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  1. Article: Preoperative and Postoperative Kinesiophobia Influences Postoperative Outcome Measures Following Anterior Cruciate Ligament Reconstruction: A Prospective Study.

    Longo, Umile Giuseppe / Marino, Martina / Rizzello, Giacomo / De Salvatore, Sergio / Piergentili, Ilaria / Denaro, Vincenzo

    Journal of clinical medicine

    2023  Volume 12, Issue 14

    Abstract: The anterior cruciate ligament (ACL) is the most injured ligament of the knee, and the treatment of choice is usually ACL reconstruction. Kinesiophobia refers to an irrational and paralyzing fear of movement caused by the feeling of being prone to injury ...

    Abstract The anterior cruciate ligament (ACL) is the most injured ligament of the knee, and the treatment of choice is usually ACL reconstruction. Kinesiophobia refers to an irrational and paralyzing fear of movement caused by the feeling of being prone to injury or reinjury. The aim of the present study is to evaluate the relationship between preoperative and postoperative kinesiophobia with postoperative outcomes of ACL-R evaluated through SF-36, ACL-RSI, KOOS, and OKS scores. Included patients all underwent ACL reconstruction. The preoperative TSK-13 questionnaire and six-month postoperative TSK-13, ACL-RSI, SF-36, KOOS, and OKS questionnaires were assessed in included patients. Normal distribution was assessed using the Shapiro-Wilk test. The study included 50 patients who filled out the questionnaires at the 6-month postoperative follow-up. Correlations between preoperative TSK-13 and postoperative outcome measures revealed a low-moderate negative correlation between preoperative TSK-13 and SF-36 PCS at 6-month follow-up. Correlations between postoperative TSK-13 and postoperative outcome measures revealed a high negative correlation between preoperative TSK-13 and ACL-RSI, KOOS Symptoms, KOOS Pain, KOOS ADL, and OKS at 6-month follow-up. Preoperative and postoperative kinesiophobia were found to influence postoperative ACL-R outcomes negatively, more specifically an increase in kinesiophobia showed a statistically significant correlation with worse postoperative SF-36 PCS scores in patients.
    Language English
    Publishing date 2023-07-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12144858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Performance Evaluation of an Immersive Virtual Reality Application for Rehabilitation after Arthroscopic Rotator Cuff Repair.

    Carnevale, Arianna / Mannocchi, Ilaria / Schena, Emiliano / Carli, Marco / Sassi, Mohamed Saifeddine Hadj / Marino, Martina / Longo, Umile Giuseppe

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 11

    Abstract: Few studies have evaluated the effectiveness of shoulder rehabilitation in virtual environments. The objective of this study was to investigate the performance of a custom virtual reality application (VR app) with a stereophotogrammetric system ... ...

    Abstract Few studies have evaluated the effectiveness of shoulder rehabilitation in virtual environments. The objective of this study was to investigate the performance of a custom virtual reality application (VR app) with a stereophotogrammetric system considered the gold standard. A custom VR app was designed considering the recommended rehabilitation exercises following arthroscopic rotator cuff repair. Following the setting of the play space, the user's arm length, and height, five healthy volunteers performed four levels of rehabilitative exercises. Results for the first and second rounds of flexion and abduction displayed low total mean absolute error values and low numbers of unmet conditions. In internal and external rotation, the number of times conditions were not met was slightly higher; this was attributed to a lack of isolated shoulder movement. Data is promising, and volunteers were able to reach goal conditions more often than not. Despite positive results, more literature comparing VR applications with gold-standard clinical parameters is necessary. Nevertheless, results contribute to a body of literature that continues to encourage the application of VR to shoulder rehabilitation programs.
    Language English
    Publishing date 2023-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10111305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Influence of Depression and Sleep Quality on Postoperative Outcomes after Total Hip Arthroplasty: A Prospective Study.

    Longo, Umile Giuseppe / De Salvatore, Sergio / Greco, Alessandra / Marino, Martina / Santamaria, Giulia / Piergentili, Ilaria / De Marinis, Maria Grazia / Denaro, Vincenzo

    Journal of clinical medicine

    2022  Volume 11, Issue 13

    Abstract: The trend of Total Hip Arthroplasty (THA) is projected to grow. Therefore, it has become imperative to find new measures to improve the outcomes of THA. Several studies have focused attention on the influence of psychological factors and sleep quality on ...

