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  1. AU="Marja Koskuvi"
  2. AU="Hu, Xinfeng"
  3. AU=Sugarman Jeremy AU=Sugarman Jeremy
  4. AU="Tandale, Babasaheb"
  5. AU="Xie, Xinming"

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  1. Artikel ; Online: Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

    Ilkka Fagerlund / Antonios Dougalis / Anastasia Shakirzyanova / Mireia Gómez-Budia / Anssi Pelkonen / Henna Konttinen / Sohvi Ohtonen / Mohammad Feroze Fazaludeen / Marja Koskuvi / Johanna Kuusisto / Damián Hernández / Alice Pebay / Jari Koistinaho / Tuomas Rauramaa / Šárka Lehtonen / Paula Korhonen / Tarja Malm

    Cells, Vol 11, Iss 124, p

    2022  Band 124

    Abstract: Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in vitro research window to the development of the cerebral cortex. However, a key player in the developing brain, the microglia, do not natively emerge in cerebral ... ...

    Abstract Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in vitro research window to the development of the cerebral cortex. However, a key player in the developing brain, the microglia, do not natively emerge in cerebral organoids. Here we show that erythromyeloid progenitors (EMPs), differentiated from induced pluripotent stem cells, migrate to cerebral organoids, and mature into microglia-like cells and interact with synaptic material. Patch-clamp electrophysiological recordings show that the microglia-like population supported the emergence of more mature and diversified neuronal phenotypes displaying repetitive firing of action potentials, low-threshold spikes and synaptic activity, while multielectrode array recordings revealed spontaneous bursting activity and increased power of gamma-band oscillations upon pharmacological challenge with NMDA. To conclude, microglia-like cells within the organoids promote neuronal and network maturation and recapitulate some aspects of microglia-neuron co-development in vivo, indicating that cerebral organoids could be a useful biorealistic human in vitro platform for studying microglia-neuron interactions.
    Schlagwörter cerebral organoid ; microglia ; neurogenesis ; neuronal function ; development ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer’s disease

    Taisia Rolova / Ying-Chieh Wu / Marja Koskuvi / Jenni Voutilainen / Tuuli-Maria Sonninen / Johanna Kuusisto / Markku Laakso / Riikka H. Hämäläinen / Jari Koistinaho / Šárka Lehtonen

    Stem Cell Research, Vol 48, Iss , Pp 101968- (2020)

    2020  

    Abstract: A673T mutation in the amyloid precursor protein (APP) is a rare variant associated with a reduced risk of late-onset Alzheimer‘s disease (AD) and age-related cognitive decline. The A673T mutation decreases beta-amyloid (Aβ) production and aggregation in ... ...

    Abstract A673T mutation in the amyloid precursor protein (APP) is a rare variant associated with a reduced risk of late-onset Alzheimer‘s disease (AD) and age-related cognitive decline. The A673T mutation decreases beta-amyloid (Aβ) production and aggregation in neuronal cultures in vitro. Here we have identified a Finnish non-diseased male individual carrying a heterozygous A673T mutation, obtained a skin biopsy sample from him, and generated an iPSC line using commercially available integration-free Sendai virus-based kit. The established iPSC line retained the mutation, expressed pluripotency markers, had a normal karyotype, and differentiated into all three germ layers in vitro.
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Metabolic alterations in Parkinson’s disease astrocytes

    Tuuli-Maria Sonninen / Riikka H. Hämäläinen / Marja Koskuvi / Minna Oksanen / Anastasia Shakirzyanova / Sara Wojciechowski / Katja Puttonen / Nikolay Naumenko / Gundars Goldsteins / Nihay Laham-Karam / Marko Lehtonen / Pasi Tavi / Jari Koistinaho / Šárka Lehtonen

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Band 14

    Abstract: Abstract In Parkinson`s disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta is associated with Lewy bodies arising from the accumulation of alpha-synuclein protein which leads ultimately to movement impairment. While ...

    Abstract Abstract In Parkinson`s disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta is associated with Lewy bodies arising from the accumulation of alpha-synuclein protein which leads ultimately to movement impairment. While PD has been considered a disease of the DA neurons, a glial contribution, in particular that of astrocytes, in PD pathogenesis is starting to be uncovered. Here, we report findings from astrocytes derived from induced pluripotent stem cells of LRRK2 G2019S mutant patients, with one patient also carrying a GBA N370S mutation, as well as healthy individuals. The PD patient astrocytes manifest the hallmarks of the disease pathology including increased expression of alpha-synuclein. This has detrimental consequences, resulting in altered metabolism, disturbed Ca2+ homeostasis and increased release of cytokines upon inflammatory stimulation. Furthermore, PD astroglial cells manifest increased levels of polyamines and polyamine precursors while lysophosphatidylethanolamine levels are decreased, both of these changes have been reported also in PD brain. Collectively, these data reveal an important role for astrocytes in PD pathology and highlight the potential of iPSC-derived cells in disease modeling and drug discovery.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-09-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Sex-specific transcriptional and proteomic signatures in schizophrenia

    Jari Tiihonen / Marja Koskuvi / Markus Storvik / Ida Hyötyläinen / Yanyan Gao / Katja A. Puttonen / Raisa Giniatullina / Ekaterina Poguzhelskaya / Ilkka Ojansuu / Olli Vaurio / Tyrone D. Cannon / Jouko Lönnqvist / Sebastian Therman / Jaana Suvisaari / Jaakko Kaprio / Lesley Cheng / Andrew F. Hill / Markku Lähteenvuo / Jussi Tohka /
    Rashid Giniatullin / Šárka Lehtonen / Jari Koistinaho

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 11

    Abstract: Noise due to genetic heterogeneity potentially impacts the the discovery of genes that contribute to diseases such as schizophrenia (SCZ). In this study, authors minimize the disease-irrelevant noise between SCZ and healthy individuals by profiling ... ...

    Abstract Noise due to genetic heterogeneity potentially impacts the the discovery of genes that contribute to diseases such as schizophrenia (SCZ). In this study, authors minimize the disease-irrelevant noise between SCZ and healthy individuals by profiling transcriptional signatures among discordant monozygotic twin pairs, and demonstrate that although sexes share many of the final common pathways, the underlying primary pathophysiology of SCZ differs between males and females.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-09-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Sex-specific transcriptional and proteomic signatures in schizophrenia

    Jari Tiihonen / Marja Koskuvi / Markus Storvik / Ida Hyötyläinen / Yanyan Gao / Katja A. Puttonen / Raisa Giniatullina / Ekaterina Poguzhelskaya / Ilkka Ojansuu / Olli Vaurio / Tyrone D. Cannon / Jouko Lönnqvist / Sebastian Therman / Jaana Suvisaari / Jaakko Kaprio / Lesley Cheng / Andrew F. Hill / Markku Lähteenvuo / Jussi Tohka /
    Rashid Giniatullin / Šárka Lehtonen / Jari Koistinaho

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 11

    Abstract: Noise due to genetic heterogeneity potentially impacts the the discovery of genes that contribute to diseases such as schizophrenia (SCZ). In this study, authors minimize the disease-irrelevant noise between SCZ and healthy individuals by profiling ... ...

    Abstract Noise due to genetic heterogeneity potentially impacts the the discovery of genes that contribute to diseases such as schizophrenia (SCZ). In this study, authors minimize the disease-irrelevant noise between SCZ and healthy individuals by profiling transcriptional signatures among discordant monozygotic twin pairs, and demonstrate that although sexes share many of the final common pathways, the underlying primary pathophysiology of SCZ differs between males and females.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-09-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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