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  1. Article ; Online: Observe, and Keep Chemotherapy Up the Sleeve.

    Marquez, Carol

    International journal of radiation oncology, biology, physics

    2018  Volume 100, Issue 3, Page(s) 550

    MeSH term(s) Hodgkin Disease ; Humans ; Lung Neoplasms/surgery ; Lymphocytes ; Pneumonectomy ; Postoperative Period
    Language English
    Publishing date 2018-02-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2017.11.006
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  2. Article ; Online: ASTRO Editorial: ONS Guidelines for Cancer Treatment-Related Radiodermatitis.

    Marquez, Carol Madellaine / Wong, William

    Practical radiation oncology

    2021  Volume 11, Issue 5, Page(s) 352–353

    MeSH term(s) Humans ; Neoplasms/radiotherapy ; Radiodermatitis ; Practice Guidelines as Topic
    Language English
    Publishing date 2021-09-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2021.05.005
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  3. Article ; Online: An Affordable Platform for Virtual Reality-Based Patient Education in Radiation Therapy.

    Schulz, Joseph B / Dubrowski, Piotr / Blomain, Erik / Million, Lynn / Qian, Yushen / Marquez, Carol / Yu, Amy S

    Practical radiation oncology

    2023  Volume 13, Issue 6, Page(s) e475–e483

    Abstract: Purpose: The goal of this study was to develop and assess the effectiveness of an affordable smartphone-based virtual reality (VR) patient education platform with 360-degree videos produced depicting a first-person patient perspective during the ... ...

    Abstract Purpose: The goal of this study was to develop and assess the effectiveness of an affordable smartphone-based virtual reality (VR) patient education platform with 360-degree videos produced depicting a first-person patient perspective during the radiation therapy (RT) care path to reduce patient anxiety.
    Methods and materials: Three disease site-specific (breast, pelvis, head and neck) VR videos were filmed using a 360-degree camera to portray the first-person perspective of a patient's standard RT appointments, including a computed tomography simulation and the first RT treatment session. Instruction is given for possible clinical implementation. Patient participation was divided into 2 groups: (1) Group A (n = 28) included patients participating before simulation and later after the first treatment, and (2) Group B (n = 33) included patients participating only while undergoing treatment. Patients viewed their disease site-specific video using an inexpensive cardboard VR viewer and their smartphone, emulating an expensive VR-headset. Surveys were administered assessing patient anxiety, comfort, satisfaction, and knowledge of RT on a 5-point Likert-type scale.
    Results: Patients in Group A and Group B while undergoing treatment both indicated that their anxiety "decreased a little" in the survey, after watching the VR video (Group A, median on a 5-point Likert-type scale, 4 [IQR, 4-5]; Group B, 4 [IQR, 4-4]). The VR aspect of the videos was especially liked by patients while undergoing treatment, with 96.4% in Group A and 90.9% in Group B reporting that the VR aspect of the videos was helpful. All Group A participants believed that the VR videos would be beneficial to new patients.
    Conclusions: Our affordable VR patient education platform effectively immerses a patient in their care path from simulation through initial treatment delivery, reducing anxiety and increasing familiarity with the treatment process.
    MeSH term(s) Humans ; Patient Education as Topic ; Virtual Reality ; Breast
    Language English
    Publishing date 2023-07-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2023.06.008
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  4. Article ; Online: Locoregional and Distant Outcomes in Women With cT1-3N1 Breast Cancer Treated With Neoadjuvant Chemotherapy With or Without Adjuvant Radiotherapy.

    Kozak, Margaret M / von Eyben, Rie / Gutkin, Paulina M / Vemuri, Meena / Jacobson, Clare E / Karl, Jamie J / Walck, Emily / Marquez, Carol / Horst, Kathleen C

    Clinical breast cancer

    2021  Volume 21, Issue 4, Page(s) 373–382

    Abstract: Background: We evaluated the impact of postmastectomy radiotherapy (PMRT) or supraclavicular radiation therapy (SCV RT) in women with cT1-3N1 breast cancer (BC) who became node negative (ypN0) after neoadjuvant chemotherapy (NAC).: Patients and ... ...

