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Book ; Thesis: Häufigkeit, Verlauf und Komplikationen von RSV-Infektionen im Säuglings- und Kleinkindalter in der Klinik und Poliklinik für Kinder- und Jungendmedizin des Universitätsklinikums Carl Gustav Carus Dresden von 2004 - 2009

Marks, Janine

2013

Author's details	von Janine Marks
Language	German
Size	XXXVI, 100 Bl. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dresden, Techn. Univ., Diss., 2013
HBZ-ID	HT018274671
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: The absorbing life of bile acids.

Marks, Joanne

Kidney international

2020 Volume 97, Issue 6, Page(s) 1099–1102

Abstract: Hyperphosphatemia increases cardiovascular complications and all-cause mortality rate in patients with chronic kidney disease. Targeting the processes involved in dietary phosphate absorption is an attractive means for reducing this phosphate burden. We ... ...

Abstract	Hyperphosphatemia increases cardiovascular complications and all-cause mortality rate in patients with chronic kidney disease. Targeting the processes involved in dietary phosphate absorption is an attractive means for reducing this phosphate burden. We do not, however, fully understand this process and how it is regulated. This commentary describes recent findings regarding the novel role of bile acids in regulating paracellular phosphate (and calcium) absorption by the small intestine and the potential cellular mechanisms involved.
MeSH term(s)	Bile Acids and Salts ; Calcium, Dietary ; Humans ; Hyperphosphatemia/etiology ; Phosphates ; Renal Insufficiency, Chronic
Chemical Substances	Bile Acids and Salts ; Calcium, Dietary ; Phosphates
Language	English
Publishing date	2020-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2020.03.020
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Article ; Online: To cut or not to cut; that is the question: surgical versus endoscopic gastrojejunostomy for the palliation of malignant gastric outlet obstruction.

Lyons, Joshua / Marks, Jeffrey

Gastrointestinal endoscopy

2023 Volume 98, Issue 3, Page(s) 360–361

MeSH term(s)	Humans ; Gastric Bypass ; Endoscopy ; Gastric Outlet Obstruction/etiology ; Gastric Outlet Obstruction/surgery
Language	English
Publishing date	2023-08-18
Publishing country	United States
Document type	Editorial
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2023.04.2096
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Article: Iron Metabolism in Skin Disease.

Marks, Janet

Journal of the Royal College of Physicians of London

2019 Volume 1, Issue 4, Page(s) 367–372

Language	English
Publishing date	2019-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	3005-3
ISSN	0035-8819
ISSN	0035-8819
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Article ; Online: The role of SLC34A2 in intestinal phosphate absorption and phosphate homeostasis.

Marks, Joanne

Pflugers Archiv : European journal of physiology

2018 Volume 471, Issue 1, Page(s) 165–173

Abstract: There has recently been significant interest in the concept of directly targeting intestinal phosphate transport to control hyperphosphatemia in patients with chronic kidney disease. However, we do not have a complete understanding of the cellular ... ...

Abstract	There has recently been significant interest in the concept of directly targeting intestinal phosphate transport to control hyperphosphatemia in patients with chronic kidney disease. However, we do not have a complete understanding of the cellular mechanisms that govern dietary phosphate absorption. Studies in the 1970s documented both active and passive pathways for intestinal phosphate absorption. However, following the cloning of the intestinal SLC34 cotransporter, NaPi-IIb, much of the research focused on the role of this protein in active transcellular phosphate absorption and the factors involved in its regulation. Generation of a conditional NaPi-IIb knockout mouse has demonstrated that this protein is critical for the maintenance of skeletal integrity during periods of phosphate restriction and that under normal physiological conditions, the passive sodium-independent pathway is likely be the more dominant pathway for intestinal phosphate absorption. The review aims to summarise the most recent developments in our understanding of the role of the intestine in phosphate homeostasis, including the acute and chronic renal adaptations that occur in response to dietary phosphate intake. Evidence regarding the overall contribution of the transcellular and paracellular pathways for phosphate absorption will be discussed, together with the clinical benefit of inhibiting these pathways for the treatment of hyperphosphatemia in chronic kidney disease.
MeSH term(s)	Animals ; Homeostasis ; Humans ; Intestinal Absorption ; Phosphates/metabolism ; Sodium-Phosphate Cotransporter Proteins, Type II/genetics ; Sodium-Phosphate Cotransporter Proteins, Type II/metabolism
Chemical Substances	Phosphates ; Sodium-Phosphate Cotransporter Proteins, Type II
Language	English
Publishing date	2018-10-20
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	6380-0
ISSN	1432-2013 ; 0031-6768
ISSN (online)	1432-2013
ISSN	0031-6768
DOI	10.1007/s00424-018-2221-1
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Article: Physiological regulation of phosphate homeostasis.

