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  1. Article ; Online: Technical modifications for cost optimization in robot-assisted ventral mesh rectopexy: an initial experience.

    Marra, A A / Campennì, P / De Simone, V / Parello, A / Litta, F / Ratto, C

    Techniques in coloproctology

    2023  Volume 27, Issue 7, Page(s) 551–557

    Abstract: Background: Robot-assisted ventral mesh rectopexy is considered a valid option in the treatment of rectal prolapse. However, it involves higher costs than the laparoscopic approach. The aim of this study is to determine if less expensive robotic surgery ...

    Abstract Background: Robot-assisted ventral mesh rectopexy is considered a valid option in the treatment of rectal prolapse. However, it involves higher costs than the laparoscopic approach. The aim of this study is to determine if less expensive robotic surgery for rectal prolapse can be safely performed.
    Methods: This study was conducted on consecutive patients who underwent robot-assisted ventral mesh rectopexy at Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, from 7 November 2020 to 22 November 2021. The cost of hospitalization, surgical procedure, robotic materials, and operating room resources in patients undergoing robot-assisted ventral mesh rectopexy with the da Vinci Xi Surgical Systems was analyzed before and after technical modifications, including the reduction of robotic arms and instruments, and the execution of a double minimal peritoneal incision at the pouch of Douglas and sacral promontory (instead of the traditional inverted J incision).
    Results: Twenty-two robot-assisted ventral mesh rectopexies were performed [21 females, 95.5%, median age 62.0 (54.8-70.0) years]. After an initial experience performing traditional robot-assisted ventral mesh rectopexy in four patients, we adopted technical modifications in other cases. No major complication or conversion to open surgery occurred. In total, mean cost of hospitalization, surgical procedure, robotic materials, and operating room resources was €6995.5 ± 1058.0, €5912.7 ± 877.0, €2797.6 ± 545.6, and €2608.3 ± 351.5, respectively. Technical modifications allowed a significant reduction in the overall cost of hospitalization (€6604.5 ± 589.5 versus €8755.0 ± 906.4, p = 0.001), number of robotic instruments (3.1 ± 0.2 versus 4.0 ± 0.8 units, p = 0.026), and operating room time (201 ± 26 versus 253 ± 16 min, p = 0.003).
    Conclusions: Considering our preliminary results, robot-assisted ventral mesh rectopexy with appropriate technical modifications can be cost-effective and safe.
    MeSH term(s) Female ; Humans ; Middle Aged ; Rectal Prolapse/surgery ; Robotics ; Laparoscopy/methods ; Surgical Mesh ; Treatment Outcome ; Robotic Surgical Procedures/methods
    Language English
    Publishing date 2023-02-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-023-02756-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Efficacy of Sphinkeeper™ implant in treating faecal incontinence.

    Litta, F / Parello, A / De Simone, V / Campennì, P / Orefice, R / Marra, A A / Goglia, M / Moroni, R / Ratto, C

    The British journal of surgery

    2020  Volume 107, Issue 5, Page(s) 484–488

    Abstract: The primary aim of this prospective study was to assess the efficacy of Sphinkeeper™ (SK) implantation in patients with faecal incontinence. Forty-two patients with faecal incontinence (14 with sphincter defects) underwent SK implantation and were ... ...

    Abstract The primary aim of this prospective study was to assess the efficacy of Sphinkeeper™ (SK) implantation in patients with faecal incontinence. Forty-two patients with faecal incontinence (14 with sphincter defects) underwent SK implantation and were followed up for a mean(s.d.) of 15·9(8·6) months. SK implantation was a safe and effective method that improved patients' quality of life. Implants and incontinence.
    MeSH term(s) Aged ; Anal Canal/diagnostic imaging ; Anal Canal/physiopathology ; Anal Canal/surgery ; Fecal Incontinence/diagnostic imaging ; Fecal Incontinence/physiopathology ; Fecal Incontinence/surgery ; Female ; Humans ; Manometry ; Middle Aged ; Prospective Studies ; Prostheses and Implants/adverse effects ; Quality of Life ; Ultrasonography
    Language English
    Publishing date 2020-02-17
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Haemorrhoidal haemodynamic changes in patients with haemorrhoids treated using Doppler-guided dearterialization.

