Article ; Online: Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system
Nature Communications, Vol 14, Iss 1, Pp 1-
2023 Volume 13
Abstract: Inhibition of 15-prostaglandin dehydrogenase (15-PGDH) is a promising therapeutic target for regenerative medicine. We report the structure of 15-PGDH in complex with two different inhibitors. Unexpectedly, access to the binding pocket is regulated by a ... ...
| Abstract | Inhibition of 15-prostaglandin dehydrogenase (15-PGDH) is a promising therapeutic target for regenerative medicine. We report the structure of 15-PGDH in complex with two different inhibitors. Unexpectedly, access to the binding pocket is regulated by a dynamic “lid” of the enzyme. |
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| Keywords | Science ; Q |
| Language | English |
| Publishing date | 2023-02-01T00:00:00Z |
| Publisher | Nature Portfolio |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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