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Article ; Online: Low Density Lipoprotein Cholesterol Decreases the Expression of Adenosine A

Chaptal, Marie-Charlotte / Maraninchi, Marie / Musto, Giorgia / Mancini, Julien / Chtioui, Hedi / Dupont-Roussel, Janine / Marlinge, Marion / Fromonot, Julien / Lalevee, Nathalie / Mourre, Florian / Beliard, Sophie / Guieu, Régis / Valero, René / Mottola, Giovanna

Cells

2024 Volume 13, Issue 6

Abstract: High blood levels of low-density lipoprotein (LDL)-cholesterol (LDL-C) are associated with atherosclerosis, mainly by promoting foam cell accumulation in vessels. As cholesterol is an essential component of cell plasma membranes and a regulator of ... ...

Abstract	High blood levels of low-density lipoprotein (LDL)-cholesterol (LDL-C) are associated with atherosclerosis, mainly by promoting foam cell accumulation in vessels. As cholesterol is an essential component of cell plasma membranes and a regulator of several signaling pathways, LDL-C excess may have wider cardiovascular toxicity. We examined, in untreated hypercholesterolemia (HC) patients, selected regardless of the cause of LDL-C accumulation, and in healthy participants (HP), the expression of the adenosine A
MeSH term(s)	Humans ; Hypercholesterolemia ; Cholesterol, LDL/metabolism ; Receptor, Adenosine A2A/metabolism ; Leukocytes, Mononuclear/metabolism ; Adenosine ; Cardiovascular Diseases ; Risk Factors ; Cholesterol ; Carrier Proteins ; Heart Disease Risk Factors ; Membrane Microdomains/metabolism ; Membrane Proteins
Chemical Substances	Cholesterol, LDL ; flotillins ; Receptor, Adenosine A2A ; Adenosine (K72T3FS567) ; Cholesterol (97C5T2UQ7J) ; Carrier Proteins ; Membrane Proteins
Language	English
Publishing date	2024-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13060488
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mortality, cardiac and cerebral damages reduction by IL-1 inhibition in a murine model of TTP.

Muller, Romain / Cauchois, Raphael / Lagarde, Marie / Roffino, Sandrine / Genovesio, Cecile / Fernandez, Samantha / Hache, Guillaume / Guillet, Benjamin / Kara, Yeter / Marlinge, Marion / Lenting, Peter J / Poullin, Pascale / Dignat-George, Françoise / Tellier, Edwige / Kaplanski, Gilles

Blood

2024

Abstract: Thrombotic thrombocytopenic purpura (TTP), a rare but fatal disease if untreated, is due to alteration in Von Willebrand factor cleavage resulting in capillary microthrombi formation and ischemic organ damage. Interleukin-1 (IL-1), has been shown to ... ...

Abstract	Thrombotic thrombocytopenic purpura (TTP), a rare but fatal disease if untreated, is due to alteration in Von Willebrand factor cleavage resulting in capillary microthrombi formation and ischemic organ damage. Interleukin-1 (IL-1), has been shown to drive sterile inflammation following ischemia and could play an essential contribution to post-ischemic organ damage in TTP. Our objectives were to evaluate IL-1 involvement during TTP and to test the efficacy of the recombinant IL-1 receptor antagonist, anakinra, in a murine TTP model. We retrospectively measured plasmatic IL-1 concentrations in TTP patients and controls. TTP patients exhibited elevated plasma IL-1α and β concentrations, which correlated with disease course and survival. In a TTP mouse model, we administered anakinra (IL-1 inhibitor) or placebo for 5 days and evaluated the efficacy of this treatment. Anakinra significantly reduced mortality of mice (P<0.001). Anakinra significantly decreased TTP-induced cardiac damages as assessed by blood troponin concentrations, evaluation of left ventricular function by echocardiography, [18F]FDG PET of myocardial glucose metabolism, and cardiac histology. Anakinra also significantly reduced brain TTP-induced damages, evaluated through blood PS100b concentrations, nuclear imaging and histology. We finally showed that IL-1α and β trigger endothelial degranulation in vitro, leading to the release of Von Willebrand factor. In conclusion, Anakinra significantly reduced TTP mortality in a pre-clinical model of the disease by inhibiting both endothelial degranulation and post-ischemic inflammation, supporting further evaluations in humans.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2023021974
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Article ; Online: Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

Paganelli, Franck / Mottola, Giovanna / Fromonot, Julien / Marlinge, Marion / Deharo, Pierre / Guieu, Régis / Ruf, Jean

International journal of molecular sciences

2021 Volume 22, Issue 4

Abstract: The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent risk factor for CVD, stroke and myocardial infarction. However, homocysteine ( ...