    Parello, A / Litta, F / De Simone, V / Campennì, P / Orefice, R / Marra, A A / Goglia, M / Santoro, L / Santoliquido, A / Ratto, C

    BJS open

    2021  Volume 5, Issue 2

    Abstract: Background: Arterial hyperflow to haemorrhoids has been implicated as a possible pathophysiological co-factor in haemorrhoidal disease. The purpose of this study was to investigate how transanal haemorrhoidal dearterialization (THD) can influence ... ...

    Abstract Background: Arterial hyperflow to haemorrhoids has been implicated as a possible pathophysiological co-factor in haemorrhoidal disease. The purpose of this study was to investigate how transanal haemorrhoidal dearterialization (THD) can influence haemodynamic parameters at the level of the haemorrhoidal piles.
    Methods: Patients with grade III haemorrhoids selected for THD between July and December 2018 were evaluated using endoanal ultrasonography and colour Doppler imaging at the level of internal haemorrhoids before and 1 year after the surgical procedure. Peak systolic velocity, pulsatility index, resistivity index, acceleration time, and end-diastolic velocity were measured, and preoperative and postoperative values compared. Symptom severity was measured using a symptom-based questionnaire (score range 0-20).
    Results: Of 21 patients treated, 17 completed the study. Compared with preoperative values, postoperative peak systolic velocity (mean(s.d.) 18.7(1.1) versus 10.3(0.4) cm/s; P < 0.05), pulsatility index (5.5(0.3) versus 2.8(0.4); P < 0.050), and resistivity index (1.0(0.2) versus 0.8(0.5); P < 0.050) decreased significantly, whereas acceleration time increased significantly (65.6(3.6) versus 83.3(4.7) cm/s2; P < 0.050); end-diastolic velocity did not change (1.9(0.2) versus 2.0(0.4); P = 0.753). Symptoms disappeared or had improved significantly in all patients by 1 year after surgery. The mean(s.d.) total symptom severity score decreased from 15.8(1.1) to 1.2(1.6) (P < 0.001).
    Conclusion: THD affects the main haemodynamic parameters at the level of internal haemorrhoids and is associated with a decrease in arterial hyperflow.
    MeSH term(s) Adult ; Anal Canal/blood supply ; Anal Canal/diagnostic imaging ; Anal Canal/surgery ; Female ; Hemodynamics ; Hemorrhoidectomy ; Hemorrhoids/diagnostic imaging ; Hemorrhoids/surgery ; Humans ; Italy ; Male ; Middle Aged ; Rectum/blood supply ; Rectum/diagnostic imaging ; Rectum/surgery ; Treatment Outcome ; Ultrasonography, Doppler
    Language English
    Publishing date 2021-04-09
    Publishing country England
    Document type Journal Article
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrab012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Simple fistula-in-ano: is it all simple? A systematic review.

    Litta, F / Parello, A / Ferri, L / Torrecilla, N O / Marra, A A / Orefice, R / De Simone, V / Campennì, P / Goglia, M / Ratto, C

    Techniques in coloproctology

    2021  Volume 25, Issue 4, Page(s) 385–399

    Abstract: Background: Simple anal fistula is one of the most common causes of proctological surgery and fistulotomy is considered the gold standard. This procedure, however, may cause complications. The aim of this systematic review was to assess the surgical ... ...

