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  1. Article ; Online: HCC in the Middle East.

    Marino, Ignazio R

    Journal of gastrointestinal cancer

    2022  Volume 54, Issue 2, Page(s) 323–324

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/therapy ; Liver Neoplasms/diagnosis ; Liver Neoplasms/epidemiology ; Liver Neoplasms/therapy ; Risk Factors ; Middle East/epidemiology
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-022-00848-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2184: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Living Kidney Donor Transplantation and Global Kidney Exchange.

    Marino, Ignazio R / Roth, Alvin E / Rees, Michael A

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2022  Volume 20, Issue Suppl 4, Page(s) 5–9

    Abstract: Global kidney exchange offers an opportunity to expand living donor kidney transplants internationally to patients with immunologic barriers. The concept has been proven to be successful in a limited number of transplants. However, a number of ... ...

    Abstract Global kidney exchange offers an opportunity to expand living donor kidney transplants internationally to patients with immunologic barriers. The concept has been proven to be successful in a limited number of transplants. However, a number of misconceptions have created obstacles to its development. We suggest that a systematic application of this innovative tool would offer opportunities to treat thousands of patients worldwide who are presently denied a transplant and often even access to dialysis.
    MeSH term(s) Humans ; Kidney ; Kidney Transplantation ; Living Donors ; Renal Dialysis ; Treatment Outcome
    Language English
    Publishing date 2022-08-26
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.DonorSymp.2022.L12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6632: Show issues Location:
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  3. Article ; Online: Criminal, Legal, and Ethical Kidney Donation and Transplantation: A Conceptual Framework to Enable Innovation.

    Roth, Alvin E / Marino, Ignazio R / Krawiec, Kimberly D / Rees, Michael A

    Transplant international : official journal of the European Society for Organ Transplantation

    2022  Volume 35, Page(s) 10551

    MeSH term(s) Criminals ; Humans ; Iran ; Kidney ; Living Donors/ethics ; Tissue and Organ Harvesting
    Language English
    Publishing date 2022-06-24
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2022.10551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2358: Show issues Location:
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  4. Article ; Online: Pediatric Liver Transplantation: Long-Term Follow-Up Issues.

    Bellini, Maria Irene / Lauro, Augusto / D'Andrea, Vito / Marino, Ignazio R

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2022  Volume 20, Issue Suppl 3, Page(s) 27–35

    Abstract: Pediatric liver transplant is an established life-saving procedure for children with end-stage liver diseases, achieving excellent graft and patient survival but with effects on quality of life and psychological welfare in the long-term. With the natural ...

    Abstract Pediatric liver transplant is an established life-saving procedure for children with end-stage liver diseases, achieving excellent graft and patient survival but with effects on quality of life and psychological welfare in the long-term. With the natural increase in the number of pediatric transplant patients becoming adults, it is essential to successfully plan and manage issues affecting late outcomes in the vulnerable pediatric transplant population. This study offers an overview of the long-term surgical complications, the consequences of immunosuppression (such as posttransplant diabetes, hypertension, cardiovascular disease, and renal dysfunction), and the infection and malignancy risks. Finally, because quality of life is now an inclusive measurement of patient satisfaction, guidance on how to facilitate the transition to adulthood, empowering transplant recipients, is also provided.
    MeSH term(s) Adult ; Child ; Follow-Up Studies ; Graft Survival ; Humans ; Immunosuppression Therapy ; Liver Transplantation/methods ; Quality of Life ; Treatment Outcome
    Language English
    Publishing date 2022-05-15
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.PediatricSymp2022.L16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6632: Show issues Location:
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  5. Article ; Online: Benign Hepatic Tumors and Liver Transplantation: A Literature Review.

    Bellini, Maria Irene / Lauro, Augusto / D'Andrea, Vito / Marino, Ignazio R

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2022  Volume 20, Issue 3, Page(s) 231–236

    Abstract: Management of benign liver tumors represents still an open debate, with no clear guidelines for patient selection,treatment options, and indications to surgical intervention. Usually, most of these diseases are conservatively treated, in view of their ... ...

