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  1. AU="Marra, A M"
  2. AU="Haider, Kathryn M"
  3. AU="Shang, Hongcai" AU="Shang, Hongcai"
  4. AU="Ho, Collin Elijah Rui Hung"
  5. AU="Akbar, Ansa"
  6. AU="Heinrich, N"
  7. AU="Almeida, Carolina Aparecida de Faria"
  8. AU="Müller, Pavel"
  9. AU="Carosi, Mariantonia"
  10. AU="Bindu Sen"
  11. AU="Kohaut, Eva"
  12. AU="Adam F. Cohen"
  13. AU="Daniele Tomassoni"
  14. AU="Bergado, Gretchen"
  15. AU="Schomberg, Harry H"
  16. AU="Halder, Prolay"
  17. AU="Miyaguchi, Ken"
  18. AU="Zhan, Na-ping"
  19. AU="Stewart Quigg"

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  1. Artikel: Eosinophil-associated diseases: the allergist's and clinical immunologist's perspective.

    Marra, A M / Rossi, C M / Piga, M A / Moroncini, G / Bilò, M B

    European annals of allergy and clinical immunology

    2024  

    Abstract: Summary: Eosinophil-associated diseases (EADs) refer to heterogeneous conditions in which eosinophils are believed to play critical pathological roles. They encompass common respiratory conditions, such as asthma, chronic rhinosinusitis with nasal ... ...

    Abstract Summary: Eosinophil-associated diseases (EADs) refer to heterogeneous conditions in which eosinophils are believed to play critical pathological roles. They encompass common respiratory conditions, such as asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), less common primary eosinophilic disorders of gastrointestinal tract, and rare conditions including eosinophilic granulomatosis with polyangiitis (EGPA) and hypereosinophilic syndrome (HES). A literature search was carried out in January 2024 in the MEDLINE and Scopus databases using the PubMed search engine (PubMed, National Library of Medicine, Bethesda, MD). We focused on blood eosinophilia and hypereosinophilia. A diagnostic workup is proposed. From allergist's point of view, we focused the review on 4 groups of eosinophilic disorders of specific interest. Our increased understanding of type 2 inflammation and biology has recently led to development of highly effective precision targeted therapies that are now approved for a growing number of eosinophilic disorders. Novel targeted biologics have a major impact on treatment strategies and have resulted in major advances in our understanding of the pathogenesis of these disorders. In the context of EADs, according to the heterogeneity of eosinophilic disorders a multidisciplinary approach should be adopted. Allergists and Clinical Immunologists play an important role as they have a clear understanding of the eosinophilic inflammation and the role of cytokines and are trained to recognize and characterize type 2 (T2) inflammation and its associated pathologies.
    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland Italy
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2105540-3
    ISSN 1764-1489 ; 0397-9148
    ISSN 1764-1489 ; 0397-9148
    DOI 10.23822/EurAnnACI.1764-1489.339
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  2. Artikel: Long-term follow-up may be useful in coronavirus disease 2019 survivors to prevent chronic complications

    Cicco, S. / Vacca, A. / Cittadini, A. / Marra, A. M.

    Infection and Chemotherapy

    Abstract: Coronavirus disease 2019 (COVID-19) is the pandemic challenge striking many health systems worldwide The new coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2), which has a well-known tropism to lung cells, is the ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is the pandemic challenge striking many health systems worldwide The new coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2), which has a well-known tropism to lung cells, is the cause
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #918288
    Datenquelle COVID19

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  3. Artikel ; Online: Eosinophilic granulomatosis with polyangiitis (EGPA) and PRES: a case-based review of literature in ANCA-associated vasculitides.

    Marra, A M / Barilaro, G / Villella, V / Granata, M

    Rheumatology international

    2015  Band 35, Heft 9, Seite(n) 1591–1595

    Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) is a small-sized vessel systemic necrotizing vasculitis and belongs to the family of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. The involvement of central nervous system in ... ...