    Abstract Background: Simple anal fistula is one of the most common causes of proctological surgery and fistulotomy is considered the gold standard. This procedure, however, may cause complications. The aim of this systematic review was to assess the surgical treatment of simple anal fistula with traditional and sphincter-sparing techniques.
    Methods: A literature research was performed using PubMed, Cochrane, and Google Scholar to identify studies on the surgical treatment of simple anal fistulas. Observational studies and randomized clinical trials were included. We assessed the risk of bias of included studies using the Jadad scale for randomized controlled trials, and the MINORS Scale for the remaining studies.
    Results: The search returned 456 records, and 66 studies were found to be eligible. The quality of the studies was generally low. A total of 4883 patients with a simple anal fistula underwent a sphincter-cutting procedure, mainly fistulotomy, with a weighted average healing rate of 93.7%, while any postoperative continence impairment was reported in 12.7% of patients. Sphincter-sparing techniques were adopted to treat 602 patients affected by simple anal fistula, reaching a weighted average success rate of 77.7%, with no study reporting a significant postoperative incontinence rate. The postoperative onset of fecal incontinence and the recurrence of the disease reduced patients' quality of life and satisfaction.
    Conclusions: Surgical treatment of simple anal fistulas with sphincter-cutting procedures provides excellent cure rates, even if postoperative fecal incontinence is not a negligible risk. A sphincter-sparing procedure could be useful in selected patients.
    MeSH term(s) Anal Canal ; Fecal Incontinence/etiology ; Humans ; Organ Sparing Treatments ; Quality of Life ; Rectal Fistula/surgery ; Treatment Outcome
    Language English
    Publishing date 2021-01-02
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-020-02385-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Impact of COVID-19 Quarantine on Advanced Hemorrhoidal Disease and the Role of Telemedicine in Patient Management

    Campennì, P. / Marra, A. A. / Ferri, L. / Orefice, R. / Parello, A. / Litta, F. / De Simone, V. / Goglia, M. / Ratto, C.

    J Clin Med

    Abstract: The aims of this population study were to assess the lockdown impact on patients waiting for hemorrhoidal surgery, and the role of telemedicine in patient management All patients on our waiting list for hemorrhoidal surgery were considered Eligible ... ...

    Abstract The aims of this population study were to assess the lockdown impact on patients waiting for hemorrhoidal surgery, and the role of telemedicine in patient management All patients on our waiting list for hemorrhoidal surgery were considered Eligible patients were contacted by phone Rørvik score was evaluated and compared to the baseline score Univariate and multivariate analyses were performed A numeric rating scale was used to estimate patient satisfaction regarding telemedicine One-hundred and ten patients were found to be eligible Finally, 103 patients were included in the study of whom 16 (15 3%) were already considered for priority surgery Patients waiting for a longer time showed significantly worse scores (p < 0 001) After telemedicine evaluation the priority waiting list increased by 43 8% (plus 23 patients) Weight loss of at least 3 kg and physical activity were found to be protective factors (p = 0 02 and p = 0 002 respectively) A high grade of satisfaction (almost 80%) towards telemedicine was registered COVID-19-related delays are linked to a deterioration of hemorrhoidal symptoms and patients' well-being Weight and lifestyle changes were deemed key factors in determining disease severity Telemedicine was a valuable tool to evaluate and re-evaluate patients waiting for hemorrhoidal surgery and was considered satisfactory by patients
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #895375
    Database COVID19

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  6. Article: High value products from low value wood

    Marra, A.A

    Forest products journal. Feb 2003. v. 53 (2)

    2003  

    Keywords wood ; wood products ; wood utilization ; waste wood ; wood technology ; composite wood products ; product development ; new products ; processing technology
    Language English
    Dates of publication 2003-02
    Size p. 6-13.
    Document type Article
    ZDB-ID 240509-x
    ISSN 0015-7473
    ISSN 0015-7473
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Adhesives for wood composites

    Marra, A.A

    Adhesives for wood : research, applications, and needs / edited by Robert H. Gillespie.

    1984  

    Keywords adhesives ; composite wood products
    Language English
    Size p. 223-227.
    Publisher Noyes Publications, c1984.
    Publishing place Park Ridge, N.J.
    Document type Article
    Note Paper presented at the symposium on Wood Adhesives--Research, Applications, and Needs, September 23-25, 1980, Madison, Wisconsin.
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Southern hardwoods in wood-foam composites

    Marra, A.A / Hausknecht, W.A / Day, R.F

    Forest products journal. Feb 1976, 26 (2)

    1976  

    Keywords forestry ; forest products ; forest industries
    Language English
    Dates of publication 1976-02
    Size p. 12-19.
    Document type Article
    ZDB-ID 240509-x
    ISSN 0015-7473
    ISSN 0015-7473
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Low density composites from high density hardwoods

