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Article ; Online: Genomic characterization of malignant pleural mesothelioma and associated clinical outcomes.

Markowitz, Paul / Patel, Malini / Groisberg, Roman / Aisner, Joseph / Jabbour, Salma K / De, Subhajyoti / Ganesan, Shridar / Malhotra, Jyoti

Cancer treatment and research communications

2020 Volume 25, Page(s) 100232

Abstract: Introduction: Malignant pleural mesothelioma (MPM) is a rare malignancy with a poor prognosis. While treatment with a platinum-based chemotherapy is the standard of care, many patients have rapid progression of disease with a median overall survival of ~ ...

Abstract	Introduction: Malignant pleural mesothelioma (MPM) is a rare malignancy with a poor prognosis. While treatment with a platinum-based chemotherapy is the standard of care, many patients have rapid progression of disease with a median overall survival of ~12 months. Limited data exist about the genomic alterations associated with MPM and their clinical implications. Methods: We report genomic alterations and clinical data for 17 patients with MPM who had next generation sequencing performed. Overall survival (OS) and progression-free survival (PFS) were analyzed with Kaplan-Meier method. Results: Median age at diagnosis was 70 years (range 55-85), and 47% of the patients were male. The most common genomic alterations in the 17 patients were NF2 (53%), BAP1 (41%), CDKN2A (41%) and TP53 (29%). The median OS was 10.8 months. When stratified by mutational status, patients had better median OS if they had a BAP1 alteration compared to TP53 alteration (median OS 14.5 vs 7.2 months). Median PFS with first-line chemotherapy was 7 months (SD ± 3.3). However, patients with TP53 mutations had worse PFS with chemotherapy with median of only 3.9 months. Tumor mutation burden (TMB) was available for 12 patients and all had low TMB (range 1 to 8.1 mutation/Mb). Median PFS with immunotherapy was poor with at 1.5 months (SD ±0.4) and there was no significant difference in PFS with immunotherapy based on molecular profile. Conclusion: Our study has identified that TP53 confers worse survival and response to platinum chemotherapy compared to BAP1. Overall PDL1 expression and TMB is low in patients with MPM resulting in limited benefit from single agent PD-1/PD-L1 agent.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Genomics/methods ; Humans ; Male ; Mesothelioma, Malignant/genetics ; Mesothelioma, Malignant/pathology ; Middle Aged ; Pleural Neoplasms/genetics ; Pleural Neoplasms/pathology ; Treatment Outcome
Language	English
Publishing date	2020-11-03
Publishing country	England
Document type	Journal Article
ISSN	2468-2942
ISSN (online)	2468-2942
DOI	10.1016/j.ctarc.2020.100232
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Book: Guide to Implementing Local Environmental Action Programs in Central and Eastern Europe

Markowitz, Paul

2000 , Page(s) 166 S.

Keywords	Umweltpolitik ; Umweltprogramm ; Umweltschutzmassnahme ; Nachhaltige Entwicklung ; Agenda-21 (Rio-Konferenz 1992) ; Lokale Agenda 21 ; Kommunale Umweltpolitik ; Evaluationsforschung ; Fallstudie ; Partizipation ; Buergerbeteiligung ; Politische Durchsetzbarkeit ; Entscheidungsprozess ; Umweltqualitaetsziel
Language	English
Document type	Book
ISBN	963-8454-77-6
Database	OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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Article ; Online: Novel Measurement of the Neutron Magnetic Form Factor from A=3 Mirror Nuclei.

Santiesteban, S N / Li, S / Abrams, D / Alsalmi, S / Androic, D / Aniol, K / Arrington, J / Averett, T / Ayerbe Gayoso, C / Bane, J / Barcus, S / Barrow, J / Beck, A / Bellini, V / Bhatt, H / Bhetuwal, D / Biswas, D / Camsonne, A / Castellanos, J /