    Abstract Eosinophilic granulomatosis with polyangiitis (EGPA) is a small-sized vessel systemic necrotizing vasculitis and belongs to the family of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. The involvement of central nervous system in this condition is pretty rare. Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological entity described for the first time by Hinchey et al. (N Engl J Med 334(8):494-500, 1996) and characterized by MRI findings of reversible subcortical vasogenic edema predominantly in the white matter of posterior cerebral lobes. There are few case reports describing the concurrence of PRES with ANCA-associated vasculitides. We describe a case of PRES in a patient with a diagnosis of EGPA with a concise review of the literature. The exact cause of this syndrome is unknown. It has been related to eclampsia, drug-induced hypertension, renal insufficiency and also to rheumatologic diseases. Endothelial injury, hypertension and immunosuppressive medications can compromise the regulation of cerebral blood flow. In ANCA-associated vasculitides, patients presenting with symptoms of PRES represent a challenge to treatment with immunosuppressive medications. However, since an inflammatory process might be implicated, judicious use of these agents along with tight control of blood pressure and a supportive therapy may contribute to the resolution of the encephalopathic syndrome treating at the same time other manifestation related to the rheumatologic disease. Larger clinical studies are warranted to optimize the management of vasculitis-associated PRES.
    Mesh-Begriff(e) Adult ; Brain/pathology ; Churg-Strauss Syndrome/complications ; Churg-Strauss Syndrome/pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Posterior Leukoencephalopathy Syndrome/complications ; Posterior Leukoencephalopathy Syndrome/pathology
    Sprache Englisch
    Erscheinungsdatum 2015-09
    Erscheinungsland Germany
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-015-3261-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Pulmonary arterial hypertension-related myopathy: An overview of current data and future perspectives

    Marra, A.M / A. Cittadini / E. Bossone / E. Grünig / M. Arcopinto / N. Ehlken

    Nutrition, metabolism, and cardiovascular diseases. 2015 Feb., v. 25, no. 2

    2015  

    Abstract: Exercise intolerance is one of the key features of pulmonary arterial hypertension (PAH). The main determinants of exercise impairment include hypoxemia, reduced right ventricular output, perfusion/ventilation mismatch, and weakness of skeletal and ... ...

    Abstract Exercise intolerance is one of the key features of pulmonary arterial hypertension (PAH). The main determinants of exercise impairment include hypoxemia, reduced right ventricular output, perfusion/ventilation mismatch, and weakness of skeletal and breathing muscles. The aim of the current review is to describe the findings in the existing literature about respiratory and muscle dysfunction in PAH. Animal and clinical studies regarding both respiratory and peripheral skeletal muscles and the effect of exercise training on muscle function in PAH patients are analyzed.PAH myopathy is characterized by reduced skeletal muscle mass, reduced volitional and non-volitional contractility, reduced generated force, a fiber switch from type I to type II, increased protein degradation through ubiquitin–proteasome system (UPS) activation, reduced mitochondrial functioning, and impaired activation–contractility coupling. Increased inflammatory response, impaired anabolic signaling, hypoxemia, and abnormalities of mitochondrial function are involved in the pathophysiology of this process. Exercise training has been shown to improve exercise capacity, peak oxygen uptake, quality of life, and possibly clinical outcomes of PAH patients.The skeletal muscles of PAH patients show a wide spectrum of cellular abnormalities that finally culminate in muscle atrophy and reduced contractility. Exercise training improves muscle function and bears a positive impact on the clinical outcomes of PAH patients.
    Schlagwörter animals ; breathing ; clinical trials ; exercise ; hypertension ; hypoxia ; inflammation ; metabolism ; mitochondria ; muscles ; muscular atrophy ; muscular diseases ; pathophysiology ; patients ; peak oxygen uptake ; protein degradation ; pulmonary artery ; quality of life ; skeletal muscle
    Sprache Englisch
    Erscheinungsverlauf 2015-02
    Umfang p. 131-139.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1067704-5
    ISSN 0939-4753
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2014.10.005
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Natural history of SARS-CoV-2 infection in healthcare workers in Northern Italy.

    Bongiovanni, M / Marra, A M / De Lauretis, A / Bini, F / Di Carlo, D / Manes, G / Bodini, B D / Pellegrini, L / Schettino, M / Picascia, D / Bellini, A

    The Journal of hospital infection

    2020  Band 106, Heft 4, Seite(n) 709–712

    Abstract: At present, the time-frame used for the quarantine of individuals with coronavirus disease 2019 (COVID-19) is the entire duration of symptoms plus 14 days after symptom recovery; however, no data have been reported specifically for healthcare workers ( ... ...

