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  1. Article ; Online: Albumin infusions and decompensated cirrhosis: No longer the elixir of life?

    Marquez, Vladimir

    Canadian liver journal

    2021  Volume 4, Issue 3, Page(s) 338–339

    Language English
    Publishing date 2021-08-09
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-4444
    ISSN (online) 2561-4444
    DOI 10.3138/canlivj-2021-0009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessment of birth cohort screening of chronic hepatitis C in colorectal cancer screening patients in British Columbia.

    Kaviani, Rojin / Chou, Frank Y / He, Chenxi / Marquez, Vladimir

    Canadian liver journal

    2024  Volume 7, Issue 2, Page(s) 286–290

    Abstract: Background: Since 2018, British Columbia (BC) has recommended chronic hepatitis C (HCV) screening for those born between 1945 and 1964, with a provincial prevalence of 2.31%. Combining HCV and colorectal cancer (CRC) screening can facilitate specialist ... ...

    Abstract Background: Since 2018, British Columbia (BC) has recommended chronic hepatitis C (HCV) screening for those born between 1945 and 1964, with a provincial prevalence of 2.31%. Combining HCV and colorectal cancer (CRC) screening can facilitate specialist referrals and follow-up. We assessed HCV screening uptake among CRC screening patients following the release of BC's birth cohort guidelines and examined the COVID-19 pandemic's impact on HCV screening practices.
    Methods: A retrospective review was conducted on patients referred to Vancouver Coastal Health Authority's CRC screening program. Two groups, Cohort A (October-December 2019) and Cohort B (December 2021), were studied to identify pandemic-related changes. Data on demographics, liver disease history, hepatitis B or HIV co-infection rates, and initial anti-hepatitis C and ribonucleic acid (RNA) testing dates were collected. Statistical analyses were performed with Stata 15.1.
    Results: A total of 579 patients were referred for the CRC screening program, of whom 465 were born between 1945 and 1964 and were included in the study. Among the 348 patients in cohort A, 144 (41%, 95% CI 36%-47%) were screened for HCV infection. Of these, four (1.2%) were positive for anti-hepatitis C, and one patient had positive RNA levels. Similar proportions of screenings were observed in cohort B (47.8%, 95% CI 39%-57%). Of those with liver disease, 66% had been screened for HCV.
    Conclusion: Birth cohort screening for HCV has been underutilized in British Columbia. Combining HCV and CRC screening could provide a practical approach to linking patients to health care.
    Language English
    Publishing date 2024-05-08
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-4444
    ISSN (online) 2561-4444
    DOI 10.3138/canlivj-2023-0024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Editorial: is there a causal link between non-selective beta blockers and portal vein thrombosis in cirrhosis?

    Marquez, Vladimir / Abraldes, Juan G

    Alimentary pharmacology & therapeutics

    2019  Volume 49, Issue 6, Page(s) 819–820

    MeSH term(s) Humans ; Liver Cirrhosis ; Longitudinal Studies ; Patients ; Portal Vein ; Prospective Studies
    Language English
    Publishing date 2019-02-27
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.15182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Editorial: screening for oesophageal varices after directly acting anti-viral therapy-do not let your guard down.

    Rathi, Sahaj / Marquez, Vladimir

    Alimentary pharmacology & therapeutics

    2019  Volume 50, Issue 4, Page(s) 461–462

    MeSH term(s) Antiviral Agents ; Esophageal and Gastric Varices ; Gastrointestinal Hemorrhage ; Hepatitis C, Chronic ; Humans ; Liver Cirrhosis ; Varicose Veins
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2019-08-24
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.15377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Elevated serum ferritin in non-alcoholic fatty liver disease is not predictive of fibrosis.

    Trasolini, Roberto / Cox, Ben / Galts, Ciaran / Yoshida, Eric M / Marquez, Vladimir

    Canadian liver journal

    2022  Volume 5, Issue 2, Page(s) 152–159

    Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is common with widely ranging severity. Non-invasive risk scores for risk stratification are recommended but misclassify a significant proportion of patients. In situations where non-invasive risk ... ...

    Abstract Background: Non-alcoholic fatty liver disease (NAFLD) is common with widely ranging severity. Non-invasive risk scores for risk stratification are recommended but misclassify a significant proportion of patients. In situations where non-invasive risk scores do not provide guidance, referral is typically made to a Hepatologist for transient elastography or liver biopsy. Serum ferritin is elevated in many patients with NAFLD related to dysmetabolic and inflammatory hyperferritinemia. Ferritin is widely available and part of a standard workup for chronic liver disease.
    Methods: To explore the association of ferritin and risk of fibrosis in NAFLD, we reviewed patients diagnosed with NAFLD at the hepatology clinic of the Vancouver General Hospital between the years of 2015 and 2018. We collected data on 317 patients retrospectively assessing for a relationship between serum ferritin and elastography score.
    Results: Two hundred twenty-four patients were included in the final analysis. Median ferritin was 145 µg/L (IQR 62-311). Median liver stiffness was 5.2 kPa with 14.3% of patients having liver stiffness ≥8.7 kPa and 17.4% ≥ 8.0 kPa. ROC curve analysis using a liver stiffness ≥8.0 kPa as a cutoff for F2 fibrosis showed an AUROC of 0.54 for serum ferritin levels. At a cut-off of both 300 µg/L; and 450 µg/L median liver stiffness did not differ significantly in those with ferritin above the cutoff (ferritin ≥300 µg/L;
    Conclusion: In this cohort of 224 patients with NAFLD, serum ferritin was not predictive of significant liver fibrosis.
    Language English
    Publishing date 2022-05-09
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-4444
    ISSN (online) 2561-4444
    DOI 10.3138/canlivj-2021-0002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID-19 infection immediately post-transplant in an unvaccinated patient: Clinical observations and ethical implications.

