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  1. Article ; Online: Risques infectieux après transplantation d’organes solides.

    Kamar, Nassim / Marion, Olivier / Del Bello, Arnaud

    La Revue du praticien

    2024  Volume 73, Issue 9, Page(s) 969–972

    Abstract: INFECTION AFTER SOLID-ORGAN-TRANSPLANTATION. Infections is one the most cause for hospitalization after solid-organ-transplantation. We distinguish donor-derived infections, reactivation of latent infection in recipients, nosocomial infections and ... ...

    Title translation Infectious risks after solid organ transplantation.
    Abstract INFECTION AFTER SOLID-ORGAN-TRANSPLANTATION. Infections is one the most cause for hospitalization after solid-organ-transplantation. We distinguish donor-derived infections, reactivation of latent infection in recipients, nosocomial infections and community infections. The first three types are observed mainly in the early period post-transplantation, while community infections can occur at any time after transplantation. Opportunistic infections and some specific infections should be assessed systematically and rapidly. This often requires invasive diagnostic procedures. Prevention altered the incidence and severity of post-transplant infections. It included vaccination, use of universal prophylaxis, systematic monitoring of some agents after transplantation and safer living.
    MeSH term(s) Humans ; Cross Infection ; Hospitalization ; Postoperative Complications ; Tissue Donors ; Organ Transplantation/adverse effects
    Language French
    Publishing date 2024-01-31
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Can the COVID-19 Pandemic Improve the Management of Solid Organ Transplant Recipients?

    Del Bello, Arnaud / Marion, Olivier / Izopet, Jacques / Kamar, Nassim

    Viruses

    2022  Volume 14, Issue 9

    Abstract: Increased mortality due to SARS-CoV-2 infection was observed among solid organ transplant patients. During the pandemic, in order to prevent and treat COVID-19 infections in this context, several innovative procedures and therapies were initiated within ... ...

    Abstract Increased mortality due to SARS-CoV-2 infection was observed among solid organ transplant patients. During the pandemic, in order to prevent and treat COVID-19 infections in this context, several innovative procedures and therapies were initiated within a short period of time. A large number of these innovations can be applied and expanded to improve the management of non-COVID-19 infectious diseases in solid organ transplant patients and in the case of a future pandemic. In this vein, the present paper reviews and discusses medical care system adaptation, modification of immunosuppression, adjuvant innovative therapies, the role of laboratory expertise, and the prevention of infections as examples of such innovations.
    MeSH term(s) COVID-19/epidemiology ; Humans ; Organ Transplantation/adverse effects ; Organ Transplantation/methods ; Pandemics/prevention & control ; SARS-CoV-2 ; Transplant Recipients
    Language English
    Publishing date 2022-08-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14091860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Réplication du virus de l’hépatite E dans les cellules intestinales - Une nouvelle facette de ce virus dévoilée.

    Izopet, Jacques / Marion, Olivier / Kamar, Nassim / Lhomme, Sébastien

    Medecine sciences : M/S

    2021  Volume 37, Issue 4, Page(s) 320–322

    Title translation Hepatitis E virus replication in intestinal cells: A new facet of this virus revealed.
    MeSH term(s) Acute Disease ; Enterocytes/virology ; Hepatitis E virus/physiology ; Hepatocytes/virology ; Humans ; Virus Replication/physiology
    Language French
    Publishing date 2021-04-28
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2021024
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  4. Article ; Online: Diagnostic and management strategies for chronic hepatitis E infection.

    Abravanel, Florence / Lhomme, Sébastien / Marion, Olivier / Péron, Jean Marie / Kamar, Nassim / Izopet, Jacques

    Expert review of anti-infective therapy

    2023  Volume 21, Issue 2, Page(s) 143–148

    Abstract: Introduction: Hepatitis E Virus (HEV) was initially thought to cause only acute infections, but the discovery of chronic hepatitis E in immunocompromised patients has profoundly changed our understanding of the virus.: Areas covered: We describe the ... ...

