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  1. Article ; Online: Genetically determined thymic function affects strength and duration of immune response in COVID patients with pneumonia.

    Roux, Hélène M / Marouf, Amira / Dutrieux, Jacques / Charmeteau-De Muylder, Bénédicte / Figueiredo-Morgado, Suzanne / Avettand-Fenoel, Véronique / Cuvelier, Pelagia / Naudin, Cécile / Bouaziz, Fatma / Geri, Guillaume / Couëdel-Courteille, Anne / Squara, Pierre / Marullo, Stefano / Cheynier, Rémi

    Science advances

    2023  Volume 9, Issue 38, Page(s) eadh7969

    Abstract: Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. ... ...

    Abstract Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. The
    MeSH term(s) Humans ; Thymus Gland ; COVID-19/genetics ; SARS-CoV-2 ; Pneumonia ; Genotype
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adh7969
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  2. Article ; Online: Correlation between thymic output and disease severity in critically ill COVID-19 patients: extended abstract.

    Marouf, Amira / Cuvelier, Pelagia / Roux, Hélène / Couëdel-Courteille, Anne / Dutrieux, Jacques / Naudin, Cécile / Charmeteau de Muylder, Bénédicte / Cheynier, Rémi / Squara, Pierre / Marullo, Stefano

    Mediastinum (Hong Kong, China)

    2022  Volume 6, Page(s) 30

    Language English
    Publishing date 2022-09-25
    Publishing country China
    Document type Editorial
    ISSN 2522-6711
    ISSN (online) 2522-6711
    DOI 10.21037/med-22-5
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  3. Article ; Online: Paraneoplastic Hyperleukocytosis Mimicking Hematologic Malignancy Revealing a Localized Lung Cancer.

    Marouf, Amira / Chapuis, Nicolas / Alary, Anne Sophie / Burroni, Barbara / Kosmider, Olivier / Alifano, Marco / Bouscary, Didier

    The Annals of thoracic surgery

    2019  Volume 109, Issue 3, Page(s) e203–e206

    Abstract: Paraneoplastic leukemoid reaction is a challenging differential diagnosis when it presents at the time of diagnosis of cancer. Severe hyperleukocytosis with elevation of blood neutrophils and monocytes counts can evoke myeloid hematologic malignancies. ... ...

    Abstract Paraneoplastic leukemoid reaction is a challenging differential diagnosis when it presents at the time of diagnosis of cancer. Severe hyperleukocytosis with elevation of blood neutrophils and monocytes counts can evoke myeloid hematologic malignancies. We report the case of a patient who presented with blood and bone marrow features highly suggestive of chronic myelomonocytic leukemia. The diagnosis of primary lung sarcomatoid carcinoma was performed. Surgical removal of this tumor which will always remain the priority led to full normalization of blood cell count.
    MeSH term(s) Diagnosis, Differential ; Humans ; Leukemia, Myelomonocytic, Chronic/pathology ; Leukemoid Reaction/pathology ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Paraneoplastic Syndromes/pathology
    Language English
    Publishing date 2019-08-10
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2019.06.064
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  4. Article ; Online: Efficacy of a short sandwich protocol, methotrexate, gemcitabine, L-asparaginase and dexamethasone chemotherapy combined with radiotherapy, in localised newly diagnosed NK/T-cell lymphoma: A French retrospective study.

    Chaubard, Sammara / Marouf, Amira / Lavergne, David / Lemonnier, François / Rossignol, Julien / Clavert, Aline / Gressin, Rémy / Cartron, Guillaume / Waultier-Rascalou, Agathe / Vargaftig, Jacques / Salles, Gilles / Bachy, Emmanuel / Ghesquières, Hervé / Tournilhac, Olivier / Chauchet, Adrien / Le Gouill, Steven / Damaj, Gandhi / Fornecker, Luc-Matthieu / Sibon, David /
    Obéric, Lucie / Michot, Jean-Marie / Gaulard, Philippe / Hermine, Olivier / Couronné, Lucile / Jaccard, Arnaud

    British journal of haematology

    2023  Volume 201, Issue 4, Page(s) 673–681

    Abstract: Extranodal NK/T-cell lymphoma, nasal type is a rare and aggressive form of lymphoma, historically associated with poor prognosis. We report here the results of a retrospective multi-centre study evaluating the efficacy of MGAD (methotrexate, gemcitabine, ...