    Abstract Management of benign liver tumors represents still an open debate, with no clear guidelines for patient selection,treatment options, and indications to surgical intervention. Usually, most of these diseases are conservatively treated, in view of their low potential malignancy and incidental diagnosis. However, when the lesions are symptomatic, with a major hepatic parenchyma involvement or life-threatening complications, liver transplant represents the only curative option. The scope of this review is to present an up-to-date state of the art of transplantable benign hepatic neoplasms.
    MeSH term(s) Humans ; Liver Neoplasms/therapy ; Liver Transplantation/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2022-01-03
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.2021.0447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6632: Show issues Location:
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  6. Article ; Online: Update on Chronic Rejection After Intestinal Transplant: An Overview From Experimental Settings to Clinical Outcomes.

    Lauro, Augusto / Marino, Ignazio R

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2019  Volume 17, Issue Suppl 1, Page(s) 18–30

    Abstract: Chronic rejection affects the long-term survival of solid-organ transplants, accounting for an incidence of between 5% and 10% after intestinal/multivisceral transplant. Because of unclear symptoms and signs and endoscopic findings, the diagnosis is ... ...

    Abstract Chronic rejection affects the long-term survival of solid-organ transplants, accounting for an incidence of between 5% and 10% after intestinal/multivisceral transplant. Because of unclear symptoms and signs and endoscopic findings, the diagnosis is often delayed. Presently, allograft removal represents the only available therapy due to the absence of effective pharmacologic approaches. Extensive research, through animal models, has been performed over the past 20 years to clarify the complex immune- and nonimmune-mediated mechanisms behind the development of chronic allograft enteropathy, with the aim of elucidating how to avert chronic rejection. The role of donor-specific antibodies and the way to challenge them in the clinic have gained acceptance among transplant centers as one of the main steps to prevent chronic rejection, although no common protocol exists that can be applied in a systematic fashion. The adjunct of a liver graft when retrans planting is needed in a sensitized recipient due to its protective effect against humoral immunity. Multicenter studies and clinical trials are required to better understand the pathogenesis of chronic rejection and to find the therapeutic answer to this clinical query.
    MeSH term(s) Animals ; Chronic Disease ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Graft Survival/drug effects ; HLA Antigens/immunology ; Histocompatibility ; Humans ; Immunosuppressive Agents/therapeutic use ; Intestines/drug effects ; Intestines/immunology ; Intestines/transplantation ; Isoantibodies/immunology ; Models, Animal ; Organ Transplantation/adverse effects ; Risk Factors ; Time Factors ; Treatment Outcome
    Chemical Substances HLA Antigens ; Immunosuppressive Agents ; Isoantibodies
    Language English
    Publishing date 2019-02-19
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.MESOT2018.L32
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6632: Show issues Location:
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  7. Article ; Online: GRG profiles: Professor Ignazio Marino.

    Marino, Ignazio R

    Digestive diseases and sciences

    2014  Volume 59, Issue 9, Page(s) 2033–2035

    MeSH term(s) History, 20th Century ; History, 21st Century ; Italy ; Liver Transplantation/history ; Politics ; United States
    Language English
    Publishing date 2014-08-22
    Publishing country United States
    Document type Autobiography ; Historical Article ; Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-014-3301-5
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    Ui V Zs.35: Show issues Location:
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  8. Article: Surgeon's perspective on short bowel syndrome: Where are we?

    Marino, Ignazio R / Lauro, Augusto

    World journal of transplantation

    2018  Volume 8, Issue 6, Page(s) 198–202

    Abstract: Short bowel syndrome (SBS) is due to a massive loss of small bowel: the reduction of gut function is below the minimum necessary to maintain health (in adults) and growth (in children) so intravenous supplementation is required. Parenteral nutrition ... ...

