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  1. Article ; Online: NSCLC With Synchronous EGFR Mutations in Li Fraumeni Syndrome: A Case Report.

    Marks, Jennifer A / Liu, Stephen V

    JTO clinical and research reports

    2023  Volume 4, Issue 6, Page(s) 100521

    Abstract: We report a case of a patient with Li Fraumeni Syndrome (LFS) who developed ... ...

    Abstract We report a case of a patient with Li Fraumeni Syndrome (LFS) who developed synchronous
    Language English
    Publishing date 2023-04-30
    Publishing country United States
    Document type Case Reports
    ISSN 2666-3643
    ISSN (online) 2666-3643
    DOI 10.1016/j.jtocrr.2023.100521
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  2. Article: Precision Immuno-Oncology in NSCLC through Gender Equity Lenses.

    Marks, Jennifer / Sridhar, Arthi / Ai, Angela / Kiel, Lauren / Kaufman, Rebekah / Abioye, Oyepeju / Mantz, Courtney / Florez, Narjust

    Cancers

    2024  Volume 16, Issue 7

    Abstract: Precision immuno-oncology involves the development of personalized cancer treatments that are influenced by the unique nature of an individual's DNA, immune cells, and their tumor's molecular characterization. Biological sex influences immunity; females ... ...

    Abstract Precision immuno-oncology involves the development of personalized cancer treatments that are influenced by the unique nature of an individual's DNA, immune cells, and their tumor's molecular characterization. Biological sex influences immunity; females typically mount stronger innate and adaptive immune responses than males. Though more research is warranted, we continue to observe an enhanced benefit for females with lung cancer when treated with combination chemoimmunotherapy in contrast to the preferred approach of utilizing immunotherapy alone in men. Despite the observed sex differences in response to treatments, women remain underrepresented in oncology clinical trials, largely as a result of gender-biased misconceptions. Such exclusion has resulted in the development of less efficacious treatment guidelines and clinical recommendations and has created a knowledge gap in regard to immunotherapy-related survivorship issues such as fertility. To develop a more precise approach to care and overcome the exclusion of women from clinical trials, flexible trial schedules, multilingual communication strategies, financial, and transportation assistance for participants should be adopted. The impact of intersectionality and other determinants of health that affect the diagnosis, treatment, and outcomes in women must also be considered in order to develop a comprehensive understanding of the unique impact of immunotherapy in all women with lung cancer.
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16071413
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  3. Article ; Online: Multiple myeloma with central nervous system relapse presenting as right pupil-sparing complete third nerve palsy.

    Tiu, Andrew / Marks, Jennifer / Aljuaid, Roaa / Alzeer, Ali / Dunleavy, Kieron

    American journal of hematology

    2022  Volume 97, Issue 12, Page(s) 1666–1668

    MeSH term(s) Humans ; Pupil ; Multiple Myeloma/complications ; Neoplasm Recurrence, Local ; Oculomotor Nerve Diseases/etiology ; Central Nervous System
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26720
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    Zs.A 1251: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Antibody-Drug Conjugates in Non-Small Cell Lung Cancer: Emergence of a Novel Therapeutic Class.

    Marks, Jennifer A / Wilgucki, Molly / Liu, Stephen V / Reuss, Joshua E

    Current oncology reports

    2022  Volume 24, Issue 12, Page(s) 1829–1841

    Abstract: Purpose of review: Antibody-drug conjugates (ADCs) are a class of therapeutics that combine target-specific monoclonal antibodies with cytotoxic chemotherapy. Here, we describe the components of ADCs and review their promising activity, safety, and ... ...

    Abstract Purpose of review: Antibody-drug conjugates (ADCs) are a class of therapeutics that combine target-specific monoclonal antibodies with cytotoxic chemotherapy. Here, we describe the components of ADCs and review their promising activity, safety, and applicability in non-small cell lung cancer (NSCLC).
    Recent findings: Technological advancements have reinvigorated ADCs as a viable treatment strategy in advanced solid tumors. Several target-specific ADCs have shown promise in treatment-refractory NSCLC, including agents targeting HER2, HER3, TROP2, CEACAM5, and MET, among others, with multiple confirmatory phase 3 trials ongoing. Critically, ADCs have demonstrated efficacy signals in both driver mutation-positive and mutation-negative advanced NSCLC, reinforcing their potential as an efficacious treatment strategy that transcends diverse tumor biology in advanced NSCLC. ADCs are a promising class of anti-cancer therapeutics that have significant potential in advanced NSCLC. Beyond confirmatory phase 3 trials, several questions remain including optimal agent sequencing, combinatorial methods, and unique toxicity management.
    MeSH term(s) Humans ; Immunoconjugates/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Antineoplastic Agents/therapeutic use ; Lung Neoplasms/drug therapy ; Antineoplastic Agents, Immunological/therapeutic use
    Chemical Substances Immunoconjugates ; Antineoplastic Agents ; Antineoplastic Agents, Immunological
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-022-01334-9
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    Zs.A 5521: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Predictors for operative treatment in pediatric proximal third both-bone diaphyseal forearm fractures in children include age and translation, but not initial angulation.

