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Book ; Thesis: Generation and characterization of novel proteins as potential inhibitors of Thymic Stromal Lymphopoietin (TSLP) receptor activation

Marković, Iva

2017

Author's details	by M. Sc. Iva Markovic
Language	English
Size	123, XXIX Seiten, Illustrationen
Publishing place	Jena
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Friedrich-Schiller University of Jena, 2017
HBZ-ID	HT019660965
Database	Catalogue ZB MED Medicine, Health

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Book ; Online: Semantic Business Process Modeling

Markovic, Ivan

2010

Abstract: This book presents a process-oriented business modeling framework based on semantic technologies. The framework consists of modeling languages, methods, and tools that allow for semantic modeling of business motivation, business policies and rules, and ... ...

Abstract	This book presents a process-oriented business modeling framework based on semantic technologies. The framework consists of modeling languages, methods, and tools that allow for semantic modeling of business motivation, business policies and rules, and business processes. Quality of the proposed modeling framework is evaluated based on the modeling content of SAP Solution Composer and several real-world business scenarios
Keywords	Business
Size	1 electronic resource (XIV, 206 p. p.)
Publisher	KIT Scientific Publishing
Publishing place	Verlagsort nicht ermittelbar
Document type	Book ; Online
Note	ENGLISH ; Open Access
HBZ-ID	HT020197688
ISBN	9783866445574 ; 3866445571
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: The Dynamic Tunability of Memristor-Based Active Filters.

Marković, Ivo / Potrebić Ivaniš, Milka / Tošić, Dejan

Micromachines

2023 Volume 14, Issue 11

Abstract: When the memristor was fabricated for the first time, it launched an entirely new field of research. Many of the published papers regarding memristors are primarily theoretical and are based on computer simulations. Some recent papers analyze the ... ...

Abstract	When the memristor was fabricated for the first time, it launched an entirely new field of research. Many of the published papers regarding memristors are primarily theoretical and are based on computer simulations. Some recent papers analyze the memristor's programming circuits, but to the best of the authors' knowledge, no memristor has been embedded into a commercial analog circuit. This paper is practically oriented and it is based on the experimental results obtained by measurements on the circuit prototype. We present a solution for automated programming of a commercially available memristor and its implementation in tunable active bandpass filter design. The novelty of this paper is that the active bandpass filter's central frequency could be programmed during the filter operation, so a pause for memristor state-switching is not required. The experimental results are promising, and open up possibilities for the memristor's application in analog systems.
Language	English
Publishing date	2023-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14112064
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Carbohydrate sulfotransferases: a review of emerging diagnostic and prognostic applications.

Begolli, Gramos / Marković, Ivana / Knežević, Jelena / Debeljak, Željko

Biochemia medica

2023 Volume 33, Issue 3, Page(s) 30503

Abstract: Carbohydrate sulfotransferases (CHST) catalyse the biosynthesis of proteoglycans that enable physical interactions and signalling between different neighbouring cells in physiological and pathological states. The study aim was to provide an overview of ... ...

Abstract	Carbohydrate sulfotransferases (CHST) catalyse the biosynthesis of proteoglycans that enable physical interactions and signalling between different neighbouring cells in physiological and pathological states. The study aim was to provide an overview of emerging diagnostic and prognostic applications of CHST. PubMed database search was conducted using the keywords "carbohydrate sulfotransferase" together with appropriate inclusion and exclusion criteria, whereby 41 publications were selected. Additionally, 40 records on CHST genetic and biochemical properties were hand-picked from UniProt, GeneCards, InterPro, and neXtProt databases. Carbohydrate sulfotransferases have been applied mainly in diagnostics of connective tissue disorders, cancer and inflammations. The lack of CHST activity was found in congenital connective tissue disorders while CHST overexpression was detected in different malignancies. Mutations of
MeSH term(s)	Humans ; Prognosis ; COVID-19 ; Sulfotransferases/genetics ; Sulfotransferases/metabolism ; Mutation ; COVID-19 Testing
Chemical Substances	Sulfotransferases (EC 2.8.2.-)
Language	English
Publishing date	2023-08-05
Publishing country	Croatia
Document type	Journal Article ; Review
ZDB-ID	1208725-7
ISSN	1846-7482 ; 1330-0962
ISSN (online)	1846-7482
ISSN	1330-0962
DOI	10.11613/BM.2023.030503
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Zs.A 4273: Show issues

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Article ; Online: INFLUENCE OF CONTINUOUS POSITIVE AIRWAY PRESSURE TREATMENT ON AUDITORY EVENT-RELATED POTENTIALS P300.

