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  1. Article: The Effect of Vancomycin and Piperacillin-Tazobactam on Incidence of Acute Kidney Injury in Patients With Obesity.

    Wuerger, Angela / Bowden, Jarred / Mitchell, Anna / Marler, Jacob

    Hospital pharmacy

    2023  Volume 58, Issue 6, Page(s) 605–613

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1468893-1
    ISSN 0018-5787
    ISSN 0018-5787
    DOI 10.1177/00185787231172388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Association of Elevated Lactate With Multiple Vasopressor Administration in Patients With Septic Shock: A Retrospective Cohort Study.

    Gales, Kee / Hunt, Molly / Marler, Jacob

    Journal of pharmacy practice

    2022  Volume 37, Issue 1, Page(s) 110–117

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Humans ; Retrospective Studies ; Shock, Septic/drug therapy ; Shock, Septic/chemically induced ; Vasoconstrictor Agents/therapeutic use ; Norepinephrine ; Phenylephrine/therapeutic use ; Lactic Acid/therapeutic use
    Chemical Substances Vasoconstrictor Agents ; Norepinephrine (X4W3ENH1CV) ; Phenylephrine (1WS297W6MV) ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1027474-1
    ISSN 1531-1937 ; 0897-1900
    ISSN (online) 1531-1937
    ISSN 0897-1900
    DOI 10.1177/08971900221128640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Risk of Major Bleeding With Apixaban Administration in Patients With Acute Kidney Injury.

    Givens, Gabrielle / Neu, Daniel / Marler, Jacob

    The Annals of pharmacotherapy

    2022  Volume 57, Issue 7, Page(s) 795–802

    Abstract: Background: Apixaban is eliminated by the kidneys and in acute kidney injury (AKI) there is potential for an increase in apixaban exposure and bleeding events. In one instance, data have shown higher than normal bleed risk in patients with AKI, unless ... ...

    Abstract Background: Apixaban is eliminated by the kidneys and in acute kidney injury (AKI) there is potential for an increase in apixaban exposure and bleeding events. In one instance, data have shown higher than normal bleed risk in patients with AKI, unless calibrated anti-factor Xa monitoring is used, which is not widely available.
    Objective: To evaluate bleeding with apixaban administration to hospitalized patients with an AKI in an unmonitored real-world scenario.
    Methods: We conducted a retrospective study of patients admitted to a large urban academic teaching hospital from April 2015 to March 2022, who received apixaban for venous thromboembolism or nonvalvular atrial fibrillation (NVAF). The primary outcome evaluated major bleeding when apixaban was administered to patients with or without an AKI.
    Results: A total of 232 patients were evaluated (116 per group). Most patients (79.7%) were on apixaban for NVAF, 32.7% had chronic kidney disease, 58.2% were on a medication increasing bleed risk, and HAS-BLED score was a median of 2 in both groups. No differences were noted between groups for bleeding (AKI group 7.8% vs non-AKI 3.4%;
    Conclusion and relevance: Although no differences between groups were noted, apixaban use in the AKI group resulted in a higher than normally reported incidence of apixaban-associated major bleeding, and concomitant antiplatelet use increased bleed risk as well. Cautious use of apixaban and further investigation with larger studies are warranted in this area.
    MeSH term(s) Humans ; Warfarin/therapeutic use ; Anticoagulants/adverse effects ; Retrospective Studies ; Hemorrhage/epidemiology ; Pyridones/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/epidemiology ; Stroke/epidemiology
    Chemical Substances Warfarin (5Q7ZVV76EI) ; Anticoagulants ; apixaban (3Z9Y7UWC1J) ; Pyridones
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/10600280221129831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Effect of Prearrest Acid-Base Status on Response to Sodium Bicarbonate and Achievement of Return of Spontaneous Circulation.

    Mclean, Heath / Wells, Lindsey / Marler, Jacob

    The Annals of pharmacotherapy

    2021  Volume 56, Issue 4, Page(s) 436–440

    Abstract: Background: The efficacy of sodium bicarbonate (SB) administration during in-hospital cardiac arrest (IHCA) for treatment of acidosis is not well described. The available literature has only evaluated out-of-hospital arrest events in patients with ... ...

