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  1. Article ; Online: Successful treatment of pituitary gigantism.

    Cunha, Clara / Saraiva, Catarina / Canas Marques, Conceição / Duarte, João Sequeira

    BMJ case reports

    2021  Volume 14, Issue 12

    Abstract: Pituitary gigantism is extremely rare, resulting from excessive secretion of growth hormone (GH) before fusion of epiphysial growth plates. We report a case of a 13-year-old boy, who presented with increased statural growth and headaches since the age of ...

    Abstract Pituitary gigantism is extremely rare, resulting from excessive secretion of growth hormone (GH) before fusion of epiphysial growth plates. We report a case of a 13-year-old boy, who presented with increased statural growth and headaches since the age of 10 years. On physical examination, his height was 180.7 cm (+3.3 SD) and Tanner stage V. Investigation revealed increased levels of serum age-adjusted and sex-adjusted insulin-like growth factor 1 (IGF-1) and failure of GH suppression during an oral glucose tolerance test (OGTT). MRI of the sellar region revealed a pituitary macroadenoma. He underwent transsphenoidal surgery and histopathological evaluation revealed mammosomatotropic adenoma. Three months after surgery, IGF-1 normalised, nadir GH during OGTT was less than 1 ng/mL and no residual tumour was found on the MRI. Genetic testing identified a mutation in the
    MeSH term(s) Acromegaly/diagnosis ; Adenoma/diagnostic imaging ; Adenoma/surgery ; Adolescent ; Child ; Gigantism ; Growth Hormone ; Human Growth Hormone ; Humans ; Insulin-Like Growth Factor I ; Male ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/surgery
    Chemical Substances Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6) ; Growth Hormone (9002-72-6)
    Language English
    Publishing date 2021-12-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-247989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Predicting Peritoneal Carcinomatosis in Locally Advanced Gastric Cancer: The Significance of Tumor Markers in the Peritoneal Washing.

    Pinheiro, João Luís / Duarte, Liliana / Santos, Andreia J / Tojal, André / Canhoto, Carolina / Ferreira, Marta / Marques, Conceição / Pereira, Jorge

    Journal of gastrointestinal cancer

    2023  Volume 55, Issue 1, Page(s) 427–434

    Abstract: Purpose: Gastric cancer is the fifth most common malignant tumor worldwide. Many attempts have been made over the years to investigate the relationship between tumor markers and the risk of recurrence. This study aims to explore the predictive value of ... ...

    Abstract Purpose: Gastric cancer is the fifth most common malignant tumor worldwide. Many attempts have been made over the years to investigate the relationship between tumor markers and the risk of recurrence. This study aims to explore the predictive value of tumor markers measured in peritoneal washing during staging laparoscopy, regarding peritoneal carcinomatosis and mortality within 1 year.
    Methods: Patients with locally advanced gastric cancer, staged as at least usT2anyNM0 were submitted to staging laparoscopy in a Portuguese single center. CA 19.9, CEA, CA 125, and CA 72.4 were measured in the peritoneal washing after being harvested during staging laparoscopy.
    Results: Thirty-eight patients were enrolled. After 1 year, 20 patients did not recur (52.5%), 11 (28.9%) developed carcinomatosis, and 7 (18.4%) had distant metastasis. Mortality reached 23.7% (n = 9). A statistically significant prediction of carcinomatosis was obtained for CA 125 (cutoff: 107.6 U/mL (p = 0.019)) and CEA (cutoff: 2.0 ng/mL (p = 0.020)) with 87.5% and 75% sensitivity, respectively. Prediction of mortality was significant for CA 125 (cutoff: 103.8 U/mL (p = 0.044)) and CA 125 + CEA (p = 0.030). CEA and CA 125 had NPVs of 87.9% and 93.1% regarding PC, respectively. NPVs of 88.9% and 89.2% were met concerning mortality, for the same tumor markers.
    Conclusion: Performing the peritoneal liquid harvest during staging laparoscopy makes this analysis cost effective, reproducible, and does not add further morbidity. CA 125 and CEA, individually and in association, are good predictors of progression of disease and mortality within a year of staging laparoscopy in GC patients.
    MeSH term(s) Humans ; Stomach Neoplasms/pathology ; Stomach Neoplasms/mortality ; Stomach Neoplasms/surgery ; Peritoneal Neoplasms/secondary ; Peritoneal Neoplasms/mortality ; Male ; Female ; Middle Aged ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/metabolism ; Aged ; Neoplasm Staging ; Peritoneal Lavage/methods ; CA-125 Antigen/analysis ; CA-125 Antigen/metabolism ; CA-125 Antigen/blood ; Laparoscopy/methods ; Carcinoembryonic Antigen/analysis ; Carcinoembryonic Antigen/metabolism ; Adult ; CA-19-9 Antigen/analysis ; CA-19-9 Antigen/metabolism ; Predictive Value of Tests ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Aged, 80 and over
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-023-00984-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2184: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Asymptomatic large duodenal GIST - An incidental finding in abdominopelvic ultrasonography: A case report.

