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  1. Article ; Online: Elusive Hepatic Nodules.

    Campani, Claudia / Guido, Maria / Marra, Fabio

    Gastroenterology

    2024  

    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.03.031
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  2. Article ; Online: Intrahepatic splenosis mimicking hepatocellular carcinoma.

    Rosi, Martina / Adotti, Valentina / Citone, Michele / Marra, Fabio

    United European gastroenterology journal

    2024  Volume 12, Issue 3, Page(s) 412–414

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnosis ; Liver Neoplasms/diagnosis ; Splenosis/diagnosis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Case Reports
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12549
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  3. Article: Successful switch to ofatumumab after liver injury associated with ocrelizumab treatment in multiple sclerosis: a case report.

    Mariottini, Alice / Barilaro, Alessandro / Lotti, Antonio / Marra, Fabio / Massacesi, Luca

    Frontiers in neurology

    2024  Volume 15, Page(s) 1363493

    Abstract: Drug-induced liver injury (DILI) is a potential adverse event of disease-modifying therapies (DMTs) for the treatment of multiple sclerosis (MS), as well as of methylprednisolone pulsed therapy used in case of MS relapse. DILI may be induced by different ...

    Abstract Drug-induced liver injury (DILI) is a potential adverse event of disease-modifying therapies (DMTs) for the treatment of multiple sclerosis (MS), as well as of methylprednisolone pulsed therapy used in case of MS relapse. DILI may be induced by different mechanisms, including idiosyncratic reaction, autoimmune hepatitis or viral reactivation. In patients receiving the humanized anti-CD20 monoclonal antibody (mAb) ocrelizumab, DILI has been rarely reported and was mostly associated with hepatitis B virus (HBV) reactivation. Here we present the case of a woman with highly active relapsing-remitting MS who had experienced two episodes of DILI while receiving different DMTs, and was successfully switched to ofatumumab, a fully human anti-CD20 mAb, after a further event associated with ocrelizumab treatment and unrelated to HBV reactivation. Despite sharing the mechanism of action, differences in structure, pharmacokinetic/pharmacodynamic profile, and use of ancillary drugs (only needed for ocrelizumab) may have accounted for the successful switch. To our knowledge, this is the first report of a successful switch from ocrelizumab to ofatumumab due to DILI. Ofatumumab may therefore represent a valid therapeutic option for patients experiencing DMTs- and ocrelizumab-induced liver injury, providing that HBV reactivation has been ruled out.
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1363493
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  4. Article ; Online: An atypical case of palmo-plantar erythrodysesthesia related to cabozantinib.

    Campani, Claudia / Pimpinelli, Nicola / Marra, Fabio

    Italian journal of dermatology and venereology

    2022  Volume 157, Issue 4, Page(s) 372–374

    MeSH term(s) Anilides/adverse effects ; Humans ; Pyridines/adverse effects
    Chemical Substances Anilides ; Pyridines ; cabozantinib (1C39JW444G)
    Language English
    Publishing date 2022-07-29
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.21.07109-7
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  5. Article ; Online: A forecasting performance comparison of dynamic factor models based on static and dynamic methods

    Marra Fabio Della

    Communications in Applied and Industrial Mathematics, Vol 8, Iss 1, Pp 43-

    2017  Volume 66

    Abstract: We present a comparison of the forecasting performances of three Dynamic Factor Models on a large monthly data panel of macroeconomic and financial time series for the UE economy. The first model relies on static principal-component and was introduced by ...

    Abstract We present a comparison of the forecasting performances of three Dynamic Factor Models on a large monthly data panel of macroeconomic and financial time series for the UE economy. The first model relies on static principal-component and was introduced by Stock and Watson (2002a, b). The second is based on generalized principal components and it was introduced by Forni, Hallin, Lippi and Reichlin (2000, 2005). The last model has been recently proposed by Forni, Hallin, Lippi and Zaffaroni (2015, 2016). The data panel is split into two parts: the calibration sample, from February 1986 to December 2000, is used to select the most performing specification for each class of models in a in- sample environment, and the proper sample, from January 2001 to November 2015, is used to compare the performances of the selected models in an out-of-sample environment. The metholodogical approach is analogous to Forni, Giovannelli, Lippi and Soccorsi (2016), but also the size of the rolling window is empirically estimated in the calibration process to achieve more robustness. We find that, on the proper sample, the last model is the most performing for the Inflation. However, mixed evidencies appear over the proper sample for the Industrial Production.
    Keywords Macroeconomic Forecasting ; Dynamic Factor Models ; Time domain methods ; Frequency domain methods ; Science ; Q ; Mathematics ; QA1-939
    Subject code 310
    Language English
    Publishing date 2017-03-01T00:00:00Z
    Publisher Società Italiana di Matematica Applicata e Industriale (SIMAI)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Management of a complex transjugular intrahepatic portosystemic shunt dysfunction with endotipsitis through rotational thrombectomy.