    Marra, A.A / Hausknecht, W.A / Day, R.F

    Feb 1975, 610

    1975  

    Title variant Low density composites from high density hardwoods [Residuewood]
    Institution Agricultural Experiment Station
    Keywords forestry ; forest products ; forest industries
    Language English
    Dates of publication 1975-02
    Size 45 p.
    Document type Article
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

    Nepogodiev D. / Bhangu A. / Glasbey J.C. / Li E. / Omar O.M. / Simoes J.F. / Abbott T.E. / Alser O. / Arnaud A.P. / Bankhead-Kendall B.K. / Breen K.A. / Cunha M.F. / Davidson G.H. / Di Saverio S. / Gallo G. / Griffiths E.A. / Gujjuri R.R. / Hutchinson P.J. / Kaafarani H.M. /
    Lederhuber H. / Loffler M.W. / Mashbari H.N. / Minaya-Bravo A. / Morton D.G. / Moszkowicz D. / Pata F. / Tsoulfas G. / Venn M.L. / Cox D. / Roslani A.C. / Alakaloko F. / de Vries J.-P.P. / Aaraj M.A. / Abbott S.J. / Abdalla M.O. / Abdelaal A.S. / Ademuyiwa A.O. / Aherne T.M. / Ali O.M. / Alkadeeki G.Z. / Almeida A.C. / Alrahawy M.M. / Ambler G.K. / Alameer E. / Andreani S.M. / De Andres-Asenjo B. / Antonanzas L.L. / Aoun S.G. / Ashoush F.M. / Augestad K.M. / Avellana R.B. / Ayeni F.A. / Ayorinde J.O. / Babu B.H. / Baig M.M. / Bajomo O.M. / Baker O.J. / Baker M.P. / Baldwin A.J. / Ban V.S. / Baron R.D. / Barranquero A.G. / Barry C.P. / DI Bartolomeo A. / Bass G.A. / Bath M.F. / Batjer H.H. / Beamish A.J. / Belgaumkar A.P. / Bence M.N. / Benson R.A. / Bernal-Sprekelsen J.C. / Bhama A.R. / Bhavaraju A.V. / Biffl W.L. / Blundell C.M. / Boddy A.P. / Borgstein A.B. / Bosanquet D.C. / Bosch K.D. / Bouhuwaish A.E. / Bozkurt M.A. / Brathwaite C.E. / Brown B.C. / Brown O.D. / Brown A.K. / Buarque I.L. / Bueno-Canones A.D. / Bulugma M.R. / Burke J.R. / Byrne M.H. / Cagigal-Ortega E.P. / Callcut R.A. / DI Candido F. / Canova M.E. / Carlos W.J. / Caruana E.J. / Cato L.D. / Catton A.B. / Ceretti A.P. / Chase T.J. / Chiara F.D. / Chowdhury A.H. / Chung E.A. / Cicerchia P.M. / Clough E.C. / Coleman N.L. / Collins C.G. / Collins M.L. / Colonna E.T. / Comini L.V. / Coughlin P.A. / Cruzado L.F.-G. / Davidson B.R. / Davies R.J. / Davies E.J. / Davis N.F. / Dawson B.E. / Dean B.J. / Delgado M.G.-C. / Diaz J.J. / Dickson K.E. / Diez-Alonso M.M. / Dixon J.R. / Doe M.J. / Drake T.D. / Drake F.T. / Duffy J.P. / Dunne D.F. / Dunne N.J. / Duran-Munoz-Cruzado V.M. / Durst A.Z. / Eardley N.J. / Edwards J.G. / Elfallal A.H. / Elfiky M.M. / Elliott J.A. / Emile S.H. / Emslie K.M. / Endorf F.W. / Engel J.L. / Enjuto D.T. / Etchill E.W. / Evans J.P. / Fahey B.A. / Faria C.S. / Feo C.V. / Ferguson H.J. / Fernandez B.D. / Fernandez A.G. / Fernandez A.J. / Fernandez-Pacheco B.C. / Fitzgerald J.E. / Fonsi G.B. / Font R.F. / Fowler A.L. / Fretwell K.R. / Fructuoso L.S. / Fusai G.K. / Garcia M.H. / Garcia-Urena M.A. / Gill C.K. / Gisbertz S.S. / Del Giudice R. / Giuffrida M.C. / Di Giuseppe M. / Gomez M.F. / Guariglia