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  1. Article: Association of

    Abdelhafez, Mohammad / Nasereddin, Abedelmajeed / Shamma, Omar Abu / Abed, Rajaa / Sinnokrot, Raghida / Marof, Omar / Heif, Tariq / Erekat, Zaid / Al-Jawabreh, Amer / Ereqat, Suheir

    Interdisciplinary perspectives on infectious diseases

    2023  Volume 2023, Page(s) 9551163

    Abstract: The clinical course and severity of COVID-19 vary among patients. This study aimed to investigate the potential correlation between the gene polymorphisms of the interferon receptor ( ...

    Abstract The clinical course and severity of COVID-19 vary among patients. This study aimed to investigate the potential correlation between the gene polymorphisms of the interferon receptor (
    Language English
    Publishing date 2023-09-16
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2478373-0
    ISSN 1687-7098 ; 1687-708X
    ISSN (online) 1687-7098
    ISSN 1687-708X
    DOI 10.1155/2023/9551163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association of IFNAR2 rs2236757 and OAS3 rs10735079 polymorphisms with susceptibility to COVID-19 infection and severity

    Abdelhafez, Mohammad / Nasereddin, Abedelmajeed / Abu Shamma, Omar / Abed, Rajaa / Sinnokrot, Raghida / Marof, Omar / Heif, Tariq / Erekat, Zaid / Al-Jawabreh, Amer / Ereqat, suheir

    medRxiv

    Abstract: The clinical course and severity of COVID-19 vary among patients. This study aimed to investigate the association of the interferon receptor ( IFNAR2 ) rs2236757 and oligoadenylate synthetase 3 ( OAS3 ) rs10735079 gene polymorphisms with risk of COVID-19 ...

    Abstract The clinical course and severity of COVID-19 vary among patients. This study aimed to investigate the association of the interferon receptor ( IFNAR2 ) rs2236757 and oligoadenylate synthetase 3 ( OAS3 ) rs10735079 gene polymorphisms with risk of COVID-19 infection and severity among Palestinian patients.  The study was conducted between April and May 2021 on 154 participants that divided into three groups: the control group (RT-PCR-negative, n=52), the community cases group (RT-PCR-positive, n= 70) and the critically ill cases (ICU group; n=32). Genotyping of the studied polymorphisms was conducted by amplicon-based next-generation sequencing. The genotype distribution of the IFNAR2 rs2236757 was significantly different among the study groups (P = 0.001), while no significant differences were observed in the distribution of OAS3 rs10735079 genotypes (P = 0.091). Logistic regression analysis adjusted for possible confounding factors revealed a significant association between the risk allele rs2236757A and critical COVID-19 illness (P < 0.025). Among all patients, the rs2236757GA carriers were more likely to have sore throat (OR, 2.52 (95% CI 1.02-6.24); P = 0.011); the risk allele rs2236757A was associated with dyspnea (OR, 4.70 (95% CI 1.80-12.27); P < 0.001), while the rs10735079A carriers were less prone to develop muscle aches (OR, 0.34  (95% CI 0.13-0.88); P = 0.0248) and sore throat (OR, 0.17 (95% CI 0.05-0.55); P < 0.001). In conclusion, our results revealed that the rs2236757A variant was associated with critical COVID-19 illness and dyspnea, whereas the rs10735079A variant was protective for muscle aches and sore throat.
    Keywords covid19
    Language English
    Publishing date 2022-09-27
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.09.27.22280425
    Database COVID19

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