    Abstract Introduction: Hepatitis E Virus (HEV) was initially thought to cause only acute infections, but the discovery of chronic hepatitis E in immunocompromised patients has profoundly changed our understanding of the virus.
    Areas covered: We describe the physiopathology, diagnosis, and clinical management of chronic HEV infection. The virus can persist in nearly two-thirds of immunosuppressed patients. Reducing immunosuppression is the first immunomodulatory strategy to cure chronic hepatitis E. But this may not always be feasible or effective. Ribavirin monotherapy for 3 months has been recommended as first-line treatment for chronically infected patients. Ribavirin is around 80% effective at eradicating HEV in retrospective studies. Apart from ribavirin, interferon has been successfully used in liver transplants recipients, but if the patient does not respond, no other alternative drug is available. The vaccine available to prevent HEV infection is one available only in China.
    Expert opinion: HEV infection is a major concern in immunocompromised patients. But the therapeutic arsenal is limited to ribavirin and interferon. Both produce several side effects and new drugs are urgently needed. Moreover, preventive strategies to limit HEV transmission and/or evolution to a chronic infection are also required.
    MeSH term(s) Humans ; Hepatitis E/diagnosis ; Hepatitis E/drug therapy ; Hepatitis E/prevention & control ; Ribavirin/therapeutic use ; Antiviral Agents/therapeutic use ; Persistent Infection ; Retrospective Studies ; Hepatitis E virus ; Interferons ; Immunocompromised Host
    Chemical Substances Ribavirin (49717AWG6K) ; Antiviral Agents ; Interferons (9008-11-1)
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2023.2166932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6106: Show issues Location:
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  5. Article: CAR T-Cell Therapy for Refractory Posttransplantation Lymphoproliferative Disorder in a Kidney Transplant Patient.

    Guy, Pierre / Marion, Olivier / Oberic, Lucie / Darres, Amandine / Cointault, Olivier / Del Bello, Arnaud / Kamar, Nassim

    Transplantation direct

    2024  Volume 10, Issue 3, Page(s) e1584

    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Belatacept Rescue Therapy in the Early Period After Simultaneous Kidney-Pancreas Transplantation.

    Esposito, Laure / Cuellar, Emmanuel / Marion, Olivier / Del Bello, Arnaud / Hebral, Anne Laure / Sallusto, Federico / Muscari, Fabrice / Prudhomme, Thomas / Kamar, Nassim

    Transplant international : official journal of the European Society for Organ Transplantation

    2024  Volume 37, Page(s) 12628

    MeSH term(s) Adult ; Female ; Humans ; Male ; Middle Aged ; Abatacept/therapeutic use ; Graft Rejection/prevention & control ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation ; Pancreas Transplantation
    Chemical Substances Abatacept (7D0YB67S97) ; Immunosuppressive Agents
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article ; Letter
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2024.12628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2358: Show issues Location:
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  7. Article ; Online: Failure of favipiravir to treat chronic norovirus infection in a kidney-transplant patient.

    Darres, Amandine / Del Bello, Arnaud / Marion, Olivier / de Lamballerie, Xavier / Malvy, Denis / Izopet, Jacques / Kamar, Nassim

    Transplant infectious disease : an official journal of the Transplantation Society

    2024  Volume 26, Issue 1, Page(s) e14235

    MeSH term(s) Humans ; Norovirus ; Kidney Transplantation/adverse effects ; Caliciviridae Infections/drug therapy ; Kidney ; Amides ; Pyrazines
    Chemical Substances favipiravir (EW5GL2X7E0) ; Amides ; Pyrazines
    Language English
    Publishing date 2024-01-05
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14235
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    Zs.A 5100: Show issues Location:
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  8. Article: Can the COVID-19 Pandemic Improve the Management of Solid Organ Transplant Recipients?

    Del Bello, Arnaud / Marion, Olivier / Izopet, Jacques / Kamar, Nassim

    Viruses. 2022 Aug. 24, v. 14, no. 9

    2022  

    Abstract: Increased mortality due to SARS-CoV-2 infection was observed among solid organ transplant patients. During the pandemic, in order to prevent and treat COVID-19 infections in this context, several innovative procedures and therapies were initiated within ... ...