    Abstract Extranodal NK/T-cell lymphoma, nasal type is a rare and aggressive form of lymphoma, historically associated with poor prognosis. We report here the results of a retrospective multi-centre study evaluating the efficacy of MGAD (methotrexate, gemcitabine, L-asparaginase and dexamethasone) regimen (two cycles) combined with 'sandwich' radiotherapy in 35 patients with localised newly diagnosed extranodal NK/T-cell lymphoma. Thirty-two patients (91%) reached complete remission. With a long median follow-up of 59.6 months, progression-free and overall survival at 2 and 5 years were 71%, 80% and 53%, 73%, respectively. Around one third of the patients experienced relapse within a median time of 14.5 months. Side-effects were manageable with grades 3-4 cytopenias, mucositis and infection in 50%, 24% and 21% of the cases, respectively. Monitoring of asparaginase activity was performed in 13 patients and showed inactivation of the drug in seven (54%) patients. Our results indicate that a short therapy by sandwich MGAD chemoradiotherapy is a tolerable and effective treatment option in localised newly diagnosed extranodal NK/T-cell lymphoma patients.
    MeSH term(s) Humans ; Gemcitabine ; Asparaginase ; Methotrexate ; Retrospective Studies ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Neoplasm Recurrence, Local/drug therapy ; Treatment Outcome ; Lymphoma, Extranodal NK-T-Cell/drug therapy ; Lymphoma, Extranodal NK-T-Cell/radiotherapy ; Dexamethasone ; Multicenter Studies as Topic
    Chemical Substances Gemcitabine ; Asparaginase (EC 3.5.1.1) ; Methotrexate (YL5FZ2Y5U1) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2023-02-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18689
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  5. Article ; Online: Thrombocytapheresis and sequential chemotherapy for extreme symptomatic thrombocytosis secondary to myelofibrosis: a case report.

    Debureaux, Pierre-Edouard / Brignier, Anne / Soret-Dulphy, Juliette / Réa, Delphine / Michonneau, David / Peffault de Latour, Régis / Sicre de Fontbrune, Flore / Pagliuca, Simona / Parquet, Nathalie / Prata, Henrique Pedro / Marouf, Amira / Xhaard, Aliénor / Kiladjian, Jean-Jacques / Socié, Gérard / Robin, Marie

    Annals of hematology

    2020  Volume 99, Issue 4, Page(s) 897–898

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Humans ; Male ; Middle Aged ; Plateletpheresis/methods ; Primary Myelofibrosis/complications ; Primary Myelofibrosis/diagnostic imaging ; Primary Myelofibrosis/therapy ; Splenectomy/adverse effects ; Splenectomy/trends ; Thrombocytosis/diagnostic imaging ; Thrombocytosis/etiology ; Thrombocytosis/therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-02-07
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-020-03948-0
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  6. Article ; Online: Outcomes of refractory or relapsed Hodgkin lymphoma patients with post-autologous stem cell transplantation brentuximab vedotin maintenance: a French multicenter observational cohort study.