Abstract	The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent risk factor for CVD, stroke and myocardial infarction. However, homocysteine (HCy)-lowering therapy does not affect the inflammatory state of CVD patients, and it has little influence on cardiovascular risk. The HCy degradation product hydrogen sulfide (H
MeSH term(s)	Animals ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/pathology ; Homocysteine/metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Hyperhomocysteinemia/complications ; Hyperhomocysteinemia/metabolism ; Receptor, Adenosine A2A/metabolism
Chemical Substances	Receptor, Adenosine A2A ; Homocysteine (0LVT1QZ0BA) ; Hydrogen Sulfide (YY9FVM7NSN)
Language	English
Publishing date	2021-02-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22041690
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Article ; Online: Sudden Onset Nephrotic-Range Proteinuria.

Fromonot, Julien / Marlinge, Marion / Petit, Camille / Burtey, Stephane / Guieu, Regis

Clinical chemistry

2019 Volume 65, Issue 4, Page(s) 600–601

MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Ascites/diagnosis ; Ascitic Fluid/chemistry ; Cystostomy/adverse effects ; Humans ; Intraoperative Complications/etiology ; Male ; Medical Errors ; Middle Aged ; Peritoneum/surgery ; Proteinuria/diagnosis ; Urinary Bladder/surgery ; Urinary Bladder Neck Obstruction/complications ; Urinary Catheterization
Language	English
Publishing date	2019-04-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1373/clinchem.2018.295519
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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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Article: Hyperoxia During Exercise: Impact on Adenosine Plasma Levels and Hemodynamic Data.

Boussuges, Alain / Rives, Sarah / Marlinge, Marion / Chaumet, Guillaume / Vallée, Nicolas / Guieu, Régis / Gavarry, Olivier

Frontiers in physiology

2020 Volume 11, Page(s) 97

Abstract: Introduction: Adenosine is an ATP derivative that is strongly implicated in the cardiovascular adaptive response to exercise. In this study, we hypothesized that during exercise the hyperemia, commonly observed during exercise in air, was counteracted ... ...

Abstract	Introduction: Adenosine is an ATP derivative that is strongly implicated in the cardiovascular adaptive response to exercise. In this study, we hypothesized that during exercise the hyperemia, commonly observed during exercise in air, was counteracted by the downregulation of the adenosinergic pathway during hyperoxic exposure. Methods: Ten healthy volunteers performed two randomized sessions including gas exposure (Medical air or Oxygen) at rest and during exercise performed at 40% of maximal intensity, according to the individual fitness of the volunteers. Investigations included the measurement of adenosine plasma level (APL) and the recording of hemodynamic data [i.e., cardiac output (CO) and systemic vascular resistances (SVR) using pulsed Doppler and echocardiography]. Results: Hyperoxia significantly decreased APL (from 0.58 ± 0.06 to 0.21 ± 0.05 μmol L Conclusion: Hyperoxia decreased APLs in healthy volunteers at rest but did not eliminate the increase in APL and the decrease in SVR during low intensity exercise.
Language	English
Publishing date	2020-02-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2020.00097
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Article ; Online: Adenosinergic System and Neuroendocrine Syncope: What Is the Link?

Guieu, Régis / Fromonot, Julien / Mottola, Giovanna / Maille, Baptiste / Marlinge, Marion / Groppelli, Antonella / Conte, Samantha / Bechah, Yassina / Lalevee, Nathalie / Michelet, Pierre / Hamdan, Mohamed / Brignole, Michele / Deharo, Jean Claude

Cells

2023 Volume 12, Issue 16

Abstract: Although very common, the precise mechanisms that explain the symptomatology of neuroendocrine syncope (NES) remain poorly understood. This disease, which can be very incapacitating, manifests itself as a drop in blood pressure secondary to vasodilation ... ...