    Vizzutti, Francesco / Casamassima, Emanuele / Falcone, Gianmarco / Gabbani, Giacomo / Rosi, Martina / Adotti, Valentina / Marra, Fabio / Fanelli, Fabrizio

    BJR case reports

    2024  Volume 10, Issue 1, Page(s) uaae005

    Abstract: Transjugular intrahepatic portosystemic shunting (TIPS) is an established strategy for the management of complications of portal hypertension. Endoprosthetic infection ("endotipsitis") is a rare but serious and difficult-to-treat complication of TIPS ... ...

    Abstract Transjugular intrahepatic portosystemic shunting (TIPS) is an established strategy for the management of complications of portal hypertension. Endoprosthetic infection ("endotipsitis") is a rare but serious and difficult-to-treat complication of TIPS placement. Here we report the occurrence of an infected thrombus complicating TIPS placement in a patient with extra-hepatic portal vein obstruction, recurrent variceal bleeding and portal biliopathy accompanied by recurrent cholangitis. Infected thrombotic material within TIPS could be removed only by employing rotational thrombectomy. This procedure revealed the presence of a biliary fistula which carried pathogens in the systemic circulation. The multiple episodes of sepsis did no longer recur following exclusion of the biliary fistula. This case highlights the possibility to use rotational thrombectomy for the management of complex cases of TIPS dysfunction.
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Case Reports
    ISSN 2055-7159
    ISSN (online) 2055-7159
    DOI 10.1093/bjrcr/uaae005
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  7. Article ; Online: NAIF: A novel artificial intelligence-based tool for accurate diagnosis of stage F3/F4 liver fibrosis in the general adult population, validated with three external datasets.

    Hassoun, Samir / Bruckmann, Chiara / Ciardullo, Stefano / Perseghin, Gianluca / Marra, Fabio / Curto, Armando / Arena, Umberto / Broccolo, Francesco / Di Gaudio, Francesca

    International journal of medical informatics

    2024  Volume 185, Page(s) 105373

    Abstract: Objective: The purpose of this study was to determine the effectiveness of a new AI-based tool called NAIF (NAFLD-AI-Fibrosis) in identifying individuals from the general population with advanced liver fibrosis (stage F3/F4). We compared NAIF's ... ...

    Abstract Objective: The purpose of this study was to determine the effectiveness of a new AI-based tool called NAIF (NAFLD-AI-Fibrosis) in identifying individuals from the general population with advanced liver fibrosis (stage F3/F4). We compared NAIF's performance to two existing risk score calculators, aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 (Fib4).
    Methods: To set up the algorithm for diagnosing severe liver fibrosis (defined as Fibroscan® values E ≥ 9.7 KPa), we used 19 blood biochemistry parameters and two demographic parameters in a group of 5,962 individuals from the NHANES population (2017-2020 pre-pandemic, public database). We then assessed the algorithm's performance by comparing its accuracy, precision, sensitivity, specificity, and F1 score values to those of APRI and Fib4 scoring systems.
    Results: In a kept-out sub dataset of the NHANES population, NAIF achieved a predictive precision of 72 %, a sensitivity of 61 %, and a specificity of 77 % in correctly identifying adults (aged 18-79 years) with severe liver fibrosis. Additionally, NAIF performed well when tested with two external datasets of Italian patients with a Fibroscan® score E ≥ 9.7 kPa, and with an external dataset of patients with diagnosis of severe liver fibrosis through biopsy.
    Conclusions: The results of our study suggest that NAIF, using routinely available parameters, outperforms in sensitivity existing scoring methods (Fib4 and APRI) in diagnosing severe liver fibrosis, even when tested with external validation datasets. NAIF uses routinely available parameters, making it a promising tool for identifying individuals with advanced liver fibrosis from the general population. Word count abstract: 236.
    MeSH term(s) Adult ; Humans ; Artificial Intelligence ; Nutrition Surveys ; Platelet Count ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/pathology
    Language English
    Publishing date 2024-02-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 1466296-6
    ISSN 1872-8243 ; 1386-5056
    ISSN (online) 1872-8243
    ISSN 1386-5056
    DOI 10.1016/j.ijmedinf.2024.105373
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  8. Article ; Online: Ghrelin and fibrogenesis: relief for a hungry liver.