    Marouf, Amira / Cottereau, Anne Segolene / Kanoun, Salim / Deschamps, Paul / Meignan, Michel / Franchi, Patricia / Sibon, David / Antoine, Clara / Gastinne, Thomas / Borel, Cecile / Hammoud, Mohammad / Sicard, Guillaume / Gille, Romane / Cavalieri, Doriane / Stamatoullas, Aspasia / Filliatre-Clement, Lauriane / Lazarovici, Julien / Chauchet, Adrien / Fornecker, Luc-Matthieu /
    Amorin, Sandy / Rocquet, Mathieu / Raus, Nicole / Burroni, Barbara / Rubio, Marie Therese / Bouscary, Didier / Quittet, Philippe / Casasnovas, Rene Olivier / Brice, Pauline / Ghesquieres, Herve / Tamburini, Jérôme / Deau, Benedicte

    Haematologica

    2022  Volume 107, Issue 7, Page(s) 1681–1686

    MeSH term(s) Brentuximab Vedotin ; Hematopoietic Stem Cell Transplantation ; Hodgkin Disease/drug therapy ; Humans ; Immunoconjugates/therapeutic use ; Salvage Therapy ; Stem Cell Transplantation ; Transplantation, Autologous
    Chemical Substances Immunoconjugates ; Brentuximab Vedotin (7XL5ISS668)
    Language English
    Publishing date 2022-07-01
    Publishing country Italy
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2021.279564
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  7. Article ; Online: Comprehensive genetic profiling reveals frequent alterations of driver genes on the X chromosome in extranodal NK/T-cell lymphoma.

    Ito, Yuta / Marouf, Amira / Kogure, Yasunori / Koya, Junji / Liévin, Raphaël / Bruneau, Julie / Tabata, Mariko / Saito, Yuki / Shingaki, Sumito / Yuasa, Mitsuhiro / Yamaguchi, Kentaro / Murakami, Koichi / Weil, Robert / Vavasseur, Manon / Andrieu, Guillaume P / Latiri, Mehdi / Veleanu, Layla / Dussiot, Michaël / André, Isabelle /
    Joshi, Akshay / Lagresle-Peyrou, Chantal / Magerus, Aude / Chaubard, Sammara / Lavergne, David / Bachy, Emmanuel / Brunet, Erika / Fataccioli, Virginie / Brouzes, Chantal / Laurent, Camille / De Leval, Laurence / Traverse-Glehen, Alexandra / Bossard, Céline / Parrens, Marie-Cécile / Meignin, Véronique / Philippe, Laure / Rossignol, Julien / Suarez, Felipe / Michot, Jean-Marie / Tournilhac, Olivier / Damaj, Gandhi / Lemonnier, François / Bôle-Feysot, Christine / Nitschké, Patrick / Tesson, Bruno / Laurent, Cécile / Molina, Thierry / Asnafi, Vahid / Watatani, Yosaku / Chiba, Kenichi / Okada, Ai / Shiraishi, Yuichi / Tsukita, Sachiko / Izutsu, Koji / Miyoshi, Hiroaki / Ohshima, Koichi / Sakata, Seiji / Dobashi, Akito / Takeuchi, Kengo / Sanada, Masashi / Gaulard, Philippe / Jaccard, Arnaud / Ogawa, Seishi / Hermine, Olivier / Kataoka, Keisuke / Couronné, Lucile

    Cancer research

    2024  

    Abstract: Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations and their functional roles in ENKTCL could help improve patient ... ...

    Abstract Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations and their functional roles in ENKTCL could help improve patient stratification and treatments. Here, we performed comprehensive genetic analysis of 177 ENKTCL cases to delineate the landscape of mutations, copy number alterations (CNAs), and structural variations, identifying 34 driver genes including six previously unappreciated ones, namely HLA-B, HLA-C, ROBO1, CD58, POT1, and MAP2K1. Among them, CD274 (24%) was the most frequently altered, followed by TP53 (20%), CDKN2A (19%), ARID1A (15%), HLA-A (15%), BCOR (14%), and MSN (14%). Chromosome X (chrX) losses were the most common arm-level CNAs in females (~40%), and alterations of four X-linked driver genes (MSN, BCOR, DDX3X, and KDM6A) were more frequent in males and females harboring chrX losses. Among X-linked drivers, MSN was the most recurrently altered, and its expression was lost in approximately one-third of cases using immunohistochemical analysis. Functional studies of human cell lines demonstrated that MSN disruption promoted cell proliferation and NF-κB activation. Moreover, MSN inactivation increased sensitivity to NF-κB inhibition in vitro and in vivo. In addition, recurrent deletions were observed at the origin of replication in the EBV genome (6%). Finally, by integrating the 34 drivers and 19 significant arm-level CNAs, non-negative matrix factorization and consensus clustering identified two molecular groups with different genetic features and prognosis irrespective of clinical prognostic factors. Together, these findings could help improve diagnostic and therapeutic strategies in ENKTCL.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-24-0132
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  8. Article ; Online: First-line treatment of double-hit and triple-hit lymphomas: Survival and tolerance data from a retrospective multicenter French study.