C.A. / Hainsworth A.J. / Hall B.J. / Hall J.R. / Hammond J.S. / Haqqani M.H. / Harrison E.M. / Hazelton J.P. / van Heinsbergen M. / Hill A.D. / Hing C.B. / Hirji S.A. / Ho M.W. / Holbrook C.M. / Holme T.J. / Hopkins J.C. / Hopkinson D.N. / Hossain F.S. / Hudson V.E. / Hughes J.L. / Hwang E.S. / Ibrahim M.A. / Isolani S.M. / Jenkinson M.D. / Jenny H.E. / Jeyaretna D.S. / Jones R.P. / Jones A.P. / Jonker P.K. / Jonsson M.L. / Joyce D.P. / Kalkwarf K.J. / Kamarajah S.K. / El Kassas M. / Kavanagh D.O. / Keatley J.M. / Khalefa M.A. / Khan J.S. / Kirmani B.H. / Kisiel A.P. / Kouris S.M. / Kowal M.R. / Labib P.L. / Larkin J.O. / Lauscher J.C. / Leclercq W.K. / Ledesma F.S. / Leite-Moreira A.M. / Leung E.Y. / Lewis S.E. / Lima M.J. / Lin D.J. / Liu H.H. / Lowery A.J. / Lozano S.M. / Luney C.R. / Maia M.M. / Mariani N.M. / Marino M.V. / Marra A.A. / Marsh C.L. / Martin R.C. / McCluney S.J. / McIntyre R.C. / Mckay S.C. / McKevitt K.L. / Meagher A.D. / Mehdi M.Q. / Mehigan B.J. / Gonzalez-De Miguel M. / De Miguel-Ardevines M.-C. / Mills S.J. / Mohan H.M. / Moir J.A. / Monson J.R. / Monteiro J.M. / Montella M.T. / Montesinos C.S. / Morgom M.M. / Moura F.S. / Muguerza J.M. / Murphy S.H. / De Nardi P. / Naumann D.N. / Neary P.C. / Neely D.T. / Ng-Kamstra J.S. / Ngu A.W. / Nguyen T.A. / Nita G.E. / Nunes Q.M. / Nygaard R.M. / O'Meara L.B. / O'Neill J.R. / Okafor B.U. / Olson S.A. / Oo A.Y. / Ormazabal P.C. / Osorio A.L. / Pachl M.J. / Parry J.T. / Patel P.K. / Perez-Sanchez L.E. / Pevidal A.N. / Pezzuto A.P. / Philp M.M. / Pinkney T.D. / Pollok J.M. / Povey M.G. / Poza A.A. / Rajgor A.D. / Rao J.N. / Raptis D.A. / Rice H.E. / Ridgway P.F. / Rivas A.M. / Rodriguez-Sanjuan J.C. / Rogers L.J. / Da Roit A. / Rollett R.A. / Romera J.L. / Rooney S.M. / Roxo V.I. / Le Roy B. / Rubio E.E. / Ruiz C.C. / Ruiz M.L. / Ryan E.J. / Saad A.R. / Saeed S.A. / Salama H.A. / Salamah A.A. / Sampietro G.M. / Sarma D.R. / Schaffer K.B. / Schnitzbauer A.A. / Scurrah R.J. / Serevina O.L. / Serralheiro P.A. / Sewards J.M. / Shackcloth M.J. / Shaw A.V. / Sheel A.R. / Sica G.S. / De Simone V. / Singh A.A. / Singh R.P. / Skelly B.L. / Smith H.G. / Sohail A.H. / Spalding D.R. / Springford L.R. / Ssentongo A.E. / Steinkamp P.J. / Stevens K.A. / Stewart G.D. / Stylianides N.A. / Sullivan T.B. / Taher A.S. / Tamimy M.S. / Tang A.M. / Tebala G.D. / Tejero-Pintor F.J. / Thaha M.A. / Thomas A.J. / De Toma G. / La Torre F. / Torres A.J. / Townshend D.N. / Trout I.M. / Tucker S.C. / Ubhi H.K. / Vega V.A. / Velmahos G.C. / Velopulos C.G. / Viswanath Y.K. / Vivas A.A. / Wade R.G. / Wadley M.S. / Wall J.J. / Walters A.M. / Warren O.J. / Weerasinghe C.K. / Wilkin R.J. / Williams K.J. / Winter S.C. / Wormald J.C. / Wright F.L. / Xyda S.E. / Young A.L. / Youssef M.M. / Yousuf F.B. / El Youzouri H. / Zappa M.A. / Abate E. / Abdalaziz H. / Abdelkarim M. / Abdou H. / Aboelkassem-Ibrahim A. / Abuown A. / Acebes-Garcia F. / Acharya