/23 cohort studies. STEP was performed on 308 patients: ... ...

    Abstract Surveys on Serial Transverse Enteroplasty (STEP) published in international literature (1 January 2003- 31 May 2021) were searched. Articles were included from 17 countries: 1/23 comparative and 22/23 cohort studies. STEP was performed on 308 patients: pediatrics, adults, and mixed ages. Pediatric group included 16 studies and the adult 6. Pre-STEP residual small bowell (SB) length for pediatrics and adults ranged from 18 to 26 cm and from 30 to 70 cm, respectively. Post-STEP increased SB length for pediatrics and adults ranged between 42 and 100% and 50% and 176%, respectively. For pediatrics, enteral autonomy was reached in 32.22% of cases, parenteral nutrition (PN) dependence was 36.11%, a repeated STEP procedure (Re-STEP) was needed in 17.22%, and a bowel transplant was performed in 6.11%. In adults, enteral autonomy was achieved in 52.38%, while PN dependence was 37.1%, and no Re-STEP or transplantation were required. For the mixed group, post-STEP bowel length increased from 2 to 50 cm, enteral autonomy was obtained in 43%, PN dependence was 57%, without reported Re-STEP or transplantation. Mortality rates were between 5.55% (pediatric) and 7.14% (adults). Preoperative length with preservation of ileocecal valve represented the main predictive factors to achieve enteral autonomy.
    MeSH term(s) Adult ; Child ; Digestive System Surgical Procedures/methods ; Goals ; Humans ; Parenteral Nutrition ; Retrospective Studies ; Short Bowel Syndrome/surgery ; Treatment Outcome
    Language English
    Publishing date 2022-07-08
    Publishing country Italy
    Document type Journal Article ; Systematic Review
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-022-01316-3
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  6. Article ; Online: Duodenal Follicular Lymphoma: Track or Treat?

    Varanese, M / Lauro, A / Lattina, I / Tripodi, D / Daralioti, T / Khouzam, S / Marino, I R / Stigliano, V / D'Andrea, V / Frattaroli, S / Sorrenti, S

    Digestive diseases and sciences

    2022  Volume 67, Issue 5, Page(s) 1733–1738

    Abstract: Duodenal follicular lymphoma (DFL) is a rare variety of non-Hodgkin's lymphoma of the gastrointestinal tract that usually carries a favorable course, recognized as a new entity in 2016. It is usually diagnosed at an early stage located predominantly in ... ...

    Abstract Duodenal follicular lymphoma (DFL) is a rare variety of non-Hodgkin's lymphoma of the gastrointestinal tract that usually carries a favorable course, recognized as a new entity in 2016. It is usually diagnosed at an early stage located predominantly in the second portion of the duodenum. We report the case of a 74-year-old male patient with epigastric pain in whom gastroscopy revealed white mucosal nodules that were pathologically diagnosed as grade 1-2 DFL. Staging investigations revealed secondary lesions in the spleen and at the base of the tongue together with latero-cervical adenopathy. The tumor was stage IV according to the Lugano staging system. We reviewed the recent (last five years) literature defining the importance of combination therapy in the advanced stage. The patient achieved complete remission of the disease through chemoimmunotherapy following the Rituximab-Bendamustine scheme.
    MeSH term(s) Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Duodenum/pathology ; Humans ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/drug therapy ; Lymphoma, Follicular/pathology ; Lymphoma, Non-Hodgkin ; Male ; Remission Induction ; Rituximab/therapeutic use
    Chemical Substances Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-022-07498-5
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  7. Article ; Online: Destiny for Rendezvous: Is Cholecysto/Choledocholithiasis Better Treated with Dual- or Single-Step Procedures?

    Vaccari, S / Minghetti, M / Lauro, A / Bellini, M I / Ussia, A / Khouzam, S / Marino, I R / Cervellera, M / D'Andrea, V / Tonini, V

    Digestive diseases and sciences

    2022  Volume 67, Issue 4, Page(s) 1116–1127

    Abstract: Biliary lithiasis is common worldwide, affecting almost 20% of the general population, though few experience symptoms. The frequency of choledocholithiasis in patients with symptomatic cholelithiasis is estimated to be 10-33%, depending on patients' age. ...

    Abstract Biliary lithiasis is common worldwide, affecting almost 20% of the general population, though few experience symptoms. The frequency of choledocholithiasis in patients with symptomatic cholelithiasis is estimated to be 10-33%, depending on patients' age. Unlike gallbladder lithiasis, the medical and surgical treatment of common bile duct stones is uncertain, having changed over the last few years. The prior gold standard treatment for cholelithiasis and choledocholithiasis was open cholecystectomy with bile duct clearance, choledochotomy, and/or surgical sphincterotomy. In the last 10-15 years, new treatment approaches to the complex pathology of choledocholithiasis have emerged with the advent of endoscopic retrograde cholangiopancreatography (ERCP), laparoscopic surgery, and advanced diagnostic procedures. Although ERCP followed by laparoscopic cholecystectomy is the preferred mode of management, a single-step strategy (laparo-endoscopic rendezvous) has gained acceptance due to lesser morbidity and a lower risk of iatrogenic damage. Given the above, a tailored approach relying on careful evaluation of the disease is necessary in order to minimize complication risks and overall costs. Yet, the debate remains open, with no consensus on the superiority of laparo-endoscopic rendezvous to more conventional approaches.
    MeSH term(s) Cholangiopancreatography, Endoscopic Retrograde ; Cholecystectomy, Laparoscopic/adverse effects ; Cholecystectomy, Laparoscopic/methods ; Choledocholithiasis/diagnostic imaging ; Choledocholithiasis/surgery ; Gallstones/complications ; Humans
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-022-07450-7
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  8. Article ; Online: Giant Pelvic Schwannoma: Case Report and Review of the Literature.

