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Article ; Online: Response to "A Caution Against the Use of C5B-9 Endothelial Assay to Support Eculizumab Therapy".

Maritati, Federica / La Manna, Gaetano / Comai, Giorgia

Kidney international reports

2024 Volume 9, Issue 5, Page(s) 1538–1539

Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2024.02.1436
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Article ; Online: IgG4-related disease: advances in pathophysiology and treatment.

Peyronel, Francesco / Fenaroli, Paride / Maritati, Federica / Schleinitz, Nicolas / Vaglio, Augusto

Expert review of clinical immunology

2023 Volume 19, Issue 5, Page(s) 537–547

Abstract: Introduction: IgG4-related disease (IgG4-RD) is a rare fibro-inflammatory disease affecting multiple organs. In recent years basic and translational research has unveiled the role of different cellular subtypes and cytokines in inducing and perpetuating ...

Abstract	Introduction: IgG4-related disease (IgG4-RD) is a rare fibro-inflammatory disease affecting multiple organs. In recent years basic and translational research has unveiled the role of different cellular subtypes and cytokines in inducing and perpetuating the pathological process, eventually leading to fibrosis of affected tissues. Hopefully, the growing knowledge of the disease pathogenesis will lead to patient-tailored treatments in the near future. Areas covered: This review focuses on the most recent discoveries concerning the pathogenic mechanisms underlying IgG4-RD and highlights their potential role as specific therapeutic targets. Expert opinion: IgG4-RD is a systemic and multifaceted disease. Its sensitivity to glucocorticoids is well known, however new targeted therapies are emerging that can reduce glucocorticoid exposure and achieve sustained clinical responses. Clinicians managing patients with such a rare and heterogeneous disease must therefore be aware of its varied phenotype and traditional and novel therapeutic strategies.
MeSH term(s)	Humans ; Immunoglobulin G4-Related Disease ; Immunoglobulin G ; Glucocorticoids/therapeutic use ; Fibrosis
Chemical Substances	Immunoglobulin G ; Glucocorticoids
Language	English
Publishing date	2023-04-06
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2274260-8
ISSN	1744-8409 ; 1744-666X
ISSN (online)	1744-8409
ISSN	1744-666X
DOI	10.1080/1744666X.2023.2195627
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Zs.A 6661: Show issues

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Article ; Online: Into Clinical Practice: Diagnosis and Therapy of Retroperitoneal Fibrosis.

Fenaroli, Paride / Maritati, Federica / Vaglio, Augusto

Current rheumatology reports

2021 Volume 23, Issue 3, Page(s) 18

Abstract: Purpose of the review: We aim to review the most relevant diagnostic features and treatment options of retroperitoneal fibrosis, in order to provide a useful guide for clinical practice.: Recent findings: The recent literature highlights the role of ... ...

Abstract	Purpose of the review: We aim to review the most relevant diagnostic features and treatment options of retroperitoneal fibrosis, in order to provide a useful guide for clinical practice. Recent findings: The recent literature highlights the role of imaging studies such as computed tomography, magnetic resonance imaging and positron emission tomography as useful tools for the diagnosis of retroperitoneal fibrosis, with retroperitoneal biopsy being reserved to atypical cases. The treatment approach is mainly conservative and is based on the use of medical therapies plus urological interventions. Medical therapies essentially comprise glucocorticoids and immunosuppressants-either traditional or biological agents such as rituximab. Surgical ureterolysis is only left for refractory cases. Recent findings in retroperitoneal fibrosis highlight the possibility of a non-invasive diagnostic approach and a conservative treatment strategy.
MeSH term(s)	Glucocorticoids/therapeutic use ; Humans ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Retroperitoneal Fibrosis/diagnostic imaging ; Retroperitoneal Fibrosis/therapy ; Tomography, X-Ray Computed
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057357-1
ISSN	1534-6307 ; 1523-3774
ISSN (online)	1534-6307
ISSN	1523-3774
DOI	10.1007/s11926-020-00966-9
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Zs.A 5531: Show issues

