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  1. Article: Hyperoxygenation During Mid-Neurogenesis Accelerates Cortical Development in the Fetal Mouse Brain.

    Markert, Franz / Storch, Alexander

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 732682

    Abstract: Oxygen tension is well-known to affect cortical development. Fetal brain hyperoxygenation during mid-neurogenesis in mice (embryonic stage E14.5. to E16.5) increases brain size evoked through an increase of neuroprecursor cells. Nevertheless, it is ... ...

    Abstract Oxygen tension is well-known to affect cortical development. Fetal brain hyperoxygenation during mid-neurogenesis in mice (embryonic stage E14.5. to E16.5) increases brain size evoked through an increase of neuroprecursor cells. Nevertheless, it is unknown whether these effects can lead to persistent morphological changes within the highly orchestrated brain development. To shed light on this, we used our model of controlled fetal brain hyperoxygenation in time-pregnant C57BL/6J mice housed in a chamber with 75% atmospheric oxygen from E14.5 to E16.5 and analyzed the brains from E14.5, E16.5, P0.5, and P3.5 mouse embryos and pups
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.732682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; Thesis: Einfluss von Sauerstoff und Katecholaminen auf die fetale kortikale Entwicklung der Maus

    Markert, Franz [Verfasser] / Storch, Alexander [Gutachter] / Peters, Kirsten Gutachter] / [Spittau, Björn [Gutachter]

    2023  

    Author's details Franz Markert ; Gutachter: Alexander Storch, Kirsten Peters, Björn Spittau
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Rostock
    Publishing place Rostock
    Document type Book ; Online ; Thesis
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  3. Article: Serial Gene Expression Profiling of Neural Stem Cells Shows Transcriptome Switch by Long-Term Physioxia from Metabolic Adaption to Cell Signaling Profile.

    Braunschweig, Lena / Lanto, Jennifer / Meyer, Anne K / Markert, Franz / Storch, Alexander

    Stem cells international

    2022  Volume 2022, Page(s) 6718640

    Abstract: Oxygen is an essential factor in the cellular microenvironment with pivotal effects on neural development with a particular sensitivity of midbrain neural stem cells (NSCs) to high atmospheric oxygen tension. However, most experiments are still performed ...

    Abstract Oxygen is an essential factor in the cellular microenvironment with pivotal effects on neural development with a particular sensitivity of midbrain neural stem cells (NSCs) to high atmospheric oxygen tension. However, most experiments are still performed at atmospheric O
    Language English
    Publishing date 2022-11-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573856-2
    ISSN 1687-9678 ; 1687-966X
    ISSN (online) 1687-9678
    ISSN 1687-966X
    DOI 10.1155/2022/6718640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Subthalamic nucleus deep brain stimulation induces nigrostriatal dopaminergic plasticity in a stable rat model of Parkinson's disease.

    Helf, Charlotte / Kober, Maria / Markert, Franz / Lanto, Jennifer / Overhoff, Leonie / Badstübner-Meeske, Kathrin / Storch, Alexander / Fauser, Mareike

    Neuroreport

    2023  Volume 34, Issue 10, Page(s) 506–511

    Abstract: Objective: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been a highly effective treatment option for middle to late stage Parkinson's disease for decades. Though, the underlying mechanisms of action, particularly effects on the ... ...

    Abstract Objective: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been a highly effective treatment option for middle to late stage Parkinson's disease for decades. Though, the underlying mechanisms of action, particularly effects on the cellular level, remain in part unclear. In the context of identifying disease-modifying effects of STN-DBS by prompting cellular plasticity in midbrain dopaminergic systems, we analyzed neuronal tyrosine hydroxylase and c-Fos expression in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA).
    Methods: We applied 1 week of continuous unilateral STN-DBS in a group of stable 6-hydroxydopamine (6-OHDA) hemiparkinsonian rats (STNSTIM) in comparison to a 6-OHDA control group (STNSHAM). Immunohistochemistry identified NeuN+, tyrosine hydroxylase+ and c-Fos+ cells within the SNpc and VTA.
    Results: After 1 week, rats in the STNSTIM group had 3.5-fold more tyrosine hydroxylase+ neurons within the SNpc (P = 0.010) but not in the VTA compared to sham controls. There was no difference in basal cell activity as indicated by c-Fos expression in both midbrain dopaminergic systems.
    Conclusion: Our data support a neurorestorative effect of STN-DBS in the nigrostriatal dopaminergic system already after 7 days of continuous STN-DBS in the stable Parkinson's disease rat model without affecting basal cell activity.
    MeSH term(s) Rats ; Animals ; Parkinson Disease/therapy ; Parkinson Disease/metabolism ; Subthalamic Nucleus/metabolism ; Oxidopamine/toxicity ; Deep Brain Stimulation ; Tyrosine 3-Monooxygenase/metabolism ; Dopamine/metabolism ; Substantia Nigra/metabolism
    Chemical Substances Oxidopamine (8HW4YBZ748) ; Tyrosine 3-Monooxygenase (EC 1.14.16.2) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-05-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049746-8
    ISSN 1473-558X ; 0959-4965
    ISSN (online) 1473-558X
    ISSN 0959-4965
    DOI 10.1097/WNR.0000000000001917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3118: Show issues Location:
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  5. Article ; Online: Early Chronic Intermittent Maternal Hyperoxygenation Impairs Cortical Development by Inhibition of Pax6-Positive Apical Progenitor Cell Proliferation.