    Abstract Background: We evaluated the impact of postmastectomy radiotherapy (PMRT) or supraclavicular radiation therapy (SCV RT) in women with cT1-3N1 breast cancer (BC) who became node negative (ypN0) after neoadjuvant chemotherapy (NAC).
    Patients and methods: We retrospectively reviewed 485 women treated with NAC for BC between 2005 and 2019. Radiation treatment fields were reviewed in detail. Pathologic complete response (pCR) was defined as ypT0/Tis ypN0. Patients who had residual nodal disease were defined as ypN+. Those who achieved complete response in the lymph nodes but not in the breast were defined as ypT+ypN0.
    Results: After excluding patients with cT4 and cN0 disease at diagnosis, a total of 185 patients with cT1-3N1 BC were included. Patients were more likely to receive PMRT if they had ypN+ disease (P < .001) and/or lymphovascular invasion (P = .03). Patients who underwent lumpectomy were more likely to receive SCV RT if they did not achieve pCR (P = .04) and/or if they had ypN+ disease (P = .01). The 5-year rates of locoregional recurrence (LRR) were 15% for all patients, 14% for patients who attained ypT+ypN0, and 5% for patients who achieved pCR. Of ypT+ypN0 patients (n = 98), 53 received PMRT or SCV RT and 45 did not. For these patients, there were no differences in LRR based on whether a patient did or did not receive PMRT or SCV RT (P = .23).
    Conclusion: Recommendations for or against PMRT or SCV RT after NAC vary based on final pathologic response. We await the results of ongoing randomized clinical trials to help guide clinical decision making in this context.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Chemotherapy, Adjuvant ; Female ; Humans ; Mastectomy ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Radiotherapy, Adjuvant ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2106734-X
    ISSN 1938-0666 ; 1526-8209
    ISSN (online) 1938-0666
    ISSN 1526-8209
    DOI 10.1016/j.clbc.2021.02.008
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  5. Article ; Online: CT-less electron radiotherapy simulation and planning with a consumer 3D camera.

    Skinner, Lawrie / Knopp, Rick / Wang, Yi-Chun / Dubrowski, Piotr / Bush, Karl K / Limmer, Alyssa / Trakul, Nicholas / Million, Lynn / Marquez, Carol M / Yu, Amy S

    Journal of applied clinical medical physics

    2021  Volume 22, Issue 7, Page(s) 128–136

    Abstract: Purpose: Electron radiation therapy dose distributions are affected by irregular body surface contours. This study investigates the feasibility of three-dimensional (3D) cameras to substitute for the treatment planning computerized tomography (CT) scan ... ...

    Abstract Purpose: Electron radiation therapy dose distributions are affected by irregular body surface contours. This study investigates the feasibility of three-dimensional (3D) cameras to substitute for the treatment planning computerized tomography (CT) scan by capturing the body surfaces to be treated for accurate electron beam dosimetry.
    Methods: Dosimetry was compared for six electron beam treatments to the nose, toe, eye, and scalp using full CT scan, CT scan with Hounsfield Unit (HU) overridden to water (mimic 3D camera cases), and flat-phantom techniques. Radiation dose was prescribed to a depth on the central axis per physician's order, and the monitor units (MUs) were calculated. The 3D camera spatial accuracy was evaluated by comparing the 3D surface of a head phantom captured by a 3D camera and that generated with the CT scan in the treatment planning system. A clinical case is presented, and MUs were calculated using the 3D camera body contour with HU overridden to water.
    Results: Across six cases the average change in MUs between the full CT and the 3Dwater (CT scan with HU overridden to water) calculations was 1.3% with a standard deviation of 1.0%. The corresponding hotspots had a mean difference of 0.4% and a standard deviation of 1.9%. The 3D camera captured surface of a head phantom was found to have a 0.59 mm standard deviation from the surface derived from the CT scan. In-vivo dose measurements (213 ± 8 cGy) agreed with the 3D-camera planned dose of 209 ± 6 cGy, compared to 192 ± 6 cGy for the flat-phantom calculation (same MUs).
    Conclusions: Electron beam dosimetry is affected by irregular body surfaces. 3D cameras can capture irregular body contours which allow accurate dosimetry of electron beam treatment as an alternative to costly CT scans with no extra exposure to radiation. Tools and workflow for clinical implementation are provided.
    MeSH term(s) Electrons ; Humans ; Phantoms, Imaging ; Radiometry ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-05-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010347-5
    ISSN 1526-9914 ; 1526-9914
    ISSN (online) 1526-9914
    ISSN 1526-9914
    DOI 10.1002/acm2.13283
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  6. Article ; Online: Call for action: expanding global access to hereditary cancer genetic testing.