Chen, J / Chen, J-P / Chrisman, D / Christy, M E / Clarke, C / Covrig, S / Cruz-Torres, R / Day, D / Dutta, D / Fuchey, E / Gal, C / Garibaldi, F / Gautam, T N / Gogami, T / Gomez, J / Guèye, P / Hague, T J / Hansen, J O / Hauenstein, F / Henry, W / Higinbotham, D W / Holt, R J / Hyde, C / Itabashi, K / Kaneta, M / Karki, A / Katramatou, A T / Keppel, C E / King, P M / Kurbany, L / Kutz, T / Lashley-Colthirst, N / Li, W B / Liu, H / Liyanage, N / Long, E / Lovato, A / Mammei, J / Markowitz, P / McClellan, R E / Meddi, F / Meekins, D / Michaels, R / Mihovilovič, M / Moyer, A / Nagao, S / Nguyen, D / Nycz, M / Olson, M / Ou, L / Owen, V / Palatchi, C / Pandey, B / Papadopoulou, A / Park, S / Petkovic, T / Premathilake, S / Punjabi, V / Ransome, R D / Reimer, P E / Reinhold, J / Riordan, S / Rocco, N / Rodriguez, V M / Schmidt, A / Schmookler, B / Segarra, E P / Shahinyan, A / Širca, S / Slifer, K / Solvignon, P / Su, T / Suleiman, R / Tang, L / Tian, Y / Tireman, W / Tortorici, F / Toyama, Y / Uehara, K / Urciuoli, G M / Votaw, D / Williamson, J / Wojtsekhowski, B / Wood, S / Ye, Z H / Zhang, J / Zheng, X

Physical review letters

2024 Volume 132, Issue 16, Page(s) 162501

Abstract: The electromagnetic form factors of the proton and neutron encode information on the spatial structure of their charge and magnetization distributions. While measurements of the proton are relatively straightforward, the lack of a free neutron target ... ...

Abstract	The electromagnetic form factors of the proton and neutron encode information on the spatial structure of their charge and magnetization distributions. While measurements of the proton are relatively straightforward, the lack of a free neutron target makes measurements of the neutron's electromagnetic structure more challenging and more sensitive to experimental or model-dependent uncertainties. Various experiments have attempted to extract the neutron form factors from scattering from the neutron in deuterium, with different techniques providing different, and sometimes large, systematic uncertainties. We present results from a novel measurement of the neutron magnetic form factor using quasielastic scattering from the mirror nuclei ^{3}H and ^{3}He, where the nuclear effects are larger than for deuterium but expected to largely cancel in the cross-section ratios. We extracted values of the neutron magnetic form factor for low-to-modest momentum transfer, 0.6<Q^{2}<2.9 GeV^{2}, where existing measurements give inconsistent results. The precision and Q^{2} range of these data allow for a better understanding of the current world's data and suggest a path toward further improvement of our overall understanding of the neutron's magnetic form factor.<br />
Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.132.162501
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Article ; Online: Measured proton electromagnetic structure deviates from theoretical predictions.

Li, R / Sparveris, N / Atac, H / Jones, M K / Paolone, M / Akbar, Z / Gayoso, C Ayerbe / Berdnikov, V / Biswas, D / Boer, M / Camsonne, A / Chen, J-P / Diefenthaler, M / Duran, B / Dutta, D / Gaskell, D / Hansen, O / Hauenstein, F / Heinrich, N /

Henry, W / Horn, T / Huber, G M / Jia, S / Joosten, S / Karki, A / Kay, S J D / Kumar, V / Li, X / Li, W B / Liyanage, A H / Malace, S / Markowitz, P / McCaughan, M / Meziani, Z-E / Mkrtchyan, H / Morean, C / Muhoza, M / Narayan, A / Pasquini, B / Rehfuss, M / Sawatzky, B / Smith, G R / Smith, A / Trotta, R / Yero, C / Zheng, X / Zhou, J

Nature

2022 Volume 611, Issue 7935, Page(s) 265–270

Abstract: The visible world is founded on the proton, the only composite building block of matter that is stable in nature. Consequently, understanding the formation of matter relies on explaining the dynamics and the properties of the proton's bound state. A ... ...

Abstract	The visible world is founded on the proton, the only composite building block of matter that is stable in nature. Consequently, understanding the formation of matter relies on explaining the dynamics and the properties of the proton's bound state. A fundamental property of the proton involves the response of the system to an external electromagnetic field. It is characterized by the electromagnetic polarizabilities<sup>1</sup> that describe how easily the charge and magnetization distributions inside the system are distorted by the electromagnetic field. Moreover, the generalized polarizabilities<sup>2</sup> map out the resulting deformation of the densities in a proton subject to an electromagnetic field. They disclose essential information about the underlying system dynamics and provide a key for decoding the proton structure in terms of the theory of the strong interaction that binds its elementary quark and gluon constituents. Of particular interest is a puzzle in the electric generalized polarizability of the proton that remains unresolved for two decades<sup>2</sup>. Here we report measurements of the proton's electromagnetic generalized polarizabilities at low four-momentum transfer squared. We show evidence of an anomaly to the behaviour of the proton's electric generalized polarizability that contradicts the predictions of nuclear theory and derive its signature in the spatial distribution of the induced polarization in the proton. The reported measurements suggest the presence of a new, not-yet-understood dynamical mechanism in the proton and present notable challenges to the nuclear theory.
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-05248-1
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Conscious and unconscious perceptions of self in children of alcoholics.

