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  1. AU="Marjanovic, Nemanja Despot"
  2. AU="Jitxin, Lim"

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  1. Article ; Online: Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.

    Lee, Joo-Hyeon / Tammela, Tuomas / Hofree, Matan / Choi, Jinwook / Marjanovic, Nemanja Despot / Han, Seungmin / Canner, David / Wu, Katherine / Paschini, Margherita / Bhang, Dong Ha / Jacks, Tyler / Regev, Aviv / Kim, Carla F

    Cell

    2017  Volume 170, Issue 6, Page(s) 1149–1163.e12

    Abstract: The diversity of mesenchymal cell types in the lung that influence epithelial homeostasis and regeneration is poorly defined. We used genetic lineage tracing, single-cell RNA sequencing, and organoid culture approaches to show that Lgr5 and Lgr6, well- ... ...

    Abstract The diversity of mesenchymal cell types in the lung that influence epithelial homeostasis and regeneration is poorly defined. We used genetic lineage tracing, single-cell RNA sequencing, and organoid culture approaches to show that Lgr5 and Lgr6, well-known markers of stem cells in epithelial tissues, are markers of mesenchymal cells in the adult lung. Lgr6
    MeSH term(s) Animals ; Homeostasis ; Lung/cytology ; Lung/physiology ; Mesoderm/cytology ; Mice ; Organoids/cytology ; Pulmonary Alveoli/cytology ; Receptors, G-Protein-Coupled/analysis ; Sequence Analysis, RNA ; Single-Cell Analysis ; Transcription, Genetic
    Chemical Substances Lgr5 protein, mouse ; Lgr6 protein, mouse ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2017-09-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2017.07.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

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  2. Article ; Online: Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.

    Marjanovic, Nemanja Despot / Hofree, Matan / Chan, Jason E / Canner, David / Wu, Katherine / Trakala, Marianna / Hartmann, Griffin G / Smith, Olivia C / Kim, Jonathan Y / Evans, Kelly Victoria / Hudson, Anna / Ashenberg, Orr / Porter, Caroline B M / Bejnood, Alborz / Subramanian, Ayshwarya / Pitter, Kenneth / Yan, Yan / Delorey, Toni / Phillips, Devan R /
    Shah, Nisargbhai / Chaudhary, Ojasvi / Tsankov, Alexander / Hollmann, Travis / Rekhtman, Natasha / Massion, Pierre P / Poirier, John T / Mazutis, Linas / Li, Ruifang / Lee, Joo-Hyeon / Amon, Angelika / Rudin, Charles M / Jacks, Tyler / Regev, Aviv / Tammela, Tuomas

    Cancer cell

    2020  Volume 38, Issue 2, Page(s) 229–246.e13

    Abstract: Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly understood. Here, we profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to ... ...

    Abstract Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly understood. Here, we profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma. The diversity of transcriptional states increases over time and is reproducible across tumors and mice. Cancer cells progressively adopt alternate lineage identities, computationally predicted to be mediated through a common transitional, high-plasticity cell state (HPCS). Accordingly, HPCS cells prospectively isolated from mouse tumors and human patient-derived xenografts display high capacity for differentiation and proliferation. The HPCS program is associated with poor survival across human cancers and demonstrates chemoresistance in mice. Our study reveals a central principle underpinning intra-tumoral heterogeneity and motivates therapeutic targeting of the HPCS.
    MeSH term(s) Animals ; Cell Differentiation/genetics ; Cell Line, Tumor ; Cell Plasticity/genetics ; Cell Proliferation/genetics ; Cells, Cultured ; Disease Models, Animal ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Genetic Heterogeneity ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mice ; Neoplastic Stem Cells/metabolism ; Single-Cell Analysis/methods ; Transcriptome/genetics
    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2020.06.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5650: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 104: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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