Marks, Joanne / Unwin, Robert J

Vitamins and hormones

2022 Volume 120, Page(s) 47–78

Abstract: Phosphate homeostasis is dependent on the interaction and coordination of four main organ systems: thyroid/parathyroids, gastrointestinal tract, bone and kidneys, and three key hormonal regulators, 1,25-hydroxyvitamin D3, parathyroid hormone and FGF23 ... ...

Abstract	Phosphate homeostasis is dependent on the interaction and coordination of four main organ systems: thyroid/parathyroids, gastrointestinal tract, bone and kidneys, and three key hormonal regulators, 1,25-hydroxyvitamin D3, parathyroid hormone and FGF23 with its co- factor klotho. Phosphorus is a critical nutritional element for normal cellular function, but in excess can be toxic to tissues, particularly the vasculature. As phosphate, it also has an important interaction and inter-dependence with calcium and calcium homeostasis sharing some of the same controlling hormones, although this is not covered in our article. We have chosen to provide a current overview of phosphate homeostasis only, focusing on the role of two major organ systems, the gastrointestinal tract and kidneys, and their contribution to the control of phosphate balance. We describe in some detail the mechanisms of intestinal and renal phosphate transport, and compare and contrast their regulation. We also consider a significant example of phosphate imbalance, with phosphate retention, which is chronic kidney disease; why consequent hyperphosphatemia is important, and some of the newer means of managing it.
MeSH term(s)	Calcium ; Fibroblast Growth Factors/physiology ; Glucuronidase/genetics ; Homeostasis ; Humans ; Kidney ; Parathyroid Hormone/physiology ; Phosphates ; Vitamin D/physiology
Chemical Substances	Parathyroid Hormone ; Phosphates ; Vitamin D (1406-16-2) ; Fibroblast Growth Factors (62031-54-3) ; Glucuronidase (EC 3.2.1.31) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-07-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	201161-x
ISSN	2162-2620 ; 0083-6729
ISSN (online)	2162-2620
ISSN	0083-6729
DOI	10.1016/bs.vh.2022.04.007
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Article ; Online: Robotic right colectomy with robotic-sewn anastomosis: a pilot case series.

Huscher, C G S / Lazzarin, Gianni / Marchegiani, F / Marks, J

Journal of robotic surgery

2022 Volume 17, Issue 2, Page(s) 427–434

Abstract: The background of this study is to assess the feasibility, clinical utility and safety of intra-corporeal robotic-sewn anastomosis (ICrA) in completely robotic right hemicolectomy (CRH) for adenocarcinoma. A protocol for completely robotic right ... ...