Markowitz, P / Craig, R J

The International journal of the addictions

1992 Volume 27, Issue 10, Page(s) 1187–1196

Abstract: The conscious and unconscious self-concept was examined in three groups of children: 23 children of alcoholics (COA), 19 children from nonalcoholic but dysfunctional families, and 23 children from normal families without alcoholism or family dysfunction. ...

Abstract	The conscious and unconscious self-concept was examined in three groups of children: 23 children of alcoholics (COA), 19 children from nonalcoholic but dysfunctional families, and 23 children from normal families without alcoholism or family dysfunction. Self-concept was assessed both objectively, using the Piers-Harris Children's Self Concept Scale, and subjectively, using the Draw-A-Person Test and the Thematic Apperception Test from rating systems designed to tap unconscious dimensions of self. The COAs and normal controls were also compared for behavioral problems with the Achenbach Child Behavior Checklist. We found that COAs made more positive self-statements on objective measures of self-concept than children from families without alcoholism, whether or not the families were dysfunctional. Subjective analyses of projective test responses revealed unconscious differences in self-concept among the COAs, though this was not corroborated with objective scores, probably due to the crudeness of the rating instrument in failing to tap these dimensions. Also COAs had significantly more behavior problems, based on parental reports, which contrasts with their objective reports of self. Implications of these findings were discussed.
MeSH term(s)	Alcoholism/genetics ; Alcoholism/psychology ; Child ; Consciousness ; Family/psychology ; Female ; Humans ; Male ; Self Concept ; Unconscious (Psychology)
Language	English
Publishing date	1992-10
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	390886-0
ISSN	0020-773X
ISSN	0020-773X
DOI	10.3109/10826089209047343
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Article: Effect of fluoxetine on self-injurious behavior in the developmentally disabled: a preliminary study.

Markowitz, P I

Journal of clinical psychopharmacology

1992 Volume 12, Issue 1, Page(s) 27–31

Abstract: Self-injury is common in mentally retarded persons and often unresponsive to pharmacotherapy. Based on the assumption that this maladaptive behavior may be related to central nervous system serotonergic imbalance or dysfunction, an open trial with a ... ...

Abstract	Self-injury is common in mentally retarded persons and often unresponsive to pharmacotherapy. Based on the assumption that this maladaptive behavior may be related to central nervous system serotonergic imbalance or dysfunction, an open trial with a serotonin uptake inhibitor was conducted. Twenty-one severely to profoundly mentally retarded persons with aggression and self-injurious behavior were treated with 20-40 mg of fluoxetine daily. Marked improvement occurred in 13 patients, moderate in 4, mild in 2, and no improvement in 2 patients treated for a minimum of 3 months. Positive changes occurred in the areas of self-injury, agitation, emotional lability, and aggression. Only one patient required discontinuation of the medication because of anorexia and weight loss; all other patients tolerated the drug without any significant side effects. All were concurrently taking other psychotropic medications, and no adverse drug interactions were noted. Future trials will focus on more homogeneous patient samples and on the therapeutic interactions between concurrently administered psychotropic medications.
MeSH term(s)	Adolescent ; Adult ; Female ; Fluoxetine/adverse effects ; Fluoxetine/therapeutic use ; Humans ; Intellectual Disability/drug therapy ; Male ; Middle Aged ; Self-Injurious Behavior/drug therapy
Chemical Substances	Fluoxetine (01K63SUP8D)
Language	English
Publishing date	1992-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/00001573-199202000-00005
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Article: Fluoxetine treatment of self-injurious behavior in mentally retarded patients.

Markowitz, P I

Journal of clinical psychopharmacology

1990 Volume 10, Issue 4, Page(s) 299–300

MeSH term(s)	Adult ; Dose-Response Relationship, Drug ; Female ; Fluoxetine/therapeutic use ; Humans ; Male ; Mental Disorders/drug therapy ; Middle Aged ; Self Mutilation/drug therapy ; Stereotyped Behavior/drug effects
Chemical Substances	Fluoxetine (01K63SUP8D)
Language	English
Publishing date	1990-08
Publishing country	United States
Document type	Letter
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
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Article: Autism in a child with congenital cytomegalovirus infection.