    Williams, Kevin / Whyte, Noelle / Carl, Jacob R / Marks, Jennifer / Segal, David / Little, Kevin J

    Journal of children's orthopaedics

    2023  Volume 17, Issue 2, Page(s) 156–163

    Abstract: Introduction: Proximal third diaphyseal fractures of the radius and ulna represent an onerous fracture pattern due to difficulty maintaining acceptable alignment with nonoperative management. Our aim was to identify the factors that increase the odds ... ...

    Abstract Introduction: Proximal third diaphyseal fractures of the radius and ulna represent an onerous fracture pattern due to difficulty maintaining acceptable alignment with nonoperative management. Our aim was to identify the factors that increase the odds for a surgical treatment of these fractures. Recognizing these factors can raise awareness to patients who are more likely to require additional care and assist clinicians in counseling families, targeting treatment plans, and constructing follow-up protocols. We hypothesized that the age of the patient, the amount of initial fracture displacement, and the angulation of the fracture would predict the need for operative treatment.
    Methods: We retrospectively reviewed 276 proximal third diaphyseal forearm fractures at a single tertiary care institution. All patients underwent a nonoperative treatment trial, and if failed continued to surgery. Following a univariate analysis, we constructed a binary multivariate logistic regression model that included age, initial translation, and initial angulation to assess the association between the tested variables.
    Results: A regression model revealed that age (10 years and older, odds ratio: 8.2, 95% confidence interval: 3.9-17.24, p < 0.001) and radius translation of more than 100% (odds ratio: 7.06, 95% confidence interval: 2.69-18.52, p < 0.001) were associated with the need for surgical treatment. Initial fracture angulation lacked an association with a surgical treatment (odds ratio: 0.81 95% confidence interval: 0.38-1.74, p = 0.59).
    Conclusion: Age above 10 years and 100% initial translation of the radius fracture increased the odds for an ultimate decision to perform a surgery. Initial angulation, although often being the most remarkable radiographic feature, was not associated with a nonoperative treatment failure. We recommend an initial reduction attempt after counseling patients and their families that there is a high rate of conversion to operative treatment when the above features are met.
    Level of evidence: level III.
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2279410-4
    ISSN 1863-2548 ; 1863-2521
    ISSN (online) 1863-2548
    ISSN 1863-2521
    DOI 10.1177/18632521231156941
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    Zs.A 6613: Show issues Location:
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  6. Article: A response to a letter to the editor: Predictors for operative treatment in pediatric proximal third both-bone diaphyseal forearm fractures in children include age and translation, but not initial angulation.

    Williams, Kevin / Whyte, Noelle / Carl, Jacob R / Marks, Jennifer / Segal, David / Little, Kevin J

    Journal of children's orthopaedics

    2023  Volume 17, Issue 6, Page(s) 628–629

    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2279410-4
    ISSN 1863-2548 ; 1863-2521
    ISSN (online) 1863-2548
    ISSN 1863-2521
    DOI 10.1177/18632521231205603
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    Zs.A 6613: Show issues Location:
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  7. Article ; Online: TP53 in AML and MDS: The new (old) kid on the block.

    Marks, Jennifer A / Wang, Xin / Fenu, Elena M / Bagg, Adam / Lai, Catherine

    Blood reviews

    2023  Volume 60, Page(s) 101055

    Abstract: MDS and AML are clonal hematopoietic stem cell disorders of increasing incidence, having a variable prognosis based, among others, on co-occurring molecular abnormalities. TP53 mutations are frequently detected in these myeloid neoplasms and portend a ... ...

    Abstract MDS and AML are clonal hematopoietic stem cell disorders of increasing incidence, having a variable prognosis based, among others, on co-occurring molecular abnormalities. TP53 mutations are frequently detected in these myeloid neoplasms and portend a poor prognosis with known therapeutic resistance. This article provides a timely review of the complexity of TP53 alterations, providing updates in diagnosis and prognosis based on new 2022 International Consensus Classification (ICC) and World Health Organization (WHO) guidelines. The article addresses optimal testing strategies and reviews current and arising therapeutic approaches. While the treatment landscape for this molecular subgroup is under active development, further exploration is needed to optimize the care of this group of patients with unmet needs.
    MeSH term(s) Humans ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/therapy ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Mutation ; Myeloproliferative Disorders ; Prognosis ; Tumor Suppressor Protein p53/genetics
    Chemical Substances TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2023.101055
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    Zs.A 2207: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article: Nivolumab-associated cutaneous T-cell lymphoma.