    Abstract At present, the time-frame used for the quarantine of individuals with coronavirus disease 2019 (COVID-19) is the entire duration of symptoms plus 14 days after symptom recovery; however, no data have been reported specifically for healthcare workers (HCWs). In the study population of 142 HCWs with COVID-19, the mean time for viral clearance was 31.8 days. Asymptomatic subjects cleared the virus more quickly than symptomatic subjects (22 vs 34.2 days; P<0.0001). The presence of fever at the time of diagnosis was associated with a longer time to viral clearance (relative risk 11.45, 95% confidence interval 8.66-14.25; P<0.0001). These findings may have a significant impact on healthcare strategies for the future management of the COVID-19 pandemic.
    Mesh-Begriff(e) Adult ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/transmission ; COVID-19/virology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Female ; Health Personnel/statistics & numerical data ; Hospitalization/statistics & numerical data ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Quarantine/standards ; SARS-CoV-2/genetics ; Viral Load/trends ; Virus Shedding/drug effects ; Virus Shedding/physiology
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2020.08.027
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Pulmonary arterial hypertension-related myopathy: an overview of current data and future perspectives.

    Marra, A M / Arcopinto, M / Bossone, E / Ehlken, N / Cittadini, A / Grünig, E

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2015  Band 25, Heft 2, Seite(n) 131–139

    Abstract: Background and aim: Exercise intolerance is one of the key features of pulmonary arterial hypertension (PAH). The main determinants of exercise impairment include hypoxemia, reduced right ventricular output, perfusion/ventilation mismatch, and weakness ... ...

    Abstract Background and aim: Exercise intolerance is one of the key features of pulmonary arterial hypertension (PAH). The main determinants of exercise impairment include hypoxemia, reduced right ventricular output, perfusion/ventilation mismatch, and weakness of skeletal and breathing muscles. The aim of the current review is to describe the findings in the existing literature about respiratory and muscle dysfunction in PAH. Animal and clinical studies regarding both respiratory and peripheral skeletal muscles and the effect of exercise training on muscle function in PAH patients are analyzed.
    Data synthesis: PAH myopathy is characterized by reduced skeletal muscle mass, reduced volitional and non-volitional contractility, reduced generated force, a fiber switch from type I to type II, increased protein degradation through ubiquitin-proteasome system (UPS) activation, reduced mitochondrial functioning, and impaired activation-contractility coupling. Increased inflammatory response, impaired anabolic signaling, hypoxemia, and abnormalities of mitochondrial function are involved in the pathophysiology of this process. Exercise training has been shown to improve exercise capacity, peak oxygen uptake, quality of life, and possibly clinical outcomes of PAH patients.
    Conclusions: The skeletal muscles of PAH patients show a wide spectrum of cellular abnormalities that finally culminate in muscle atrophy and reduced contractility. Exercise training improves muscle function and bears a positive impact on the clinical outcomes of PAH patients.
    Mesh-Begriff(e) Animals ; Disease Models, Animal ; Exercise ; Exercise Tolerance ; Humans ; Hypertension, Pulmonary/complications ; Hypertension, Pulmonary/pathology ; Hypertension, Pulmonary/therapy ; Mitochondria/metabolism ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiopathology ; Muscular Atrophy/pathology ; Muscular Diseases/complications ; Muscular Diseases/pathology ; Muscular Diseases/therapy ; Oxygen Consumption ; Proteasome Endopeptidase Complex/metabolism ; Quality of Life ; Randomized Controlled Trials as Topic ; Ubiquitin/metabolism
    Chemische Substanzen Ubiquitin ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Sprache Englisch
    Erscheinungsdatum 2015-02
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2014.10.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Heart failure management during the COVID-19 outbreak in Italy

    Salzano, A. / D'Assante, R. / Stagnaro, F. M. / Valente, V. / Crisci, G. / Giardino, F. / Arcopinto, M. / Bossone, E. / Marra, A. M. / Cittadini, A.

    a telemedicine experience from a heart failure university tertiary referral centre

    2020  

    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsland it
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Natural history of SARS-CoV-2 infection in healthcare workers in Northern Italy

    Bongiovanni, M. / Marra, A.M. / De Lauretis, A. / Bini, F. / Di Carlo, D. / Manes, G. / Bodini, B.D. / Pellegrini, L. / Schettino, M. / Picascia, D. / Bellini, A.