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Article ; Online: Response to: 'Eosinophilic granulomatosis with polyangiitis can manifest lacrimal and salivary glands swelling by granulomatous inflammation: a potential mimicker of IgG4-related disease' by Akiyama

Vaglio, Augusto / Maritati, Federica / Zwerina, Jochen

Annals of the rheumatic diseases

2020 Volume 81, Issue 7, Page(s) e121

MeSH term(s)	Churg-Strauss Syndrome ; Edema ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Humans ; Immunoglobulin G4-Related Disease/complications ; Immunoglobulin G4-Related Disease/diagnosis ; Inflammation ; Salivary Glands
Language	English
Publishing date	2020-06-26
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2020-218174
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Uh III Zs.114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 167: Show issues

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Article ; Online: IgG4-related disease: a clinical perspective.

Maritati, Federica / Peyronel, Francesco / Vaglio, Augusto

Rheumatology (Oxford, England)

2020 Volume 59, Issue Suppl 3, Page(s) iii123–iii131

Abstract: IgG4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory disorder that can affect almost any organ. Common presentations include major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal ... ...

Abstract	IgG4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory disorder that can affect almost any organ. Common presentations include major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal fibrosis and tubulointerstitial nephritis. The main histopathological features are a dense, polyclonal, lymphoplasmacytic infiltrate rich in IgG4+ plasma cells, storiform fibrosis and obliterative phlebitis. The precise pathogenic mechanisms of IgG4-RD are still unclear. CD4+ T and B cells, including IgG4-expressing plasmablasts, constitute the major inflammatory cell populations and are believed to cause organ damage and tissue fibrosis. The diagnosis of the disease may be challenging and should be based on specific histopathological findings, typical laboratory and radiological aspects and an appropriate clinical context. The first-line treatment of IgG4-RD is based on glucocorticoids, which are usually efficacious. However, B cell depletion induced by rituximab has also been found to induce remission in steroid-resistant disease or has been used as steroid-sparing agent for relapsing disease. This review provides an update on clinical and therapeutic aspects of IgG4-RD.
MeSH term(s)	Humans ; Immunoglobulin G4-Related Disease/diagnosis ; Immunoglobulin G4-Related Disease/therapy
Language	English
Publishing date	2020-04-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kez667
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Zs.B 240: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 497: Show issues

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Article ; Online: Adult-onset IgA vasculitis (Henoch-Schönlein): Update on therapy.

Maritati, Federica / Canzian, Alice / Fenaroli, Paride / Vaglio, Augusto

Presse medicale (Paris, France : 1983)

2020 Volume 49, Issue 3, Page(s) 104035

Abstract: Immunoglobulin A vasculitis (IgAV, formerly Henoch-Schönlein purpura) is a systemic inflammatory disease affecting small vessels. While it is common and usually benign in childhood, in adults it is rarer has a more severe course. Its main manifestations ... ...

