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  1. Article: Changing landscape in living kidney donation in Greece.

    Karydis, Nikolaos / Maroulis, Ioannis

    World journal of transplantation

    2023  Volume 13, Issue 2, Page(s) 28–35

    Abstract: Patients with end-stage renal disease in Greece are facing long waiting times to receive a kidney transplant from a deceased donor. Living kidney donation offers a valuable alternative that provides optimal outcomes and significantly expands the donor ... ...

    Abstract Patients with end-stage renal disease in Greece are facing long waiting times to receive a kidney transplant from a deceased donor. Living kidney donation offers a valuable alternative that provides optimal outcomes and significantly expands the donor pool but still remains relatively underutilised. Developments around the world in the field of kidney transplantation mandate a change in current practice to include additional options for living donation through paired exchange, antibody-incompatible transplantation and other strategies, following careful consideration of the cultural and ethical factors involved in these complex clinical decisions. An increase in living donation rates may be achieved in several ways, including targeted campaigning to overcome potential barriers. Educating clinicians on transplantation will prove as equally important as informing patients and prospective donors but requires training and resources. Adoption of established practices and implementation of new strategies must be tailored to the needs of the Greek donor and recipient population. Local beliefs about donation, perception of associated risk and other social characteristics must be considered in the design of future strategies. Facilitating living donation in a safe environment with appropriate donor and recipient education will form the solid foundation of a new era of kidney transplantation in Greece.
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2220-3230
    ISSN 2220-3230
    DOI 10.5500/wjt.v13.i2.28
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Epithelial to mesenchymal transition (EMT) in metaplastic breast cancer and phyllodes breast tumors.

    Akrida, Ioanna / Mulita, Francesk / Plachouri, Kerasia-Maria / Benetatos, Nikolaos / Maroulis, Ioannis / Papadaki, Helen

    Medical oncology (Northwood, London, England)

    2023  Volume 41, Issue 1, Page(s) 20

    Abstract: Epithelial-mesenchymal transition (EMT), a transdifferentiation program whereby epithelial cells acquire mesenchymal phenotype, is essential during embryonic development. EMT has also been implicated in cancer progression by conferring migratory and ... ...

    Abstract Epithelial-mesenchymal transition (EMT), a transdifferentiation program whereby epithelial cells acquire mesenchymal phenotype, is essential during embryonic development. EMT has also been implicated in cancer progression by conferring migratory and metastatic potential, as well as cell plasticity and stem cell like traits, to cancer cells. Metaplastic breast carcinoma (MBC) is a rare aggressive type of breast cancer characterized by the presence of heterologous elements, typically by the existence of epithelial and mesenchymal components. Phyllodes tumors (PTs) are uncommon fibroepithelial neoplasms consisting of epithelial and mesenchymal elements. Although various hypotheses have been proposed on the pathogenesis of these biphasic tumors, there is growing evidence supporting the theory that PTs and MBC could both correlate with cancer related EMT. This review summarizes the existing literature on the emerging role of EMT in the pathogenesis of MBC and PTs. Both malignant PTs and MBC are characterized by poor prognosis. Therefore, several anti-EMT targeting strategies such as blocking upstream signaling pathways, targeting the molecular drivers of EMT and targeting mesenchymal cells and the extracellular matrix, could potentially represent a promising therapeutic approach for patients suffering from these aggressive neoplasms.
    MeSH term(s) Humans ; Female ; Epithelial-Mesenchymal Transition/genetics ; Breast Neoplasms/pathology ; Phyllodes Tumor ; Cell Transdifferentiation ; Stem Cells/metabolism
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-023-02259-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Comprehensive Analysis of DNA Methyltransferases Expression in Primary and Relapsed Ovarian Carcinoma.

    Papakonstantinou, Efthymia / Pappa, Ioanna / Androutsopoulos, Georgios / Adonakis, Georgios / Maroulis, Ioannis / Tzelepi, Vasiliki

    Cancers

    2023  Volume 15, Issue 20

    Abstract: Background: Despite recent advances in epithelial ovarian carcinoma (EOC) treatment, its recurrence and mortality rates have not improved significantly. DNA hypermethylation has generally been associated with an ominous prognosis and chemotherapy ... ...

    Abstract Background: Despite recent advances in epithelial ovarian carcinoma (EOC) treatment, its recurrence and mortality rates have not improved significantly. DNA hypermethylation has generally been associated with an ominous prognosis and chemotherapy resistance, but the role of DNA methyltransferases (DNMTs) in EOC remains to be investigated.
    Methods: In the current study, we systematically retrieved gene expression data from patients with EOC and studied the immunohistochemical expression of DNMTs in 108 primary and 26 relapsed tumors.
    Results: Our results showed that the DNMT1, DNMT3A, DNMT3B and DNMT3L RNA levels were higher and the DNMT2 level was lower in tumors compared to non-neoplastic tissue, and DNMT3A and DNMT2 expression decreased from Stage-II to Stage-IV carcinomas. The proteomic data also suggested that the DNMT1 and DNMT3A levels were increased in the tumors. Similarly, the DNMT1, DNMT3A and DNMT3L protein levels were overexpressed and DNMT2 expression was reduced in high-grade carcinomas compared to non-neoplastic tissue and low-grade tumors. Moreover, DNMT1 and DNMT3L were increased in relapsed tumors compared to their primaries. The DNMT3A, DNMT1 and DNMT3B mRNA levels were correlated with overall survival.
    Conclusions: Our study demonstrates that DNMT1 and DNMT3L are upregulated in primary high-grade EOC and further increase in relapses, whereas DNMT3A is upregulated only in the earlier stages of cancer progression. DNMT2 downregulation highlights the presumed tumor-suppressor activity of this gene in ovarian carcinoma.
    Language English
    Publishing date 2023-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15204950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: An Updated Review on the Emerging Role of Indocyanine Green (ICG) as a Sentinel Lymph Node Tracer in Breast Cancer.