    Cox, Ben / Hussani, Trana / Marquez, Vladimir / Omar, Mahmoud / Segedi, Maja / Yoshida, Eric M

    Canadian liver journal

    2022  Volume 5, Issue 4, Page(s) 540–542

    Abstract: We report the case of a 28-year-old woman who presented with acute liver failure from suspected drug-induced liver injury. She was not vaccinated against COVID-19 and expressed considerable reluctance to become vaccinated, prompting discussions within ... ...

    Abstract We report the case of a 28-year-old woman who presented with acute liver failure from suspected drug-induced liver injury. She was not vaccinated against COVID-19 and expressed considerable reluctance to become vaccinated, prompting discussions within the transplant group regarding her candidacy. She received a liver transplant and acquired COVID-19 immediately post-operatively that was treated with sotrovimab. She recovered well and was discharged shortly following her transplant. This case suggests that unwillingness to receive COVID-19 vaccination pre-transplant should not represent an absolute contraindication to a life-saving liver transplantation.
    Language English
    Publishing date 2022-11-07
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-4444
    ISSN (online) 2561-4444
    DOI 10.3138/canlivj-2022-0023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Exception points for liver transplantation: A Canadian review.

    Congly, Stephen E / Marquez, Vladimir / Bhanji, Rahima A / Bhat, Mamatha / Wong, Philip / Huard, Geneviève / Zhu, Julie H / Brahmania, Mayur

    Canadian liver journal

    2023  Volume 6, Issue 2, Page(s) 201–214

    Abstract: Background: Exception points for liver transplant (LT) allocation are used to account for mortality risk not reflected by scoring systems such as the Model for End-Stage Liver Disease with sodium (MELD-Na). Currently, there is no formal policy regarding ...

    Abstract Background: Exception points for liver transplant (LT) allocation are used to account for mortality risk not reflected by scoring systems such as the Model for End-Stage Liver Disease with sodium (MELD-Na). Currently, there is no formal policy regarding exception points in Canada, and differences across the country are not well understood. As such, a review of the criteria and exception points granted throughout the country for LT was conducted.
    Methods: Seven LT centres in five provinces were surveyed (Vancouver, Edmonton, London, Toronto, Montréal, Halifax) regarding the indications and criteria for exception points granted, the number of points granted, how points would be accrued, and the maximum points granted.
    Results: Programs in British Columbia and Nova Scotia grant variable exception points based on the median MELD-Na score with modifications; Alberta, Ontario, and Quebec grant exception points using specific values based on the indication. Overall, there was significant heterogeneity regarding exception points granted nationally with agreement only for awarding exception points for hepatopulmonary syndrome and polycystic liver disease. The second most common agreed-upon indications for exception points were portopulmonary hypertension and recurrent cholangitis offered by four provinces. Quebec had the most formal criteria for non-cirrhosis-based conditions.
    Conclusions: There is substantial variance across the country regarding the indications for granting exception points as well as the number of points granted. Future work on developing a national consensus will be important for the development of equity in LT across Canada.
    Language English
    Publishing date 2023-07-26
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-4444
    ISSN (online) 2561-4444
    DOI 10.3138/canlivj-2022-0026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: B-type peptides to predict post-liver transplant mortality: systematic review and meta-analysis.

    Chahal, Daljeet / Yau, Alan / Casciato, Paola / Marquez, Vladimir

    Canadian liver journal

    2019  Volume 2, Issue 1, Page(s) 4–18

    Abstract: Background: Cirrhotic patients undergoing liver transplantation are at risk of cardiac complications. Brain natriuretic peptide (BNP) and amino terminal brain natriuretic peptide (NT-BNP) are used in cardiac risk stratification. Their significance in ... ...