    Bychkovsky, Brittany / Rana, Huma Q / Ademuyiwa, Foluso / Plichta, Jennifer / Anderson, Karen / Nogueira-Rodrigues, Angélica / Santa-Maria, Cesar A / Coffman, Lan G / Marquez, Carol / Das, Arunangshu / Taghian, Alphonse / Koeller, Diane R / Sandoval, Renata L / Park, Ben Ho / Dizon, Don S

    The Lancet. Oncology

    2022  Volume 23, Issue 9, Page(s) 1124–1126

    MeSH term(s) Genetic Counseling ; Genetic Predisposition to Disease ; Genetic Testing ; Humans ; Neoplasms/diagnosis ; Neoplasms/genetics
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00378-3
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  7. Article ; Online: ONS Guidelines™ for Cancer Treatment-Related Radiodermatitis.

    Gosselin, Tracy / Ginex, Pamela K / Backler, Chelsea / Bruce, Susan D / Hutton, Andrea / Marquez, Carol M / McGee, Lisa A / Shaftic, Anne Marie / Suarez, Lauren V / Moriarty, Kerri A / Maloney, Christine / Vrabel, Mark / Morgan, Rebecca L

    Oncology nursing forum

    2020  Volume 47, Issue 6, Page(s) 654–670

    Abstract: Purpose: Radiodermatitis is a side effect of radiation therapy. Evidence-based interventions to minimize severity or delay progression are important for clinical care. This guideline intends to support individuals with cancer, clinicians, and others in ... ...

    Abstract Purpose: Radiodermatitis is a side effect of radiation therapy. Evidence-based interventions to minimize severity or delay progression are important for clinical care. This guideline intends to support individuals with cancer, clinicians, and others in decisions regarding radiodermatitis treatment.
    Methodologic approach: A panel of healthcare professionals with patient representation was convened to develop a national clinical practice guideline for the management of radiodermatitis. GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology and the National Academies of Sciences, Engineering, and Medicine criteria for trustworthy guidelines were followed. The Cochrane Collaboration risk-of-bias tool was used, and certainty of the evidence was assessed using the GRADE approach. A quantitative and narrative synthesis of the evidence was completed.
    Findings: The panel agreed on eight recommendations and made a conditional recommendation for deodorant/antiperspirant. Aloe vera and oral curcumin had knowledge gaps and were recommended only in the context of a clinical trial. The panel suggested against emu oil, calendula, and nonsteroidal interventions.
    Implications for nursing: This guideline summarizes evidence-based interventions for the management of radiodermatitis to guide clinical care.
    Supplementary material can be found at https: //bit.ly/2GEwJtT.
    MeSH term(s) Humans ; Neoplasms ; Radiodermatitis/drug therapy ; Radiodermatitis/etiology
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604886-9
    ISSN 1538-0688 ; 0190-535X ; 1538-0688
    ISSN (online) 1538-0688 ; 0190-535X
    ISSN 1538-0688
    DOI 10.1188/20.ONF.654-670
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  8. Article ; Online: Representation of Women Among Invited Speakers at Medical Specialty Conferences.

    Larson, Allison R / Sharkey, Katherine M / Poorman, Julie A / Kan, Carolyn K / Moeschler, Susan M / Chandrabose, Rekha / Marquez, Carol M / Dodge, Daleela G / Silver, Julie K / Nazarian, Rosalynn M

    Journal of women's health (2002)

    2019  Volume 29, Issue 4, Page(s) 550–560

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Congresses as Topic/statistics & numerical data ; Cross-Sectional Studies ; Female ; Humans ; Physicians, Women/statistics & numerical data ; Sex Factors ; Societies, Medical/organization & administration ; United States ; Workforce/statistics & numerical data
    Language English
    Publishing date 2019-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2019.7723
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  9. Article ; Online: Cerebrospinal fluid shunting and hearing loss in patients treated for medulloblastoma.

    Guillaume, Daniel J / Knight, Kristin / Marquez, Carol / Kraemer, Dale F / Bardo, Dianna M E / Neuwelt, Edward A

    Journal of neurosurgery. Pediatrics

    2012  Volume 9, Issue 4, Page(s) 421–427

    Abstract: Object: Cerebrospinal fluid shunting has previously been associated with hearing loss. Although the mechanism for this is unclear, it is thought that changes in CSF pressure can affect cochlear physiology via endolymph expansion in the setting of a ... ...