    Colecchia, L / Lauro, A / Vaccari, S / Pirini, M G / D'Andrea, V / Marino, I R / Buia, F / Cervellera, M / Tonini, V

    Digestive diseases and sciences

    2020  Volume 65, Issue 5, Page(s) 1315–1320

    Abstract: Introduction: Pelvic schwannomas are rare, mostly benign tumors. They are usually asymptomatic until their massive growth compresses adjacent organs. We describe the case of a 53-year-old man with a pelvic schwannoma who initially complained of ... ...

    Abstract Introduction: Pelvic schwannomas are rare, mostly benign tumors. They are usually asymptomatic until their massive growth compresses adjacent organs. We describe the case of a 53-year-old man with a pelvic schwannoma who initially complained of constipation and urinary retention.
    Areas covered: We analyzed the clinical presentation, histopathology, diagnostic imaging tools, and the treatment options for pelvic schwannomas, compared with the few other cases reported in the literature.
    Expert commentary: Pelvic schwannomas are masses that can grow to considerable size, producing symptoms over time. Due to their size and localization, surgery, although difficult, is the only available treatment.
    MeSH term(s) Humans ; Male ; Middle Aged ; Neurilemmoma/pathology ; Pelvic Neoplasms/pathology
    Language English
    Publishing date 2020-02-08
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-020-06128-2
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  9. Article ; Online: Two's a Charm: Endoscopic Therapy of Multiple Pancreatic Pseudocysts.

    Minghetti, M / Lauro, A / Pagano, N / Vaccari, S / D'Andrea, V / Marino, I R / Cervellera, M / Tonini, V

    Digestive diseases and sciences

    2019  Volume 65, Issue 1, Page(s) 66–70

    Abstract: Pancreatic pseudocysts commonly complicate acute pancreatitis. They can evolve either asymptomatically or with important symptoms. Treatment can be surgical, endoscopic, or percutaneous. The authors present a case report of a 78-year-old man who ... ...

    Abstract Pancreatic pseudocysts commonly complicate acute pancreatitis. They can evolve either asymptomatically or with important symptoms. Treatment can be surgical, endoscopic, or percutaneous. The authors present a case report of a 78-year-old man who developed symptoms of an acute abdomen during hospitalization. A CT scan showed two pancreatic pseudocysts (diameters 10 cm and 7.5 cm) that were successfully drained endoscopically. Multiple pancreatic pseudocysts can be treated successfully via an endoscopic approach.
    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Drainage/instrumentation ; Drainage/methods ; Endoscopy, Digestive System/instrumentation ; Enterobacter/isolation & purification ; Humans ; Male ; Pancreatic Pseudocyst/diagnostic imaging ; Pancreatic Pseudocyst/microbiology ; Pancreatic Pseudocyst/therapy ; Pseudomonas aeruginosa/isolation & purification ; Stents ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-11-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-019-05947-2
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  10. Article ; Online: The Great View Forward: The Use of a Colonoscope for Distal Duodenal Stent Placement.

    Minervini, A / Lauro, A / Pagano, N / Vaccari, S / D'Andrea, V / Marino, I R / Cervellera, M / Tonini, V

    Digestive diseases and sciences

    2019  Volume 64, Issue 9, Page(s) 2445–2448

    Abstract: Introduction: Stent placement in the distal duodenum can be difficult. We describe a case report of a 94-year-old man with metastatic pancreatic head cancer compressing the third and fourth portions of the duodenum, treated by endoscopic stent placement ...

    Abstract Introduction: Stent placement in the distal duodenum can be difficult. We describe a case report of a 94-year-old man with metastatic pancreatic head cancer compressing the third and fourth portions of the duodenum, treated by endoscopic stent placement using a colonoscope.
    Areas covered: A literature review highlighted two possible procedures for stent placement in the distal duodenum, namely forward-viewing and side-viewing endoscopies. Gastroscopes, duodenoscopes, enteroscopes, and colonoscopes have all been suggested for the purpose. For distal lesions, especially when the duodenal wall is stiffened due to compression or infiltration by neoplastic lesions, a conventional upper endoscope can be too short to reach the narrowed site in "push mode," necessitating the use of a longer endoscope.
    Expert commentary: A colonoscope can be safely and effectively used to accomplish distal duodenal stent placement.
    MeSH term(s) Aged, 80 and over ; Colonoscopes ; Duodenal Diseases/etiology ; Duodenal Diseases/surgery ; Duodenoscopy/instrumentation ; Humans ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Male ; Palliative Care ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/secondary ; Prosthesis Implantation/instrumentation ; Self Expandable Metallic Stents
    Language English
    Publishing date 2019-08-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-019-05768-3
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