Abstract	The background of this study is to assess the feasibility, clinical utility and safety of intra-corporeal robotic-sewn anastomosis (ICrA) in completely robotic right hemicolectomy (CRH) for adenocarcinoma. A protocol for completely robotic right hemicolectomy (CRH) and intra-corporeal robotic-sewn anastomosis (ICrA), was established at the authors' institution from January 2012 through December 2017. Univariate and multivariable models were constructed to explore the prognostic significance of clinical and surgical findings. Survival and recurrence analysis were performed using standard univariable and multivariable methods. The study population consisted of 123 patients. The median number of examined lymph nodes (ELN) was 25 (range 1-59), the median number of positive lymph nodes (PLN) was 1 (range 0-21). Mean operative time was 240 min (SD 43.56, range 180-360 min), and conversion to open rate was 0%. Anastomotic leaks rate was 1.6%. The median overall survival was 69 months. This pilot series, in which an intra-corporeal robotic-sewn anastomosis (ICrA) was performed during CRH, demonstrated the safety and feasibility of this approach. Compared to the current standard of care at a high-volume center, ICrA was associated with post-operative surgical outcomes similar to those reported in the literature. These results call for further validation in a prospective and controlled setting to be fully incorporated into clinical practice.
MeSH term(s)	Humans ; Robotic Surgical Procedures/methods ; Prospective Studies ; Robotics ; Colectomy/methods ; Anastomosis, Surgical/methods ; Laparoscopy/methods ; Colonic Neoplasms/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-06-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2268283-1
ISSN	1863-2491 ; 1863-2483
ISSN (online)	1863-2491
ISSN	1863-2483
DOI	10.1007/s11701-022-01435-4
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Article ; Online: Laparoscopic right colectomy: correct technique based on key anatomical principles.

Lirici, Marco Maria / Dapri, Giovanni / Huescher, Cristiano G S / Marks, John

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy

2024 , Page(s) 1–13

Abstract: Since the early1990s, laparoscopic right colon resections have been the most performed advanced laparoscopic procedures just after laparoscopic left colectomies and sigmoid resections. Indications for laparoscopic right colectomies are either benign or ... ...

Abstract	Since the early1990s, laparoscopic right colon resections have been the most performed advanced laparoscopic procedures just after laparoscopic left colectomies and sigmoid resections. Indications for laparoscopic right colectomies are either benign or malignant diseases. Despite its many indications, a laparoscopic right or extended right colectomy is mostly performed for cancer of the caecum, the ascending colon, the hepatic flexure or the proximal transverse colon. Worldwide, colorectal cancer is the third most diagnosed cancer: an estimated 1,880,725 people were diagnosed with colorectal cancer in 2020, out of which 1,148,515 were colon cancer cases and 40% were located in the right colon. These figures make an oncologic sound surgery for right colon cancer of the utmost relevance. More recently, complete mesocolic excision has been advocated as the optimal choice in term of radicality, especially in node-positive patients with right colon cancer. Laparoscopic standard right colectomy and extended right colectomy with or without CME should be performed according to defined principles based on a close knowledge of key anatomical landmarks. This knowledge will allow to trace anatomical structures and drive instruments along the correct surgical planes and has its foundations in teachings from surgeons and scientists of past and present time.
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1317160-4
ISSN	1365-2931 ; 1364-5706
ISSN (online)	1365-2931
ISSN	1364-5706
DOI	10.1080/13645706.2024.2332880
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Article ; Online: Decreased bed mobility function is associated with post-discharge mortality for cancer patients in inpatient rehabilitation.

Roy, Ishan / Marks, Julia / Fram, Julia / Jayabalan, Prakash / Spill, Gayle

American journal of physical medicine & rehabilitation

2024

Abstract: Objective: The establishment of rehabilitation goals for hospitalized cancer patients depends on accurate medical prognosis and matching goals to clinical timelines. Current tools for estimating prognosis are limited. We hypothesized that bed mobility ... ...