Šarić-Jurić, Jelena / Jurić, Stjepan / Marković, Ivana

Acta clinica Croatica

2023 Volume 61, Issue 3, Page(s) 373–378

Abstract: Obstructive sleep apnea (OSA) is a sleep-related breathing disorder characterized by obstructions of the upper airway during sleep, resulting in repetitive breathing pauses accompanied by oxygen desaturation and arousal from sleep. OSA can be ... ...

Abstract	Obstructive sleep apnea (OSA) is a sleep-related breathing disorder characterized by obstructions of the upper airway during sleep, resulting in repetitive breathing pauses accompanied by oxygen desaturation and arousal from sleep. OSA can be successfully treated with continuous positive airway pressure (CPAP), weight loss, positional therapy, oral appliances, hypoglossal nerve stimulation, and surgical procedures. It has been observed that untreated OSA is related to chronic disorders including hypertension, arrhythmias, congestive heart failure, coronary heart disease, diabetes mellitus, hyperlipidemia, stroke, depression, and cognitive decline. Event-related potentials (ERPs) is the procedure that has been widely used for evaluating cognitive brain functions. Using auditory event-related potentials (P300), this study aimed to examine the effect of CPAP therapy on cognitive functions in patients with moderate and severe OSA. The results of the study showed improvement in P300 latency and amplitude after 3 months of CPAP therapy, indicating a positive effect of CPAP therapy in the prevention of cognitive decline in patients with OSA.
MeSH term(s)	Humans ; Continuous Positive Airway Pressure/methods ; Sleep Apnea, Obstructive/therapy ; Sleep Apnea, Obstructive/complications ; Sleep ; Brain ; Evoked Potentials
Language	English
Publishing date	2023-07-11
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1478635-7
ISSN	1333-9451 ; 0353-9466
ISSN (online)	1333-9451
ISSN	0353-9466
DOI	10.20471/acc.2022.61.03.01
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Zs.A 5057: Show issues

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Article ; Online: Early arteriopathy in Aicardi-Goutières syndrome 5. Case report and review of literature.

Markovic, Ivana / Jocic-Jakubi, Bosanka / Milenkovic, Zoran

The neuroradiology journal

2023 Volume 36, Issue 6, Page(s) 740–745

Abstract: Aicardi-Goutières syndrome (AGS) is an autosomal recessive disease that mimics congenital viral infection and mainly affects the brain, immune system, and skin. The dominant clinical symptom is the subacute onset of severe encephalopathy, which manifests ...

Abstract	Aicardi-Goutières syndrome (AGS) is an autosomal recessive disease that mimics congenital viral infection and mainly affects the brain, immune system, and skin. The dominant clinical symptom is the subacute onset of severe encephalopathy, which manifests as irritability, loss of ability, slowing of head growth, and poor nutrition. Arteriopathy in AGS is an uncommon manifestation usually associated with mutations in the SAMHD1 gene. We present a rare case of a 3-year-old male due to failure to thrive, global developmental delay, microcephaly, poor vision, upper and lower limbs spasticity, and gastroesophageal reflux disease (GERD), who harbored early stenotic lesions of the large and medium intracranial arteries with ischemic sequelae in the early postnatal life. Performed genetic testing confirmed homozygous gene mutation, SAMHD1 associated with AGS type 5. By reviewing the available literature, we were able to find only one patient whose arterial lesions were diagnosed after 6 months.
MeSH term(s)	Male ; Humans ; Child, Preschool ; SAM Domain and HD Domain-Containing Protein 1/genetics ; Nervous System Malformations/diagnostic imaging ; Nervous System Malformations/genetics ; Autoimmune Diseases of the Nervous System/genetics ; Autoimmune Diseases of the Nervous System/diagnosis ; Autoimmune Diseases of the Nervous System/pathology ; Mutation/genetics
Chemical Substances	SAM Domain and HD Domain-Containing Protein 1 (EC 3.1.5.-)
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2257770-1
ISSN	2385-1996 ; 1971-4009 ; 1120-9976
ISSN (online)	2385-1996
ISSN	1971-4009 ; 1120-9976
DOI	10.1177/19714009231154677
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Zs.A 2823: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Very Early Diagnosis of Systemic Sclerosis in Clinical Practice - Case Report and Review of the Literature.