    Abstract Background: The efficacy of sodium bicarbonate (SB) administration during in-hospital cardiac arrest (IHCA) for treatment of acidosis is not well described. The available literature has only evaluated out-of-hospital arrest events in patients with suspected acidosis caused by prolonged arrest.
    Objective: This study evaluated SB and its effects on return of spontaneous circulation (ROSC) in patients experiencing IHCA, based on presence of acidosis at baseline as determined by prearrest bicarbonate levels.
    Methods: We conducted a retrospective cohort study of patients who all received intravenous SB during IHCA. Patients with prearrest bicarbonate levels >21 mmol/L (nonacidotic group) were compared with those with prearrest bicarbonate levels ≤21 mmol/L (acidotic group) for the primary outcome of ROSC.
    Results: A total of 225 patients (102 acidotic, 123 nonacidotic) were evaluated. Asystole (37.3% vs 34.1%;
    Conclusions and relevance: In this cohort study, administration of SB for IHCA in patients with prearrest acidosis was not associated with increased incidence of ROSC compared with those without prearrest acidosis. Our data suggest that there may be no benefit to the administration of SB in the setting of IHCA, regardless of prearrest acidotic status. Further investigation into the effect of SB for treatment of acidosis in IHCA is warranted.
    MeSH term(s) Cardiopulmonary Resuscitation ; Cohort Studies ; Humans ; Retrospective Studies ; Return of Spontaneous Circulation ; Sodium Bicarbonate/therapeutic use
    Chemical Substances Sodium Bicarbonate (8MDF5V39QO)
    Language English
    Publishing date 2021-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/10600280211038393
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  5. Article: Impact of Fentanyl Continuous Infusion Dosing Strategies for Analgosedation on Medication Usage.

    Peters, Michael J / Ellingson, Samantha L / Kimmons, Lauren A / Marler, Jacob L

    Hospital pharmacy

    2020  Volume 56, Issue 5, Page(s) 408–409

    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1468893-1
    ISSN 0018-5787
    ISSN 0018-5787
    DOI 10.1177/0018578720925371
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  6. Article: Safety of Propofol When Used for Rapid Sequence Intubation in Septic Patients: A Multicenter Cohort Study.

    Marler, Jacob / Howland, Rachel / Kimmons, Lauren A / Mohrien, Kerry / Vandigo, Joseph E / Jones, G Morgan

    Hospital pharmacy

    2021  Volume 57, Issue 2, Page(s) 287–293

    Abstract: Purpose: Septic patients are at risk for hypotension, and this risk may increase during rapid sequence intubation (RSI). Sedatives such as propofol must be used carefully due to its ability to reduce vascular sympathetic tone. Since the safety of ... ...

    Abstract Purpose: Septic patients are at risk for hypotension, and this risk may increase during rapid sequence intubation (RSI). Sedatives such as propofol must be used carefully due to its ability to reduce vascular sympathetic tone. Since the safety of propofol for RSI is not well described in sepsis, this was a study evaluating propofol and its effects on hemodynamics when used for RSI in a septic population.
    Materials and methods: We conducted a multicenter, retrospective, cohort study of patients with sepsis or severe sepsis requiring sedation for RSI. Patients receiving a propofol bolus for RSI were compared to patients undergoing RSI without a propofol bolus. The safety profile of propofol was evaluated according to the rates of post-intubation hypotension and vasopressor utilization between groups.
    Results: A total of 179 patients (79 propofol, 100 non-propofol) were evaluated. There were no differences in hypotension (81% vs 78%;
    Conclusions: In this cohort study, administration of propofol for RSI in patients with sepsis and severe sepsis did not increase incidence of hypotension or vasopressor use, but acute illness may have introduced provider selection bias causing less propofol use in the non-propofol group. Larger prospective studies are needed to better characterize the adverse hemodynamic effects of propofol, before propofol bolus doses for RSI can be considered for safe use in this population.
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1468893-1
    ISSN 0018-5787
    ISSN 0018-5787
    DOI 10.1177/00185787211029547
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  7. Article ; Online: Severe Ceftaroline-Induced Thrombocytopenia With Rapid Onset on Rechallenge.

    Marler, Jacob / Twilla, Jennifer D / Finch, Christopher K / Animalu, Chinelo

    The Annals of pharmacotherapy

    2019  Volume 54, Issue 2, Page(s) 187–188

    Language English
    Publishing date 2019-09-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/1060028019879086
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  8. Article ; Online: Assessing the Quality of Database Search Strategies Utilized by Meta-analyses That Evaluate Infectious Disease Drug Therapy.

    Marler, Jacob L / Curry, Kiana Y / Suda, Katie J

    Therapeutic innovation & regulatory science

    2016  Volume 48, Issue 3, Page(s) 336–340

    Abstract: Meta-analyses are increasingly influencing clinical practice, but significant methodological flaws have been reported. The purpose of this study was to evaluate the quality of search strategies utilized by anti-infective meta-analyses. The Embase ... ...