Abstract	Although very common, the precise mechanisms that explain the symptomatology of neuroendocrine syncope (NES) remain poorly understood. This disease, which can be very incapacitating, manifests itself as a drop in blood pressure secondary to vasodilation and/or extreme slowing of heart rate. As studies continue, the involvement of the adenosinergic system is becoming increasingly evident. Adenosine, which is an ATP derivative, may be involved in a large number of cases. Adenosine acts on G protein-coupled receptors with seven transmembrane domains. A
MeSH term(s)	Animals ; Syncope ; Adenosine ; Anura ; Blood Pressure ; Heart Rate
Chemical Substances	Adenosine (K72T3FS567)
Language	English
Publishing date	2023-08-08
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12162027
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Article: Blood Adenosine Increase During Apnea in Spearfishermen Reinforces the Efficiency of the Cardiovascular Component of the Diving Reflex.

Marlinge, Marion / Chefrour, Mohamed / Billaut, François / Zavarro, Marion / Rostain, Jean-Claude / Coulange, Mathieu / Guieu, Régis / Joulia, Fabrice

Frontiers in physiology

2021 Volume 12, Page(s) 743154

Abstract: The physiopathology consequences of hypoxia during breath-hold diving are a matter of debate. Adenosine (AD), an ATP derivative, is suspected to be implicated in the adaptive cardiovascular response to apnea, because of its vasodilating and bradycardic ... ...

Abstract	The physiopathology consequences of hypoxia during breath-hold diving are a matter of debate. Adenosine (AD), an ATP derivative, is suspected to be implicated in the adaptive cardiovascular response to apnea, because of its vasodilating and bradycardic properties, two clinical manifestations observed during voluntary apnea. The aim of this study was to evaluate the adenosine response to apnea-induced hypoxia in trained spearfishermen (SFM) who are used to perform repetitive dives for 4-5 h. Twelve SFM (11 men and 1 woman, mean age 41 ± 3 years, apnea experience: 18 ± 9 years) and 10 control (CTL) subjects (age 44 ± 7 years) were enrolled in the study. Subjects were asked to main a dry static apnea and stopped it when they began the struggle phase (average duration: SFM 120 ± 78 s, CTL 78 ± 12 s). Capillary blood samples were collected at baseline and immediately after the apnea and analyzed for standard parameters and adenosine blood concentration ([AD]b). Heart rate (HR), systolic (SBP), and diastolic (DBP) blood pressures were also recorded continuously during the apnea. During the apnea, an increase in SBP and DBP and a decrease in HR were observed in both SFM and CTL. At baseline, [AD]b was higher in SFM compared with CTL (1.05 ± 0.2 vs. 0.73 ± 0.11 μM,
Language	English
Publishing date	2021-10-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.743154
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Article: Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation.

Maille, Baptiste / Lalevée, Nathalie / Marlinge, Marion / Vahdat, Juliette / Mottola, Giovanna / Degioanni, Clara / De Maria, Lucille / Klein, Victor / Thuny, Franck / Franceschi, Frédéric / Deharo, Jean-Claude / Guieu, Régis / Fromonot, Julien

Biomedicines

2022 Volume 10, Issue 11

Abstract: Atrial fibrillation (AF) is the most common arrhythmia in the world. Because the key to developing innovative therapies that limit the onset and the progression of AF is to fully understand the underlying molecular mechanisms of AF, the aim of the ... ...

Abstract	Atrial fibrillation (AF) is the most common arrhythmia in the world. Because the key to developing innovative therapies that limit the onset and the progression of AF is to fully understand the underlying molecular mechanisms of AF, the aim of the present narrative review is to report the most recent advances in the potential role of the adenosinergic system in the pathophysiology of AF. After a comprehensive approach describing adenosinergic system signaling and the mechanisms of the initiation and maintenance of AF, we address the interactions of the adenosinergic system's signaling with AF. Indeed, adenosine release can activate four G-coupled membrane receptors, named A
Language	English
Publishing date	2022-11-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10112963
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Article: Adenosine Receptors Profile in Fibromuscular Dysplasia.