    Abstract Increased mortality due to SARS-CoV-2 infection was observed among solid organ transplant patients. During the pandemic, in order to prevent and treat COVID-19 infections in this context, several innovative procedures and therapies were initiated within a short period of time. A large number of these innovations can be applied and expanded to improve the management of non-COVID-19 infectious diseases in solid organ transplant patients and in the case of a future pandemic. In this vein, the present paper reviews and discusses medical care system adaptation, modification of immunosuppression, adjuvant innovative therapies, the role of laboratory expertise, and the prevention of infections as examples of such innovations.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; adjuvants ; immunosuppression ; mortality ; organ transplantation ; pandemic
    Language English
    Dates of publication 2022-0824
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14091860
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Humoral and Cellular Responses to a Delayed Fourth SARS-CoV-2 mRNA-Based Vaccine in Weak Responders to 3 Doses Kidney Transplant Recipients.

    Del Bello, Arnaud / Kamar, Nassim / Marion, Olivier / Izopet, Jacques / Abravanel, Florence

    Vaccines

    2022  Volume 10, Issue 9

    Abstract: While kidney transplant recipients (KTRs) represent a high-risk population for severe SARS-CoV-2 infection, almost half of them do not develop adequate levels of antibodies conferring clinical protection despite 3 doses of the mRNA vaccine. In the ... ...

    Abstract While kidney transplant recipients (KTRs) represent a high-risk population for severe SARS-CoV-2 infection, almost half of them do not develop adequate levels of antibodies conferring clinical protection despite 3 doses of the mRNA vaccine. In the present study we retrospectively analyzed the humoral and cellular responses resulting from a fourth dose of vaccine administered to KTRs having an anti-SARS-CoV-2 antibody titer below 142 binding antibody unit (BAU)/mL at 3 months post-third-dose. We observed a significant increase in anti-SARS-CoV-2 antibody concentration from 6.1 (Q1 4.3; Q3 12.7) BAU/mL on the day of the fourth dose to 1054.0 (Q1 739.6; Q3 1649.0) BAU/mL one month later (
    Language English
    Publishing date 2022-09-01
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10091439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of imlifidase treatment on immunoglobulins in an HLA-hypersensitized lupus nephritis patient with anti-SSA/SSB antibodies after kidney transplantation: A case report.

    Milhès, Jean / Marion, Olivier / Puissant, Benedicte / Carlé, Caroline / Bouthemy, Charlène / Del Bello, Arnaud / Kamar, Nassim / Renaudineau, Yves / Congy-Jolivet, Nicolas

    Journal of translational autoimmunity

    2023  Volume 7, Page(s) 100223

    Abstract: Bacterial recombinant cysteine protease Ides (imlifidase, Idefirix®, Hansa Biopharma) is used to prevent humoral transplant rejection in highly HLA-sensitized recipients, and to control IgG-mediated autoimmune diseases. We report the case of a 51 years ... ...

    Abstract Bacterial recombinant cysteine protease Ides (imlifidase, Idefirix®, Hansa Biopharma) is used to prevent humoral transplant rejection in highly HLA-sensitized recipients, and to control IgG-mediated autoimmune diseases. We report the case of a 51 years old woman suffering from lupus nephritis with end stage kidney disease, grafted for the second time and pre-treated with imlifidase. The patient was HLA-hypersensitized (calculated Panel Reactive Antibodies [Abs], cPRA>99 %) and has three preformed Donor Specific Antibodies (DSA). Circulating immunoglobulins were monitored at initiation (0, 6, 36, 72 and 96 h), and at Ab recovery one and two months following imlifidase injection. From baseline, the higher depletion was reported after 36h for total IgG (-75 %) and IgG subclasses (-87 % for IgG1, IgG2 and IgG3, -78 % for IgG4), while no significant impact on IgA and IgM was observed. Anti-SSA 60 kDa and anti-SSB auto-Abs quickly decreased after imlifidase injection (-96 % for both after 36 h) as well as post-vaccinal specific IgG (-95 % for tetanus toxoid, -97 % for pneumococcus and -91 % for
    Language English
    Publishing date 2023-12-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-9090
    ISSN (online) 2589-9090
    DOI 10.1016/j.jtauto.2023.100223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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