Abstract	Immunoglobulin A vasculitis (IgAV, formerly Henoch-Schönlein purpura) is a systemic inflammatory disease affecting small vessels. While it is common and usually benign in childhood, in adults it is rarer has a more severe course. Its main manifestations are cutaneous purpura, arthralgias or arthritis, acute enteritis and glomerulonephritis. Renal involvement is associated with a poor prognosis in adults. The treatment of adult-onset IgAV is still a matter of debate: although in patients with a non-severe phenotype remission can occur spontaneously, more severe cases may need immunosuppressive therapy. There are some areas of uncertainty with respect to the efficacy of immunosuppressive regimens: almost all data come from studies performed in children or from patients with IgA nephropathy and/or IgA-crescentic glomerulonephritis. The only randomised study performed in adults with IgAV and renal involvement showed that immunosuppressive therapy with cyclophosphamide did not improve renal outcome nor did it affect patient survival. The possible efficacy of other drugs is reported only in small case series. Recent evidences show that rituximab could be an effective therapeutic option for adult-onset IgAV, but this also needs to be confirmed in controlled trials. In this review, we focus on therapeutic options for adult-onset IgAV treatment, and discuss the main results of the studies performed so far.
MeSH term(s)	Adult ; Age of Onset ; Cardiology/methods ; Cardiology/trends ; Child ; Glomerulonephritis, IGA/drug therapy ; Glomerulonephritis, IGA/pathology ; Hematology/methods ; Hematology/trends ; Humans ; Immunoglobulin A/adverse effects ; Immunoglobulin A/immunology ; Immunosuppressive Agents/therapeutic use ; Purpura, Schoenlein-Henoch/epidemiology ; Purpura, Schoenlein-Henoch/pathology ; Purpura, Schoenlein-Henoch/therapy ; Rituximab/therapeutic use ; Therapies, Investigational/methods ; Therapies, Investigational/trends
Chemical Substances	Immunoglobulin A ; Immunosuppressive Agents ; Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2020-07-06
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2020.104035
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Zs.A 794: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Ua VI Zs.87: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Idiopathic Retroperitoneal Fibrosis.

Vaglio, Augusto / Maritati, Federica

Journal of the American Society of Nephrology : JASN

2016 Volume 27, Issue 7, Page(s) 1880–1889

Abstract: Idiopathic retroperitoneal fibrosis (RPF), reviewed herein, is a rare fibro-inflammatory disease that develops around the abdominal aorta and the iliac arteries, and spreads into the adjacent retroperitoneum, where it frequently causes ureteral ... ...

Abstract	Idiopathic retroperitoneal fibrosis (RPF), reviewed herein, is a rare fibro-inflammatory disease that develops around the abdominal aorta and the iliac arteries, and spreads into the adjacent retroperitoneum, where it frequently causes ureteral obstruction and renal failure. The clinical phenotype of RPF is complex, because it can be associated with fibro-inflammatory disorders involving other organs, is considered part of the spectrum of IgG4-related disease, and often arises in patients with other autoimmune conditions. Obstructive uropathy is the most common complication, although other types of renal involvement may occur, including stenosis of the renal arteries and veins, renal atrophy, and different types of associated GN. Environmental and genetic factors contribute to disease susceptibility, whereas the immunopathogenesis of RPF is mediated by different immune cell types that eventually promote fibroblast activation. The diagnosis is made on the basis of computed tomography or magnetic resonance imaging, and positron emission tomography is a useful tool in disease staging and follow-up. Treatment of idiopathic RPF aims at relieving ureteral obstruction and inducing disease regression, and includes the use of glucocorticoids, combined or not with other traditional immunosuppressants. However, biologic therapies such as the B cell-depleting agent rituximab are emerging as potentially efficacious agents in difficult-to-treat cases.
MeSH term(s)	Algorithms ; Autoimmune Diseases/complications ; Humans ; Inflammation/complications ; Retroperitoneal Fibrosis/complications ; Retroperitoneal Fibrosis/diagnosis ; Retroperitoneal Fibrosis/etiology ; Retroperitoneal Fibrosis/therapy ; Treatment Outcome
Language	English
Publishing date	2016-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2015101110
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Zs.A 3344: Show issues

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Article ; Online: Microarray evaluation of allergen-specific IgE in eosinophilic granulomatosis with polyangiitis.

Bello, Federica / Maritati, Federica / Radice, Antonella / Sinico, Renato Alberto / Emmi, Giacomo / Vaglio, Augusto

Annals of the rheumatic diseases

2021 Volume 80, Issue 9, Page(s) 1247–1248

Language	English
Publishing date	2021-04-21
Publishing country	England
Document type	Letter
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2021-220111
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Uh III Zs.114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 167: Show issues

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Article ; Online: Chronic Periaortitis: an Update.