    Abstract Short bowel syndrome (SBS) is due to a massive loss of small bowel: the reduction of gut function is below the minimum necessary to maintain health (in adults) and growth (in children) so intravenous supplementation is required. Parenteral nutrition represents the milestone of treatment and surgical attempts should be limited only when the residual bowel is sufficient to increase absorption, reducing diarrhea and slowing the transit time of nutrients, water and electrolytes. The surgical techniques lengthen the bowel (tapering it) or reverse a segment of it: developed in children, nowadays are popular also among adults. The issue is mainly represented by the residual length of the small bowel where ileum has shown increased adaptive function than jejunum, but colon should be considered because of its importance in the digestive process. These concepts have been translated also in intestinal transplantation, where a colonic graft is nowadays widely used and the terminal ileum is the selected segment for a living-related donation. The whole replacement by a bowel or multivisceral transplant is still affected by poor long term outcome and must be reserved to a select population of SBS patients, affected by intestinal failure associated with irreversible complications of parenteral nutrition.
    Language English
    Publishing date 2018-06-30
    Publishing country United States
    Document type Editorial
    ISSN 2220-3230
    ISSN 2220-3230
    DOI 10.5500/wjt.v8.i6.198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Autocrine IGF-II-Associated Cancers: From a Rare Paraneoplastic Event to a Hallmark in Malignancy.

    Scalia, Pierluigi / Marino, Ignazio R / Asero, Salvatore / Pandini, Giuseppe / Grimberg, Adda / El-Deiry, Wafik S / Williams, Stephen J

    Biomedicines

    2023  Volume 12, Issue 1

    Abstract: The paraneoplastic syndrome referred in the literature as non-islet-cell tumor hypoglycemia (NICTH) and extra-pancreatic tumor hypoglycemia (EPTH) was first reported almost a century ago, and the role of cancer-secreted IGF-II in causing this blood ... ...

    Abstract The paraneoplastic syndrome referred in the literature as non-islet-cell tumor hypoglycemia (NICTH) and extra-pancreatic tumor hypoglycemia (EPTH) was first reported almost a century ago, and the role of cancer-secreted IGF-II in causing this blood glucose-lowering condition has been widely established. The landscape emerging in the last few decades, based on molecular and cellular findings, supports a broader role for IGF-II in cancer biology beyond its involvement in the paraneoplastic syndrome. In particular, a few key findings are constantly observed during tumorigenesis, (a) a relative and absolute increase in fetal insulin receptor isoform (IR
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12010040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: New Developments in Orthotopic Liver Transplant for Hepatocellular Carcinoma.

    Marino, Ignazio R / Carr, Brian I

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2017  Volume 15, Issue Suppl 2, Page(s) 1–6

    Abstract: The use of orthotopic liver transplant for hepatocellular carcinoma was a major advance, pioneered by Thomas E. Starzl as a way to circumvent the limitations imposed on the liver surgeon by the presence of cirrhosis and liver failure. Patients with a few ...

    Abstract The use of orthotopic liver transplant for hepatocellular carcinoma was a major advance, pioneered by Thomas E. Starzl as a way to circumvent the limitations imposed on the liver surgeon by the presence of cirrhosis and liver failure. Patients with a few small tumors, whatever their degree of liver damage, may expect prolonged survival (70% at 5 years). Patients with more advanced tumors have high recurrence rates and more limited survival, possibly due to immune suppression or pretransplant understaging of their tumors. Another possibility is that patients with micrometastases have a longer survival time, during which the metastases eventually become evident. Recent advances include the identification of patients using levels of tumor markers to allow more careful patient selection with better outcomes. The contributions of molecular signatures and the new, effective antiviral agents are possibly significant.
    MeSH term(s) Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Biopsy ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/secondary ; Carcinoma, Hepatocellular/surgery ; Combined Modality Therapy ; Humans ; Liver Neoplasms/blood ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Liver Transplantation/adverse effects ; Liver Transplantation/methods ; Molecular Diagnostic Techniques ; Neoplasm Micrometastasis ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Patient Selection ; Risk Factors ; Treatment Outcome ; Tumor Burden
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2017-03
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.TOND16.L2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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