    Markert, Franz / Müller, Luisa / Badstübner-Meeske, Kathrin / Storch, Alexander

    Journal of neuropathology and experimental neurology

    2020  Volume 79, Issue 11, Page(s) 1223–1232

    Abstract: Maternal hyperoxygenation is a feasible, noninvasive method to treat fetal diseases, such as heart hypoplasia, but effects of maternal hyperoxygenation on the developing brain remain poorly understood. Previous studies showed that short-term maternal ... ...

    Abstract Maternal hyperoxygenation is a feasible, noninvasive method to treat fetal diseases, such as heart hypoplasia, but effects of maternal hyperoxygenation on the developing brain remain poorly understood. Previous studies showed that short-term maternal hyperoxygenation during midneurogenic phase (E14-E16) but not in earlier development (E10-E12) increases oxygen tension and enhances neurogenesis in the developing mouse cortex. We investigated effects of early chronic maternal hyperoxygenation (CMH) as a potential clinical treatment. Pregnant C57BL/6J mice were housed in a chamber at 75% atmospheric oxygen and the brains of E16 fetuses were analyzed using immunohistochemistry. The mitosis marker phH3 showed a significant reduction of proliferation in the dorsolateral cortices of CMH-treated E16 fetuses. Numbers of Tbr2-positive intermediate progenitor cells were unaffected whereas numbers of Pax6-positive apical progenitor cells were significantly reduced in CMH-treated mice. This resulted in altered cortical plate development with fewer Satb2-positive upper layer neurons but more Tbr1-positive neurons corresponding to the deeper layer 6. Thus, maternal hyperoxygenation affects the developing cortex depending on timing and length of applied oxygen. Early CMH causes a severe reduction of neuroprogenitor proliferation likely affecting cortical development. Further studies are needed to investigate the mechanisms underlying these findings and to assess the clinical and neurodevelopmental outcomes of the pups.
    MeSH term(s) Animals ; Cell Proliferation/drug effects ; Cerebral Cortex/drug effects ; Cerebral Cortex/pathology ; Embryonic Development/drug effects ; Female ; Mice ; Mice, Inbred C57BL ; Neural Stem Cells/drug effects ; Neural Stem Cells/pathology ; Neurogenesis/drug effects ; Oxygen/toxicity ; PAX6 Transcription Factor ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced ; Prenatal Exposure Delayed Effects/pathology
    Chemical Substances PAX6 Transcription Factor ; Pax6 protein, mouse ; Oxygen (S88TT14065)
    Language English
    Publishing date 2020-09-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlaa072
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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.134: Show issues Location:
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  6. Article: Catecholaminergic Innervation of Periventricular Neurogenic Regions of the Developing Mouse Brain.

    Fauser, Mareike / Weselek, Grit / Hauptmann, Christine / Markert, Franz / Gerlach, Manfred / Hermann, Andreas / Storch, Alexander

    Frontiers in neuroanatomy

    2020  Volume 14, Page(s) 558435

    Abstract: The major catecholamines-dopamine (DA) and norepinephrine (NE)-are not only involved in synaptic communication but also act as important trophic factors and might ultimately be involved in mammalian brain development. The catecholaminergic innervation of ...

