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  1. Article: Diagnosis and management of pulmonary hypertension related to chronic respiratory disease.

    Krompa, Anastasia / Marino, Philip

    Breathe (Sheffield, England)

    2023  Volume 18, Issue 4, Page(s) 220205

    Abstract: Pulmonary hypertension (PH) is a recognised and significant complication of chronic lung disease (CLD) and hypoxia (referred to as group 3 PH) that is associated with increased morbidity, decreased quality of life and worse survival. The prevalence and ... ...

    Abstract Pulmonary hypertension (PH) is a recognised and significant complication of chronic lung disease (CLD) and hypoxia (referred to as group 3 PH) that is associated with increased morbidity, decreased quality of life and worse survival. The prevalence and severity of group 3 PH varies within the current literature, with the majority of CLD-PH patients tending to have non-severe disease. The aetiology of this condition is multifactorial and complex, while the prevailing pathogenetic mechanisms include hypoxic vasoconstriction, parenchymal lung (and vascular bed) destruction, vascular remodelling and inflammation. Comorbidities such as left heart dysfunction and thromboembolic disease can further confound the clinical picture. Noninvasive assessment is initially undertaken in suspected cases (
    Language English
    Publishing date 2023-01-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0205-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Esposizione al Radon : anche in questo caso è meglio aprire la finestra.

    Del Gaudio, M / Lauro, A / Marino, P

    Igiene e sanita pubblica

    2022  Volume 80, Issue 6, Page(s) 693–702

    Abstract: Although many areas of the Italian territory are of volcanic origin, there is not much attention to the prevention of risks due to exposure to Radon gas. This gas is produced during the decay of uranium present in volcanic rocks and, if inhaled, its ... ...

    Title translation Radon exposure: also in this case it is better to open the window.
    Abstract Although many areas of the Italian territory are of volcanic origin, there is not much attention to the prevention of risks due to exposure to Radon gas. This gas is produced during the decay of uranium present in volcanic rocks and, if inhaled, its further decay produces radioactive radiation responsible for damage to lung tissues. It is estimated that these radiations are responsible for 10% of lung cancers. In conditions of poor air exchange, the concentration of Radon gas can easily reach high concentrations, particularly in underground rooms or on the ground floor that are in direct contact with the ground. In these territories, the designers of new buildings do not always consider this risk and the population is also poorly informed on the behavior to be adopted for prevention.
    MeSH term(s) Air Pollutants, Radioactive/analysis ; Air Pollutants, Radioactive/toxicity ; Air Pollution, Indoor/statistics & numerical data ; Humans ; Italy ; Radon/analysis ; Radon/toxicity
    Chemical Substances Air Pollutants, Radioactive ; Radon (Q74S4N8N1G)
    Language Italian
    Publishing date 2022-02-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3031485-9
    ISSN 0019-1639
    ISSN 0019-1639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pulmonary Hypertension and the Gut Microbiome.

    Mason, Thomas / Mukherjee, Bhashkar / Marino, Philip

    Biomedicines

    2024  Volume 12, Issue 1

    Abstract: The gut microbiome and its associated metabolites are integral to the maintenance of gut integrity and function. There is increasing evidence that its alteration, referred to as dysbiosis, is involved in the development of a systemic conditions such as ... ...

    Abstract The gut microbiome and its associated metabolites are integral to the maintenance of gut integrity and function. There is increasing evidence that its alteration, referred to as dysbiosis, is involved in the development of a systemic conditions such as cardiovascular disease (e.g., systemic hypertension, atherosclerosis). Pulmonary hypertension (PH) is a condition characterised by progressive remodelling and vasoconstriction of the pulmonary circulation, ultimately leading to right ventricular failure and premature mortality if untreated. Initial studies have suggested a possible association between dysbiosis of the microbiome and the development of PH. The aim of this article is to review the current experimental and clinical data with respect to the potential interaction between the gut microbiome and the pathophysiology of pulmonary hypertension. It will also highlight possible new therapeutic targets that may provide future therapies.
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12010169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular phylogeny of the grasshopper family Pyrgomorphidae (Caelifera, Orthoptera) reveals rampant paraphyly and convergence of traditionally used taxonomic characters.

    Zahid, Sundus / Mariño-P Rez, Ricardo / Song, Hojun

    Zootaxa

    2021  Volume 4969, Issue 1, Page(s) 101118

    Abstract: The grasshopper family Pyrgomorphidae is one of the most colorful orthopteran lineages, and includes biologically fascinating and culturally important species. Recent attempts to reconstruct the phylogeny of this family have resulted in a large degree of ...

