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  1. Article ; Online: COVID-19 and Testicular Tumors

    Tej Patel / Jai B. Patel / Caitlyn Calhoun / Mark R. Wakefield / Yujiang Fang

    Annals of Urologic Oncology, Vol

    2023  Volume 6

    Abstract: This is a letter to the editor on the discussion on COVID-19 and testicular tumors. ...

    Abstract This is a letter to the editor on the discussion on COVID-19 and testicular tumors.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Asian Medical Press Ltd.(H.K.)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: COVID-19 and Erectile Dysfunction

    Jason P. Nayar / Aidan J. Heslin / Damien B. Beck / Mark R. Wakefield / Yujiang Fang

    Journal of Men's Health, Vol 18, Iss 9, p

    2022  Volume 190

    Abstract: Background: The SARS-CoV-2 virus displays a strong impact on the respiratory, digestive, and reproductive systems, and has led to questions about long-term effects. Erectile dysfunction is the inability for a male to achieve or sustain an erection during ...

    Abstract Background: The SARS-CoV-2 virus displays a strong impact on the respiratory, digestive, and reproductive systems, and has led to questions about long-term effects. Erectile dysfunction is the inability for a male to achieve or sustain an erection during sexual intercourse, and commonly develops in men due to both physiological and psychologic factors. SARS-CoV-2 can affect the vasculature that surrounds endothelial tissue and thus has raised the question of a possible relationship between SARS-CoV-2 infection and erectile dysfunction (ED). Thus far, no studies have established a relationship between COVID-19 and ED. In this review, we analyze current available data and summarize the concepts regarding the current known relationship between COVID-19 and ED. Such a study might be helpful for urologists and andrologists to manage patients with ED and a history off COVID-19 infection. Methods: A systematic review was used to analyze the relationship between COVID-19 and ED. A literature search on three databases, Google Scholar, PubMed, and ResearchGate was conducted. Search terms used were COVID-19, erectile dysfunction, and SARS-CoV-2. All available studies were analyzed up to December 2021. Results: The COVID-19 pandemic led to a significant increase in male reproductive and sexual health diagnoses, including ED, with numbers showing that COVID-19 increases the chance of developing ED nearly sixfold. Physiological issues were also found in the reproductive system of men who had contracted COVID-19. For example, endothelial progenitor cells were much lower in patients positive with COVID-19 even when compared to men with severe ED who had never contracted COVID-19. However, it is still not clear how consistent it is to find SARS-CoV-2 in the reproductive system as one study showed only two out of five testes were positive for SARS-CoV-2 in the reproductive system and another study showed that there were only 3 out of 26 cases in which the SARS-CoV-2 spike existed in the endothelia of the blood-testis barrier, ...
    Keywords covid-19 ; erectile dysfunction ; sars-cov-2 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher MRE Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Diagnosis and Treatment of Adrenal Metastasis in Modern Era

    Sarah E. Matusofsky / Paris M. Fang / Ellie R. Monnette / Austin M. Kim / Mark R. Wakefield

    Annals of Urologic Oncology, Vol

    2023  Volume 6

    Abstract: The adrenal glands are a common site of metastases in many advanced stages of cancers such as lung cancer and breast cancer. Given the frequent asymptomatic nature of these adrenal metastatic tumors, patients seldom get screened for adrenal metastases ... ...

    Abstract The adrenal glands are a common site of metastases in many advanced stages of cancers such as lung cancer and breast cancer. Given the frequent asymptomatic nature of these adrenal metastatic tumors, patients seldom get screened for adrenal metastases unless otherwise medically indicated for. Therefore, it is essential that screening methods should be as accurate and precise as possible. In this review, we summarize the pivotal role of modern screening in the early detection of adrenal metastatic lesions and detail the advancements that have contributed to improved detection. Through our review, we reaffirm that there has yet to be a “gold standard” in the screening process for adrenal metastases. Such a study can help medical professionals more comprehensively understand the contemporary screening methods, promoting early detection and better prognosis of adrenal metastases.
    Keywords adrenal metastatic tumors ; biopsy ; imaging ; Medicine ; R
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Asian Medical Press Ltd.(H.K.)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Image-guided percutaneous cryo-ablation of peri-urethral unresectable recurrent pelvic malignancy

    Michael E. Nance, PhD, MSc / Mark R. Wakefield, MD / Ambarish P. Bhat, MD / Ryan M. Davis, MD

    Radiology Case Reports, Vol 16, Iss 5, Pp 1227-

    A case report and brief review

    2021  Volume 1232

    Abstract: Recurrent or metastatic peri-urethral pelvic malignancies are a difficult-to-treat entity. Re-resection is recommended when possible but is frequently unfavorable due to scar tissue, fibrosis, and obliteration of tissue planes following previous ... ...