    Abstract Meta-analyses are increasingly influencing clinical practice, but significant methodological flaws have been reported. The purpose of this study was to evaluate the quality of search strategies utilized by anti-infective meta-analyses. The Embase database was searched for meta-analyses evaluating anti-infective drug therapy; 103 of 268 identified citations met inclusion criteria and were evaluated. A total of 80.6% of meta-analyses used search terms, and an average of 4.3 databases (Medline, 98.1%; Cochrane, 93.2%; Embase, 76.7%) were searched to identify relevant articles for inclusion. The majority of meta-analyses used a quality assessment tool (84.5%) and reported positive results (59.2%). The average impact factor of journals publishing meta-analyses was 5.7 ± 3.4. The number of resources searched was associated with the impact factor ( P = .0013). The majority of anti-infective meta-analyses used rigorous search strategies to identify all relevant studies for evaluation. This finding is inconsistent with reports in other therapeutic areas that have questioned the quality of meta-analyses, and it may increase confidence in anti-infective meta-analyses.
    Language English
    Publishing date 2016-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2708397-4
    ISSN 2168-4804 ; 2168-4790
    ISSN (online) 2168-4804
    ISSN 2168-4790
    DOI 10.1177/2168479013516774
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  9. Article ; Online: Improving Antibiotic Administration Efficiency and Patient Outcomes in the Emergency Department.

    Wiss, Adam / Turner, Stephen / Negrete, Ana / Wheeler, Brian / Usery, Justin / Marler, Jacob

    The American journal of emergency medicine

    2019  Volume 38, Issue 6, Page(s) 1275–1276

    MeSH term(s) APACHE ; Adult ; Aged ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Cohort Studies ; Emergency Service, Hospital/organization & administration ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Sepsis/drug therapy ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-11-18
    Publishing country United States
    Document type Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2019.10.036
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  10. Article ; Online: Continuous Infusion Antiepileptic Medications for Refractory Status Epilepticus: A Review for Nurses.

    Wiss, Adam L / Samarin, Michael / Marler, Jacob / Jones, G Morgan

    Critical care nursing quarterly

    2017  Volume 40, Issue 1, Page(s) 67–85

    Abstract: Status epilepticus requires treatment with emergent initial therapy with a benzodiazepine and urgent control therapy with an additional antiepileptic drug (AED) to terminate clinical and/or electrographic seizure activity. However, nearly one-third of ... ...

    Abstract Status epilepticus requires treatment with emergent initial therapy with a benzodiazepine and urgent control therapy with an additional antiepileptic drug (AED) to terminate clinical and/or electrographic seizure activity. However, nearly one-third of patients will prove refractory to the aforementioned therapies and are prone to a higher degree of neuronal injury, resistance to pharmacotherapy, and death. Current guidelines for refractory status epilepticus (RSE) recommend initiating a continuous intravenous (CIV) anesthetic over bolus dosing with a different AED. Continuous intravenous agents most commonly used for this indication include midazolam, propofol, and pentobarbital, but ketamine is an alternative option. Comparative studies illustrating the optimal agent are lacking, and selection is often based on adverse effect profiles and patient-specific factors. In addition, dosing and titration are largely based on small studies and expert opinion with continuous electroencephalogram monitoring used to guide intensity and duration of treatment. Nonetheless, the doses required to halt seizure activity are likely to produce profound adverse effects that clinicians should anticipate and combat. The purpose of this review was to summarize the available RSE literature focusing on CIV midazolam, pentobarbital, propofol, and ketamine, and to serve as a primer for nurses providing care to these patients.
    MeSH term(s) Adjuvants, Anesthesia/therapeutic use ; Anesthetics, Intravenous/therapeutic use ; Anticonvulsants/therapeutic use ; Drug Resistant Epilepsy/drug therapy ; Drug Therapy, Combination ; Humans ; Midazolam/therapeutic use ; Pentobarbital/therapeutic use ; Propofol/therapeutic use ; Status Epilepticus/drug therapy
    Chemical Substances Adjuvants, Anesthesia ; Anesthetics, Intravenous ; Anticonvulsants ; Pentobarbital (I4744080IR) ; Midazolam (R60L0SM5BC) ; Propofol (YI7VU623SF)
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639095-x
    ISSN 1550-5111 ; 0887-9303
    ISSN (online) 1550-5111
    ISSN 0887-9303
    DOI 10.1097/CNQ.0000000000000143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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