    Santos, Andreia J / Tojal, André / Duarte, Liliana / Marques, Conceição / Pinheiro, Luís F / Casimiro, Carlos

    International journal of surgery case reports

    2020  Volume 76, Page(s) 301–304

    Abstract: Introduction: Duodenal GISTs are rare mesenchymal tumors of the digestive tract. They usually present as gastrointestinal bleeding or non-specific abdominal pain, but they can also be asymptomatic. High-risk GISTs have malignant potential. Surgical ... ...

    Abstract Introduction: Duodenal GISTs are rare mesenchymal tumors of the digestive tract. They usually present as gastrointestinal bleeding or non-specific abdominal pain, but they can also be asymptomatic. High-risk GISTs have malignant potential. Surgical resection is the only curative option and its extension depends on different factors. Tyrosine kinase inhibitors are of the utmost importance in high-risk and metastatic disease.
    Case description: We herein report the case of a 75-year-old male, referred to our general surgery outpatient clinic, with an asymptomatic duodenal mass incidentally diagnosed during an abdominopelvic ultrasonography. Abdominal CT suggested GIST. Since no other lesions were found, a segmental duodenectomy was performed and the patient recovery was uneventful. Histologic exam confirmed the presence of a high-risk GIST, therefore adjuvant therapy with imatinib was initiated.
    Discussion: Duodenal involvement by GISTs is rare, even more in its third/fourth portions. The widespread clinical use of radiological exams such as ultrasonography may lead to the diagnosis of asymptomatic masses. Surgical treatment is the gold-standard giving the malignant potential of these neoplasms. There are risk stratification scores that may be used to assess the need for adjuvant therapy.
    Conclusion: Even large GISTs can by asymptomatic. Giving their malignant potential, early diagnosis and treatment are crucial. The histologic findings and genetic profile have an impact on the patient's survival.
    Language English
    Publishing date 2020-09-29
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2020.09.176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Granular cell tumour of the neurohypophysis: an unusual cause of hypopituitarism.

    Bello, Carlos Tavares / Cipriano, Patricia / Henriques, Vanessa / Duarte, João Sequeira / Marques, Conceição Canas

    Endocrinology, diabetes & metabolism case reports

    2018  Volume 2018

    Abstract: Granular cell tumours (GCT) are rare, slow-growing, benign neoplasms that are usually located in the head and neck. They are more frequent in the female gender and typically have an asymptomatic clinical course, being diagnosed only at autopsy. ... ...

    Abstract Granular cell tumours (GCT) are rare, slow-growing, benign neoplasms that are usually located in the head and neck. They are more frequent in the female gender and typically have an asymptomatic clinical course, being diagnosed only at autopsy. Symptomatic GCT of the neurohypophysis are exceedingly rare, being less than 70 cases described so far. The authors report on a case of a 28-year-old male that presented to the Endocrinology clinic with clinical and biochemical evidence of hypogonadism. He also reported minor headaches without any major visual symptoms. Further laboratory tests confirmed hypopituitarism (hypogonadotrophic hypogonadism, central hypothyroidism and hypocortisolism) and central nervous system imaging revealed a pituitary macroadenoma. The patient underwent transcranial pituitary adenoma resection and the pathology report described a GCT of the neurohypophysis with low mitotic index. The reported case is noteworthy for the rarity of the clinicopathological entity.
    Learning points: Symptomatic GCTs are rare CNS tumours whose cell of origin is not well defined that usually give rise to visual symptoms, headache and endocrine dysfunction.Imaging is quite unspecific and diagnosis is difficult to establish preoperatively.Surgical excision is challenging due to lesion's high vascularity and propensity to adhere to adjacent structures.The reported case is noteworthy for the rarity of the clinicopathological entity.
    Language English
    Publishing date 2018-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2785530-2
    ISSN 2052-0573
    ISSN 2052-0573
    DOI 10.1530/EDM-17-0178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pseudotumoral acute hemicerebellitis in a child.

    Morais, Rita B / Sousa, Inês / Leiria, Maria J / Marques, Conceição / Ferreira, José C / Cabral, Pedro

    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

    2013  Volume 17, Issue 2, Page(s) 204–207

    Abstract: Acute cerebellitis is an inflammatory disorder usually involving both sides of the cerebellum and presenting with localized signs such as ataxia. Hemicerebellitis is extremely rare in children and may clinically and radiologically resemble a tumor. There ...