    Laude, Marie-Charlotte / Lebras, Laure / Sesques, Pierre / Ghesquieres, Herve / Favre, Simon / Bouabdallah, Krimo / Croizier, Carolyne / Guieze, Romain / Drieu La Rochelle, Laurianne / Gyan, Emmanuel / Chin, Roza / Aurran-Schleinitz, Thérèse / Marouf, Amira / Deau-Fischer, Bénédicte / Coppo, Paul / Malot, Sandrine / Roussel, Xavier / Chauchet, Adrien / Schwarz, Marianne /
    Bescond, Charles / Lamy de la Chapelle, Thierry / Bussot, Lucile / Carras, Sylvain / Burlet, Bénédicte / Rossi, Cédric / Daniel, Adrien / Morschhauser, Franck / Subtil, Fabien / Michallet, Anne-Sophie

    American journal of hematology

    2020  Volume 96, Issue 3, Page(s) 302–311

    Abstract: Historically, double or triple hit lymphoma (DHL and THL) have poor outcomes with conventional chemotherapy, but there is currently no guideline. We report the French experience in managing DHL and THL in first line using collective data on both survival ...

    Abstract Historically, double or triple hit lymphoma (DHL and THL) have poor outcomes with conventional chemotherapy, but there is currently no guideline. We report the French experience in managing DHL and THL in first line using collective data on both survival and tolerance. All consecutive patients with newly diagnosis of large B-cell lymphoma with MYC, BCL2, and/or BCL6 rearrangements, as determined by FISH between January 2013 and April 2019 were included. Based on the eligibility criteria, 160 patients were selected among the 184 patients identified. With a median follow-up of 32 months, 2- and 4-year progression free survival (PFS) rates were 40% and 28% with R-CHOP compared with 57% and 52% with intensive chemotherapy (P = .063). There was no difference in overall survival (OS). For advanced stages, PFS was significantly longer with intensive chemotherapy than with R-CHOP (P = .029). There was no impact of autologous stem cell transplantation among patient in remission. For patients with central nervous system (CNS) involvement, the 2-year PFS and OS rate was 21% and 39%, vs 57% and 75% without CNS disease (P = .007 and P < .001). By multivariate analysis, elevated IPI score and CNS disease were strongly and independently associated with a poorer survival, whereas treatment was not significantly associated with OS. This is the largest series reporting the treatment of DHL and THL in Europe. The PFS was significantly longer with an intensive regimen for advanced stage, but no difference in OS, supporting the need for a prospective randomized trial.
    MeSH term(s) Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Central Nervous System/pathology ; Combined Modality Therapy ; Drug Evaluation ; Female ; Follow-Up Studies ; France/epidemiology ; Gastrointestinal Diseases/chemically induced ; Genes, bcl-2 ; Genes, myc ; Hematologic Diseases/chemically induced ; Hematopoietic Stem Cell Transplantation ; Humans ; In Situ Hybridization, Fluorescence ; Kaplan-Meier Estimate ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Male ; Middle Aged ; Progression-Free Survival ; Proto-Oncogene Proteins c-bcl-6/genetics ; Remission Induction ; Retrospective Studies ; Salvage Therapy ; Transplantation Conditioning ; Transplantation, Autologous
    Chemical Substances BCL6 protein, human ; Proto-Oncogene Proteins c-bcl-6
    Language English
    Publishing date 2020-12-29
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Multicenter Study
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26068
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