    Abstract The trend of Total Hip Arthroplasty (THA) is projected to grow. Therefore, it has become imperative to find new measures to improve the outcomes of THA. Several studies have focused attention on the influence of psychological factors and sleep quality on surgical outcomes. The consequences of depressive states may affect outcomes and also interfere with rehabilitation. In addition, sleep quality may be an essential factor in determining surgical outcomes. To our knowledge, few articles focus on the influence of these factors on THA results. The present study investigates a possible correlation between preoperative depression or sleep quality and postoperative outcomes of THA. This study was conducted with 61 consecutive patients undergoing THA from January 2020 to January 2021. Patients were assessed preoperatively using GDS and PSQI, and six months postoperatively using FJS-12, SF-36, WOMAC, PSQI, and GDS. To simplify comparisons, the overall scores were normalized to range from 0 (worst condition) to 100 points (best condition). A total of 37 patients (60.7%) were classified as depressed and 24 as not depressed (39.3 %) in the preoperative assessment. A low-moderate positive correlation between preoperative GDS score and FJS-12 (rho = 0.22,
    Language English
    Publishing date 2022-07-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11133845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exploring the association between specific genes and the onset of idiopathic scoliosis: a systematic review.

    De Salvatore, Sergio / Ruzzini, Laura / Longo, Umile Giuseppe / Marino, Martina / Greco, Alessandra / Piergentili, Ilaria / Costici, Pier Francesco / Denaro, Vincenzo

    BMC medical genomics

    2022  Volume 15, Issue 1, Page(s) 115

    Abstract: Background: Idiopathic Scoliosis (IS) is the most common spinal deformity in adolescents, accounting for 80% of all spinal deformities. However, the etiology remains uncertain in most cases, being identified as Adolescent Idiopathic Scoliosis (AIS). IS ... ...

    Abstract Background: Idiopathic Scoliosis (IS) is the most common spinal deformity in adolescents, accounting for 80% of all spinal deformities. However, the etiology remains uncertain in most cases, being identified as Adolescent Idiopathic Scoliosis (AIS). IS treatments range from observation and sport to bracing or surgery. Several risk factors including sex and familiarity, have been linked with IS. Although there are still many uncertainties regarding the cause of this pathology, several studies report a greater incidence of the defect in families in which at least one other first degree relative is affected. This study systematically reviews the available literature to identify the most significant genes or variants related to the development and onset of IS.
    Methods: The research question was formulated using a PIOS approach on the following databases: Medline, Embase, Cinahl, Scopus, Web of Science and Google Scholar. The search was performed from July to August 2021, and articles from the inception of the database to August 2021 were searched.
    Results: 24 of the 919 initially identified studies were included in the present review. The 24 included studies observed a total of 16,316 cases and 81,567 controls. All the considered studies stated either the affected gene and/or specific SNPs. CHD7, SH2B1, ESR, CALM1, LBX1, MATN1, CHL1, FBN1 and FBN2 genes were associated with IS development.
    Conclusions: Although association can be found in some candidate genes the field of research regarding genetic association with the onset of IS still requires more information.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adolescent ; Humans ; Polymorphism, Single Nucleotide ; Scoliosis/genetics ; Scoliosis/surgery
    Chemical Substances Adaptor Proteins, Signal Transducing ; SH2B1 protein, human
    Language English
    Publishing date 2022-05-19
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2411865-5
    ISSN 1755-8794 ; 1755-8794
    ISSN (online) 1755-8794
    ISSN 1755-8794
    DOI 10.1186/s12920-022-01272-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Supervised versus unsupervised rehabilitation following total knee arthroplasty: A systematic review and meta-analysis.

    Bravi, Marco / Longo, Umile Giuseppe / Laurito, Andrea / Greco, Alessandra / Marino, Martina / Maselli, Mirella / Sterzi, Silvia / Santacaterina, Fabio

    The Knee

    2022  Volume 40, Page(s) 71–89

    Abstract: Background: Outcomes after total knee arthroplasty (TKA) are strongly influenced by the adequacy of rehabilitation and the consequent functional recovery. The economic impact of rehabilitation it is not negligible. Inpatient rehabilitation can be 5 to ... ...