    Abstract Object: Cerebrospinal fluid shunting has previously been associated with hearing loss. Although the mechanism for this is unclear, it is thought that changes in CSF pressure can affect cochlear physiology via endolymph expansion in the setting of a patent cochlear aqueduct. Patients undergoing radiation and cisplatin chemotherapy are at risk for hearing loss. The authors hypothesized that the incidence and severity of hearing loss in patients undergoing radiation and chemotherapy for medulloblastoma would be greater in those with shunts than in those without shunts.
    Methods: Baseline and longitudinal audiology data were collected in 33 patients with medulloblastoma who were receiving radiation and cisplatin chemotherapy. Additional data included age, sex, details of shunt placement and revision, and details of chemotherapy and radiation. Hearing sensitivity and peripheral auditory function measures included pure tone audiometry, immittance audiometry, and distortion product evoked otoacoustic emissions. Ototoxicity was determined according to the American Speech-Language-Hearing Association criteria. Severity of hearing loss was determined using the Brock hearing loss grades. Incidence of hearing loss and association with shunting was determined.
    Results: Thirteen (39.4%) of the 33 patients evaluated had undergone shunt placement. Hearing loss occurred in 14 (70%) of 20 patients without shunts and in 13 (100%) of 13 patients with shunts. The difference between the rates of hearing loss in patients with shunts versus those without the devices was highly significant (p = 0.0008). The odds ratio for hearing loss in patients with a CSF shunt compared with those without a shunt was 23.49 (95% CI 4.21-131.15). Age, side of shunt, evidence of dissemination, diameter of cochlear aqueduct, and treatment protocol did not have a significant effect on shunt-related ototoxicity.
    Conclusions: This study suggests an independent association between CSF shunting and hearing loss in children undergoing treatment for medulloblastoma, laying the foundation for a prospective study evaluating hearing loss in children with shunts who are not treated with ototoxic therapy.
    MeSH term(s) Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Auditory Threshold ; Cerebrospinal Fluid Shunts/adverse effects ; Chemoradiotherapy, Adjuvant ; Child ; Child, Preschool ; Cisplatin/administration & dosage ; Cisplatin/adverse effects ; Evoked Potentials, Auditory ; Female ; Hearing/drug effects ; Hearing/radiation effects ; Hearing Loss/diagnosis ; Hearing Loss/etiology ; Hearing Loss/physiopathology ; Humans ; Incidence ; Male ; Medulloblastoma/drug therapy ; Medulloblastoma/radiotherapy ; Odds Ratio ; Otoacoustic Emissions, Spontaneous ; Severity of Illness Index
    Chemical Substances Antineoplastic Agents ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2012-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2403985-8
    ISSN 1933-0715 ; 1933-0707
    ISSN (online) 1933-0715
    ISSN 1933-0707
    DOI 10.3171/2011.12.PEDS11357
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  10. Article: Utilizing traditional storytelling to promote wellness in American Indian communities.

    Hodge, Felicia Schanche / Pasqua, Anna / Marquez, Carol A / Geishirt-Cantrell, Betty

    Journal of transcultural nursing : official journal of the Transcultural Nursing Society

    2001  Volume 13, Issue 1, Page(s) 6–11

    Abstract: Utilizing storytelling to transmit educational messages is a traditional pedagogical method practiced by many American Indian tribes. American Indian stories are effective because they present essential ideas and values in a simple, entertaining form. ... ...

    Abstract Utilizing storytelling to transmit educational messages is a traditional pedagogical method practiced by many American Indian tribes. American Indian stories are effective because they present essential ideas and values in a simple, entertaining form. Different story characters show positive and negative behaviors. The stories illustrate consequences of behaviors and invite listeners to come to their own conclusions after personal reflection. Because stories have been passed down through tribal communities for generations, listeners also have the opportunity to reconnect and identify with past tribal realities. This article reports on a research intervention that is unique in promoting health and wellness through the use of storytelling. The project utilized stories to help motivate tribal members to once more adopt healthy, traditional life-styles and practices. The authors present and discuss the stories selected, techniques used in their telling, the preparation and setting for the storytelling, and the involvement and interaction of the group.
    MeSH term(s) Attitude to Health/ethnology ; Communication ; Curriculum ; Folklore ; Health Behavior/ethnology ; Health Education/methods ; Health Knowledge, Attitudes, Practice ; Health Promotion/methods ; Humans ; Indians, North American/psychology ; Life Style ; Models, Educational ; Motivation ; Mythology/psychology ; Needs Assessment ; Nursing Evaluation Research ; Pilot Projects ; Rural Health
    Language English
    Publishing date 2001-12-28
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1291524-5
    ISSN 1043-6596
    ISSN 1043-6596
    DOI 10.1177/104365960201300102
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