    Akrida, Ioanna / Michalopoulos, Nikolaos V / Lagadinou, Maria / Papadoliopoulou, Maria / Maroulis, Ioannis / Mulita, Francesk

    Cancers

    2023  Volume 15, Issue 24

    Abstract: Sentinel lymph node biopsy (SLNB) has become the standard of care for clinically node-negative breast cancer and has recently been shown by clinical trials to be also feasible for clinically node-positive patients treated with primary systemic therapy. ... ...

    Abstract Sentinel lymph node biopsy (SLNB) has become the standard of care for clinically node-negative breast cancer and has recently been shown by clinical trials to be also feasible for clinically node-positive patients treated with primary systemic therapy. The dual technique using both radioisotope (RI) and blue dye (BD) as tracers for the identification of sentinel lymph nodes is considered the gold standard. However, allergic reactions to blue dye as well as logistics issues related to the use of radioactive agents, have led to research on new sentinel lymph node (SLN) tracers and to the development and introduction of novel techniques in the clinical practice. Indocyanine green (ICG) is a water-soluble dye with fluorescent properties in the near-infrared (NIR) spectrum. ICG has been shown to be safe and effective as a tracer during SLNB for breast cancer and accumulating evidence suggests that ICG is superior to BD and at least comparable to RI alone and to RI combined with BD. Thus, ICG was recently proposed as a reliable SLN tracer in some breast cancer clinical practice guidelines. Nevertheless, there is lack of consensus regarding the optimal role of ICG for SLN mapping. Specifically, it is yet to be determined whether ICG should be used in addition to BD and/or RI, or if ICG could potentially replace these long-established traditional SLN tracers. This article is an updated overview of somerecent studies that compared ICG with BD and/or RI regarding their accuracy and effectiveness during SLNB for breast cancer.
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15245755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Enlarged cystic artery.

    Mulita, Francesk / Benetatos, Nikolaos / Maroulis, Ioannis / Germanos, Stylianos

    BMJ case reports

    2021  Volume 14, Issue 1

    MeSH term(s) Adenoma, Liver Cell/diagnosis ; Adenoma, Liver Cell/surgery ; Cholecystectomy, Laparoscopic ; Female ; Gallbladder/blood supply ; Gallbladder/pathology ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/surgery ; Middle Aged
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-240056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Strangulated femoral hernia without intestinal obstruction? Be aware of Meckel's diverticulum: a case report of a Littre's hernia.

    Kehagias, Dimitrios / Iliopoulos, Evangelos / Maroulis, Ioannis / Mulita, Francesk

    BMJ case reports

    2021  Volume 14, Issue 6

    MeSH term(s) Hernia, Abdominal ; Hernia, Femoral/complications ; Hernia, Femoral/diagnostic imaging ; Hernia, Femoral/surgery ; Humans ; Intestinal Obstruction/diagnostic imaging ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Meckel Diverticulum/complications ; Meckel Diverticulum/diagnostic imaging ; Meckel Diverticulum/surgery ; Vascular Diseases
    Language English
    Publishing date 2021-06-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-243840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Transient small bowel intussusception in a 30-year-old male.

    Mulita, Francesk / Tchabashvili, Levan / Liolis, Elias / Maroulis, Ioannis

    Przeglad gastroenterologiczny

    2021  Volume 16, Issue 3, Page(s) 252–253

    Language English
    Publishing date 2021-09-17
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2596134-2
    ISSN 1897-4317 ; 1895-5770
    ISSN (online) 1897-4317
    ISSN 1895-5770
    DOI 10.5114/pg.2021.108991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Reply to letter to the editor.

    Vailas, Michail / Sotiropoulou, Maria / Mulita, Francesk / Maroulis, Ioannis

    European surgery : ACA : Acta chirurgica Austriaca

    2021  Volume 53, Issue 5, Page(s) 261–262

    Language English
    Publishing date 2021-06-25
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 2073941-2
    ISSN 1682-4016 ; 1682-8631 ; 1682-1769
    ISSN (online) 1682-4016
    ISSN 1682-8631 ; 1682-1769
    DOI 10.1007/s10353-021-00729-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fear of COVID-19 infection among surgeons and hesitancy for vaccination. Who is the culprit to blame?

    Vailas, Michail / Sotiropoulou, Maria / Mulita, Francesk / Maroulis, Ioannis

    The British journal of surgery

    2021  Volume 108, Issue 4, Page(s) e184

    MeSH term(s) COVID-19 ; Fear ; Humans ; SARS-CoV-2 ; Surgeons ; Vaccination/adverse effects
    Language English
    Publishing date 2021-04-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znab032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Changing surgical practice in management of intrahepatic cholangiocarcinoma during the pandemic. Is bridging with systemic therapy safe for our patients?

    Vailas, Michail / Sotiropoulou, Maria / Maroulis, Ioannis

    The British journal of surgery

    2021  Volume 108, Issue 3, Page(s) e145

    MeSH term(s) Bile Duct Neoplasms/epidemiology ; Bile Duct Neoplasms/surgery ; COVID-19 ; Cholangiocarcinoma/epidemiology ; Cholangiocarcinoma/surgery ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-04-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znab002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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