Guiol, Claire / El Harake, Sarah / Fromonot, Julien / Chefrour, Mohamed / Gastaldi, Marguerite / Alibouch, Yassine / Doublier, Maxime / Deharo, Pierre / Sarlon, Gabrielle / Marlinge, Marion / Lalevee, Nathalie / Guieu, Régis / Silhol, François

Biomedicines

2022 Volume 10, Issue 11

Abstract: Fibromuscular dysplasia (FMD) is a non-inflammatory vascular disease that is characterized by unexplained systemic hypertension occurring in young people, associated with arterial stenosis, aneurysm rupture, intracranial/renal infarction, and stroke. ... ...

Abstract	Fibromuscular dysplasia (FMD) is a non-inflammatory vascular disease that is characterized by unexplained systemic hypertension occurring in young people, associated with arterial stenosis, aneurysm rupture, intracranial/renal infarction, and stroke. Although the gold standard for the diagnosis remains catheter-angiography, biological markers would be helpful due to the delay from first symptom to diagnosis. Adenosine is an ATP derivative, that may be implicated in FMD pathophysiology. We hypothesized that changes in adenosine blood level (ABL) and production of adenosine receptors may be associated with FMD. Using peripheral blood mononuclear cells, we evaluated A1, A2A, and A2B receptor production by Western blot, in 67 patients (17 men and 50 women, mean (range) age 55 (29−77) years and 40 controls, 10 men and 30 women, mean (range) age 56 (37−70)). ABL was evaluated by liquid chromatography, mass spectrometry. ABL was significantly higher in patients vs. controls, mean (range): 1.7 (0.7−3) µmol/L vs. controls 0.6 (0.4−0.8) µmol/L (+180%) p < 0.001. While A1R and A2AR production did not differ in patients and controls, we found an over-production of A2BR in patients: 1.70 (0.90−2.40; arbitrary units) vs. controls = 1.03 (0.70−1.40), mean + 65% (p < 0.001). A2BR production with a cut off of 1.3 arbitrary units, gives a good sensitivity and specificity for the diagnosis. Production measurement of A2BR on monocytes and ABL could help in the diagnosis, especially in atypical or with poor symptoms.
Language	English
Publishing date	2022-11-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10112831
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Article: Plasma A

Paganelli, Franck / Cappiello, Gabriel / Aliouane, Soumeya / Kipson, Nathalie / Criado, Christine / Hamou, Khadidja / Ntawanga, Jehuel / Peroni, Erika / Carreno, Maria / Methlin, Lucas / Mottola, Giovanna / Fromonot, Julien / Deharo, Pierre / Gaudry, Marine / Marlinge, Marion / Guieu, Régis / Ruf, Jean

Biomedicines

2022 Volume 10, Issue 8

Abstract: The evaluation of suspected coronary artery disease (CAD) in the medical community is challenging. Patients with suspected coronary chronic syndrome (CCS) are referred by the medical community to be assessed by specialists for the performance of ... ...

Abstract	The evaluation of suspected coronary artery disease (CAD) in the medical community is challenging. Patients with suspected coronary chronic syndrome (CCS) are referred by the medical community to be assessed by specialists for the performance of noninvasive tests that have high rates of false positives and false negatives. While troponins are the gold standard for evaluate myocardial injuries, there is no biomarker to assess myocardial ischemia in patient populations with negative electrocardiography or without an increase in troponin level. A2A adenosine receptors control the coronary blood flow through its vasodilating properties. It has been shown that patients with CAD have a lower A2AR expression on peripheral blood mononuclear cells, suggesting a link between A2AR production and the severity of CAD. Herein, we present a new and innovative method of inhibition ELISA for A2AR in the plasma of patients who permit the evaluation of the amount of soluble A2AR. For this analysis, the total study sample was 54, including 31 patients with CAD with stenosis > 50% and a significant fractional flow reserve (FFR < 0.8) (Group 1) and 23 patients with normal or non-obstructive coronary arteries (stenosis < 50% and nonsignificant FFR > 0.8) (Group 2). The % inhibition (which is linked to the presence of soluble receptors) with the plasma of patients with FFR < 0.8 was significantly lower than that of patients with FFR > 0.8 (median [range]: 68% [20.7−86.9] vs. 83% [67−88.4]; p < 0.001). The ROC curve indicated a good sensitivity/specificity ratio with a cut off of 72.5% and an area under the curve of 0.87. In conclusion, a rapid ELISA to assess soluble A2AR in the plasma shows promise to screen patients suspected of having CAD.
Language	English
Publishing date	2022-08-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10081849
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