Marković, Ivan / Posavec, Anja Ljilja / Morović-Vergles, Jadranka / Mitrović, Joško

Acta dermatovenerologica Croatica : ADC

2023 Volume 30, Issue 4, Page(s) 251–255

Abstract: Systemic sclerosis (SSc) is a systemic autoimmune disease characterised by generalized microangiopathy and fibrosis of skin and internal organs. The 2013 American College of Rheumatology (ACR) / European League Against Rheumatism (EULAR) criteria have ... ...

Abstract	Systemic sclerosis (SSc) is a systemic autoimmune disease characterised by generalized microangiopathy and fibrosis of skin and internal organs. The 2013 American College of Rheumatology (ACR) / European League Against Rheumatism (EULAR) criteria have contributed considerably to classifying patients with SSc in earlier stages, but they still lack sensitivity for a very early stage of the disease. Criteria for a very early diagnosis of SSc (VEDOSS) have been proposed by EULAR Scleroderma Trial and Research group (EUSTAR) which include three red flags: Raynaud's phenomenon, puffy fingers and antinuclear antibody positivity, plus SSc specific antibodies positivity and/or abnormal nailfold capillaroscopy. We report a case of a 54-year-old female patient with 6-week history of puffy fingers, Raynaud phenomenon and positive antinuclear antibodies. Further workup revealed early pathologic capillary pattern by nailfold capillaroscopy and positive anticentromere antibodies. Screening for internal organ involvement detected no heart, lung, or upper gastrointestinal tract involvement. The patient was started on pentoxifylline with further follow-up. The aim of the implementation of VEDOSS criteria is to diagnose SSc at the earliest possible stage, so that subclinical internal organ involvement could be detected and appropriate treatment started at a potentially reversible stage.
MeSH term(s)	Female ; Humans ; Middle Aged ; Scleroderma, Systemic/diagnosis ; Rheumatology ; Early Diagnosis ; Raynaud Disease/diagnosis ; Raynaud Disease/etiology ; Scleroderma, Localized
Language	English
Publishing date	2023-03-08
Publishing country	Croatia
Document type	Review ; Case Reports
ZDB-ID	1180727-1
ISSN	1847-6538 ; 1330-027X
ISSN (online)	1847-6538
ISSN	1330-027X
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Zs.A 3934: Show issues

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Article ; Online: Retinal Ciliopathy in the Patient with Transplanted Kidney: Case Report.

Bućan, Ivona / Bjeloš, Mirjana / Marković, Irena / Bućan, Diana

International journal of molecular sciences

2022 Volume 23, Issue 14

Abstract: A review of a rare case of a proven mutation in the RP1 gene (RP1c.2029C>T, p. (ARG677*) in a kidney transplant patient was presented herein. According to his medical history, he had tonsillectomy performed at the age of 20 due to erythrocyturia, and at ... ...

Abstract	A review of a rare case of a proven mutation in the RP1 gene (RP1c.2029C>T, p. (ARG677*) in a kidney transplant patient was presented herein. According to his medical history, he had tonsillectomy performed at the age of 20 due to erythrocyturia, and at the age of 32 he was treated for malignant hypertension. The patient had been diagnosed with chronic renal failure at age 56 years. During an eye examination in 2016, retinitis pigmentosa was suspected and the patient was advised to run further tests. After an ophthalmological examination and tests, genetic testing was performed and a mutation in the RP1 gene encoding a family of proteins which are components of microtubules in photoreceptor primary cilia was proven. The literature search found that mutations in the RP1 gene have so far been exclusively associated with a non-syndromic form of retinal degeneration. However, the RP1 protein is expressed in the kidneys, and it remains unclear why the mutation of this gene so far was only specifically related to retinal photoreceptor function and not to arterial hypertension and renal disease. Primary cilia are thought to act as potential mechanosensory fluid-flow receptors in the vascular endothelium and kidney and their dysfunction results in atherosclerotic changes, hypertension, and chronic renal failure.
MeSH term(s)	Ciliopathies/genetics ; Eye Proteins/metabolism ; Humans ; Hypertension ; Kidney/metabolism ; Kidney Failure, Chronic/surgery ; Male ; Microtubule-Associated Proteins/metabolism ; Middle Aged ; Mutation
Chemical Substances	Eye Proteins ; Microtubule-Associated Proteins
Language	English
Publishing date	2022-07-08
Publishing country	Switzerland
Document type	Case Reports ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23147582
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Article ; Online: Adolescent and young adult allergic asthma treatment challenges.