Palmisano, Alessandra / Maritati, Federica / Vaglio, Augusto

Current rheumatology reports

2018 Volume 20, Issue 12, Page(s) 80

Abstract: Purpose of review: We aim to review traditional concepts and recent developments on the nosology, pathophysiology, clinical phenotypes and treatment of chronic periaortitis (CP).: Recent findings: CP is a rare disorder hallmarked by a periaortic ... ...

Abstract	Purpose of review: We aim to review traditional concepts and recent developments on the nosology, pathophysiology, clinical phenotypes and treatment of chronic periaortitis (CP). Recent findings: CP is a rare disorder hallmarked by a periaortic fibro-inflammatory tissue. It can present as an isolated disease, but it can also be associated with other autoimmune and fibro-inflammatory lesions (e.g., fibrosing mediastinitis, sclerosing pancreato-cholangitis) that are part of the spectrum of IgG4-related disease. In a subgroup of patients, it also involves the thoracic aorta (so-called "diffuse periaortitis"), which supports the notion of an inflammatory disorder of large arteries. The pathogenesis of CP is multifactorial: recent studies have elucidated the predisposing role of immunogenetic variants and exposures to environmental agents such as smoking and asbestos. CP is a rare immune-mediated disease that affects the abdominal aorta and the iliac arteries and, in some cases, the thoracic aorta. It may overlap with manifestations of IgG4-related disease, and its treatment comprises glucocorticoids, conventional and biological immunosuppressive agents.
MeSH term(s)	Aorta, Abdominal/immunology ; Aorta, Abdominal/pathology ; Glucocorticoids/therapeutic use ; Humans ; Immunoglobulin G/blood ; Retroperitoneal Fibrosis/diagnosis ; Retroperitoneal Fibrosis/drug therapy ; Retroperitoneal Fibrosis/immunology ; Retroperitoneal Fibrosis/pathology
Chemical Substances	Glucocorticoids ; Immunoglobulin G
Language	English
Publishing date	2018-11-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057357-1
ISSN	1534-6307 ; 1523-3774
ISSN (online)	1534-6307
ISSN	1523-3774
DOI	10.1007/s11926-018-0789-2
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Zs.A 5531: Show issues

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Article ; Online: Precision Nephrology in Patients with Diabetes and Chronic Kidney Disease.

Provenzano, Michele / Maritati, Federica / Abenavoli, Chiara / Bini, Claudia / Corradetti, Valeria / La Manna, Gaetano / Comai, Giorgia

International journal of molecular sciences

2022 Volume 23, Issue 10

Abstract: Diabetes is the leading cause of kidney failure and specifically, diabetic kidney disease (DKD) occurs in up to 30% of all diabetic patients. Kidney disease attributed to diabetes is a major contributor to the global burden of the disease in terms of ... ...

Abstract	Diabetes is the leading cause of kidney failure and specifically, diabetic kidney disease (DKD) occurs in up to 30% of all diabetic patients. Kidney disease attributed to diabetes is a major contributor to the global burden of the disease in terms of clinical and socio-economic impact, not only because of the risk of progression to End-Stage Kidney Disease (ESKD), but also because of the associated increase in cardiovascular (CV) risk. Despite the introduction of novel treatments that allow us to reduce the risk of future outcomes, a striking residual cardiorenal risk has been reported. This risk is explained by both the heterogeneity of DKD and the individual variability in response to nephroprotective treatments. Strategies that have been proposed to improve DKD patient care are to develop novel biomarkers that classify with greater accuracy patients with respect to their future risk (prognostic) and biomarkers that are able to predict the response to nephroprotective treatment (predictive). In this review, we summarize the principal prognostic biomarkers of type 1 and type 2 diabetes and the novel markers that help clinicians to individualize treatments and the basis of the characteristics that predict an optimal response.
MeSH term(s)	Biomarkers ; Diabetes Mellitus, Type 2/complications ; Diabetic Nephropathies/etiology ; Humans ; Nephrology ; Renal Insufficiency, Chronic/complications
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-05-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23105719
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