    Journal of Hospital Infection

    2020  Band 106, Heft 4, Seite(n) 709–712

    Schlagwörter Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2020.08.027
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel: The role of skin tests with polyethylene glycol and polysorbate 80 in the vaccination campaign for COVID-19: results from an Italian multicenter survey.

    Montera, M C / Giordano, A / Asperti, C / Aruanno, A / Barzaghi, C E / Bignardi, D / Borrelli, P / Bommarito, L / Busa, M / Calafiore, P / Carusi, V / Cinquini, M / Cortellini, G / Cocchi, R / D'Auria, F / De Caro, F / Demonte, A / Di Leo, E / Di Lizia, M /
    Di Rienzo, A / Fumagalli, F / Kihlgren, P / Lodi Rizzini, F / Macchia, D / Manzotti, G / Marra, A M / Mileto, P / Mietta, S / Montagni, M / Nettis, E / Nucera, E / Peveri, S / Pivetta, D / Pirisi, M / Ramirez, G A / Rivolta, F / Rizzi, A / Savoia, A / Pedicini, A / Scarpa, A / Zambito, M / Zisa, G / Yacoub, M-R

    European annals of allergy and clinical immunology

    2023  Band 56, Heft 1, Seite(n) 17–25

    Abstract: Summary: Background. ...

    Abstract Summary: Background.
    Mesh-Begriff(e) Humans ; Polysorbates/adverse effects ; Polyethylene Glycols/adverse effects ; COVID-19 Vaccines/adverse effects ; COVID-19/epidemiology ; COVID-19/prevention & control ; Excipients/adverse effects ; Anaphylaxis/diagnosis ; Anaphylaxis/epidemiology ; Retrospective Studies ; Hypersensitivity, Immediate ; Immunization Programs ; Skin Tests ; Italy/epidemiology
    Chemische Substanzen Polysorbates ; Polyethylene Glycols (3WJQ0SDW1A) ; COVID-19 Vaccines ; Excipients
    Sprache Englisch
    Erscheinungsdatum 2023-03-16
    Erscheinungsland Italy
    Dokumenttyp Multicenter Study ; Journal Article
    ZDB-ID 2105540-3
    ISSN 1764-1489 ; 0397-9148
    ISSN 1764-1489 ; 0397-9148
    DOI 10.23822/EurAnnACI.1764-1489.291
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: The Tosca Registry: An Ongoing, Observational, Multicenter Registry for Chronic Heart Failure.

    Arcopinto, M / Salzano, A / Ferrara, F / Bobbio, E / Marra, A M / Abete, R / Stagnaro, F / Polizzi, R / Giallauria, F / Illario, M / Menditto, E / Vigorito, C / Bossone, E / Cittadini, A

    Translational medicine @ UniSa

    2016  Band 14, Seite(n) 21–27

    Abstract: The ageing of the population in western countries, the continuous increase of the prevalence of chronic diseases, the frequent coexistence of several morbid conditions (comorbidity) requires health professionals and Institutions to face difficult ... ...

    Abstract The ageing of the population in western countries, the continuous increase of the prevalence of chronic diseases, the frequent coexistence of several morbid conditions (comorbidity) requires health professionals and Institutions to face difficult challenges, including increasing costs, need for more effective and sustainable therapies, and organizational issues. The European Innovation Partnership on Active and Healthy Ageing aims at enabling European citizens to lead healthy, active and independent lives while ageing. We herein discuss some key concepts bearing a special significance in the light of the Partnership aims, and present research and educational projects active in our local environment. Among these, the multicentre project TOSCA (Trattamento Ormonale nello Scompenso CArdiaco) that, although primarily focused on the understanding of the interactions between hormones and chronic heart failure (CHF), is also aimed at developing more effective models of clinical care. We provide the scientific background and current stage of the project. In the context of a growing complexity of the patients' clinical management, the polipharmacy is a new arising challenge for clinicians, bearing direct economic, organizational and clinical implications. A better understanding, characterization and management of this issue represent an additional target of the TOSCA network.
    Sprache Englisch
    Erscheinungsdatum 2016-05-16
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ISSN 2239-9747
    ISSN 2239-9747
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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