Abstract	Objective: The establishment of rehabilitation goals for hospitalized cancer patients depends on accurate medical prognosis and matching goals to clinical timelines. Current tools for estimating prognosis are limited. We hypothesized that bed mobility is a predictor of mortality in cancer patients admitted to inpatient rehabilitation. Design: In a retrospective cohort of 187 subjects with non-neurologic cancer admitted to inpatient rehabilitation, Functional Independence Measure (FIM) scores and 6-month mortality were analyzed. Results: In the cohort, survival rate was 71% at 6 months. In univariate analysis, discharge bed mobility score (OR = 0.75, 95%CI = 0.61 to 0.90, p = 0.003), bed mobility FIM gain (OR = 0.66, 95%CI = 0.51 to 0.85, p = 0.002), and bed mobility FIM efficiency (OR = 0.011, 95%CI = 0.00032 to 0.21, p = 0.006) were inversely associated with 6-month mortality after discharge from IRF. In multivariate analysis with additional motor FIM items, only bed mobility (OR = 0.73, 95%CI = 0.54 to 0.97, p = 0.029) and grooming (OR = 0.79, 95% CI = 0.63 to 0.99, p = 0.041) were independently associated with mortality. Conclusions: Lower discharge and lower change in bed mobility FIM scores are associated with mortality in cancer patients in inpatient rehabilitation. Bed mobility could serve as a clinical tool for estimating medical prognosis in hospitalized cancer patients and should be validated in prospective studies.
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	219390-5
ISSN	1537-7385 ; 0002-9491 ; 0894-9115
ISSN (online)	1537-7385
ISSN	0002-9491 ; 0894-9115
DOI	10.1097/PHM.0000000000002406
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Article ; Online: Granadilla swimwear

Marks, Jonathan

Emerald Emerging Markets Case Studies

finding opportunity in times of crisis

2020 Volume 10, Issue 3, Page(s) 1–9

Abstract: Learning outcomes The main learning outcomes that can develop from this case are as follows. These have been articulated for an approximately 90-min class discussion. Opportunity identification in times of crisis: at a macro-level, the case serves to ... ...

Abstract	Learning outcomes The main learning outcomes that can develop from this case are as follows. These have been articulated for an approximately 90-min class discussion. Opportunity identification in times of crisis: at a macro-level, the case serves to illustrate the nature of identifying and exploiting opportunities in times of crisis. In particular, it shows how an agile small team and quickly respond to need and develop a sustainable and scalable business. Pivoting the business model: the case raises an interesting and important debate as regards what constitutes a “pivot”. While the classical interpretation would be a change in direction without a change in strategy, this case within the context of Covid-19 challenges this definition. Resource use and allocation: The case illustrates well how existing resources, networks and skills can be used in a very different business venture to alleviate immediate cash flow needs and potentially build another business venture. Case overview/synopsis This case study explores how two Cape Town-based entrepreneurs, Josh Meltz and Adam Duxbury, responded to the Covid-19 crisis and the subsequent lockdown in South Africa. The pair had built a successful swimwear brand – Granadilla Swimwear – and two other businesses: a function venue and a kombucha brand sold at a well-known food market. As the Covid-19 lockdown tool effect, the entrepreneurs saw not only declining revenue in their food and function venue business but were about to enter a six-month period of negative cash flow on their seasonal swimwear business. The entrepreneurs saw an opportunity to deliver food boxes of fresh fruit, vegetables, bread and other staples within the Cape Town metropolitan area. Their kombucha brand had a ready-made food processing and handling facility (including cold storage) and existing relationships with customers, suppliers and other vendors at the food market gave them ready access to a range of locally produced food products available immediately and on consignment. Meltz & Duxbury quickly launched an online shop and started marketing via Instagram. Within 48 h, they were delivering food boxes, with little risk and upfront capital investment. As the lockdown continued and other competitors entered the market, the team wondered at the longevity of the pivot and whether this was a business that would sustain itself or whether it was just a short-term fix for their immediate cash flow problems. Complexity academic level Undergraduate and postgraduate Supplementary materials Teaching Notes are available for educators only. Subject code CSS: 3 Entrepreneurship.
Keywords	covid19
Language	English
Publisher	Emerald
Publishing country	uk
Document type	Article ; Online
ISSN	2045-0621
DOI	10.1108/eemcs-05-2020-0164
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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