    Abstract Background: Outcomes after total knee arthroplasty (TKA) are strongly influenced by the adequacy of rehabilitation and the consequent functional recovery. The economic impact of rehabilitation it is not negligible. Inpatient rehabilitation can be 5 to 26 times more expensive than the home-based rehabilitation. This topic is extremely relevant as the COVID-19 pandemic has highlighted the importance of unsupervised rehabilitation in orthopedic surgery. The aim of this review and meta-analysis is to investigate the scientific evidence regarding the comparison between supervised and unsupervised rehabilitation following TKA.
    Materials and methods: Following PRISMA guideline, a comprehensive search of PubMed, Cochrane and Scopus databases using combinations of keywords and MeSH descriptors: "total "Knee replacement," "Arthroplasty", "Rehabilitation" was performed from inception to December 2021. All relevant articles were retrieved, and their bibliographies were searched for further relevant references. Only English written randomized controlled trials comparing supervised and unsupervised rehabilitation following TKA were included in this systematic review. The outcomes considered were long-term pain, physical function, knee flexion and extension ROM, 6 minute walking test (6MWT) and timed up and go test (TUG).
    Results: 11 studies (2.181 patients in total) were included in this systematic review. The long-term pain outcome showed no significant differences (Std. Mean Difference [SMD] = 0.00, 95 % confidence interval [CI] -0.16, 0.017) between the supervised (n = 397) and unsupervised (n = 255). Physical function showed no significant differences among the two groups (mean difference [MD] = 0.84, 95 % CI = -1.82, 3.50). Non-significant differences were also found for knee ROM flexion (mean difference [MD] = -0.46, 95 % CI = -2.95, 2.04) and for knee extension (mean difference [MD] = 0.54, 95 % CI = -0.89, 1.97). At the 52-week follow-up, the unsupervised group showed significant better results in 6MWT (mean difference [MD] = -26.10, 95 % CI = -47.62, -4.59) and in Timed up and go test (mean difference [MD] = 1.33, 95 % CI = 0.50, 2.15).
    Conclusion: This systematic review did not show a significant clinical difference in improving pain, function, and mobility outcomes after TKA between supervised PT and unsupervised PT. Therefore, it would appear that supervised rehabilitation did not had additional benefits compared to unsupervised rehabilitation.
    MeSH term(s) Humans ; Arthroplasty, Replacement, Knee/rehabilitation ; Postural Balance ; Pandemics ; COVID-19 ; Time and Motion Studies ; Pain
    Language English
    Publishing date 2022-11-18
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 1200476-5
    ISSN 1873-5800 ; 0968-0160
    ISSN (online) 1873-5800
    ISSN 0968-0160
    DOI 10.1016/j.knee.2022.11.013
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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Prenatal Diagnosis of Clubfoot: Where Are We Now? Systematic Review and Meta-Analysis.

    Ruzzini, Laura / De Salvatore, Sergio / Longo, Umile Giuseppe / Marino, Martina / Greco, Alessandra / Piergentili, Ilaria / Costici, Pier Francesco / Denaro, Vincenzo

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 12

    Abstract: The primary methods for prenatal diagnosis of Clubfoot are ultrasound (US) and magnetic resonance imaging (MRI). An ultrasound is performed between the 1st trimester and the 28th week of pregnancy and it is reported to be used as a diagnostic method ... ...

    Abstract The primary methods for prenatal diagnosis of Clubfoot are ultrasound (US) and magnetic resonance imaging (MRI). An ultrasound is performed between the 1st trimester and the 28th week of pregnancy and it is reported to be used as a diagnostic method alone or in combination with MRI. So far, an international consensus on the most effective screening method has not been reached. This systematic review and meta-analysis were performed to establish the most effective and reliable exam for prenatal diagnosis of Clubfoot. The literature search was conducted using a PIOS-approach from May 2021 to June 2021. Studies reporting cases of prenatal diagnosis of Clubfoot made through US and MRI conducted from January 2010 to June 2021 were included in the study and reviewed by 2 authors. The 23 selected studies included 2318 patients. A total of 11 of the studies included details on the accuracy, while the rest were used to obtain information about the primary methodology utilized. In all the selected studies, US was used as the primary diagnostic instrument. Thirteen of the studies used the US exclusively, while three used MRI in addition to US and seven performed karyotyping after US diagnosis. The US has been shown to be the instrument of choice for the prenatal diagnosis of Clubfoot. International guidelines for an ultrasonography classification of congenital clubfoot are required to reduce the inter-variability accuracy of this procedure.
    Language English
    Publishing date 2021-11-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11122235
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  7. Article ; Online: The COVID-19 pandemic and management of GIMEMA clinical trials: changes and challenges.

    Piciocchi, Alfonso / Messina, Monica / Soddu, Stefano / La Sala, Edoardo / Paoloni, Francesca / Giuliani, Giorgia / Marino, Martina R / Petrelli, Claudia / Gorreo Renzulli, Livia / Fazi, Paola / Vignetti, Marco

    British journal of haematology

    2020  Volume 190, Issue 4, Page(s) e211–e214

    MeSH term(s) Adult ; COVID-19/epidemiology ; COVID-19/therapy ; Clinical Trials as Topic ; Female ; Humans ; Leukemia/epidemiology ; Leukemia/therapy ; Male ; Multicenter Studies as Topic ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-26
    Publishing country England
    Document type Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16996
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  8. Article: The COVID-19 pandemic and management of GIMEMA clinical trials: changes and challenges

    Piciocchi, Alfonso / Messina, Monica / Soddu, Stefano / La Sala, Edoardo / Paoloni, Francesca / Giuliani, Giorgia / Marino, Martina R / Petrelli, Claudia / Gorreo Renzulli, Livia / Fazi, Paola / Vignetti, Marco

    Br. j. haematol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #629930
    Database COVID19

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  9. Article ; Online: The COVID‐19 pandemic and management of GIMEMA clinical trials

    Piciocchi, Alfonso / Messina, Monica / Soddu, Stefano / La Sala, Edoardo / Paoloni, Francesca / Giuliani, Giorgia / Marino, Martina R. / Petrelli, Claudia / Gorreo Renzulli, Livia / Fazi, Paola / Vignetti, Marco

    British Journal of Haematology

    changes and challenges

    2020  Volume 190, Issue 4

    Keywords Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16996
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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