    Marks, Jennifer A / Parker, Douglas C / Garrot, L Crain / Lechowicz, Mary Jo

    JAAD case reports

    2021  Volume 9, Page(s) 39–41

    Language English
    Publishing date 2021-01-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2020.12.033
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  9. Article ; Online: Presentation and Management of the Pediatric Trigger Finger: A Multicenter Retrospective Cohort Study.

    Jia, Lori / King, John D / Goubeaux, Craig / Belardo, Zoe E / Little, Kevin J / Samora, Julie B / Marks, Jennifer / Shah, Apurva S

    The Journal of hand surgery

    2023  Volume 48, Issue 7, Page(s) 665–672

    Abstract: Purpose: Pediatric trigger finger (PTF) is an acquired condition that is uncommon and anatomically complex. Currently, the literature is characterized by a small number of retrospective case series with limited sample sizes. This investigation sought to ...

    Abstract Purpose: Pediatric trigger finger (PTF) is an acquired condition that is uncommon and anatomically complex. Currently, the literature is characterized by a small number of retrospective case series with limited sample sizes. This investigation sought to evaluate the presentation, management, and treatment outcomes of PTF in a large, multicenter cohort.
    Methods: A retrospective review of pediatric patients with a diagnosis of PTF between 2009 and 2020 was performed at three tertiary referral hospitals. Patient demographics, PTF characteristics, treatment strategies, and outcomes were abstracted from the electronic medical records. Patients and families also were contacted by telephone to assess the downstream persistence or recurrence of triggering symptoms.
    Results: In total, 321 patients with 449 PTFs were included at a mean follow-up of 3.9 ± 4.0 years. There were approximately equal numbers of boys and girls, and the mean age of symptom onset was 5.4 ± 5.1 years. The middle (34.7%) and index (11.6%) fingers were the most and least commonly affected digits, respectively. Overall, PTFs managed operatively achieved significantly higher rates of complete resolution compared with PTFs managed nonsurgically (97.1% vs 30.0%). Seventy-five percent of PTFs that achieved complete resolution with nonsurgical management did so within 6 months, and approximately 90% did so within 12 months. Patients with multidigit involvement, higher Quinnell grade at presentation, or palpable nodularity were significantly more likely to undergo surgery. There was no significant difference in the rate of complete resolution between splinted versus not splinted PTFs or across operative techniques.
    Conclusions: Only 30% of the PTFs managed nonsurgically achieved complete resolution. Splinting did not improve resolution rates in children treated nonsurgically. In contrast, surgical intervention has a high likelihood of restoring motion and function of the affected digit.
    Type of study/level of evidence: Therapeutic IV.
    MeSH term(s) Male ; Female ; Humans ; Child ; Infant ; Child, Preschool ; Trigger Finger Disorder/therapy ; Trigger Finger Disorder/surgery ; Retrospective Studies ; Fingers ; Treatment Outcome ; Splints
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 605716-0
    ISSN 1531-6564 ; 0363-5023
    ISSN (online) 1531-6564
    ISSN 0363-5023
    DOI 10.1016/j.jhsa.2023.03.015
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    Zs.A 1431: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Insulin analogues.

    Marks, Jennifer

    Postgraduate medicine

    2009  Volume 112, Issue 5 Suppl Designer, Page(s) 8–12

    Abstract: Development of the insulin analogues has made it possible to reproduce much more accurately the physiologic insulin profiles seen in people who do not have diabetes. The rapidacting analogues, such as insulin aspart and insulin lispro, offer improved ... ...

    Abstract Development of the insulin analogues has made it possible to reproduce much more accurately the physiologic insulin profiles seen in people who do not have diabetes. The rapidacting analogues, such as insulin aspart and insulin lispro, offer improved postprandial glycemic control and reduced risk of hypoglycemia. The long-acting analogues, such as insulin glargine and insulin detemir, mimic the insulin secretory profile of basal insulin. Together, they approximate physiologic insulin secretion.
    MeSH term(s) Diabetes Mellitus/drug therapy ; Humans ; Hypoglycemic Agents/pharmacokinetics ; Hypoglycemic Agents/therapeutic use ; Insulin/analogs & derivatives ; Insulin/metabolism ; Insulin/pharmacokinetics ; Insulin/therapeutic use ; Insulin Aspart ; Insulin Detemir ; Insulin Glargine ; Insulin Lispro ; Insulin Secretion ; Insulin, Long-Acting
    Chemical Substances Hypoglycemic Agents ; Insulin ; Insulin Lispro ; Insulin, Long-Acting ; Insulin Glargine (2ZM8CX04RZ) ; Insulin Detemir (4FT78T86XV) ; Insulin Aspart (D933668QVX)
    Language English
    Publishing date 2009-08-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.3810/pgm.11.2002.suppl21.111
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