    Abstract Acute cerebellitis is an inflammatory disorder usually involving both sides of the cerebellum and presenting with localized signs such as ataxia. Hemicerebellitis is extremely rare in children and may clinically and radiologically resemble a tumor. There are very few reports of hemicerebellitis needing decompressive surgery. We report a case of hemicerebellitis in a 15 year old child presenting with severe headache but no cerebellar symptoms whose brain CT revealed an ill-defined mass compressing the fourth ventricle (pseudotumoral). MRI of the posterior fossa revealed a swollen left cerebellar hemisphere, supra-tentorial hydrocephalus and tonsil herniation, without any cerebral or brain stem lesions. Due to worsening symptoms she required a decompressive craniectomy, and the biopsy revealed an inflammatory process, possibly viral. At follow-up she was asymptomatic and the MRI revealed only slight cerebellar atrophy. This case had an atypical clinical presentation and illustrates that though a self-limited evolution is expected, surgical intervention may be needed in acute cerebellitis.
    MeSH term(s) Adolescent ; Brain Neoplasms/diagnosis ; Cerebellum/pathology ; Diagnosis, Differential ; Encephalitis/diagnosis ; Encephalitis/physiopathology ; Female ; Functional Laterality ; Humans ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2013-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1397146-3
    ISSN 1532-2130 ; 1090-3798
    ISSN (online) 1532-2130
    ISSN 1090-3798
    DOI 10.1016/j.ejpn.2012.06.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4867: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 641: Show issues

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  6. Article ; Online: Non-adenomatous sellar lesions: single-centre 10-year experience.

    Sousa Santos, Francisco / Nunes Dias, Lídia / Henriques, Vanessa / Canas Marques, Conceição / Chorão, Martinha / Sequeira Duarte, João / Limbert, Clotilde / Costa, João / Graça, Joana / Vasconcelos, Carlos / Cabral, José / Ramos, Sância

    Hormones (Athens, Greece)

    2018  Volume 17, Issue 4, Page(s) 557–563

    Abstract: Objective: A minority of lesions found in the sellar region are non-adenomatous neoplastic, inflammatory, or cystic masses. Our study aims to describe the prevalence and characteristics of these lesions in a multidisciplinary pituitary outpatient clinic. ...

    Abstract Objective: A minority of lesions found in the sellar region are non-adenomatous neoplastic, inflammatory, or cystic masses. Our study aims to describe the prevalence and characteristics of these lesions in a multidisciplinary pituitary outpatient clinic.
    Design: We conducted an observational study which included 36 patients (15.9% of those followed up in this outpatient clinic between 2006 and 2016 who had pituitary surgery) submitted to pituitary surgery with histological results showing a non-adenomatous sellar lesion. We evaluated clinical, radiological, and biochemical (pituitary function) characteristics during the pre-operative and post-operative period.
    Results: Thirty-six patients (50% female) with a mean age of 41.3 ± 21.9 years and a mean follow-up duration of 8.0 ± 9.0 years were included. Histologic diagnoses were divided into benign neoplasms (80.6%), malignant neoplasms (11.1%), inflammatory lesions (5.6%), and cystic masses (2.8%). The most common clinical presentation was headache (66.7%) and visual defects (61.1%). Forty-seven percent of patients had at least one pituitary axis insufficiency at the time of diagnosis. In the majority of cases (58.3%), a transsphenoidal approach was used for the initial pituitary surgery. Thirteen patients had more than one pituitary surgery and eight also had radiotherapy. At the time of data retrieval, five patients had no pituitary hormonal insufficiency and 13 patients had some visual defect improvement.
    Conclusions: Although rare, non-adenomatous sellar lesions may be associated with significant causes of morbidity, such as hypopituitarism and visual defects, per se or due to the various treatment modalities employed. Moreover, since the lesions are difficult to distinguish from adenomas, these patients require a careful multidisciplinary approach.
    MeSH term(s) Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Outcome and Process Assessment (Health Care)/statistics & numerical data ; Pituitary Diseases/diagnosis ; Pituitary Diseases/pathology ; Pituitary Diseases/therapy ; Sella Turcica/pathology ; Young Adult
    Language English
    Publishing date 2018-10-03
    Publishing country Switzerland
    Document type Journal Article ; Observational Study
    ZDB-ID 2075912-5
    ISSN 2520-8721 ; 1109-3099
    ISSN (online) 2520-8721
    ISSN 1109-3099
    DOI 10.1007/s42000-018-0064-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5613: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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