Markowitz, P I

Journal of autism and developmental disorders

1983 Volume 13, Issue 3, Page(s) 249–253

Abstract: A case is reported of early infantile autism associated with a congenital cytomegalovirus infection. The diagnosis of autism is based on the child's failure to develop good interpersonal relationships, poor eye contact, delayed and deviant use of ... ...

Abstract	A case is reported of early infantile autism associated with a congenital cytomegalovirus infection. The diagnosis of autism is based on the child's failure to develop good interpersonal relationships, poor eye contact, delayed and deviant use of language, and her rote and nonthematic use of objects and playthings. Resistance to change and self-stimulatory behavior were also present. Onset was before 2 years of age. Congenital cytomegalovirus infection was suggested by the presence of an antibody response to the virus, culture of the virus from the urine, sensorineural hearing loss, and inflammatory damage to the retina of the eye. Although over time improvement was noted, at last examination at the age of 5 years her behavior is still markedly deviant. This and other reported cases suggest that congenital viral infection may be an important cause of infantile autism. It is hypothesized that an ability of the agent to establish chronic infection may predispose to behavioral aberration.
MeSH term(s)	Autistic Disorder/etiology ; Autistic Disorder/psychology ; Child ; Child Abuse ; Child Development ; Child, Preschool ; Cytomegalovirus Infections/congenital ; Cytomegalovirus Infections/psychology ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn
Language	English
Publishing date	1983-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/bf01531564
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Book: Town energy planning

Markowitz, Paul

a framework for action

(Vermont. Agricultural Experiment Station. Bulletin ; 691)

1983

Author's details	by Paul Markowitz ; developed cooperatively by the Center for Rural Studies, College of Agriculture, University of Vermont and the Agency of Development and Community Affairs. --
Series title	Vermont. Agricultural Experiment Station. Bulletin ; 691
Language	English
Size	iv, 102 p. :, forms ;, 28 cm. --
Publisher	Agricultural Experiment Station, University of Vermont
Publishing place	Burlington
Document type	Book
Note	"October 1983."
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Unique Access to u-Channel Physics: Exclusive Backward-Angle Omega Meson Electroproduction.

Li, W B / Huber, G M / Blok, H P / Gaskell, D / Horn, T / Semenov-Tian-Shansky, K / Pire, B / Szymanowski, L / Laget, J-M / Aniol, K / Arrington, J / Beise, E J / Boeglin, W / Brash, E J / Breuer, H / Chang, C C / Christy, M E / Ent, R / Gibson, E F /

Holt, R J / Jin, S / Jones, M K / Keppel, C E / Kim, W / King, P M / Kovaltchouk, V / Liu, J / Lolos, G J / Mack, D J / Margaziotis, D J / Markowitz, P / Matsumura, A / Meekins, D / Miyoshi, T / Mkrtchyan, H / Niculescu, I / Okayasu, Y / Pentchev, L / Perdrisat, C / Potterveld, D / Punjabi, V / Reimer, P E / Reinhold, J / Roche, J / Roos, P G / Sarty, A / Smith, G R / Tadevosyan, V / Tang, L G / Tvaskis, V / Volmer, J / Vulcan, W / Warren, G / Wood, S A / Xu, C / Zheng, X

Physical review letters

2019 Volume 123, Issue 18, Page(s) 182501

Abstract: Backward-angle meson electroproduction above the resonance region, which was previously ignored, is anticipated to offer unique access to the three quark plus sea component of the nucleon wave function. In this Letter, we present the first complete ... ...

Abstract	Backward-angle meson electroproduction above the resonance region, which was previously ignored, is anticipated to offer unique access to the three quark plus sea component of the nucleon wave function. In this Letter, we present the first complete separation of the four electromagnetic structure functions above the resonance region in exclusive ω electroproduction off the proton, ep→e^{'}pω, at central Q^{2} values of 1.60, 2.45 GeV^{2}, at W=2.21 GeV. The results of our pioneering -u≈-u_{min} study demonstrate the existence of a unanticipated backward-angle cross section peak and the feasibility of full L/T/LT/TT separations in this never explored kinematic territory. At Q^{2}=2.45 GeV^{2}, the observed dominance of σ_{T} over σ_{L}, is qualitatively consistent with the collinear QCD description in the near-backward regime, in which the scattering amplitude factorizes into a hard subprocess amplitude and baryon to meson transition distribution amplitudes: universal nonperturbative objects only accessible through backward-angle kinematics.
Language	English
Publishing date	2019-11-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.123.182501
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