    Marra, Fabio

    Journal of hepatology

    2011  Volume 55, Issue 1, Page(s) 221–223

    Language English
    Publishing date 2011-07
    Publishing country Netherlands
    Document type Comment ; Journal Article
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2011.01.027
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    Zs.A 2027: Show issues Location:
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  9. Article ; Online: Metabolic Disorders After Liver Transplantation.

    Gitto, Stefano / Falcini, Margherita / Marra, Fabio

    Metabolic syndrome and related disorders

    2020  Volume 19, Issue 2, Page(s) 65–69

    Abstract: Early after surgery, liver transplant (LT) recipients often develop weight gain due to an increase of caloric intake and fat mass (without recovery of muscle frame). This modification of body composition together with a negative metabolic impact of ... ...

    Abstract Early after surgery, liver transplant (LT) recipients often develop weight gain due to an increase of caloric intake and fat mass (without recovery of muscle frame). This modification of body composition together with a negative metabolic impact of immunosuppressive drugs leads to a high prevalence of all the main metabolic disorders. Indeed, as expected, transplanted patients show a higher cardiovascular risk in comparison with general population. Notably, seeing the increase of mean age of transplanted population, metabolic disorders represent the true challenge for the transplant community. Considering the lack of evidences or clear indications about prevention, early diagnosis and treatment of metabolic disorders after LT, it would be mandatory to develop targeted further studies on this matter.
    MeSH term(s) Animals ; Body Composition/physiology ; Humans ; Liver Transplantation/adverse effects ; Liver Transplantation/statistics & numerical data ; Metabolic Diseases/diagnosis ; Metabolic Diseases/epidemiology ; Metabolic Diseases/etiology ; Metabolic Diseases/therapy ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Prevalence ; Risk Factors
    Language English
    Publishing date 2020-10-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2020.0068
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  10. Article: The Role of the Hedgehog Pathway in Cholangiocarcinoma.

    Anichini, Giulia / Carrassa, Laura / Stecca, Barbara / Marra, Fabio / Raggi, Chiara

    Cancers

    2021  Volume 13, Issue 19

    Abstract: Cholangiocarcinoma (CCA) is a poorly treatable type of cancer and, along with hepatocellular carcinoma (HCC), is the predominant type of primitive liver cancer in adults. The lack of understanding of CCA biology has slowed down the identification of ... ...

    Abstract Cholangiocarcinoma (CCA) is a poorly treatable type of cancer and, along with hepatocellular carcinoma (HCC), is the predominant type of primitive liver cancer in adults. The lack of understanding of CCA biology has slowed down the identification of novel targets and the development of effective treatments. While tumors share some general characteristics, detailed knowledge of specific features is essential for the development of effectively tailored therapeutic approaches. The Hedgehog (HH) signaling cascade regulates stemness biology, embryonal development, tissue homeostasis, and cell proliferation and differentiation. Its aberrant activation has been associated with a variety of solid and hematological human malignancies. Several HH-inhibiting compounds have been indeed developed as potential anticancer agents in different types of tumors, with Smoothened and GLI inhibitors showing the most promising results. Beside its well-established function in other tumors, findings regarding the HH signaling in CCA are still controversial. Here we will give an overview of the most important clinical and molecular features of cholangiocarcinoma, and we will discuss the available evidence of the crosstalk between the HH signaling pathway and the cholangiocarcinoma cell biology.
    Language English
    Publishing date 2021-09-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13194774
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