Vukičević Lazarević, Vesna / Marković, Ivan / Šola, Ana Marija

BMJ case reports

2022 Volume 15, Issue 10

Abstract: The transition from paediatric care to adult care is often difficult, especially in children with chronic diseases like asthma. A significant number of children reach remission throughout puberty; consequently, they are not tracked down for subsequent ... ...

Abstract	The transition from paediatric care to adult care is often difficult, especially in children with chronic diseases like asthma. A significant number of children reach remission throughout puberty; consequently, they are not tracked down for subsequent follow-ups and are not included in transition programmes to adult care. This case report focuses on a young adult with asthma that began in childhood and went into remission during adolescence, only to experience a recurrence when the patient was a young adult. Due to failing to complete the transition process into adult care services, she had poor adherence to therapy and asthma control.Adherence and asthma control significantly improved after a multidisciplinary approach in an adult care setting. In conclusion, appropriate transition and a multidisciplinary approach are critical for the effective management of asthma in young adults.
MeSH term(s)	Child ; Female ; Young Adult ; Adolescent ; Humans ; Adult ; Asthma/drug therapy ; Chronic Disease ; Self Care
Language	English
Publishing date	2022-10-31
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-251244
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer.

Marković, Iva / Savvides, Savvas N

Frontiers in immunology

2020 Volume 11, Page(s) 1557

Abstract: Thymic Stromal Lymphopoietin (TSLP) and Interleukin-7 (IL-7) are widely studied cytokines within distinct branches of immunology. On one hand, TSLP is crucially important for mediating type 2 immunity at barrier surfaces and has been linked to widespread ...

Abstract	Thymic Stromal Lymphopoietin (TSLP) and Interleukin-7 (IL-7) are widely studied cytokines within distinct branches of immunology. On one hand, TSLP is crucially important for mediating type 2 immunity at barrier surfaces and has been linked to widespread allergic and inflammatory diseases of the airways, skin, and gut. On the other hand, IL-7 operates at the foundations of T-cell and innate lymphoid cell (ILC) development and homeostasis and has been associated with cancer. Yet, TSLP and IL-7 are united by key commonalities in their structure and the structural basis of the receptor assemblies they mediate to initiate cellular signaling, in particular their cross-utilization of IL-7Rα. As therapeutic targeting of TSLP and IL-7 via diverse approaches is reaching advanced stages and in light of the plethora of mechanistic and structural data on receptor signaling mediated by the two cytokines, the time is ripe to provide integrated views of such knowledge. Here, we first discuss the major pathophysiological roles of TSLP and IL-7 in autoimmune diseases, inflammation and cancer. Subsequently, we curate structural and mechanistic knowledge about receptor assemblies mediated by the two cytokines. Finally, we review therapeutic avenues targeting TSLP and IL-7 signaling. We envision that such integrated view of the mechanism, structure, and modulation of signaling assemblies mediated by TSLP and IL-7 will enhance and fine-tune the development of more effective and selective approaches to further interrogate the role of TSLP and IL-7 in physiology and disease.
MeSH term(s)	Animals ; Autoimmune Diseases/etiology ; Autoimmune Diseases/metabolism ; Cytokines/chemistry ; Cytokines/genetics ; Cytokines/metabolism ; Disease Susceptibility ; Genetic Variation ; Humans ; Inflammation/etiology ; Inflammation/metabolism ; Interleukin-7/chemistry ; Interleukin-7/genetics ; Interleukin-7/metabolism ; Neoplasms/etiology ; Neoplasms/metabolism ; Receptors, Cytokine/chemistry ; Receptors, Cytokine/metabolism ; Receptors, Interleukin-7/chemistry ; Receptors, Interleukin-7/metabolism ; Signal Transduction ; Structure-Activity Relationship
Chemical Substances	Cytokines ; IL7 protein, human ; Interleukin-7 ; Receptors, Cytokine ; Receptors, Interleukin-7 ; TSLP protein, human
Language	English
Publishing date	2020-07-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.01557
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