M. / Adamina M. / Addae-Boateng E. / Aftab R. / Agarwal A. / Aguilar J. / Ahmed Y. / Aitken E. / Al-Azzawi M. / Al-Embideen S. / Al-Masri M. / Al-Najjar H. / Al-Sukaini A. / Alam R. / Alderson D. / Aliyeva Z. / Aljanadi F. / Almasri M. / Alonso-Ortuno P. / Altintoprak F. / Amira G. / Amjad R. / Anania G. / Andabaka T. / Angelou D. / Annamalai S. / Annessi V. / Anthoney J. / Anwar S. / Anwer M. / Aragon-Chamizo J. / Ardito A. / Arigoni M. / Armao T. / Arminio A. / Armstrong L. / Arnaud A. / Asaad P. / Ashcroft J. / Ashmore C. / Asqalan A. / Asti E. / Aubry E. / Aytac E. / Ayuso-Herrera E. / Baeza M. / Bailon-Cuadrado M. / Bakmaz B. / Baldi C. / Baldini E. / Baldo S. / Ballabio M. / Baloyiannis I. / Baltazar G. / Bambina F. / Bandiera A. / Barlow E. / Barmasse R. / Barmpagianni C. / Baronio G. / Barra F. / Bartsch A.-M. / Basgaran A. / 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Gomez Diaz C.J. / Garcia Galocha J.L. / de Gheldere C.A. / Ataide Gomes G.M. / Beltran de Heredia J. / Blazer III D.G. / Nugent III W.C. / Ali karar A.A. / Borja De Lacy F. / Blas Laina J.L. / Shane Lester M.J. / Liyanage A.S.D. / Al Maadany F.S. / De Marchi J.A. / Ramos-De la Medina A. / Mithany R.H.M. / Sanchez del Pueblo C. / van Ramshorst G.H. / De Salas M.M. / De Souza A.C. / Dolores Del Toro M. / Archer J.E. / Odeh A. / Erridge S. / Salem H.K. / Jones G.P. / Gardner A. / Tripathi S.S. / Gregg A. / Jeganathan R. / Siddique M.H. / Lombardi C.P. / Martin B. / Leo C.A. / Dass D. / Di Franco G. / Jiao L.R. / Mari G.M. / Capitan-Morales L.-C. / Connelly T.M. / Alanbuki A. / De Virgilio A. / Schilling C. / San Miguel Mendez C. / Kulkarni G. / Nizami K. / Walsh S. / Dean H. / Ruiz-Marin M. / Houston R. / Trompetto M. / Chrastek D. / Kouritas V. / Cannoletta M. / Rosato F. / Kaushal M.V. / Costa P.M. / Elkadi H.H. / Johnstone J.R. / Irvine E. / Alvarez M.R. / Corbellini C. / Venkatesan G.S. / Mateo-Sierra O. / Martinez-Perez C. / Serrano Gonzalez J. / Hernandez Bartolome M.A. / Diaz Perez D. / Gutierrez Samaniego M. / Galindo Jara P. / Sharma N. / Smart N.J. / Keller D.S.

    an international cohort study

    2020  

    Abstract: Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and ... ...

    Abstract Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p<0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p<0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p<0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
    Keywords Adult ; Aged ; Betacoronavirus ; Coronavirus Infections ; Elective Surgical Procedures ; Emergency Medical Services ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia ; Viral ; Postoperative Complications ; Respiratory Tract Diseases ; Retrospective Studies ; Surgical Procedures ; Operative ; Young Adult ; covid19
    Subject code 610 ; 616
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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