    Abstract Recurrent or metastatic peri-urethral pelvic malignancies are a difficult-to-treat entity. Re-resection is recommended when possible but is frequently unfavorable due to scar tissue, fibrosis, and obliteration of tissue planes following previous interventions such as surgical resection and/or radiation therapy. Curative options for patients that have unresectable cancer are limited. Cryo-ablation has been extensively studied in the treatment of unresectable renal, liver and lung malignancies and has the potential to provide definitive treatment for recurrent pelvic malignancy. There is a paucity of reports of salvage cryo-ablation in patients with recurrent pelvic malignancies, as most of these tumors are located close to critical structures that could be irreversibly injured by thermal ablation and are hence treated with some form of radiation therapy. But, for patients who fail surgical and radiation treatments, options are limited. Here, we describe two cases of regional tumor recurrence in the pelvis treated with percutaneous cryoablation using protective techniques to avoid thermal injury to adjacent structures. In each case, cryo-ablation was performed successfully despite extensive previous surgical and radiation interventions. Salvage cryo-ablation resulted in a positive clinical and imaging response with an improvement in quality of life and absence of recurrence on follow-up imaging which continues to persist at the writing of this manuscript about 8 and 12-months following treatment.
    Keywords Cryo-ablation ; Recurrent pelvic tumor ; Image-guided ; Prostate cancer ; Anal cancer ; Peri-urethral cancer ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 616
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: SARS-CoV-2 Spike Protein Influences Expression of ICOSL and ICAM-2 in Prostate Cancer

    McKay Echols / Zuliang Deng / Coby Powers / Huaping Xiao / Ziwen Zhu / Marco Lequio / Samuel Leung / Qian Bai / Mark R. Wakefield / Yujiang Fang

    Journal of Men's Health, Vol 18, Iss 10, p

    2022  Volume 201

    Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel coronavirus responsible for the COVID-19 pandemic. The viral protein of SARS-CoV-2, spike protein (SP), mediates entry into host cells, contributing to pathogenesis of ... ...

    Abstract Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel coronavirus responsible for the COVID-19 pandemic. The viral protein of SARS-CoV-2, spike protein (SP), mediates entry into host cells, contributing to pathogenesis of COVID-19. Prostate cancer is the most common cancer among men in the United States. Inducible T-cell costimulator ligand (ICOSL) and intercellular cell adhesion molecule 2 (ICAM-2) are expressed in cancer cells and their roles in cancer growth remain controversial. It is unknown if SP can affect the expression of ICAM-2 or ICOSL in prostate cancer. This study investigated the effects of SARS-CoV-2 SP on the expression of ICAM-2 and ICOSL and the time-dependent effect of SP on growth and survival of prostate cancer cells. Methods: The effect of SARS-CoV-2 SP on the survival of a widely-used prostate cancer cell line, LNCaP, was assessed using clonogenic cell survival assay and quick cell proliferation assay. Reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC) were performed to investigate the expression of ICAM-2 and ICOSL. The survival of an additional prostate cancer cell line, PC-3, was also evaluated by clonogenic survival assay. Results: After 3 days, a significant decrease in the percentage of colonies in LNCaP cells treated with SP was found, which was paralleled by a decrease in optical density (OD) value in LNCaP cells in the presence of SP. A significant decrease in the percentage of colonies treated with SP was also found in PC-3 cells evaluated by clonogenic survival assay. In addition, the mRNA expression of ICAM-2 was lower, whereas the mRNA expression of ICOSL was higher in SP-treated LNCaP cells. This was supported by protein expressions for ICAM-2 and ICOSL evaluated with IHC. Conclusions: In LNCaP cells, SARS-CoV-2 SP downregulates the expression of ICAM-2 but upregulates the expression of ICOSL. SARS-CoV-2 SP inhibits growth of prostate cancer cells in a time-dependent manner. Further studies are needed to ...
    Keywords sars-cov-2 ; spike protein ; prostate cancer ; icam-2 ; icosl ; Medicine (General) ; R5-920
    Subject code 570
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MRE Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Genomic sequencing of a strain of Acinetobacter baumannii and potential mechanisms to antibiotics resistance

    Zhao, Lei / Hongru Li / Mark R. Wakefield / Ying Ye / Yujiang Fang / Ziwen Zhu

    Infection, genetics, and evolution. 2017 June, v. 50

    2017  

    Abstract: Acinetobacter baumannii has been becoming a great challenge to clinicians due to their resistance to almost all available antibiotics. In this study, we sequenced the genome from a multiple antibiotics resistant Acinetobacter baumannii stain which was ... ...

    Abstract Acinetobacter baumannii has been becoming a great challenge to clinicians due to their resistance to almost all available antibiotics. In this study, we sequenced the genome from a multiple antibiotics resistant Acinetobacter baumannii stain which was named A. baumannii-1isolated from China by SMRT sequencing technology to explore its potential mechanisms to antibiotic resistance. We found that several mechanisms might contribute to the antibiotic resistance of Acinetobacter baumannii. Specifically, we found that SNP in genes associated with nucleotide excision repair and ABC transporter might contribute to its resistance to multiple antibiotics; we also found that specific genes associated with bacterial DNA integration and recombination, DNA-mediated transposition and response to antibiotics might contribute to its resistance to multiple antibiotics; Furthermore, specific genes associated with penicillin and cephalosporin biosynthetic pathway and specific genes associated with CHDL and MBL β-lactamase genes might contribute to its resistance to multiple antibiotics. Thus, the detailed mechanisms by which Acinetobacter baumannii show extensive resistance to multiple antibiotics are very complicated. Such a study might be helpful to develop new strategies to control Acinetobacter baumannii infection.
    Keywords ABC transporters ; Acinetobacter baumannii ; antibiotic resistance ; beta-lactamase ; biochemical pathways ; cephalosporins ; DNA ; DNA repair ; genes ; penicillins ; sequence analysis ; single nucleotide polymorphism ; transposition (genetics) ; China
    Language English
    Dates of publication 2017-06
    Size p. 20-24.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2017.02.001
    Database NAL-Catalogue (AGRICOLA)

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