Artikel ; Online: Bloodstream infection and ventilator-associated pneumonia in patients with coronavirus disease 2019 (COVID-19) supported by extracorporeal membrane oxygenation.
Infection control and hospital epidemiology
2022 Band 44, Heft 9, Seite(n) 1443–1450
Abstract: Objective: Extracorporeal membrane oxygenation (ECMO) has been widely used in the care of patients with respiratory failure from coronavirus disease 2019 (COVID-19). We characterized bloodstream infections (BSIs) and ventilator-associated pneumonias ( ... ...
| Abstract | Objective: Extracorporeal membrane oxygenation (ECMO) has been widely used in the care of patients with respiratory failure from coronavirus disease 2019 (COVID-19). We characterized bloodstream infections (BSIs) and ventilator-associated pneumonias (VAPs) in COVID-19 patients supported with ECMO, and we investigated their impact on patient outcomes. Design: Retrospective cohort study from March 1, 2020, to June 30, 2021. Setting: Academic tertiary-care referral center. Patients: Consecutive adult patients admitted for COVID-19 who received ECMO. Methods: We identified BSIs and VAPs and described their epidemiology and microbiology. Cumulative antimicrobial use and the specific management of BSIs were determined. Multivariate time-dependent Cox proportional hazards models were constructed to evaluate the impact of BSIs and VAPs on mortality, controlling for age, receipt of COVID-19-specific therapeutics, and new renal replacement therapy. Results: We identified 136 patients who received ECMO for COVID-19 pneumonia during the study period. BSIs and VAPs occurred in 81 patients (59.6%) and 93 patients (68.4%), respectively. The incidence of BSIs was 29.5 per 1,000 ECMO days and increased with duration of ECMO cannulation. Enterococci, Enterobacterales, and Conclusions: BSIs and VAPs are common in COVID-19 ECMO-supported patients. Efforts to optimize their diagnosis, prevention, and management should be prioritized. |
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| Mesh-Begriff(e) | Adult ; Humans ; COVID-19/epidemiology ; COVID-19/therapy ; COVID-19/etiology ; Extracorporeal Membrane Oxygenation/adverse effects ; Pneumonia, Ventilator-Associated/drug therapy ; Pneumonia, Ventilator-Associated/epidemiology ; Pneumonia, Ventilator-Associated/etiology ; Retrospective Studies ; Staphylococcus aureus ; Sepsis/etiology | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2022-12-01 | |||||
| Erscheinungsland | United States | |||||
| Dokumenttyp | Journal Article | |||||
| ZDB-ID | 639378-0 | |||||
| ISSN | 1559-6834 ; 0195-9417 ; 0899-823X | |||||
| ISSN (online) | 1559-6834 | |||||
| ISSN | 0195-9417 ; 0899-823X | |||||
| DOI | 10.1017/ice.2022.290 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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