    Abstract The grasshopper family Pyrgomorphidae is one of the most colorful orthopteran lineages, and includes biologically fascinating and culturally important species. Recent attempts to reconstruct the phylogeny of this family have resulted in a large degree of conflicts between a morphology-based study and a molecular-based study, mainly due to convergent morphological traits that affected phylogenetic reconstruction. In this study, a molecular phylogeny of Pyrgomorphidae based on 32 ingroup species and mitochondrial genome data is proposed, which is used to test the monophyly of the taxonomic groupings used in the current classification scheme. Using the ancestral character state reconstruction analyses and character mapping, we demonstrate that some of the morphological characters, including the male genitalia, which were considered to be taxonomically important, have evolved convergently across the phylogeny. We discuss the discrepancies between our phylogeny and the previous studies and propose an approach to establish a natural classification scheme for Pyrgomorphidae.
    MeSH term(s) Animals ; Genome, Mitochondrial ; Grasshoppers/anatomy & histology ; Grasshoppers/classification ; Male ; Phylogeny
    Language English
    Publishing date 2021-05-10
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.4969.1.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Construction and preliminary validation of a tool to measure the needs of adolescents and young adults (AYA) diagnosed with cancer: the QUestionnaire nEEd Cancer AYAs: QUEEC-AYAs.

    Justafré, S / Marino, P / Touzani, R / Dupeyre-Alvarez, F / Dantin, P / Viens, P / Vey, N / Calvin, S

    Health and quality of life outcomes

    2024  Volume 22, Issue 1, Page(s) 36

    Abstract: Context: In France, 2300 adolescents and young adults (AYAs, 15-25 years old) are diagnosed with cancer each year. As soon as the disease is diagnosed, a number of physical, psychological and social needs may arise. The aim of this study is to develop a ...

    Abstract Context: In France, 2300 adolescents and young adults (AYAs, 15-25 years old) are diagnosed with cancer each year. As soon as the disease is diagnosed, a number of physical, psychological and social needs may arise. The aim of this study is to develop a tool to measure unmet needs that will allow the specificities of AYAs to be understood while allowing health care staff to mobilise the necessary actors to resolve them.
    Methods: We developed the Questionnaire nEEd Cancer AYAs (QUEEC-AYAs questionnaire), from two existing questionnaires: the Cancer Needs Questionnaire Young People and the Needs Assessment & Service Bridge. A main sample of 103 AYAs then received and completed the questionnaire in order to conduct an exploratory factor analysis.
    Results: The final structure of the QUEEC-AYAs is composed of 7 dimensions and 48 items: information (8 items), cancer care team (6 items), Physical health (4 items), Emotional health (14 items), Sexual & reproductive health (6 items), Health behaviors & wellness (4 items), Daily life (6 items). The questionnaire has a good acceptability and all domains have a Cronbach's alphas value above 0.80.
    Conclusion: The QUEEC-AYAs is the first measure of the psychosocial needs of AYAs available in French. Its systematic use in health care services should improve the coordination of care required by AYAs during and after treatment.
    Trial registration: This study was approved by the ethics committee of the Paoli-Calmettes Institute (IRB # IPC 2021-041, 2021 May 20).
    MeSH term(s) Humans ; Surveys and Questionnaires ; Adolescent ; Neoplasms/psychology ; Neoplasms/therapy ; Young Adult ; Female ; Male ; Needs Assessment ; France ; Adult ; Psychometrics ; Reproducibility of Results ; Health Services Needs and Demand ; Quality of Life/psychology
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2098765-1
    ISSN 1477-7525 ; 1477-7525
    ISSN (online) 1477-7525
    ISSN 1477-7525
    DOI 10.1186/s12955-024-02249-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: New targeted therapies in the treatment of pulmonary arterial hypertension: getting to the heart of the problem.

    Marino, Philip

    Respirology (Carlton, Vic.)

    2016  Volume 21, Issue 3, Page(s) 406–407

    Language English
    Publishing date 2016-04
    Publishing country Australia
    Document type Comment ; Editorial
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.12761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4957: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Coût des technologies de séquençage haut débit (NGS) : revue de la littérature et enseignements.

    Bayle, Arnaud / Marino, Patricia / Baffert, Sandrine / Margier, Jennifer / Bonastre, Julia

    Bulletin du cancer

    2023  Volume 111, Issue 2, Page(s) 190–198

    Abstract: Although high-throughput sequencing technologies (Next-Generation Sequencing [NGS]) are revolutionizing medicine, the estimation of their production cost for pricing/tariffication by health systems raises methodological questions. The objective of this ... ...