    Abstract Background: Cirrhotic patients undergoing liver transplantation are at risk of cardiac complications. Brain natriuretic peptide (BNP) and amino terminal brain natriuretic peptide (NT-BNP) are used in cardiac risk stratification. Their significance in predicting mortality risk in cirrhotic patients during or after liver transplantation is unknown. We conducted a systematic review and meta-analysis to answer this question.
    Methods: An electronic search of EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews (2005-September 2016), Google Scholar, and study bibliographies was conducted. Study quality was determined, and demographic and outcome data were gathered. Random effects meta-analyses of mortality-based BNP and NT-BNP level or presence of post-transplant heart failure were conducted.
    Results: Seven studies including 2,010 patients were identified. Demographics were similar between patients with high or low BNP or NT-BNP levels. Hepatitis C was the most prevalent etiology of cirrhosis (38%). Meta-analysis revealed a pooled relative risk of 3.1 (95% CI 1.9% to 5.0%) for post-transplant mortality based on elevated BNP or NT-BNP level. Meta-analysis also revealed a pooled relative risk of 1.6 (95% CI 1.3% to 2.1%) for post-transplant mortality if patients had demonstrated post-transplant heart failure.
    Conclusions: Our analysis suggests that BNP or NT-BNP measurement may help in risk stratification and provides data on post-operative mortality in cirrhotic patients undergoing liver transplantation. Discriminatory thresholds are higher in cirrhotic patients relative to prior studies with non-cirrhotic patients. However, the number of analyzed studies is limited, and our findings should be validated further through larger, prospective studies.
    Language English
    Publishing date 2019-02-25
    Publishing country Canada
    Document type Journal Article ; Review
    ISSN 2561-4444
    ISSN (online) 2561-4444
    DOI 10.3138/canlivj.2018-0014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Treatment journey of patients with hepatocellular carcinoma using real-world data in British Columbia, Canada.

    Seung, Soo Jin / Saherawala, Hasnain / Zagorski, Brandon / Tong, Carman / Lim, Howard / Kim, Peter / Marquez, Vladimir / Gill, Sharlene / Liu, David / Davies, Janine M

    Hepatic oncology

    2024  Volume 10, Issue 4, Page(s) HEP50

    Abstract: Aim: This study examined treatment patterns, survival outcomes and healthcare costs related to hepatocellular carcinoma (HCC) in British Columbia.: Methods: The study utilized data from two physician databases (HCC and MOTION) and the provincial ... ...

    Abstract Aim: This study examined treatment patterns, survival outcomes and healthcare costs related to hepatocellular carcinoma (HCC) in British Columbia.
    Methods: The study utilized data from two physician databases (HCC and MOTION) and the provincial British Columbia transplant database.
    Results: The analysis revealed diverse treatment approaches and identified the varying treatment journeys of patients. Liver transplant and systemic therapies demonstrated improved survival rates. However, there was a scarcity of Canadian-specific cost data.
    Conclusion: The research emphasizes the complexities of managing HCC and underscores the need for personalized treatment strategies to enhance patient outcomes. These findings contribute valuable insights into HCC management and provide a foundation for future studies and interventions aimed at optimizing care and resource allocation.
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2756098-3
    ISSN 2045-0931 ; 2045-0923
    ISSN (online) 2045-0931
    ISSN 2045-0923
    DOI 10.2217/hep-2023-0004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparing the performance of Fibrosis-4 and Non-Alcoholic Fatty Liver Disease Fibrosis Score with transient elastography scores of people with non-alcoholic fatty liver disease.

    Cox, Ben / Trasolini, Roberto / Galts, Ciaran / Yoshida, Eric M / Marquez, Vladimir

    Canadian liver journal

    2021  Volume 4, Issue 3, Page(s) 275–282

    Abstract: Background: With the rate of non-alcoholic fatty liver disease (NAFLD) on the rise, the necessity of identifying patients at risk of cirrhosis and its complications is becoming ever more important. Liver biopsy remains the gold standard for assessing ... ...

    Abstract Background: With the rate of non-alcoholic fatty liver disease (NAFLD) on the rise, the necessity of identifying patients at risk of cirrhosis and its complications is becoming ever more important. Liver biopsy remains the gold standard for assessing fibrosis, although costs, risks, and availability prohibit its widespread use with at-risk patients. Transient elastography has proven to be a non-invasive and accurate way of assessing fibrosis, although the availability of this modality is often limited in primary care settings. The Fibrosis-4 (FIB-4) and Non-Alcoholic Fatty Liver Disease Fibrosis Score (NFS) are scoring systems that incorporate commonly measured lab parameters and BMI to predict fibrosis.
    Method: In this study, we compared FIB-4 and NFS scores with transient elastography scores to assess the accuracy of these inexpensive and readily available scoring systems in detecting fibrosis.
    Results: Using an NFS score cut-off of -1.455 and a FibroScan score cut-off of ≥8.7 kPa, the NFS score had a negative predictive value of 94.1%. Using a FibroScan score cut-off of ≥8.7 kPa, the FIB-4 score had a negative predictive value of 91.6%.
    Conclusion: The NFS and FIB-4 are non-invasive, inexpensive scoring systems that have high negative predictive value for fibrosis compared with transient elastography scores. These findings suggest that the NFS and FIB-4 can provide adequate reassurance to rule out fibrosis in patients with NAFLD and can be used with select patients to circumvent the need for transient elastography or liver biopsy.
    Language English
    Publishing date 2021-08-09
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-4444
    ISSN (online) 2561-4444
    DOI 10.3138/canlivj-2021-0004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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