    Abstract The major catecholamines-dopamine (DA) and norepinephrine (NE)-are not only involved in synaptic communication but also act as important trophic factors and might ultimately be involved in mammalian brain development. The catecholaminergic innervation of neurogenic regions of the developing brain and its putative relationship to neurogenesis is thus of pivotal interest. We here determined DA and NE innervation around the ventricular/subventricular zone (VZ/SVZ) bordering the whole ventricular system of the developing mouse brain from embryonic day 14.5 (E14.5), E16.5, and E19.5 until postnatal day zero (P0) by histological evaluation and HPLC with electrochemical detection. We correlated these data with the proliferation capacity of the respective regions by quantification of MCM2
    Language English
    Publishing date 2020-09-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452969-2
    ISSN 1662-5129
    ISSN 1662-5129
    DOI 10.3389/fnana.2020.558435
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  7. Article: Notch is Not Involved in Physioxia-Mediated Stem Cell Maintenance in Midbrain Neural Stem Cells.

    Herrmann, Anne / Meyer, Anne K / Braunschweig, Lena / Wagenfuehr, Lisa / Markert, Franz / Kolitsch, Deborah / Vukicevic, Vladimir / Hartmann, Christiane / Siebert, Marlen / Ehrhart-Bornstein, Monika / Hermann, Andreas / Storch, Alexander

    International journal of stem cells

    2023  Volume 16, Issue 3, Page(s) 293–303

    Abstract: Background and objectives: The physiological oxygen tension in fetal brains (∼3%, physioxia) is beneficial for the maintenance of neural stem cells (NSCs). Sensitivity to oxygen varies between NSCs from different fetal brain regions, with midbrain NSCs ... ...

    Abstract Background and objectives: The physiological oxygen tension in fetal brains (∼3%, physioxia) is beneficial for the maintenance of neural stem cells (NSCs). Sensitivity to oxygen varies between NSCs from different fetal brain regions, with midbrain NSCs showing selective susceptibility. Data on Hif-1α/Notch regulatory interactions as well as our observations that Hif-1α and oxygen affect midbrain NSCs survival and proliferation prompted our investigations on involvement of Notch signalling in physioxia-dependent midbrain NSCs performance.
    Methods and results: Here we found that physioxia (3% O
    Conclusions: Notch signalling does not influence the fate decision of midbrain NSCs cultured
    Language English
    Publishing date 2023-04-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2914134-5
    ISSN 2005-5447 ; 2005-3606
    ISSN (online) 2005-5447
    ISSN 2005-3606
    DOI 10.15283/ijsc22168
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  8. Article ; Online: Subthalamic nucleus deep brain stimulation induces sustained neurorestoration in the mesolimbic dopaminergic system in a Parkinson's disease model.

    Fauser, Mareike / Ricken, Manuel / Markert, Franz / Weis, Nikolai / Schmitt, Oliver / Gimsa, Jan / Winter, Christine / Badstübner-Meeske, Kathrin / Storch, Alexander

    Neurobiology of disease

    2021  Volume 156, Page(s) 105404

    Abstract: Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapeutic principle in Parkinson's disease, but the underlying mechanisms, particularly mediating non-motor actions, remain largely enigmatic.: Objective/ ... ...

    Abstract Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapeutic principle in Parkinson's disease, but the underlying mechanisms, particularly mediating non-motor actions, remain largely enigmatic.
    Objective/hypothesis: The delayed onset of neuropsychiatric actions in conjunction with first experimental evidence that STN-DBS causes disease-modifying effects prompted our investigation on how cellular plasticity in midbrain dopaminergic systems is affected by STN-DBS.
    Methods: We applied unilateral or bilateral STN-DBS in two independent cohorts of 6-hydroxydopamine hemiparkinsonian rats four to eight weeks after dopaminergic lesioning to allow for the development of a stable dopaminergic dysfunction prior to DBS electrode implantation.
    Results: After 5 weeks of STN-DBS, stimulated animals had significantly more TH
    Conclusions: Our data support sustained neurorestorative effects of STN-DBS not only in the nigrostriatal but also in the mesolimbic system as a potential factor mediating long-latency neuropsychiatric effects of STN-DBS in Parkinson's disease.
    MeSH term(s) Animals ; Corpus Striatum/metabolism ; Deep Brain Stimulation/methods ; Dopaminergic Neurons/metabolism ; Female ; Limbic System/metabolism ; Male ; Oxidopamine/toxicity ; Parkinsonian Disorders/chemically induced ; Parkinsonian Disorders/metabolism ; Parkinsonian Disorders/therapy ; Rats ; Rats, Wistar ; Substantia Nigra/metabolism ; Subthalamic Nucleus/metabolism ; Tyrosine 3-Monooxygenase/metabolism ; Ventral Tegmental Area/metabolism
    Chemical Substances Oxidopamine (8HW4YBZ748) ; Tyrosine 3-Monooxygenase (EC 1.14.16.2)
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2021.105404
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4444: Show issues Location:
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