    Title translation Cost of high-throughput sequencing (NGS) technologies: Literature review and insights.
    Abstract Although high-throughput sequencing technologies (Next-Generation Sequencing [NGS]) are revolutionizing medicine, the estimation of their production cost for pricing/tariffication by health systems raises methodological questions. The objective of this review of cost studies of high-throughput sequencing techniques is to draw lessons for producing robust cost estimates of these techniques. We analyzed, using an eleven item analysis framework, micro-costing studies of high-throughput sequencing technologies (n=17), including two studies conducted in the French context. The factors of variability between the studies that we identified were temporality (early evaluation of the innovation vs. evaluation of a mature technology), the choice of cost evaluation method (scope, micro- vs. gross-costing technique), the choice of production steps observed and the transposability of these studies. The lessons we have learned are that it is necessary to have a comprehensive vision of the sequencing production process by integrating all the steps from the collection of the biological sample to the delivery of the result to the clinician. It is also important to distinguish between what refers to the local context and what refers to the general context, by favouring the use of mixed methods to calculate costs. Finally, sensitivity analyses and periodic re-estimation of the costs of the techniques must be carried out in order to be able to revise the tariffs according to changes linked to the diffusion of the technology and to competition between reagent suppliers.
    MeSH term(s) Humans ; Costs and Cost Analysis ; High-Throughput Nucleotide Sequencing
    Language French
    Publishing date 2023-10-16
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2023.08.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.15: Show issues Location:
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  8. Article ; Online: Prototype of an IoT-Based Low-Cost Sensor Network for the Hydrological Monitoring of Landslide-Prone Areas.

    Marino, Pasquale / Roman Quintero, Daniel Camilo / Santonastaso, Giovanni Francesco / Greco, Roberto

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 4

    Abstract: Steep slopes covered by loose unsaturated pyroclastic deposits widely dispersed in Campania, Southern Italy, are often subjected to shallow landslides that turn into fast debris flows causing a large amount of damage and many casualties, triggered by ... ...

    Abstract Steep slopes covered by loose unsaturated pyroclastic deposits widely dispersed in Campania, Southern Italy, are often subjected to shallow landslides that turn into fast debris flows causing a large amount of damage and many casualties, triggered by heavy and persistent precipitation. The slope of Cervinara, located around 40 km northeast of Naples, was involved in a destructive flowslide between 15 and 16 December 1999, triggered by a rain event of 325 mm in 48 h. Hydrometeorological monitoring activities have been carried out near the landslide scarp of 1999 since 2017 to assess the water balance and to identify major hydrological processes involving the cover and the shallow groundwater system developing in the upper part of the underlying limestone fractured bedrock. Since 1 December 2022, a remotely accessible low-cost network has been installed to expand the field hydrological monitoring. The use of a network of low-cost capacitive sensors, communicating within the domain of Internet of Things (IoT) technology, aiming at dispersed monitoring of soil moisture, has been tested. Specifically, the tested prototype network allows measurements of the soil water content at two different points, communicating through a Wi-Fi-based IoT system using ESP32 boards. The ThingSpeak
    Language English
    Publishing date 2023-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23042299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Measuring the cost of chemotherapy is important, but it is not enough.

    Marino, P

    Annals of oncology : official journal of the European Society for Medical Oncology

    2008  Volume 19, Issue 3, Page(s) 409–410

    MeSH term(s) Antineoplastic Agents/adverse effects ; Antineoplastic Agents/economics ; Breast Neoplasms/drug therapy ; Breast Neoplasms/mortality ; Complementary Therapies/economics ; Cost of Illness ; Cost-Benefit Analysis ; Docetaxel ; Drug Costs ; Humans ; Neutropenia/chemically induced ; Neutropenia/economics ; Paclitaxel/therapeutic use ; Quality of Life ; Quality-Adjusted Life Years ; Survival Analysis ; Taxoids/therapeutic use ; Therapies, Investigational/economics
    Chemical Substances Antineoplastic Agents ; Taxoids ; Docetaxel (15H5577CQD) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2008-01-30
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdn004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2862: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: The promise of glycomics for discovery of new biomarkers.

    Marino, Pamela

    Cancer biomarkers : section A of Disease markers

    2014  Volume 14, Issue 1, Page(s) 1

    MeSH term(s) Biomarkers, Tumor/analysis ; Biomarkers, Tumor/metabolism ; Glycomics/methods ; Glycosylation ; Humans ; Neoplasms/metabolism
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2014-01-24
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2203517-5
    ISSN 1875-8592 ; 1574-0153 ; 1875-8592
    ISSN (online) 1875-8592 ; 1574-0153
    ISSN 1875-8592
    DOI 10.3233/cbm-2014-14101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6127: Show issues Location:
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